Cited by 1,693Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Nakashima, Y, Plump, A S, Raines, E W, Breslow, J L, Ross, R·1994·Arteriosclerosis and Thrombosis: A Journal of Vascular Biology

DOI 10.1161/01.atv.14.1.133

Open this paper in CoChat — free account

Abstract

Initial description of apolipoprotein (apo) E-deficient transgenic mice demonstrated the development of severe hypercholesterolemia due to probable delayed clearance of large atherogenic particles from the circulation. Examination of these mice demonstrated foam cell accumulation in the aortic root and pulmonary arteries by 10 weeks of age. In the present study, the animals were fed either chow or a high-fat, Western-type diet and examined at ages ranging from 6 to 40 weeks. Gross examination by dissection microscopy revealed a predilection for development of lesions in the aortic root, at the lesser curvature of the aortic arch, the principal branches of the aorta, and in the pulmonary and carotid arteries. Monocyte attachment to endothelial cells was observed by light and electron microscopic examination at 6 weeks, the earliest time point examined. Foam cell lesions developed as early as 8 weeks, and after 15 weeks advanced lesions (fibrous plaques) were observed. The latter consisted of a fibrous cap containing smooth muscle cells surrounded by connective tissue matrix that covered a necrotic core with numerous foamy macrophages. Mice fed the Western-type diet generally had more advanced lesions than those fed a chow diet. The apoE-deficient mouse contains the entire spectrum of lesions observed during atherogenesis and is the first mouse model to develop lesions similar to those in humans. This model should provide numerous opportunities to study the pathogenesis and therapy of atherosclerosis in a small, genetically defined animal.

Integrity signals

Registry

Crossref · 10.1161/01.atv.14.1.133

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
Self-citation
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Self-citation
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.
Rg, G. (1981) · PubMed Central · Cited by 1,314
Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.
Faggiotto, A., Ross, R., & Harker, L. A. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.4.323 · Cited by 978
Self-citation
Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.
Gown, A. M., Tsukada, T., & Ross, R. (1986) · PubMed · Cited by 678
Self-citation
Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.
Faggiotto, A., & Ross, R. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.4.341 · Cited by 466
Self-citation
The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.
Gerrity, R. G. (1981) · PubMed · Cited by 459
Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein
Marotti, K. R., Castle, C. K., Boyle, T. P., Lin, A. H., Murray, R. W., & Melchior, G. W. (1993) · Nature · doi:10.1038/364073a0 · Cited by 444
Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II
Warden, C. H., Hedrick, C. C., Qiao, J.-H., Castellani, L. W., & Lusis, A. J. (1993) · Science · doi:10.1126/science.8332912 · Cited by 359

Show all 28 references

Sorted by citations

Items 501–600 of 1,000

Models to Study Atherosclerosis: A Mechanistic Insight
Singh, V., Tiwari, R. L., Dikshit, M., & Barthwal, M. K. (2009) · Current Vascular Pharmacology · doi:10.2174/157016109787354097 · Cited by 65
Impact of Glutathione Peroxidase-1 Deficiency on Macrophage Foam Cell Formation and Proliferation: Implications for Atherogenesis
Cheng, F., Torzewski, M., Degreif, A., Rossmann, H., Canisius, A., & Lackner, K. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072063 · Cited by 66
Expression of sonic hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis
Gofflot, F., Gaoua, W., Bourguignon, L., Roux, C., & Picard, J. J. (2001) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 27
Attenuation of Atherosclerosis in Apolipoprotein E-Deficient Mice by Ramipril is Dissociated from Its Antihypertensive Effect and from Potentiation of Bradykinin
Keidar, S., Attias, J., Coleman, R., WIRTH, K. J., Schölkens, B. A., & Hayek, T. (2000) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200001000-00008 · Cited by 63
All ApoB-Containing Lipoproteins Induce Monocyte Chemotaxis and Adhesion When Minimally Modified
Lee, C., Sigari, F., Segrado, T., Hörkkö, S., Hama, S. Y., Subbaiah, P. V., Miwa, M., Navab, M., Witztum, J. L., & Reaven, P. D. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.6.1437 · Cited by 63
Chlamydia pneumoniae Does Not Increase Atherosclerosis in the Aortic Root of Apolipoprotein E–Deficient Mice
Aalto‐Setälä, K., Laitinen, K., Erkkilä, L., Leinonen, M., Jauhiainen, M., Ehnholm, C., Tamminen, M., Puolakkainen, M. H., Penttilä, I., & Saikku, P. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.4.578 · Cited by 63
Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a “Western-style diet” by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels
Qin, Y., Ye, P., He, J., Sheng, L., Wang, L., & Du, J. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.109 · Cited by 62
Oxytocin Attenuates Atherosclerosis and Adipose Tissue Inflammation in Socially Isolated ApoE−/− Mice
Nation, D. A., Szeto, A., Mendez, A. J., Brooks, L., Zaias, J., Herderick, E. E., Gonzales, J. A., Noller, C. M., Schneiderman, N., & McCabe, P. M. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d74c48 · Cited by 65
Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions
Roncal, C., Buysschaert, I., Gerdes, N., Γεωργιάδου, Μ., Овчинникова, О. А., Fischer, C., Stassen, J. M., Moons, L., Collen, D., Bock, K. D., et al. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp380 · Cited by 62
Aging and vascular dysfunction: beneficial melatonin effects
Rodella, L. F., Favero, G., Rossini, C., Foglio, E., Bonomini, F., Reiter, R. J., & Rezzani, R. (2011) · AGE · doi:10.1007/s11357-011-9336-z · Cited by 62
Chlamydophila pneumoniae (Chlamydia pneumoniae) accelerates the formation of complex atherosclerotic lesions in Apo E3-Leiden mice
Ezzahiri, R., Nelissen-Vrancken, H. J. M. G., Kurvers, H. A. J. M., Stassen, F. R. M., Vliegen, I., Grauls, G., VANPUL, M., Kitslaar, P. J. E. H. M., & Bruggeman, C. A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00544-8 · Cited by 62
Reduced Levels of microRNAs miR-124a and miR-150 Are Associated with Increased Proinflammatory Mediator Expression in Krüppel-like Factor 2 (KLF2)-deficient Macrophages
Manoharan, P., Basford, J. E., Pilcher-Roberts, R., Neumann, J. C., Hui, D. Y., & Lingrel, J. B. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.579763 · Cited by 61
Fluorine MR Imaging of Inflammation in Atherosclerotic Plaque in Vivo
van Heeswijk, R. B., Pellegrin, M., Flögel, U., Gonzales, C., Aubert, J.-F., Mazzolai, L., Schwitter, J., & Stuber, M. (2014) · Radiology · doi:10.1148/radiol.14141371 · Cited by 61
Chronic treatment with sulfhydryl angiotensin-converting enzyme inhibitors reduce susceptibility of plasma LDL to in vitro oxidation, formation of oxidation-specific epitopes in the arterial wall, and atherogenesis in apolipoprotein E knockout mice
de Nigris, F., D’Armiento, F. P., Somma, P., Casini, A., Andreini, I., Sarlo, F., Mansueto, G., Rosa, G. D., Bonaduce, D., Condorelli, M., et al. (2001) · International Journal of Cardiology · doi:10.1016/s0167-5273(01)00542-3 · Cited by 61
Effects of Isoflurane on Coronary Blood Flow Velocity in Young, Old and ApoE−/− Mice Measured by Doppler Ultrasound
Hartley, C. J., Reddy, A. K., Madala, S., Michael, L. H., Entman, M. L., & Taffet, G. E. (2007) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.11.002 · Cited by 60
Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice
Glaros, E. N., Kim, W. S., Quinn, C. M., Jessup, W., Rye, K., & Garner, B. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700261-jlr200 · Cited by 60
Iron-Ion Radiation Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice
Yu, T., Parks, B. W., Yu, S., Srivastava, R., Gupta, K. B., Wu, X., Khaled, S., Chang, P. Y., Kabarowski, J. H. S., & Kucik, D. F. (2011) · Radiation Research · doi:10.1667/rr2482.1 · Cited by 60
Mesangial expansion associated with glomerular endothelial cell activation and macrophage recruitment is developing in hyperlipidaemic apoE null mice
Bruneval, P. (2002) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/17.12.2099 · Cited by 60
Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice
Garner, B., Priestman, D. A., Stocker, R., Harvey, D. J., Butters, T. D., & Platt, F. M. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30162-0 · Cited by 60
Magnetic Resonance Imaging of Coronary Arteries and Heart Valves in a Living Mouse: Techniques and Preliminary Results
Ruff, J., Wiesmann, F., Lanz, T. E., & Haase, A. (2000) · Journal of Magnetic Resonance · doi:10.1006/jmre.2000.2147 · Cited by 60
Modulation of Expression of Endothelial Intercellular Adhesion Molecule-1, Platelet–Endothelial Cell Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Aortic Arch Lesions of Apolipoprotein E–Deficient Compared With Wild-Type Mice
Zibara, K., Chignier, E., Covacho, C., Poston, R. N., Canard, G., Hardy, P., & McGregor, J. L. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.10.2288 · Cited by 60
Uptake of type III hypertriglyceridemic VLDL by macrophages is enhanced by oxidation, especially after remnant formation
Whitman, S. C., Miller, D. B., Wolfe, B. M., Hegele, R. A., & Huff, M. W. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.9.1707 · Cited by 59
Artemisinin Attenuated Atherosclerosis in High-Fat Diet–Fed ApoE−/− Mice by Promoting Macrophage Autophagy Through the AMPK/mTOR/ULK1 Pathway
Cao, Q., Du, H., Fu, X., Duan, N., Liu, C., & Li, X. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000794 · Cited by 59
Sexual dimorphism in rodent models of hypertension and atherosclerosis
Bubb, K. J., Khambata, R. S., & Ahluwalia, A. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02036.x · Cited by 59
Quantitative Assay for Mouse Atherosclerosis in the Aortic Root
Baglione, J., & Smith, J. D. (2006) · Humana Press eBooks · doi:10.1385/1-59745-213-0:83 · Cited by 59
Fractalkine Is Expressed in Early and Advanced Atherosclerotic Lesions and Supports Monocyte Recruitment via CX3CR1
Stolla, M., Pelisek, J., von Brühl, M.-L., Schäfer, A., Barocke, V., Heider, P., Lorenz, M., Tirniceriu, A., Steinhart, A., Bauersachs, J. K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043572 · Cited by 60
Chronic Stress Accelerates Atherosclerosis in the Apolipoprotein E Deficient Mouse
Meena Kumari, B., Grahame-Clarke, C. N., Shanks, N. M., Marmot, M. G., Lightman, S. L., & Vallance, P. J. (2003) · Stress · doi:10.1080/10253890310001619461 · Cited by 59
Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism inC57BL/6andApoe−/−Mice—An Integrative Systems Toxicology Analysis
Titz, B., Boué, S., Phillips, B. W., Talikka, M., Vihervaara, T., Schneider, T. L., Nury, C., Elamin, A., Guedj, E., Peck, M. J., et al. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv244 · Cited by 59
Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE−/− mice
Kumar, S., Chen, M., Li, Y., Wong, F. H. S., Thiam, C. H., Hossain, M. Z., Poh, K. K., Hirohata, S., Ogawa, H., Angéli, V., et al. (2016) · Scientific Reports · doi:10.1038/srep31130 · Cited by 59
Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12
Liu, S., Bajpai, A., Hawthorne, E. A., Bae, Y., Castagnino, P. A., Monslow, J., Puré, E., Spiller, K. L., & Assoian, R. K. (2019) · JCI Insight · doi:10.1172/jci.insight.122742 · Cited by 59
Atherogenic Effect of Interleukin-2 and Antiatherogenic Effect of Interleukin-2 Antibody in Apo-E-Deficient Mice
Upadhya, S., Mooteri, S., Peckham, N. H., & Pai, R. G. (2004) · Angiology · doi:10.1177/000331970405500308 · Cited by 59
P-selectin as a candidate target in atherosclerosis
Molenaar, T. J. M., Twisk, J., Haas, S., Peterse, N., Vogelaar, B. J. C. P., van Leeuwen, S. H., Michon, I. N., van Berkel, T. J. C., Kuiper, J., & Biessen, E. A. L. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00387-3 · Cited by 59
Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice
Nong, Z., Navarro, H. G., Amar, M. J., Freeman, L. A., Knapper, C. L., Neufeld, E. B., Paigen, B. J., Hoyt, R. F., Fruchart‐Najib, J., & Santamarina-Fojo, S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16484 · Cited by 59
Genetically modified mice for the study of apolipoprotein B
Kim, E. J.-H., & Young, S. G. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32560-8 · Cited by 59
Phenotypic Correction of Hypercholesterolemia in ApoE-Deficient Mice by Adenovirus-Mediated In Vivo Gene Transfer
Stevenson, S. C., Marshall-Neff, J., Teng, B., Lee, C. B., Roy, S., & McClelland, A. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.4.479 · Cited by 59
Selective Inhibition of Tumor Necrosis Factor–Induced Vascular Cell Adhesion Molecule-1 Gene Expression by a Novel Flavonoid
Wölle, J., Hill, R. R., Ferguson, E., Devall, L. J., Trivedi, B., Newton, R. S., & Saxena, U. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.12.1501 · Cited by 60
Mice deficient in apolipoprotein E but not LDL receptors are resistant to accelerated atherosclerosis associated with obesity
Schreyer, S. A., Lystig, T., Vick, C. M., & LeBoeuf, R. C. (2003) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.07.010 · Cited by 58
Towards understanding acute destabilization of vulnerable atherosclerotic plaques
Dickson, B. C., & Gotlieb, A. I. (2003) · Cardiovascular Pathology · doi:10.1016/s1054-8807(03)00072-3 · Cited by 58
Interplay between sepsis and chronic health
Yende, S. P., Iwashyna, T. J., & Angus, D. C. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.02.005 · Cited by 60
Interleukin-17–Dependent Autoimmunity to Collagen Type V in Atherosclerosis
Dart, M. L., Jankowska−Gan, E., Huang, G., Roenneburg, D. A., Keller, M. R., Torrealba, J. R., Rhoads, A., Kim, B., Bobadilla, J. L., Haynes, L. D., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.221069 · Cited by 58
A Leukocyte-Mimetic Magnetic Resonance Imaging Contrast Agent Homes Rapidly to Activated Endothelium and Tracks With Atherosclerotic Lesion Macrophage Content
McAteer, M. A., Mankia, K. S., Ruparelia, N., Jefferson, A., Nugent, H. B., Stork, L., Channon, K. M., Schneider, J. E., & Choudhury, R. P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.241844 · Cited by 61
A20, a regulator of NFκB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains
Idel, S., Dansky, H. M., & Breslow, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1835672100 · Cited by 58
Self-citation
The Multiple Roles of Macrophage Scavenger Receptors (MSR) in vivo : Resistance to Atherosclerosis and Susceptibility to Infection in MSR Knockout Mice
Suzuki, H., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Sakaguchi, H., Kruijt, J. K., Higashi, T., Suzuki, T., et al. (1997) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.4.1 · Cited by 58
Homozygous Familial Defective Apolipoprotein B-100
Schaefer, J. R., Scharnagl, H., Baumstark, M. W., Schweer, H., Zech, L. A., Seyberth, H. J., Winkler, K., Steinmetz, A., & März, W. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.2.348 · Cited by 59
Impact of high fat diet on long non-coding RNAs and messenger RNAs expression in the aortas of ApoE(−/−) mice
Bao, M., Luo, H.-Q., Chen, L.-H., Tang, L., Ma, K.-F., Xiang, J., Dong, L.-P., Zeng, J., Li, G.-Y., & Li, J.-M. (2016) · Scientific Reports · doi:10.1038/srep34161 · Cited by 55
