Cited by 390Adipokines, Inflammation, and Metabolic DiseasesBlood Coagulation and Thrombosis MechanismsCardiovascular Disease and Adiposity

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PAI-1 and the Metabolic Syndrome: Links, Causes, and Consequences

Alessi, Marie-Christine, Juhan-Vague, Irène·2006·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/01.atv.0000242905.41404.68

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Abstract

The link between plasminogen activator inhibitor (PAI)-1 and the metabolic syndrome with obesity was established many years ago. Increased PAI-1 level can be now considered a true component of the syndrome. The metabolic syndrome is associated with an increased risk of developing cardiovascular disease, and PAI-1 overexpression may participate in this process. The mechanisms of PAI-1 overexpression during obesity are complex, and it is conceivable that several inducers are involved at the same time at several sites of synthesis. Interestingly, recent in vitro and in vivo studies showed that besides its role in atherothrombosis, PAI-1 is also implicated in adipose tissue development and in the control of insulin signaling in adipocytes. These findings suggest PAI-1 inhibitors serve in the control of atherothrombosis and insulin resistance.

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Authors: Alessi, M.-C., & Juhan-Vague, I.
Affiliations: Inserm (FR)
From the Laboratory of Hematology, INSERM UMR 626, Faculty of Medicine, Marseilles, France.
ORCID: Alessi, Marie-Christine
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-10
Volume: 26
Issue: 10
Pages: 2200-2207
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000242905.41404.68
OpenAlex: W2120559894
Cited by: 390
References: 124
Citations by year: 2026: 17 · 2025: 16 · 2024: 22 · 2023: 14 · 2022: 24 · 2021: 19 · 2020: 11 · 2019: 13 · 2018: 12 · 2017: 18 · 2016: 23 · 2015: 17 · 2014: 16 · 2013: 22 · 2012: 19
FWCI: 3.51
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Arteriosclerosis Thrombosis and Vascular Biology
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: plasminogen activator inhibitor-1, metabolic syndrome, obesity, cardiovascular risk, atherothrombosis, insulin resistance, adipose tissue development, PAI-1 inhibitors
MeSH terms: Cardiovascular Diseases, Humans, Obesity, Plasminogen Activator Inhibitor 1, Metabolic Syndrome

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PAI-1 and the Metabolic Syndrome: Links, Causes, and Consequences

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