PAI-1 and the Metabolic Syndrome: Links, Causes, and Consequences

Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

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The metabolic syndrome

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The metabolic syndrome

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Increased oxidative stress in obesity and its impact on metabolic syndrome

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Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

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The Metabolic Syndrome: Time for a Critical Appraisal

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Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis

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Impact of the Metabolic Syndrome on Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in United States Adults

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Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris

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A transgenic model of visceral obesity and the metabolic syndrome

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An RNA Aptamer Targeting PAI-1 That Restores tPA Activity, Unexpectedly Suppresses Cancer Cell Progression

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Bariatric surgery improves fibrinolysis in individuals with obesity with and without concomitant type 2 diabetes

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Metabolic Syndrome in Children and Adolescents: Looking to New Markers

Fazeli, M., Mohammad‐Zadeh, M., Meshkat, Z., Ghazizadeh, H., Barati, E., Ferns, G. A., & Ghayour‐Mobarhan, M. (2021) · Current Treatment Options in Pediatrics · doi:10.1007/s40746-021-00226-7 · Cited by 2

Venous Thromboembolism in Hospitalized Patients With Surgical Breast Cancer: Risks and Outcomes

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Associations of ALT/AST, a marker of hepatosteatosis, with pulse rate in young women and with blood pressure in middle-aged women independently of abdominal fat accumulation and insulin resistance

Minato-Inokawa, S., Tsuboi-Kaji, A., Honda, M., Takeuchi, M., Kitaoka, K., Kurata, M., Wu, B., Kazumi, T., & Fukuo, K. (2024) · Diabetology International · doi:10.1007/s13340-023-00689-z · Cited by 2

Effects of Aging on Secreted Adipocytokines in Visceral Fat of Female C3H/HeJ Mice Consuming a Long-Term High-Fat Diet

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Dioxin-Induced PAI-1 Expression: A Novel Pathway to Pancreatic β-Cell Failure in Type 2 Diabetes

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Whole blood gene expression analysis of spontaneous hypertriglyceridemia in dogs suggests an underlying pro-thrombotic process

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Type 2 Diabetes and Fibrinolysis

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Inhibidor del activador del plasminógeno tipo 1 (PAI-1) y su relación con la aterosclerosis coronaria

Ciszek, A., Bermúdez, V., Bermúdez, F., Cano, R., Finol, F., Faría, J., Acosta, L., Arráiz, N., Reyes, F., & Gómez, F. (2007) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 2

Die Bedeutung thrombophiler Risikofaktoren bei Patienten mit arteriellen Thrombosen

Zotz, R. B. (2008) · Hämostaseologie · doi:10.1055/s-0037-1617169 · Cited by 2

Association of Metabolic Syndrome with Serum Adipokines in Community-Living Elderly Japanese Women: Independent Association with Plasminogen Activator-Inhibitor-1

Takeuchi, M., Tsuboi, A., Kurata, M., Fukuo, K., & Kazumi, T. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0014 · Cited by 2

Tissu adipeux viscéral et thrombose

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Aging: Thromboembolic Disease, Metabolic Syndrome, Type 2 Diabetes Mellitus, and Alzheimer’s Disease

Lasierra-Cirujeda, J., Pascual-Salcedo, M. J. A., Lasierra-Ibañez, A., AZA, C. L., & Aza‐Pascual‐Salcedo, M. (2016) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2016.45001 · Cited by 3

Fibrinolytic parameters under ischemic stroke with diabetes mellitus combination

Tymoshenko, M. (2019) · Periodicum Biologorum · doi:10.18054/pb.v120i2-3.6703 · Cited by 2

Risk factors and treatment interventions associated with incomplete thrombus resolution and pulmonary hypertension after pulmonary embolism

Fang, A. S., Mayorga‐Carlin, M., Han, P., Cassady, S. J., John, T., LaRocco, A. M., Etezadi, V., Jones, K. M., Nagarsheth, K., Toursavadkohi, S. A., et al. (2023) · Journal of Vascular Surgery Venous and Lymphatic Disorders · doi:10.1016/j.jvsv.2023.08.006 · Cited by 2

Evaluación de parámetros inflamatorios, trombóticos y variantes genéticas en pacientes con ataque cerebrovascular isquémico que se asisten en un hospital de Uruguay

López, E., Bonino, L. E., Medeiros, R., Lena, A., Vaucher, A., & Esperón, P. (2023) · Revista Uruguaya de Medicina Interna · doi:10.26445/08.03.4 · Cited by 2

Role of plasminogen activator inhibitor and free fatty acids in diagnosis of insulin resistance in patients with myocardial infarction

Gruzdeva, O. V., Барбараш, О. Л., Евгеньевна, А. О., Федорова, Т. С., Ивановна, П. Е., Kashtalap, V. V., Dyleva, Y., Силонова, А. А., Sionina, E. V., & Учасова, Е. Г. (2011) · Diabetes Mellitus · doi:10.14341/2072-0351-5811 · Cited by 2

Adipose Tissue and Blood Pressure Regulation

Cassis, L. A., & Police, S. B. (2010) · Wiley eBooks · doi:10.1002/9783527629527.ch13 · Cited by 2

Obesity and Dyslipidemia: Importance of Body Fat Distribution

Tchernof, A., & Després, J. (2009) · Wiley eBooks · doi:10.1002/9781444307627.ch13 · Cited by 2

Mechanisms and effects of low plasminogen activator inhibitor type 1 activity

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Plasminogen activator inhibitor-1 levels in prior gestational diabetes mellitus: A systematic review and meta-analysis

Tiongco, R. E., Dizon, G., Catacata, M., Dominguez, M. J., Navarro, A., Villavieja, A., & Pineda-Cortel, M. R. (2024) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-024-01352-2 · Cited by 1

Indications of the SERPINE 1 variant rs1799768’s role in anti-VEGF therapy resistance in neovascular age-related macular degeneration

Çevik, M. Ö., Altuntaş, Z. M., & Çevik, S. G. (2025) · PLoS ONE · doi:10.1371/journal.pone.0317511 · Cited by 1

Varietal Differences in Kidney Beans Modulate Gut Microbiota and Inflammation During High-Fat Diet-Induced Obesity in Male Mice

Rodrigue, A. F., Pereira, B. B., Freije, G., Sweet, A., Mahmoudian, L., Aly, M., Mahmoodianfard, S., Kishore, L., Audet, M., Minicucci, M. F., et al. (2026) · Nutrients · doi:10.3390/nu18030461 · Cited by 1

Pathophysiology and pharmacotherapy of cardiovascular complications in metabolic syndrome

Dhalla, N. S., Patel, C. A., Beladiya, J., Mehta, A. A., & Gandhi, T. R. (2026) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2026.04.007 · Cited by 1

Bioactivities of Milk Polar Lipids in Influencing Intestinal Barrier Integrity, Systemic Inflammation, and Lipid Metabolism

Zhou, A. L. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/a9ed-ea57 · Cited by 1

Low PAI‐1 activity in relation to inflammatory parameters, insulin profile and body mass index

Ågren, A., Wiman, B., & Schulman, S. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01999.x · Cited by 1

PAI-1 and lifestyle-related illnesses

Yamamoto, K. (2008) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.19.55 · Cited by 1

Metabolic syndrome-related markers in obese university students in Kagoshima, Japan: Implications of uric acid and plasminogen activator inhibitor type-1

Nagata, M., Ijichi, S., Hashiguchi, T., Morioka, H., & Arimura, K. (2009) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2009.02.009 · Cited by 1

Metformin in patients with ischemic heart disease and type 2 diabetes mellitus: mechanism of action and clinical efficiency

Кравчук, Е. Н., & Galagudza, M. M. (2013) · Diabetes Mellitus · doi:10.14341/2072-0351-3590 · Cited by 1

Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders

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Obesity and cardiovascular disease in reproductive health

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Metabolic Syndrome

Sawhney, A. G., & Rothkopf, M. M. (2014) · CRC Press eBooks · doi:10.1201/b17616-7 · Cited by 2

Insulin resistance, metabolic syndrome and micro-RNA-122 serum level in patients with cerebral venous sinus thrombosis: a case-control study

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Blood Biomarkers Associated with Metabolic Syndrome: Implications for Public Health Screening

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An updated systematic review and meta-analysis: correlation between circulating plasminogen activator inhibitor-1 levels and metabolic dysfunction-associated steatotic liver disease

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Evaluating PAI-1 as a biomarker for stress in diving: human serum total PAI-1 is unaltered after 2 h dry exposures to 280 kPa hyperbaric air

Eftedal, I., Fredriksen, H. A., Hjelde, A., & Møllerløkken, A. (2015) · Physiological Reports · doi:10.14814/phy2.12437 · Cited by 1

Relationship between 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene and obesity in Argentinian Hispanic adults

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Off-target genomic effects in MRP8-Cre driver mice complicate its use in weight gain and metabolic studiesPreprint

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Impairment of Endothelial Thromboprotective Function by Haemodynamic and Inflammatory Stress Implications for hypertensive disease

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Adipocitocinas na síndrome antifosfolípide primária: potenciais marcadores de inflamação, resistência insulínica e síndrome metabólica

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BLOOD PRESSURE ELEVATION: IMPACT ON CARDIOVASCULAR STRUCTURE AND ENDOGENOUS FIBRINOLYSIS

Ridderstråle, W. (2008) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Cardiovascular risk factors and risk of venous thromboembolism

Brækkan, S. K. (2010) · NORA - Norwegian Open Research Archives

Receptor cross talk in arsenic-impaired fat metabolism

Garciafigueroa, D. Y. (2014) · D-Scholarship@Pitt (University of Pittsburgh)

HepG2細胞におけるインスリンと酸化ストレスのPAI-1産生に対する影響の解析: メタボリックシンドロームの易血栓性の病態解明を指向して

宮川隆, 朝倉健文, 友美, 中., 由樹, 佐., 浩美, 岡., Iwaki, S., & 聡, 藤. (2010) · 心臓 · doi:10.11281/shinzo.42.1153

The association between fibrinolysis markers and body composition in black adults in the North West Province of South Africa

Eksteen, P. (2014)

The role of the fibrinolytic system in arterial and venous thrombosis

Meltzer, M. E. (2010) · Utrecht University Repository (Utrecht University)

Siofor influence on the process of lipid peroxidation and antioxidant status at patients with metabolic syndrome

Чернышева, Е. Н., & Панова, Т. Н. (2014) · Russian Open Medical Journal · doi:10.15275/rusomj.2014.0402

Impact of antibiotic use, alternative therapies and inflammation on the intestinal microbiota

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Diabetes Mellitus and Cardiovascular Risk : epidemiology, etiology and intervention

Rautio, A. (2016) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Syndrome métabolique et compléments alimentaires

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Single fluorescence probes along the reactive center loop reveal site-specific changes during the latency transition of PAI-1

Qureshi, T., & Peterson, C. B. (2015) · Protein Science · doi:10.1002/pro.2839

Effect of processing techniques on yield and quality of Western Australian olive oil

Chih, H. (2009) · eSpace (Curtin University)

Современный подход к оценке артериальной гипертензии в сочетании с метаболическими нарушениями

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Role of Antioxidants and Polyphenols in Thrombosis and Haemostatic Function

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Biomarkers of cerebral atherosclerosis: The potential for early diagnosis and individual risk prognosis

Tanashyan, M. M., Раскуражев, А. А., Шабалина, А. А., Лагода, О. В., & Gnedovskaya, E. V. (2016) · Human Physiology · doi:10.1134/s0362119716080132

Venous and arterial thromboembolism: a questionable dichotomy

van Schouwenburg, I. M. (2012)

Intakes of Whole and Refined Grains and Dietary Fibre In Relation to Plasma Inflammatory Protein Concentrations

Masters, R. C. (2009) · TSpace (University of Toronto)

Impact of White and Dark Red Kidney Beans on Intestinal and Metabolic Health in C57Bl/6 Male Mice

Rodrigue, A. F. (2019) · uO Research (University of Ottawa) · doi:10.20381/ruor-24172

Prevalence and Risk Factors of Adolescent Venous Thromboembolism

Mahjerin, A., Jaffray, J., & Branchford, B. R. (2020) · Springer eBooks · doi:10.1007/978-3-030-48446-0_13

Functional Characterization of Fibrinolysis-Modulating Proteins Using High Throughput Phage Display

Huttinger, Z. M. (2018) · Deep Blue (University of Michigan)

NAFLD and Cardiovascular and Cardiac Disease: Clinical Implications

Scorletti, E., & Byrne, C. D. (2020) · Springer eBooks · doi:10.1007/978-3-319-95828-6_9

Additional file 2 of Metabolic syndrome and the plasma proteome: from association to causation

Elhadad, M. A., Wilson, R., Zaghlool, S. B., Huth, C., Gieger, C., Grallert, H., Graumann, J., Rathmann, W., Köenig, W., Sinner, M. F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14634053

METABOLIC SYNDROME AND RISK OF CARDIOVASCULAR DISEASE WITH THYROID DISORDER

Shankar, R., Sharma, N., Kumar, A., Ram, R., & Kushwaha, A. (2024) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2024v17i7.51844

Anticancer properties and prevention of metabolic syndrome by probiotic-enriched powdered human milk

Robichaud, V., Shankar, S., Holkem, A. T., Salmieri, S., Aguilar‐Uscanga, B. R., Millette, M., & Lacroix, M. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105354

Significance of Adipose Tissue as an Endocrine Organ

Avtanski, D. B., & Stojchevski, R. (2024) · Contemporary Endocrinology · doi:10.1007/978-3-031-72570-8_1

Plasminogen activator inhibitor-1 regulates Zika virus infectionPreprint

Stojanov, M., Chiu, Y.-C., Fahmi, A., Schultz-Pernice, I., David, T., Jarrige, M., Akrouti, D. E., Déglon, N., Perrier, A. L., Alves, M. P., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-5866223/v1

Is intervening inflammatory pathways a way to treat type 2-diabetes

Pareek, A. K., Nikam, S., & Akolekar, R. (2025) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20251074

Platelets and Fibrinolysis

Semeraro, F., Semeraro, N., & Colucci, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-96344-5_15

Circulating miR-122 and miR-139-3p: Association with Lipid, Inflammatory, and Glycemic Profile in Adolescents with Insulin-Resistant and Overweight

Payolla, T. B., Brandão‐Lima, P. N., de Carvalho, G. B., Sarti, F. M., Fisberg, R. M., & Rogero, M. M. (2025) · Endocrines · doi:10.3390/endocrines6040051

Additional file 1 of Elevated plasma factor XI predicts cardiovascular events in patients with type 2 diabetes: a long-term observational study

Paszek, E., Polak, M., Bryk, A. H., Konieczyńska, M., & Undas, A. (2024) · Figshare · doi:10.6084/m9.figshare.26604721

Additional file 1 of Metabolic syndrome and the plasma proteome: from association to causation

Elhadad, M. A., Wilson, R., Zaghlool, S. B., Huth, C., Gieger, C., Grallert, H., Graumann, J., Rathmann, W., Koenig, W., Sinner, M. F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14634050

Pathophysiology of Arterial and Venous Thrombosis

Robert‐Ebadi, H., & Righini, M. (2026) · Springer eBooks · doi:10.1007/978-3-031-82232-2_4

Regular black tea kombucha consumption is associated with improved insulin resistance and increased ADIPOQ expression in adults with obesity: a pre–post clinical trial

Costa, M. A. D. C., Fraiz, G. M., Cardoso, R. R., da Silva, A. A., Duarte, V. D. S., Cruz, C. E. S. G., Rodrigues, E. G., Shaikh, M. W., Keshavarzian, A., Hamaker, B. R., et al. (2026) · Food & Function · doi:10.1039/d5fo02226f · Cited by 1

Pathology and Vascular Biology of Atherosclerosis in Patients With Type 2 Diabetes

Plutzky, J., Virmani, R., & Schmidt, A. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-87862-3.00007-0

Carotid Intima–media Thickness is Lower after Sleeve Gastrectomy, with Concurrent Changes in Oxidized LDL and PAI-1

Hany, M., Torensma, B., Arida, R. E., Demerdash, H. M., Ibrahim, M., Shaaban, A., Hany, Z. M., & Roushdy, M. N. (2026) · Obesity Surgery · doi:10.1007/s11695-026-08538-z

Étude de l'implication des cellules musculaires lisses vasculaires dans la distensibilité et le phénotype thrombotique dans des modèles murins

Ait‐Aissa, K. (2012) · theses.fr (ABES) · doi:10.70675/077ec5f1zf195z4fd7zb837z1faecfd730ab

Metabolic and cardiovascular effects of nitric oxide-cyclic guanosine monophosphate (NO-cGMP) signaling pathway modulation : Study in the WHHL rabbit as an experimental model of high fructose high fat diet-induced metabolic syndrome.

Moughaizel, M. (2020) · theses.fr (ABES) · doi:10.70675/d21b4f34z8e9az4348za233z7629490bce9e

Étude de bioactivité, de bioconversion et d’absorption par cellules CACO-2 d’un principe actif d’origine végétale pour la prévention du diabète de type 2

Haguet, Q. (2021) · theses.fr (ABES) · doi:10.70675/d41afb26z3461z49fdza225zb7758bb535b8

Effets bénéfiques de la finerénone, antagoniste du récepteur minéralocorticoïde, dans les conséquences cardiovasculaires d'un syndrome métabolique, chez des souris en conditions de post-ménopause ou après amaigrissement de souris mâles obèses.

Pieronne-Deperrois, M. (2022) · theses.fr (ABES) · doi:10.70675/71ef46cfz0230z4862za32aze1072fe4be66

TM5441, a PAI-1 inhibitor, attenuates chronic stress-induced anxio-depressive-like behaviors by restoring the hippocampal PAI-1/tPA/BDNF axis

Bahí, A., & Dreyer, J. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07091-y

Helminth infection induces RELMα-dependent adipose tissue transcriptional reprogramming and protection against diet-induced obesityPreprint

Jennett, J., Ruggiero-Ruff, R. E., Lam, K. M., Anesko, K., Chen, G., Midou, S., Ge, S., & Nair, M. G. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.04.730169

Routine contrast-enhanced CT screening identifies asymptomatic pulmonary embolism after minimally invasive esophagectomy: incidence and associated factors

Saito, A., Ariyoshi, T., Goto, S., Yamashita, T., Motegi, K., Kohmoto, M., Otsuka, K., Murakami, M., & Aoki, T. (2026) · Esophagus · doi:10.1007/s10388-026-01224-0

The Serpin Superfamily in Adipose Tissue Remodeling: Molecular Drivers of Immune–Metabolic Crosstalk and Insulin Sensitivity

Alwisi, N., Abdelhamid, A. H., Al-Quradaghi, A., Talhami, M., Alkuwari, A., Alsharif, N., Saliba, J. L., & Shaito, A. A. (2026) · Biology · doi:10.3390/biology15130989

PAI-1 at the Intersection of Lipid Metabolism and Fibroblast-Mediated Inflammatory Disease

Michelle, T. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1016386

Adipokine, endocrine, and fibrinolysis-related alterations across abdominal obesity and metabolic syndrome phenotypes in young adults

Puhalo-Sladoje, D., Dragojević, I. M., Bokonjić, D., Zečević, L., Čančar, O., Hasanefendić, B., & Kisić, B. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1900593

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