Pharmacological Targeting of the CCL2/CCR2 Axis for Atheroprotection: A Meta-Analysis of Preclinical Studies
Živković, L., Asare, Y., Bernhagen, J., Dichgans, M., & Georgakis, M. K. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.317492 · Cited by 62
Monocyte‐Targeting Supramolecular Micellar Assemblies: A Molecular Diagnostic Tool for Atherosclerosis
Chung, E. J., Mlinar, L. B., Nord, K., Sugimoto, M. J., Wonder, E. A., Alenghat, F. J., Fang, Y. H., & Tirrell, M. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400336 · Cited by 56
In vitro models of aortic valve calcification: solidifying a system
Bowler, M. A., & Merryman, W. D. (2014) · Cardiovascular Pathology · doi:10.1016/j.carpath.2014.08.003 · Cited by 60
Endothelial dysfunctions: common denominators in vascular disease
Caterina, R. D. (2000) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200011000-00007 · Cited by 57
Oxytocin administration attenuates atherosclerosis and inflammation in Watanabe Heritable Hyperlipidemic rabbits
Szeto, A., Rossetti, M. A., Mendez, A. J., Noller, C. M., Herderick, E. E., Gonzales, J. A., Schneiderman, N., & McCabe, P. M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.08.009 · Cited by 59
The role of oxysterols in control of endothelial stiffness
Shentu, T., Singh, D. K., Oh, M. J., Sun, S., Saadat, L., Makino, A., Mazzone, T., Subbaiah, P. V., Cho, M., & Levitan, I. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m027102 · Cited by 57
Supplementation with Cyanidin-3-O-ß-Glucoside Protects against Hypercholesterolemia-Mediated Endothelial Dysfunction and Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice
Wang, Y., Zhang, Y., Wang, X., Liu, Y., & Xia, M. (2012) · Journal of Nutrition · doi:10.3945/jn.112.157701 · Cited by 57
Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation
Lietz, M., Berges, A., Lebrun, S., Meurrens, K., Steffen, Y., Stolle, K., Schueller, J., Boué, S., Vuillaume, G., Vanscheeuwijck, P., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.03.036 · Cited by 57
Atherosclerotic lesions in genetically modified mice quantified in vivo by non-invasive high-resolution magnetic resonance microscopy
Choudhury, R. P., Aguinaldo, J. G. S., Rong, J. X., Kulak, J. L., Kulak, A., Reis, E. D., Fallon, J. T., Fuster, V., Fisher, E. A. A., & Fayad, Z. A. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00730-4 · Cited by 57
Arterial Injury Increases Expression of Inflammatory Adhesion Molecules in the Carotid Arteries of Apolipoprotein-E-Deficient Mice 1
Manka, D. R., Wiegman, P., Din, S., Sanders, J. M., Green, S. A., Gimple, L. W., Ragosta, M., Powers, E. R., Ley, K. F., & Sarembock, I. J. (1999) · Journal of Vascular Research · doi:10.1159/000025676 · Cited by 57
Time-dependent changes to lipids and antioxidants in plasma and aortas of apolipoprotein E knockout mice
Letters, J., Witting, P. K., Christison, J. K., Eriksson, A. W., Pettersson, K. S., & Stocker, R. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33514-8 · Cited by 57
Non-invasive assessment of pulse wave velocity in mice by means of ultrasound images
Lascio, N. D., Stea, F., Kusmic, C., Sicari, R., & Faita, F. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.08.033 · Cited by 56
Longitudinal common carotid artery wall motion is associated with plaque burden in man and mouse
Svedlund, S., & Gan, L. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.02.046 · Cited by 56
Hepatic Expression of Apolipoprotein E Inhibits Progression of Atherosclerosis without Reducing Cholesterol Levels in LDL Receptor-Deficient Mice
Tsukamoto, K., Tangirala, R. K., Chun, S. H., Usher, D. C., Puré, E., & Rader, D. J. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0028 · Cited by 56
Characterization of aortic root atherosclerosis in ApoE knockout mice: High‐resolution in vivo and ex vivo MRM with histological correlation
Itskovich, V. V., Choudhury, R. P., Aguinaldo, J. G. S., Fallon, J. T., Omerhodzic, S., Fisher, E. A. A., & Fayad, Z. A. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10360 · Cited by 56
Total panax notoginsenosides prevent atherosclerosis in apolipoprotein E-knockout mice: Role of downregulation of CD40 and MMP-9 expression
Liu, G., Wang, B., Zhang, J., Jiang, H., & Liu, F. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.08.014 · Cited by 56
Prevention of Fatty Streak Formation of 17β-Estradiol Is Not Mediated by the Production of Nitric Oxide in Apolipoprotein E– Deficient Mice
Elhage, R., Bayard, F., Richard, V. J., Holvoet, P., Duverger, N., Fiévet, C., & Arnal, J. (1997) · Circulation · doi:10.1161/01.cir.96.9.3048 · Cited by 56
CircRNA–miRNA interactions in atherogenesis
Tong, K.-L., Tan, K., Lim, Y., Tien, X.-Y., & Wong, P. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04455-8 · Cited by 59
The androgen receptor confers protection against diet‐induced atherosclerosis, obesity, and dyslipidemia in female mice
Fagman, J. B., Wilhelmson, A. S., Motta, B. M., Pirazzi, C., Alexanderson, C., Gendt, K. D., Verhoeven, G., Holmäng, A. B., Anesten, F., Jansson, J., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-259234 · Cited by 55
Homocysteine: a sulph’rous fire
Hajjar, K. A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12369 · Cited by 55
Loss of the Lysophosphatidylcholine Effector, G2A, Ameliorates Aortic Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice
Parks, B. W., Lusis, A. J., & Kabarowski, J. H. S. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000246774.02426.71 · Cited by 55
Genistein alleviates the development of nonalcoholic steatohepatitis in A po E ―/― mice fed a high‐fat diet
Jeon, S., Park, Y., & Kwon, Y. H. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300112 · Cited by 54
Complete Prevention of Atherosclerosis in ApoE-Deficient Mice by Hepatic Human ApoE Gene Transfer With Adeno-Associated Virus Serotypes 7 and 8
Kitajima, K., Marchadier, D. H. L., Miller, G. C., Gao, G.-P., Wilson, J. M., & Rader, D. J. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000231520.26490.54 · Cited by 54
Piecewise Pulse Wave Imaging (pPWI) for Detection and Monitoring of Focal Vascular Disease in Murine Aortas and Carotids In Vivo
Apostolakis, I., Nandlall, S. D., & Konofagou, E. E. (2015) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2015.2453194 · Cited by 54
Magnetic Nanoparticles Conjugated with Peptides Derived from Monocyte Chemoattractant Protein-1 as a Tool for Targeting Atherosclerosis
Kao, C.-W., Wu, P., Liao, M., Chung, I.-J., Yang, K., Tseng, W. I., & Yu, J. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10020062 · Cited by 54
Dietary Cholesterol Plays a Role in CD36-Mediated Atherogenesis in LDLR-Knockout Mice
Kennedy, D. J., Kuchibhotla, S., Guy, E. C., Park, Y. M., Nimako, G. K., Vanegas, D., Morton, R. E., & Febbraio, M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.191940 · Cited by 60
Effects of Lipid Interaction on the Lysine Microenvironments in Apolipoprotein E
Lund‐Katz, S., Zaiou, M., Wehrli, S. L., Dhanasekaran, P., Baldwin, F., Weisgraber, K. H., & Phillips, M. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005265200 · Cited by 54
Intravascular Optical Coherence Tomography Detection of Atherosclerosis and Inflammation in Murine Aorta
Tahara, S., Morooka, T., Wang, Z., Bezerra, H. G., Rollins, A. M., Simon, D. I., & Costa, M. A. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.243626 · Cited by 53
Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation
Wei, H.-J., Li, Y., Shi, G. Y., Liu, S.-L., Chang, P.-C., Kuo, C., & Wu, H. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr220 · Cited by 53
Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice
Jung, Y. S., Park, J. H., Kim, H., Kim, S. Y., Hwang, J. Y., Hong, K. W., Bae, S. S., Choi, B. T., Lee, S., & Shin, H. K. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.51 · Cited by 53
Increased Cholesterol Efflux in Apolipoprotein AI (ApoAI)–Producing Macrophages as a Mechanism for Reduced Atherosclerosis in ApoAI (−/−) Mice
Major, A. S., Dove, D. E., Ishiguro, H., Su, Y. R., Brown, A. M., Liu, L., Carter, K. J., Linton, M. F., & Fazio, S. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1101.097798 · Cited by 53
Lack of regression of atherosclerotic lesions in phytosterol-treated apo E-deficient mice
Moghadasian, M. H., Godin, D. V., McManus, B. M., & Frohlich, J. J. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00029-6 · Cited by 53
p66ShcDeletion Confers Vascular Protection in Advanced Atherosclerosis in Hypercholesterolemic Apolipoprotein E Knockout Mice
Martin-Padura, I., de Nigris, F., Migliaccio, E., Mansueto, G., Minardi, S., Rienzo, M., Lerman, L. O., Stendardo, M., Giorgio, M., De Rosa, G., et al. (2008) · Endothelium · doi:10.1080/10623320802487791 · Cited by 52
Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet
Pejnovic, N. N., Vratimos, A., Lee, S. E., Popadic, D. M., Takeda, K., Akira, S., & Chan, W. L. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2008.12.032 · Cited by 53
Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses
Khan, S., Rahman, H., Okamoto, T., Matsunaga, T., Fujiwara, Y., Sawa, T., Yoshitake, J., Ono, K., Ahmed, K. A., Rahaman, M. M., et al. (2014) · Scientific Reports · doi:10.1038/srep04680 · Cited by 53
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
Venegas-Pino, D. E., Banko, N. S., Khan, M. I. U., Shi, Y., & Werstuck, G. H. (2013) · Journal of Visualized Experiments · doi:10.3791/50933 · Cited by 52
Dietary Flaxseed Oil Prevents Western‐Type Diet‐Induced Nonalcoholic Fatty Liver Disease in Apolipoprotein‐E Knockout Mice
Han, H., Qiu, F., Zhao, H., Tang, H., Li, X., & Shi, D. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3256241 · Cited by 53
Macrophage-Enriched lncRNA RAPIA
Sun, C., Fu, Y., Gu, X., Xi, X., Peng, X., Wang, C., Sun, Q., Wang, X., Qian, F., Qin, Z., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313749 · Cited by 52
Polymorphism of class A scavenger receptors in C57BL/6 mice
Daugherty, A., Whitman, S. C., Block, A., & Rateri, D. L. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31989-1 · Cited by 52
Recombinant apolipoproteins for the treatment of vascular diseases
Sirtori, C. R., Calabresi, L., & Franceschini, G. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00247-0 · Cited by 51
Subcutaneous immunization with heat shock protein-65 reduces atherosclerosis in Apoe/ mice
Klingenberg, R., Ketelhuth, D. F. J., Strodthoff, D., Gregori, S., & Hansson, G. K. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.06.006 · Cited by 51
Oxidized low-density lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA-210
Chen, K., Liao, Y., Wang, J., Lin, Y., Chen, C.-H., & Juo, S. H. (2015) · Oncotarget · doi:10.18632/oncotarget.4152 · Cited by 51
Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice
Salim, H. M., Fukuda, D., Higashikuni, Y., Tanaka, K., Hirata, Y., Yagi, S., Soeki, T., Shimabukuro, M., & Sata, M. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.03.003 · Cited by 51
A new approach to the diagnosis and treatment of atherosclerosis: the era of the liposome
Kiaie, N., Gorabi, A. M., Penson, P. E., Watts, G. F., Johnston, T. P., Banach, M., & Sahebkar, A. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.09.005 · Cited by 51
Anti-Atherosclerosis Effect of Angong Niuhuang Pill via Regulating Th17/Treg Immune Balance and Inhibiting Chronic Inflammatory on ApoE-/- Mice Model of Early and Mid-Term Atherosclerosis
Fan, Q., Liu, Y., Rao, J., Zhang, Z., Xiao, W. L., Zhu, T., Chai, X., Ye, K., Ning, N., Zhen, Y., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01584 · Cited by 51
Gene Expression in Atherosclerotic Lesion of ApoE Deficient Mice
Wuttge, D. M., Sirsjö, A., Eriksson, P. O., & Stemme, S. (2001) · Molecular Medicine · doi:10.1007/bf03402184 · Cited by 51
Oral Magnesium Supplementation Induces Favorable Antiatherogenic Changes in ApoE-Deficient Mice
Ravn, H. B., Korsholm, T. L., & Falk, E. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.5.858 · Cited by 51
Low-Density Lipoprotein From Apolipoprotein E-Deficient Mice Induces Macrophage Lipid Accumulation in a CD36 and Scavenger Receptor Class A-Dependent Manner
Zhao, Z., de Beer, M. C., Cai, L., Asmis, R., de Beer, F. C., de Villiers, W. J. S., & van der Westhuyzen, D. R. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000149145.00865.d9 · Cited by 51
CCR2: From Cloning to the Creation of Knockout Mice
Charo, I. F. (1999) · KARGER eBooks · doi:10.1159/000058724 · Cited by 51
Smooth Muscle Cell—Macrophage Interactions Leading to Foam Cell Formation in Atherosclerosis: Location, Location, Location
Xiang, P., Blanchard, V., & Francis, G. A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.921597 · Cited by 53
Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications
McNeill, E., Channon, K. M., & Greaves, D. R. (2010) · Clinical Science · doi:10.1042/cs20090488 · Cited by 51
Atherosclerotic plaque imaging using phase-contrast X-ray computed tomography
Shinohara, M., Yamashita, T., Tawa, H., Takeda, M., Sasaki, N., Takaya, T., Toh, R., Takeuchi, A., Ohigashi, T., Shinohara, K., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01149.2007 · Cited by 50
Comparative Lipid and Lipoprotein Metabolism
Bauer, J. E. (1996) · Veterinary Clinical Pathology · doi:10.1111/j.1939-165x.1996.tb00968.x · Cited by 50
Mouse Cytomegalovirus M33 Is Necessary and Sufficient in Virus-Induced Vascular Smooth Muscle Cell Migration
Melnychuk, R., Smith, P. P., Kreklywich, C. N., Ruchti, F., Totonchy, J. E., Hall, L., Loh, L. C., Nelson, J. A., Orloff, S. L., & Streblow, D. N. (2005) · Journal of Virology · doi:10.1128/jvi.79.16.10788-10795.2005 · Cited by 50
Hawthorn fruit extract reduced trimethylamine-N-oxide (TMAO)-exacerbated atherogenesis in mice via anti-inflammation and anti-oxidation
He, Z., Kwek, E., Hao, W., Zhu, H., Liu, J., Ma, K. Y., & Chen, Z. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-020-00535-y · Cited by 51

Authors: Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R.
Affiliations: University of Washington (US)
ORCID: Nakashima, Y
Breslow, J L
Venue: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1994-01
Volume: 14
Issue: 1
Pages: 133-140
ISSN: 1049-8834 (ISSN-L)
DOI: 10.1161/01.atv.14.1.133
OpenAlex: W1964814612
Cited by: 1,693
References: 28
Citations by year: 2026: 18 · 2025: 32 · 2024: 40 · 2023: 42 · 2022: 54 · 2021: 60 · 2020: 47 · 2019: 57 · 2018: 45 · 2017: 66 · 2016: 50 · 2015: 69 · 2014: 71 · 2013: 73 · 2012: 78
FWCI: 14.99
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis and Thrombosis A Journal of Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Bristol-Myers Squibb
National Institutes of Health (5r01hl033714-17, 18645, HL 18645)
National Heart, Lung, and Blood Institute (HL-18645, HL 33714, R01HL032435, HL32435, P01HL018645)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: apolipoprotein E deficiency, atherosclerosis, atherosclerotic plaque development, Western diet, hypercholesterolemia, fibrous cap, necrotic core, aortic root lesions, mouse model of atherosclerosis, atherogenesis
MeSH terms: Animals, Aorta, Aorta, Thoracic, Apolipoproteins E, Arteriosclerosis, Carotid Arteries, Coronary Vessels, Diet, Endothelium, Vascular, Hypercholesterolemia, Leukocytes, Mononuclear, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Pulmonary Artery, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks