Cited by 1,693Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Nakashima, Y, Plump, A S, Raines, E W, Breslow, J L, Ross, R·1994·Arteriosclerosis and Thrombosis: A Journal of Vascular Biology

DOI 10.1161/01.atv.14.1.133

Open this paper in CoChat — free account

Abstract

Initial description of apolipoprotein (apo) E-deficient transgenic mice demonstrated the development of severe hypercholesterolemia due to probable delayed clearance of large atherogenic particles from the circulation. Examination of these mice demonstrated foam cell accumulation in the aortic root and pulmonary arteries by 10 weeks of age. In the present study, the animals were fed either chow or a high-fat, Western-type diet and examined at ages ranging from 6 to 40 weeks. Gross examination by dissection microscopy revealed a predilection for development of lesions in the aortic root, at the lesser curvature of the aortic arch, the principal branches of the aorta, and in the pulmonary and carotid arteries. Monocyte attachment to endothelial cells was observed by light and electron microscopic examination at 6 weeks, the earliest time point examined. Foam cell lesions developed as early as 8 weeks, and after 15 weeks advanced lesions (fibrous plaques) were observed. The latter consisted of a fibrous cap containing smooth muscle cells surrounded by connective tissue matrix that covered a necrotic core with numerous foamy macrophages. Mice fed the Western-type diet generally had more advanced lesions than those fed a chow diet. The apoE-deficient mouse contains the entire spectrum of lesions observed during atherogenesis and is the first mouse model to develop lesions similar to those in humans. This model should provide numerous opportunities to study the pathogenesis and therapy of atherosclerosis in a small, genetically defined animal.

Integrity signals

Registry

Crossref · 10.1161/01.atv.14.1.133

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
Self-citation
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Self-citation
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.
Rg, G. (1981) · PubMed Central · Cited by 1,314
Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.
Faggiotto, A., Ross, R., & Harker, L. A. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.4.323 · Cited by 978
Self-citation
Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.
Gown, A. M., Tsukada, T., & Ross, R. (1986) · PubMed · Cited by 678
Self-citation
Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.
Faggiotto, A., & Ross, R. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.4.341 · Cited by 466
Self-citation
The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.
Gerrity, R. G. (1981) · PubMed · Cited by 459
Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein
Marotti, K. R., Castle, C. K., Boyle, T. P., Lin, A. H., Murray, R. W., & Melchior, G. W. (1993) · Nature · doi:10.1038/364073a0 · Cited by 444
Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II
Warden, C. H., Hedrick, C. C., Qiao, J.-H., Castellani, L. W., & Lusis, A. J. (1993) · Science · doi:10.1126/science.8332912 · Cited by 359

Show all 28 references

Sorted by citations

Items 901–1,000 of 1,000

Plasma proteomic profiles of bovine growth hormone transgenic mice as they age
Ding, J., Berryman, D. E., & Kopchick, J. J. (2011) · Transgenic Research · doi:10.1007/s11248-011-9499-5 · Cited by 27
Intervertebral disc degeneration and ectopic bone formation in apolipoprotein E knockout mice
Zhang, D., Jin, L., Reames, D. L., Shen, F. H., Shimer, A. L., & Li, X. J. (2012) · Journal of Orthopaedic Research® · doi:10.1002/jor.22216 · Cited by 26
NMR‐based metabolomics of urine for the atherosclerotic mouse model using apolipoprotein‐E deficient mice
Leo, G. C., & Darrow, A. L. (2009) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.2470 · Cited by 26
Development of a quantitative mechanical test of atherosclerotic plaque stability
Wang, Y., Ning, J., Johnson, J. A., Sutton, M. A., & Lessner, S. M. (2011) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2011.06.026 · Cited by 26
Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice
Schroeter, M. R., Humboldt, T., Schäfer, K., & Konstantinides, S. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.11.013 · Cited by 26
Delivery of negatively charged liposomes into the atherosclerotic plaque of apolipoprotein E-deficient mouse aortic tissue
Zhaorigetu, S., Rodriguez‐Aguayo, C., Sood, A. K., Lopez‐Berestein, G., & Walton, B. L. (2014) · Journal of Liposome Research · doi:10.3109/08982104.2013.863208 · Cited by 26
Dietary flaxseed oil improved western-type diet-induced atherosclerosis in apolipoprotein-E knockout mice
Han, H., Qiu, F., Zhao, H., Tang, H., Li, X., & Shi, D. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.11.031 · Cited by 26
Addition of Estradiol to Cross-Sex Testosterone Therapy Reduces Atherosclerosis Plaque Formation in Female ApoE−/− Mice
Goetz, T. G., Mamillapalli, R., Şahin, Ç., Zolbin, M. M., Ge, G., Mani, A., & Taylor, H. S. (2017) · Endocrinology · doi:10.1210/en.2017-00884 · Cited by 27
Xyloketal B Attenuates Atherosclerotic Plaque Formation and Endothelial Dysfunction in Apolipoprotein E Deficient Mice
Zhao, L., Li, J., Yuan, F., Li, M., Zhang, Q., Pang, J., Zhang, B., Sun, F., Sun, H., Li, Q., et al. (2015) · Marine Drugs · doi:10.3390/md13042306 · Cited by 27
State of the art: Atherosclerosis in a limited edition
Rader, D. J., & FitzGerald, G. A. (1998) · Nature Medicine · doi:10.1038/nm0898-899 · Cited by 26
Dietary γ-Linolenic Acid Modulates Macrophage–Vascular Smooth Muscle Cell Interactions
Fan, Y.-Y., Ramos, K. S., & Chapkin, R. S. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.9.1397 · Cited by 26
Murine Mentors: Transgenic and Knockout Models of Surgical Disease
Arbeit, J. M., & Hirose, R. (1999) · Annals of Surgery · doi:10.1097/00000658-199901000-00004 · Cited by 26
A peptide antagonist of F11R/JAM-A reduces plaque formation and prolongs survival in an animal model of atherosclerosis
Babińska, A., Clement, C. C., Przygodzki, T., Talar, M., Li, Y., Braun, M., Wzorek, J., Świątkowska, M., Ehrlich, Y. H., Kornecki, E., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.02.014 · Cited by 25
Auto-Antibody Production During Experimental Atherosclerosis in ApoE-/- Mice
Hutchinson, M. A., Park, H.-S., Zanotti, K. J., Álvarez, J. A. G., Zhang, J., Zhang, L., Telljohann, R. S., Wang, M., Lakatta, E. G., Gearhart, P. J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.695220 · Cited by 25
Iron metabolism and atherosclerosis
Guo, Q., Qian, C., & Qian, Z. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.04.003 · Cited by 28
Modes of Defining Atherosclerosis in Mouse Models: Relative Merits and Evolving Standards
Daugherty, A., Lu, H. S., Howatt, D. A., & Rateri, D. L. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-247-6_1 · Cited by 25
Intermedin ameliorates atherosclerosis in apoE null mice by modifying lipid profiles
Zhang, X., Gu, L., Chen, X., Wang, S., Deng, X., Liu, K., Lv, Z., Yang, R., He, S., Peng, Y., et al. (2012) · Peptides · doi:10.1016/j.peptides.2012.07.011 · Cited by 25
Two adjacent domains (141–150 and 151–160) of apoE covalently linked to a class A amphipathic helical peptide exhibit opposite atherogenic effects
Nayyar, G., Handattu, S. P., Monroe, C. E., Chaddha, M., Datta, G., Mishra, V., Keenum, T. D., Palgunachari, M. N., Garber, D. W., & Anantharamaiah, G. M. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.09.030 · Cited by 25
Evaluation of Aortic Remodeling in Apolipoprotein E-deficient Mice and Renovascular Hypertensive Mice
Nogueira, B. V., Peotta, V. A., Meyrelles, S. S., & Vasquez, E. C. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.06.005 · Cited by 25
Synergistic effects of high fat feeding and apolipoprotein E deletion on enterocytic amyloid-beta abundance
Galloway, S., Pallebage‐Gamarallage, M. M., Takechi, R., Jian, L., Johnsen, R. D., Dhaliwal, S. S., & Mamo, J. C. L. (2008) · Lipids in Health and Disease · doi:10.1186/1476-511x-7-15 · Cited by 25
Effect of 12-O-tetradecanoylphorbol-13-acetate-induced psoriasis-like skin lesions on systemic inflammation and atherosclerosis in hypercholesterolaemic apolipoprotein E deficient mice
Madsen, M., Hansen, P. R., Nielsen, L. B., Hartvigsen, K., Pedersen, A. E., Christensen, J. P., Aarup, A., & Pedersen, T. X. (2016) · BMC Dermatology · doi:10.1186/s12895-016-0046-1 · Cited by 25
Apolipoprotein A-I Mimetic Peptides
Ditiatkovski, M., Palsson, J., Chin-Dusting, J. P. F., Remaley, A. T., & Sviridov, D. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309523 · Cited by 25
The Role of Age-Related Intimal Remodeling and Stiffening in Atherosclerosis
VanderBurgh, J. A., & Reinhart‐King, C. A. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.08.008 · Cited by 24
Atorvastatin has distinct effects on endothelial markers in different mouse models of atherosclerosis.
Nachtigal, P., Jamborova, G., Pospisilova, N., Pospěchová, K., Solichová, D., Zdansky, P., & Semecký, V. (2006) · PubMed · Cited by 25
The LDL receptor-related protein (LRP1/A2MR) and coronary atherosclerosis - novel genomic variants and functional consequences
Schulz, S., Schagdarsurengin, U., Greiser, P., Birkenmeier, G., Müller‐Werdan, U., Hagemann, M. M., Riemann, D., Werdan, K., & Gläser, C. (2002) · Human Mutation · doi:10.1002/humu.9070 · Cited by 25
Low-density lipoprotein receptor-related protein in atherosclerosis development: up-regulation of gene expression in patients with coronary obstruction
Handschug, K., Schulz, S., Schnürer, C., Köhler, S., Wenzel, K., Teichmann, W., & Gläser, C. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050255 · Cited by 25
Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3
Huebbe, P., Bilke, S., Rueter, J., Schloesser, A., Campbel, G., Glüer, C.-C., Lucius, R., Röcken, C., Tholey, A., & Rimbach, G. (2024) · Aging and disease · doi:10.14336/ad.2023.0530 · Cited by 24
Adenosine A 3 Receptor: A promising therapeutic target in cardiovascular disease
Nishat, S., Khan, L. A., Ansari, Z. M., & Basir, S. F. (2016) · Current Cardiology Reviews · doi:10.2174/1573403x12666160111125116 · Cited by 24
Immunohistochemical biomarkers and distribution of telocytes in ApoE−/− mice
Xu, Y., Tian, H., Cheng, J., Liang, S., Li, T., & Liu, J. (2019) · Cell Biology International · doi:10.1002/cbin.11128 · Cited by 24
Pathways linking aging and atheroprotection in Mif ‐deficient atherosclerotic mice
Krammer, C., Yang, B., Reichl, S., Besson‐Girard, S., Ji, H., Bolini, V., Schulte, C., Noels, H., Schlepckow, K., Jocher, G., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202200056r · Cited by 26
FoxO4 inhibits atherosclerosis through its function in bone marrow derived cells
Zhu, M., Zhang, Q.-J., Wang, L., Li, H., & Liu, Z.-P. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.09.038 · Cited by 24
Cardiovascular Autonomic Imbalance and Baroreflex Dysfunction in the Apolipoprotein E-deficient Mouse
Vasquez, E. C., Peotta, V. A., & Meyrelles, S. S. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000277623 · Cited by 24
Improved Endothelial Dysfunction by Cynanchum wilfordii in Apolipoprotein E −/− Mice Fed a High Fat/Cholesterol Diet
Choi, D. H., Lee, Y. J., Oh, H. C., Cui, Y., Kim, J. S., Kang, D. G., & Lee, H. S. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1222 · Cited by 24
Atorvastatin attenuates plaque vulnerability by downregulation of EMMPRIN expression via COX-2/PGE2 pathway
Liang, X., Yang, L., Guo, R., Shi, Y.-K., Hou, X., Yang, Z., Zhou, X., & Liu, H. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4062 · Cited by 24
Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis
Vilšķe̅rsts, R., Kuka, J., Liepinsh, E., Makrecka‐Kuka, M., Volska, K., Makarova, E., Sevostjanovs, E., Cirule, H., Grı̄nberga, S., & Dambrova, M. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.05.005 · Cited by 24
Selective role of Nck1 in atherogenic inflammation and plaque formation
Alfaidi, M., Acosta, C. H., Wang, D., Traylor, J. G., & Orr, A. W. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135552 · Cited by 24
Ultrasonic tissue characterization of collagen in lipid-rich plaques in apoE-deficient mice
Saijo, Y. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00435-x · Cited by 24
Quantitative Trait Locus Analysis of Carotid Atherosclerosis in an Intercross Between C57BL/6 and C3H Apolipoprotein E–Deficient Mice
Li, Q., Li, Y., Zhang, Z., Gilbert, T. R., Matsumoto, A. H., Dobrin, S. E., & Shi, W. (2007) · Stroke · doi:10.1161/strokeaha.107.492165 · Cited by 24
Apolipoprotein E and Lipoprotein Lipase Increase Triglyceride-Rich Particle Binding but Decrease Particle Penetration in Arterial Wall
Mullick, A. E., Deckelbaum, R. J., Goldberg, I. J., Al-Haideri, M. T., & Rutledge, J. C. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000040221.70377.19 · Cited by 24
Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice
Yoshida, H., Hasty, A. H., Major, A. S., Ishiguro, H., Su, Y. R., Gleaves, L. A., Babaev, V. R., Linton, M. F., & Fazio, S. (2001) · Circulation · doi:10.1161/hc4801.100034 · Cited by 24
Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease
Pal, R., Ke, Q., Pihan, G. A., Yesilaltay, A., Penman, M., Wang, L., Chitraju, C., Kang, P. M., Krieger, M., & Kocher, O. N. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00463.2016 · Cited by 23
Apolipoprotein E Deficiency Causes Endothelial Dysfunction in the Mouse Retina
Zadeh, J. K., Zhutdieva, M. B., Laspas, P., Yüksel, C., Musayeva, A., Pfeiffer, N., Brochhausen, C., Oelze, M. W., Daiber, A., Xia, N., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5181429 · Cited by 24
Digestive n‐6 Lipid Oxidation, a Key Trigger of Vascular Dysfunction and Atherosclerosis in the Western Diet: Protective Effects of Apple Polyphenols
Boléa, G., Philouze, C., Dubois, M., Risdon, S., Humberclaude, A., Giniès, C., Charles, A., Gény, B., Reboul, C., Arnaud, C., et al. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000487 · Cited by 23
HAP-Multitag, a PET and Positive MRI Contrast Nanotracer for the Longitudinal Characterization of Vascular Calcifications in Atherosclerosis
Pellico, J., Fernández‐Barahona, I., Ruı́z-Cabello, J., Gutiérrez, L., Muñoz-Hernando, M., Sánchez-Guisado, M. J., Aiestarán-Zelaia, I., Martínez‐Parra, L., Rodríguez, I., Bentzon, J. F., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c13417 · Cited by 23
Chronic apical periodontitis exacerbates atherosclerosis in apolipoprotein E‐deficient mice and leads to changes in the diversity of gut microbiota
Gan, G., Lu, B., Zhang, R., Luo, Y., Chen, S., Lei, H., Li, Y., Cai, Z., & Huang, X. (2021) · International Endodontic Journal · doi:10.1111/iej.13655 · Cited by 23
P2X7 receptor-specific radioligand 18F-FTTM for atherosclerotic plaque PET imaging
Fu, Z., Lin, Q., Xu, Z., Zhao, Y., Cheng, Y., Shi, D., Fu, W., Yang, T., Shi, H., & Cheng, D. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-022-05689-w · Cited by 23
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery
May, L. T., Bartolo, B. A. D., Harrison, D. G., Guzik, T. J., Drummond, G. R., Figtree, G. A., Ritchie, R. H., Rye, K., & de Haan, J. B. (2022) · Clinical Science · doi:10.1042/cs20210862 · Cited by 23
Essential oil from Fructus Alpinia zerumbet ameliorates atherosclerosis by activating PPARγ-LXRα-ABCA1/G1 signaling pathway
Wang, S.-Q., Xiang, J. H., Zhang, G., Fu, L., Xu, Y., Chen, Y., Tao, L., Hu, X., & Shen, X. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155227 · Cited by 23
Novel insights into the development of atherosclerosis in hemophilia A mouse models
Fabri, D. R., Paula, E. V. D., Costa, D. S. P., Annichino‐Bizzacchi, J. M., & Arruda, V. R. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04410.x · Cited by 23
The enhanced expression of IL-17-secreting T cells during the early progression of atherosclerosis in ApoE-deficient mice fed on a western-type diet
Jeon, U. S., Choi, J., Kim, Y., Sung-Ho, R., & Kim, Y.-K. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.19 · Cited by 23
VPO1 Mediates ApoE Oxidation and Impairs the Clearance of Plasma Lipids
Yang, Y., Cao, Z., Tian, L., Garvey, W. T., & Cheng, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057571 · Cited by 23
Effects of Mutated Pregnancy-Associated Plasma Protein-A on Atherosclerotic Lesion Development in Mice
Boldt, H. B., Bale, L. K., Resch, Z. T., Oxvig, C., Overgaard, M. T., & Conover, C. A. (2012) · Endocrinology · doi:10.1210/en.2012-1552 · Cited by 23
Why should a doctor be interested in oral disease?
Ford, P. J., Raphael, S. L., Cullinan, M. P., Jenkins, A. J., West, M., & Seymour, G. J. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.109 · Cited by 23
Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse
Okutsu, M., Lira, V. A., Higashida, K., Peake, J. M., Higuchi, M., & Suzuki, K. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.11.076 · Cited by 24
Mouse Genome-Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor
Kelly, N. J., Radder, J. E., Baust, J., Burton, C. L., Lai, Y., Potoka, K. C., Agostini, B., Wood, J. P., Bachman, T. N., Vanderpool, R. R., et al. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0176oc · Cited by 23
Fenretinide treatment accelerates atherosclerosis development in apoE‐deficient mice in spite of beneficial metabolic effects
Busnelli, M., Manzini, S., Bonacina, F., Soldati, S., Barbieri, S. S., Amadio, P., Sandrini, L., Arnaboldi, F., Donetti, E., Laaksonen, R., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14869 · Cited by 23
Modelling of atherosclerosis in genetically modified animals.
Mushenkova, N. V., Summerhill, V. I., Silaeva, Y. Y., Deykin, A. V., & Orekhov, A. N. (2019) · Europe PMC (PubMed Central) · Cited by 23
Structural and functional remodeling of the female Apoe−/− mouse aorta due to chronic cigarette smoke exposure
Farra, Y. M., Matz, J., Ramkhelawon, B., Oakes, J. M., & Bellini, C. M. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00893.2020 · Cited by 23
Variation in Type 2 Diabetes-Related Phenotypes among Apolipoprotein E-Deficient Mouse Strains
Liu, S., Li, J., Chen, M., Liu, Z., & Shi, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120935 · Cited by 23
Hypercholesterolemia Induced Immune Response and Inflammation on Progression of Atherosclerosis in Apobtm2SgyLdlrtm1Her/J Mice
Rao, L. N., Ponnusamy, T., Philip, S., Mukhopadhyay, R., Kakkar, V. V., & Mundkur, L. (2015) · Lipids · doi:10.1007/s11745-015-4046-4 · Cited by 23
Roles of Apolipoprotein E (ApoE) and Inducible Nitric Oxide Synthase (iNOS) in Inflammation and Apoptosis in Preeclampsia Pathogenesis and Progression
Mao, L., Zhou, Q., Zhou, S., Wilbur, R. R., & Li, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058168 · Cited by 23
Calcium-channel modulators for cardiovascular disease
Godfraind, T. (2006) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.11.1.49 · Cited by 23
Differential effects of angiotensin II on atherogenesis at the aortic sinus and descending aorta of apolipoprotein-E-deficient mice
Zhou, Y., CHEN, R., Catanzaro, S., Hu, L., Dansky, H. M., & Catanzaro, D. F. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.11.005 · Cited by 23
99mTc-labelled anti-CD11b SPECT/CT imaging allows detection of plaque destabilization tightly linked to inflammation
Liu, G., Hu, Y., Xiao, J., Li, X., Li, Y., Tan, H., Zhao, Y., Cheng, D., & Shi, H. (2016) · Scientific Reports · doi:10.1038/srep20900 · Cited by 23
Persistence of the Nitric Oxide Pathway in the Aorta of Hypercholesterolemic Apolipoprotein-E-Deficient Mice
Villeneuve, N., Fortuño, A., Sauvage, M., Fournier, N., Breugnot, C., Jacquemin, C., Petit, C., Gosgnach, W., Carpentier, N., Vanhoutte, P. M., et al. (2003) · Journal of Vascular Research · doi:10.1159/000070705 · Cited by 23
Probucol
Pfuetze, K. D., & Dujovne, C. A. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0094-0 · Cited by 23
Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering
Ramms, B., Patel, S., Sun, X., Pessentheiner, A. R., Ducasa, G. M., Mullick, A. E., Lee, R. G., Crooke, R. M., Tsimikas, S., Witztum, J. L., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158414 · Cited by 22
Protein Kinase C Controls Vesicular Transport and Secretion of Apolipoprotein E from Primary Human Macrophages
Karunakaran, D., Kockx, M., Owen, D. M., Burnett, J. R., Jessup, W., & Kritharides, L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.428961 · Cited by 22
Macrophages, dendritic cells, and regression of atherosclerosis
Feig, J. E., & Feig, J. L. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00286 · Cited by 22
Hypercholesterolemia impairs exercise capacity in mice
Maxwell, A. J., Niebauer, J., Lin, P. S., Tsao, P. S., Bernstein, D., & Cooke, J. P. (2009) · Vascular Medicine · doi:10.1177/1358863x08100040 · Cited by 22
Elevated Plasma Levels of LDL Cholesterol Promote Dissecting Thoracic Aortic Aneurysms in Angiotensin II–Induced Mice
Tanaka, H., 飯田, 泰., Iwaki, T., Suzuki, Y., Sano, H., Miyajima, C., Zaima, N., Sasaki, T., Sumioka, A., Hakamata, S., et al. (2017) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2017.10.006 · Cited by 22
Differential urinary proteins to diagnose coronary heart disease based on iTRAQ quantitative proteomics
Sun, H., Wang, D., Liu, D., Guo, Z., Shao, C., Sun, W., & Zeng, Y. (2019) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-019-01668-7 · Cited by 21
Moxibustion at CV4 alleviates atherosclerotic lesions through activation of the LXRα/ABCA1 pathway in apolipoprotein-E-deficient mice
Cui, Y., Liu, J., Huang, C., & Zhao, B. (2019) · Acupuncture in Medicine · doi:10.1136/acupmed-2016-011317 · Cited by 22
Soyasaponins A 1 and A 2 exert anti-atherosclerotic functionalities by decreasing hypercholesterolemia and inflammation in high fat diet (HFD)-fed ApoE −/− mice
Xie, Q., Xiong, F., Wu, X., Chen, J., Gu, X., Su, C., Xiao, L., Zheng, Z., Wei, Y., Ullah, H., et al. (2019) · Food & Function · doi:10.1039/c9fo02654a · Cited by 22
Decreased Sensitivity to Nitric Oxide in the Aorta of Severely Hypercholesterolemic Apolipoprotein E-Deficient Mice
Yaghoubi, M., Oliver-Krasinski, J. M., Cayatte, A. J., & Cohen, R. A. (2000) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200012000-00010 · Cited by 22
Participatory role of natural killer and natural killer T cells in atherosclerosis: lessons learned from in vivo mouse studiesThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.
Whitman, S. C., & Ramsamy, T. A. (2006) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y05-159 · Cited by 22
A 1,3-diacylglycerol-rich oil induces less atherosclerosis and lowers plasma cholesterol in diabetic apoE-deficient mice
Fujii, A., Allen, T. J., & Nestel, P. J. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.08.024 · Cited by 22
Direct Evidence for a Crucial Role of the Arterial Wall in Control of Atherosclerosis Susceptibility
Pei, H., Wang, Y., Miyoshi, T., Zhang, Z., Matsumoto, A. H., Helm, G. A., Tellides, G., & Shi, W. (2006) · Circulation · doi:10.1161/circulationaha.106.640185 · Cited by 22
Generation of monoclonal antibodies specific for mouse apolipoprotein B-100 in apolipoprotein B-48-only mice
Zlot, C. H., Flynn, L. M., Véniant, M. M., Kim, E., Raabe, M., McCormick, S. P. A., Ambroziak, P., McEvoy, L. M., & Young, S. G. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33341-1 · Cited by 22
Apolipoprotein E-Deficient Mouse Model of Human Atherosclerosis
O’Neill, T. (1997) · Toxicologic Pathology · doi:10.1177/019262339702500104 · Cited by 21
Endothelial HuR deletion reduces the expression of proatherogenic molecules and attenuates atherosclerosis
Fu, X., Zhai, S., & Ji, Y. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.09.023 · Cited by 21
Endometriosis promotes atherosclerosis in a murine model
Mamillapalli, R., Toffoloni, N., Habata, S., Huang, Q., Atwani, R. W., Stachenfeld, N. S., & Taylor, H. S. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.03.040 · Cited by 21
Genetic Analysis of Atherosclerosis and Glucose Homeostasis in an Intercross Between C57BL/6 and BALB/cJ Apolipoprotein E–Deficient Mice
Zhang, Z., Rowlan, J. S., Wang, Q., & Shi, W. (2012) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.961649 · Cited by 21
Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice
Heinonen, S. E., Merentie, M., Hedman, M., Mäkinen, P. I., Loponen, E., Kholová, I., Bosch, F., Laakso, M., & Ylä‐Herttuala, S. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-59 · Cited by 21
Quantitative Trait Locus Analysis of Neointimal Formation in an Intercross Between C57BL/6 and C3H/HeJ Apolipoprotein E–Deficient Mice
Yuan, Z., Pei, H., Roberts, D. J., Zhang, Z., Rowlan, J. S., Matsumoto, A. H., & Shi, W. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.108.792499 · Cited by 21
Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice
Liu, F., Sahoo, R., Ge, X., Wu, L., Ghosh, P., Qin, X., & Halperin, J. A. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.08.021 · Cited by 21
FoxO transcription factors are required for hepatic HDL cholesterol clearance
Lee, S. X., Heine, M., Schlein, C., Ramakrishnan, R., Liu, J., Belnavis, G., Haimi, I., Fischer, A. W., Ginsberg, H. N., Heeren, J., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci94230 · Cited by 22
Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis
González-Ramos, S., Fernández-García, V., Recalde, M., Rodrı́guez, C., Martínez‐González, J., Andrés, V., Martín‐Sanz, P., & Boscá, L. (2020) · Cells · doi:10.3390/cells9092067 · Cited by 21
Aging and Hypercholesterolemia Differentially Affect the Unfolded Protein Response in the Vasculature of ApoE −/− Mice
Zhou, Y., Wan, X., Seidel, K., Zhang, M., Goodman, J. B., Seta, F., Hamburg, N. M., & Han, J. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.020441 · Cited by 21
Prevalence of the Apolipoprotein E Arg145Cys Dyslipidemia At-Risk Polymorphism in African-Derived Populations
Abou Ziki, M. D., Strulovici-Barel, Y., Hackett, N. R., Rodriguez-Flores, J. L., Mezey, J. G., Salit, J., Radisch, S., Hollmann, C., Chouchane, L., Malek, J., et al. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.09.021 · Cited by 21
Immunological aspects of atherosclerosis
Garrido‐Urbani, S., Meguenani, M., Montecucco, F., & Imhof, B. A. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0402-8 · Cited by 21
Altered Gene Expression in Early Atherosclerosis Is Blocked by Low Level Apolipoprotein E
Ma, Y., Malbon, C. C., Williams, D. L., & Thorngate, F. E. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002503 · Cited by 21
H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice
Raveendran, V. V., Kassel, K. M., Smith, D. D., Luyendyk, J. P., Williams, K. J., Cherian, R., Reed, G. A., Flynn, C. A., Csanaky, I. L., Lickteig, A. J., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00027.2014 · Cited by 21
Influence of Apolipoprotein E Genotype on Progression of Diabetic Nephropathy
Joss, N., Jardine, A. G., Gaffney, D. F., & Boulton‐Jones, J. M. (2005) · Nephron Experimental Nephrology · doi:10.1159/000087577 · Cited by 21
Alterations in Internal Elastic Lamina Permeability As a Function of Age and Anatomical Site Precede Lesion Development in Apolipoprotein E–Null Mice
Lee, K., Forudi, F., Saidel, G. M., & Penn, M. S. (2005) · Circulation Research · doi:10.1161/01.res.0000181026.94390.c9 · Cited by 21
Neointimal formation in two apolipoprotein E-deficient mouse strains with different atherosclerosis susceptibility
Shi, W., Pei, H., Fischer, J. J., James, J. C., Angle, J. F., Matsumoto, A. H., Helm, G. A., & Sarembock, I. J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400254-jlr200 · Cited by 21
Hepatic overexpression of bovine scavenger receptor type I in transgenic mice prevents diet-induced hyperbetalipoproteinemia.
Wolle, S., Via, D. P., Chan, L., Cornicelli, J. A., & Bisgaier, C. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118030 · Cited by 21
Updates on Approaches for Studying Atherosclerosis
Wu, C., Daugherty, A., & Lu, H. S. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312001 · Cited by 21
Pathophysiology of ischaemia-reperfusion injury
Carden, D. L., & Granger, D. N. (2000) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(200002)190:3 · Cited by 5
Untitled work
(1996) · PubMed Central · Cited by 32

Authors: Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R.
Affiliations: University of Washington (US)
ORCID: Nakashima, Y
Breslow, J L
Venue: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1994-01
Volume: 14
Issue: 1
Pages: 133-140
ISSN: 1049-8834 (ISSN-L)
DOI: 10.1161/01.atv.14.1.133
OpenAlex: W1964814612
Cited by: 1,693
References: 28
Citations by year: 2026: 18 · 2025: 32 · 2024: 40 · 2023: 42 · 2022: 54 · 2021: 60 · 2020: 47 · 2019: 57 · 2018: 45 · 2017: 66 · 2016: 50 · 2015: 69 · 2014: 71 · 2013: 73 · 2012: 78
FWCI: 14.99
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis and Thrombosis A Journal of Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Bristol-Myers Squibb
National Institutes of Health (5r01hl033714-17, 18645, HL 18645)
National Heart, Lung, and Blood Institute (HL-18645, HL 33714, R01HL032435, HL32435, P01HL018645)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: apolipoprotein E deficiency, atherosclerosis, atherosclerotic plaque development, Western diet, hypercholesterolemia, fibrous cap, necrotic core, aortic root lesions, mouse model of atherosclerosis, atherogenesis
MeSH terms: Animals, Aorta, Aorta, Thoracic, Apolipoproteins E, Arteriosclerosis, Carotid Arteries, Coronary Vessels, Diet, Endothelium, Vascular, Hypercholesterolemia, Leukocytes, Mononuclear, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Pulmonary Artery, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks