Cited by 1,693Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Nakashima, Y, Plump, A S, Raines, E W, Breslow, J L, Ross, R·1994·Arteriosclerosis and Thrombosis: A Journal of Vascular Biology

DOI 10.1161/01.atv.14.1.133

Open this paper in CoChat — free account

Abstract

Initial description of apolipoprotein (apo) E-deficient transgenic mice demonstrated the development of severe hypercholesterolemia due to probable delayed clearance of large atherogenic particles from the circulation. Examination of these mice demonstrated foam cell accumulation in the aortic root and pulmonary arteries by 10 weeks of age. In the present study, the animals were fed either chow or a high-fat, Western-type diet and examined at ages ranging from 6 to 40 weeks. Gross examination by dissection microscopy revealed a predilection for development of lesions in the aortic root, at the lesser curvature of the aortic arch, the principal branches of the aorta, and in the pulmonary and carotid arteries. Monocyte attachment to endothelial cells was observed by light and electron microscopic examination at 6 weeks, the earliest time point examined. Foam cell lesions developed as early as 8 weeks, and after 15 weeks advanced lesions (fibrous plaques) were observed. The latter consisted of a fibrous cap containing smooth muscle cells surrounded by connective tissue matrix that covered a necrotic core with numerous foamy macrophages. Mice fed the Western-type diet generally had more advanced lesions than those fed a chow diet. The apoE-deficient mouse contains the entire spectrum of lesions observed during atherogenesis and is the first mouse model to develop lesions similar to those in humans. This model should provide numerous opportunities to study the pathogenesis and therapy of atherosclerosis in a small, genetically defined animal.

Integrity signals

Registry

Crossref · 10.1161/01.atv.14.1.133

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
Self-citation
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Self-citation
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.
Rg, G. (1981) · PubMed Central · Cited by 1,314
Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.
Faggiotto, A., Ross, R., & Harker, L. A. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.4.323 · Cited by 978
Self-citation
Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.
Gown, A. M., Tsukada, T., & Ross, R. (1986) · PubMed · Cited by 678
Self-citation
Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.
Faggiotto, A., & Ross, R. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.4.341 · Cited by 466
Self-citation
The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.
Gerrity, R. G. (1981) · PubMed · Cited by 459
Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein
Marotti, K. R., Castle, C. K., Boyle, T. P., Lin, A. H., Murray, R. W., & Melchior, G. W. (1993) · Nature · doi:10.1038/364073a0 · Cited by 444
Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II
Warden, C. H., Hedrick, C. C., Qiao, J.-H., Castellani, L. W., & Lusis, A. J. (1993) · Science · doi:10.1126/science.8332912 · Cited by 359

Show all 28 references

Sorted by citations

Items 401–500 of 1,000

Atherosclerosis Progression in LDL Receptor–Deficient and Apolipoprotein E–Deficient Mice Is Independent of Genetic Alterations in Plasminogen Activator Inhibitor-1
Sjöland, H., Eitzman, D. T., Gordon, D., Westrick, R. J., Nabel, E. G., & Ginsburg, D. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.846 · Cited by 86
Enhanced Thrombosis in Atherosclerosis-Prone Mice Is Associated With Increased Arterial Expression of Plasminogen Activator Inhibitor-1
Schäfer, K., Müller, K., Hecke, A., Mounier, E., Goebel, J., Loskutoff, D. J., & Konstantinides, S. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000097766.36623.df · Cited by 86
Low magnesium and atherosclerosis: an evidence-based link
Maier, J. A. M. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(02)00095-x · Cited by 85
Essential role of transient receptor potential vanilloid type 1 in evodiamine‐mediated protection against atherosclerosis
Wei, J., Ching, L. ‐., Zhao, J. ‐., Shyue, S., Lee, H. ‐., Kou, Y. R., & Lee, T. (2012) · Acta Physiologica · doi:10.1111/apha.12005 · Cited by 85
Animal models of atherosclerosis
Lee, Y. T., Laxton, V., Lin, H. Y., Chan, Y. W. F., Fitzgerald-Smith, S., To, T. L. O., Yan, B. P., Liu, T., & Tse, G. (2017) · Biomedical Reports · doi:10.3892/br.2017.843 · Cited by 84
Atherosclerosis
Rahman, M. S., & Woollard, K. J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-57613-8_7 · Cited by 87
Augmented angiogenesis in adventitia promotes growth of atherosclerotic plaque in apolipoprotein E-deficient mice
Tanaka, K., Nagata, D., Hirata, Y., Tabata, Y., Nagai, R., & Sata, M. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.01.016 · Cited by 84
Antioxidant effects and the therapeutic mode of action of calcium channel blockers in hypertension and atherosclerosis
Godfraind, T. (2005) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1774 · Cited by 84
Accelerated atherosclerosis and premature calcified cartilaginous metaplasia in the aorta of diabetic male Apo E knockout mice can be prevented by chronic treatment with 17β-estradiol
Tse, J., Martin-McNulty, B., Halks‐Miller, M., Kauser, K. Z., DelVecchio, V., Vergona, R. A., Sullivan, M. E., & Rubanyi, G. M. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00325-6 · Cited by 84
The value of apolipoprotein E knockout mice for studying the effects of dietary fat and cholesterol on atherogenesis
Osada, J., Joven, J., & Maeda, N. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200002000-00004 · Cited by 84
Dietary Soy Protein Isolate, Compared with Casein, Reduces Atherosclerotic Lesion Area in Apolipoprotein E–Deficient Mice
Ni, W., Tsuda, Y., Sakono, M., & Imaizumi, K. (1998) · Journal of Nutrition · doi:10.1093/jn/128.11.1884 · Cited by 83
Proteome Analysis of Serum from Type 2 Diabetics with Nephropathy
Kim, H.-J., Cho, E.-H., Yoo, J.-H., Kim, P.-K., Shin, J., Kim, M.-R., & Kim, C. (2007) · Journal of Proteome Research · doi:10.1021/pr060489g · Cited by 82
Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis
Manea, S., Vlad, M.-L., Fenyo, I. M., Lazar, A.-G., Raicu, M., Mureşian, H., Simionescu, M., & Manea, A. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101338 · Cited by 81
Characterization of atherosclerosis in LDL receptor knockout mice: macrophage accumulation correlates with rapid and sustained expression of aortic MCP-1/JE
Kowala, M. C., Recce, R., Beyer, S. M., Gu, C., & Valentine, M. T. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00342-1 · Cited by 82
Molecular evidence for arterial repair in atherosclerosis
Karra, R., Vemulapalli, S., Dong, C., Herderick, E. E., Song, X., Slosek, K., Nevins, J. R., West, M., Goldschmidt‐Clermont, P. J., & Seo, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507718102 · Cited by 82
Postmenopausal changes in serum cytokine levels and hormone replacement therapy
Kamada, M., Irahara, M., Maegawa, M., Ohmoto, Y., Takeji, T., Yasui, T., & Aono, T. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.109940 · Cited by 82
Unraveling Pleiotropic Effects of Statins on Plaque Rupture
Palinski, W., & Claudio Napoli, A. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000038754.39483.cd · Cited by 84
IL-6 and the acute phase response in murine atherosclerosis.
Song, L., & Schindler, C. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.06.018 · Cited by 85
Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment
Lucerna, M., Zernecke, A., de Nooijer, R., de Jager, S. C. A., Bot, I., van der Lans, C., Kholová, I., Liehn, E. A., van Berkel, T. J. C., Ylä‐Herttuala, S., et al. (2006) · Blood · doi:10.1182/blood-2006-07-031773 · Cited by 81
The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice
Watson, A. M. D., Li, J., Schumacher, C., de Gasparo, M., Feng, B., Thomas, M. C., Allen, T. J., Cooper, M. E., & Jandeleit-Dahm, K. A. M. (2009) · Diabetologia · doi:10.1007/s00125-009-1540-3 · Cited by 83
Peripheral arterial occlusive disease: Global gene expression analyses suggest a major role for immune and inflammatory responses
Fu, S., Zhao, H., Shi, J., Abzhanov, A., Crawford, K. D., Lucila Ohno-machado, A., Zhou, J., Du, Y., Kuo, W. P., Zhang, J., et al. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-369 · Cited by 81
Chronic Exposure to the Carcinogenic Compound Benzo[a]Pyrene Induces Larger and Phenotypically Different Atherosclerotic Plaques in ApoE-Knockout Mice
Curfs, D. M. J., Lutgens, E., Gijbels, M. J., Kockx, M. M., Daemen, M. J. A. P., & van Schooten, F. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63101-x · Cited by 81
MicroRNA-27 Prevents Atherosclerosis by Suppressing Lipoprotein Lipase-Induced Lipid Accumulation and Inflammatory Response in Apolipoprotein E Knockout Mice
Xie, W., Li, L., Zhang, M., Cheng, H., Gong, D., Lv, Y.-C., Yao, F., He, P., Ouyang, X.-P., Lan, G., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157085 · Cited by 81
Comprehensive Plasma Metabolomic Analyses of Atherosclerotic Progression Reveal Alterations in Glycerophospholipid and Sphingolipid Metabolism in Apolipoprotein E-deficient Mice
Dang, V. T., Huang, A., Zhong, L. H., Shi, Y., & Werstuck, G. H. (2016) · Scientific Reports · doi:10.1038/srep35037 · Cited by 80
Macrophage Phenotype in Mice Deficient in Both Macrophage-Colony–Stimulating Factor (Op) and Apolipoprotein E
de Villiers, W. J. S., Smith, J. D., Miyata, M., Dansky, H. M., Darley, E., & Gordon, S. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.4.631 · Cited by 80
Cytomegalovirus infection aggravates atherogenesis in apoE knockout mice by both local and systemic immune activation
Vliegen, I., Duijvestijn, A., Grauls, G., Herngreen, S., Bruggeman, C., & Stassen, F. (2004) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.024 · Cited by 80
Melatonin and its atheroprotective effects: A review
Favero, G., Rodella, L. F., Reiter, R. J., & Rezzani, R. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.11.016 · Cited by 79
Pathogen-Mediated Inflammatory Atherosclerosis Is Mediated in Part via Toll-Like Receptor 2-Induced Inflammatory Responses
Hayashi, C., Madrigal, A. G., Liu, X., Ukai, T., Goswami, S., Gudino, C. V., Gibson, F. C., & Genco, C. A. (2010) · Journal of Innate Immunity · doi:10.1159/000314686 · Cited by 82
Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in Apolipoprotein-E knockout mice fed a high cholesterol diet
Xu, S., Little, P. J., Lan, T., Huang, Y. Y., Le, K., Wu, X., Shen, X., Huang, H., Cai, Y., Tang, F., et al. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.08.006 · Cited by 80
Nitric Oxide Synthases and Cardiovascular Diseases Insights From Genetically Modified Mice
Tsutsui, M., Shimokawa, H., Otsuji, Y., Ueta, Y., Sasaguri, Y., & Yanagihara, N. (2009) · Circulation Journal · doi:10.1253/circj.cj-09-0208 · Cited by 80
THE AGE/RAGE AXIS IN DIABETES‐ACCELERATED ATHEROSCLEROSIS
Jandeleit-Dahm, K. A. M., Watson, A. M. D., & Soro‐Paavonen, A. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04875.x · Cited by 80
Açaí juice attenuates atherosclerosis in ApoE deficient mice through antioxidant and anti-inflammatory activities
Xie, C., Kang, J., Burris, R. L., Ferguson, M. E., Schauss, A. G., Nagarajan, S., & Wu, X. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.02.035 · Cited by 80
Infection and atherosclerosis. An alternative view on an outdated hypothesis.
Stassen, F. R. M., Vainas, T., & Bruggeman, C. A. (2008) · PubMed · Cited by 79
Hyperlipidaemia and cardioprotection: Animal models for translational studies
Andreadou, I., Schulz, R., Badimón, L., Adameová, A., Kleinbongard, P., Lecour, S., Nikolaou, P., Falcão‐Pires, I., Vilahur, G., Woudberg, N. J., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14931 · Cited by 87
Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells
Kim, S., Kim, C. E., & Kim, M. H. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.115 · Cited by 79
The Constitutive Function of Native TRPC3 Channels Modulates Vascular Cell Adhesion Molecule-1 Expression in Coronary Endothelial Cells Through Nuclear Factor κB Signaling
Smedlund, K., Tano, J.-Y., & Vázquez, G. (2010) · Circulation Research · doi:10.1161/circresaha.109.213314 · Cited by 79
Platelet Dense-Granule Secretion Plays a Critical Role in Thrombosis and Subsequent Vascular Remodeling in Atherosclerotic Mice
King, S. M., McNamee, R. A., Houng, A. K., Patel, R., Brands, M. W., & Reed, G. L. (2009) · Circulation · doi:10.1161/circulationaha.108.845461 · Cited by 78
μCT of ex-vivo stained mouse hearts and embryos enables a precise match between 3D virtual histology, classical histology and immunochemistry
Dullin, C., Ufartes, R., Larsson, E., Martin, S., Lazzarini, M., Tromba, G., Missbach‐Guentner, J., Pinkert‐Leetsch, D., Katschinski, D. M., & Alves, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170597 · Cited by 78
Fibrinogen deficiency is compatible with the development of atherosclerosis in mice.
Xiao, Q., Danton, M. J. S., Witte, D. P., Kowala, M. C., Valentine, M. T., & Degen, J. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1461 · Cited by 78
Effect of probucol on LDL oxidation and atherosclerosis in LDL receptor-deficient mice
Bird, D. A., Tangirala, R. K., Fruebis, J., Steinberg, D. H., Witztum, J. L., & Palinski, W. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33877-3 · Cited by 78
Apo A-I inhibits foam cell formation in apo E–deficient mice after monocyte adherence to endothelium
Dansky, H. M., Charlton, S. A., Barlow, C. B., Tamminen, M., Smith, J. D., Frank, J. S., & Breslow, J. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6577 · Cited by 78
Self-citation
Arg123-Tyr166 Domain of Human ApoA-I Is Critical for HDL-Mediated Inhibition of Macrophage Homing and Early Atherosclerosis in Mice
Holvoet, P., Peeters, K., Lund‐Katz, S., Mertens, A. C., Verhamme, P. B., Quarck, R. A., Stengel, D., Lox, M., Deridder, E., Bernar, H., et al. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1201.100221 · Cited by 78
Investigation of Wall Shear Stress in Cardiovascular Research and in Clinical Practice—From Bench to Bedside
Urschel, K., Tauchi, M., Achenbach, S. S., & Dietel, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115635 · Cited by 77
Artemisinin and Procyanidins loaded multifunctional nanocomplexes alleviate atherosclerosis via simultaneously modulating lipid influx and cholesterol efflux
Zhou, H., You, P., Liu, H., Fan, J., Tong, C., Yang, A., Jiang, Y., & Liu, B. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.12.021 · Cited by 77
Panax notoginseng Reduces Atherosclerotic Lesions in ApoE-Deficient Mice and Inhibits TNF-α-Induced Endothelial Adhesion Molecule Expression and Monocyte Adhesion
Wan, J., Lee, S. M., Wang, J.-D., Wang, N., He, C., Wang, Y., & Kang, J. X. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900529w · Cited by 77
Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease
Tabibiazar, R., Wagner, R. A., Ashley, E. A., King, J. Y., Ferrara, R., Spin, J. M., Sanan, D. A., Narasimhan, B., Tibshirani, R. J., Tsao, P. S., et al. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00001.2005 · Cited by 77
Animal models of myocardial infarction: Mainstay in clinical translation
Kumar, M., Kasala, E. R., Bodduluru, L. N., Dahiya, V., Sharma, D., Kumar, V., & Lahkar, M. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.03.005 · Cited by 77
In Silico Quantitative Trait Locus Map for Atherosclerosis Susceptibility in Apolipoprotein E–Deficient Mice
Smith, J. D., James, D., Dansky, H. M., Wittkowski, K. M., Moore, K. J., & Breslow, J. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000047461.18902.80 · Cited by 77
Self-citation
Beijing ambient particle exposure accelerates atherosclerosis in ApoE knockout mice
Chen, T., Jia, G., Wei, Y., & Li, J. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.09.004 · Cited by 76
Red Wine Does Not Reduce Mature Atherosclerosis in Apolipoprotein E–Deficient Mice
Bentzon, J. F., Skovenborg, E., Hansen, C. P., Møller, J., de Gaulejac, N. V., Proch, J., & Falk, E. (2001) · Circulation · doi:10.1161/01.cir.103.12.1681 · Cited by 76
Rosiglitazone Reduces the Accelerated Neointima Formation After Arterial Injury in a Mouse Injury Model of Type 2 Diabetes
Phillips, J. W., Barringhaus, K. G., Sanders, J. M., Yang, Z., Chen, M., Hesselbacher, S. E., Czarnik, A. C., Ley, K. F., Nadler, J. L., & Sarembock, I. J. (2003) · Circulation · doi:10.1161/01.cir.0000092886.52404.50 · Cited by 76
Genetic Determination of Cartilaginous Metaplasia in Mouse Aorta
Qiao, J.-H., Fishbein, M. C., Demer, L. L., & Lusis, A. J. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.12.2265 · Cited by 76
Rosuvastatin displays anti-atherothrombotic and anti-inflammatory properties in apoE-deficient mice
Monetti, M., Canavesi, M., Camera, M., Parente, R., Paoletti, R., Tremoli, E., Corsini, A., & Bellosta, S. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.02.001 · Cited by 75
Animal Models of Atherosclerosis
Fuster, J. J., Castillo, A. I., Zaragoza, C., Ibáñez, B., & Andrés, V. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394596-9.00001-9 · Cited by 75
Role of extracellular retention of low density lipoproteins in atherosclerosis
Borén, J., Gustafsson, M. V., Skålén, K., Flood, C., & Innerarity, T. L. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200010000-00002 · Cited by 75
Morphological and functional alterations of the cochlea in apolipoprotein E gene deficient mice
Guo, Y., Zhang, C., Du, X., Nair, U., & Yoo, T. J. (2005) · Hearing Research · doi:10.1016/j.heares.2005.05.010 · Cited by 74
Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice
Miyoshi, T., Li, Y., Shih, D. M., Wang, X., Laubach, V. E., Matsumoto, A. H., Helm, G. A., Lusis, A. J., & Shi, W. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.01.043 · Cited by 74
Dual-Energy Computed Tomography Imaging of Atherosclerotic Plaques in a Mouse Model Using a Liposomal-Iodine Nanoparticle Contrast Agent
Bhavane, R. C., Badea, C. T., Ghaghada, K. B., Clark, D. P., Vela, D. C., Moturu, A., Annapragada, A. V., Johnson, G. A., Willerson, J. T., & Annapragada, A. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.112.000119 · Cited by 73
The Role of Intestinal Dysbacteriosis Induced Arachidonic Acid Metabolism Disorder in Inflammaging in Atherosclerosis
Sun, Y., Wu, D., Zeng, W., Chen, Y., Guo, M., Lü, B., Li, H., Sun, C. X., Yang, L., Jiang, X., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.618265 · Cited by 72
Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment
Zhang, X., Centurion, F., Misra, A., Patel, S., & Gu, Z. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114709 · Cited by 76
Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development
Conover, C. A., Mason, M. A., Bale, L. K., Harrington, S. C., Nyegaard, M., Oxvig, C., & Overgaard, M. T. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00904.2009 · Cited by 72
Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgrounds
Maeda, N., Johnson, L. A., Kim, S., Hagaman, J. R., Friedman, M. H., & Reddick, R. L. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.12.006 · Cited by 72
Raman Spectroscopic Evaluation of the Effects of Diet and Lipid-Lowering Therapy on Atherosclerotic Plaque Development in Mice
van de Poll, S. W. E., Römer, T. J., Volger, O. L., Delsing, D. J. M., Schut, T. C. B., Princen, H. M. G., Havekes, L. M., Jukema, J. W., van der Laarse, A., & Puppels, G. J. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1001.096651 · Cited by 72
Native LDL and minimally oxidized LDL differentially regulate superoxide anion in vascular endothelium in situ
Stepp, D. W., Ou, J., Ackerman, A. W., Welak, S. R., Klick, D. E., & Pritchard, K. A. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00029.2002 · Cited by 71
The Role of Proteomics in Clinical Cardiovascular Biomarker Discovery
Edwards, A. V. G., White, M. Y., & Cordwell, S. J. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r800007-mcp200 · Cited by 73
Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis
Nus, M., Martı́nez-Poveda, B., MacGrogan, D., Chevre, R., D’Amato, G., Sbroggió, M., Rodrı́guez, C., Martínez‐González, J., Andrés, V., Hidalgo, A., et al. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw193 · Cited by 71
Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention
Vlad, A., & Zingg, J.-M. A. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.07.001 · Cited by 71
Pathologic intimal thickening in human atherosclerosis is formed by extracellular accumulation of plasma-derived lipids and dispersion of intimal smooth muscle cells
Nakagawa, K., & Nakashima, Y. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.03.039 · Cited by 70
Self-citation
Site-specific targeting of antibody activity in vivo mediated by disease-associated proteases
Erster, O., Thomas, J. M., Hamzah, J., Jabaiah, A. M., Getz, J. A., Schoep, T. D., Hall, S. S., Ruoslahti, E. I., & Daugherty, P. S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.035 · Cited by 70
Molecular Imaging of Matrix Metalloproteinase Expression in Atherosclerotic Plaques of Mice Deficient in Apolipoprotein E or Low-Density-Lipoprotein Receptor
Ohshima, S., Petrov, A. D., Fujimoto, S., Zhou, J. F., Azure, M. T., Edwards, D. S., Murohara, T., Narula, N., Tsimikas, S., & Narula, J. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.055889 · Cited by 70
Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AI
Crauwels, H. M. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00353-5 · Cited by 70
Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species
Binderup, T., Duivenvoorden, R., Fay, F., van Leent, M. M. T., Malkus, J., Baxter, S., Ishino, S., Zhao, Y., Sánchez-Gaytán, B. L., Teunissen, A. J. P., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw7736 · Cited by 70
Fusobacterium nucleatum GroEL induces risk factors of atherosclerosis in human microvascular endothelial cells and ApoE−/− mice
Lee, H., Jun, H., Kim, H., Lee, S. H., & Choi, B. (2011) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2011.00636.x · Cited by 71
Anti-atherogenic property of ferulic acid in apolipoprotein E-deficient mice fed Western diet: Comparison with clofibrate
Kwon, E., Do, G., Cho, Y. Y., Park, Y. B., Jeon, S., & Choi, M. S. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.05.063 · Cited by 69
Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation
Harada, N., Ito, K., Hosoya, T., Mimura, J., Maruyama, A., Noguchi, N., Yagami, K.-I., Morito, N., Takahashi, S., Maher, J. M., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.001 · Cited by 69
Gremlin-1 Is an Inhibitor of Macrophage Migration Inhibitory Factor and Attenuates Atherosclerotic Plaque Growth in ApoE−/− Mice
Müller, I. I., Schönberger, T., Schneider, M., Borst, O., Ziegler, M., Seizer, P., Leder, C., Müller, K., Lang, M., Appenzeller, F., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.477745 · Cited by 69
Mouse model of heterotopic aortic arch transplantation
Chereshnev, I., Trogan, E., Omerhodzic, S., Itskovich, V. V., Aguinaldo, J.-G., Fayad, Z. A., Fisher, E. A. A., & Reis, E. D. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(03)00039-8 · Cited by 69
Apolipoprotein E regulates dietary cholesterol absorption and biliary cholesterol excretion: Studies in C57BL/6 apolipoprotein E knockout mice
Sehayek, E., Shefer, S., Nguyen, L. B., Ono, J. G., Merkel, M., & Breslow, J. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050016197 · Cited by 69
Self-citation
Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice
Zhou, J., Møller, J., Ritskes-Hoitinga, M. J., Larsen, M. L., Austin, R. C., & Falk, E. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00138-2 · Cited by 69
Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall
Guri, A. J., Misyak, S. A., Hontecillas, R., Hasty, A. H., Liu, D., Si, H., & Bassaganya-Riera, J. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.10.003 · Cited by 68
Interleukin-18-induced atherosclerosis involves CD36 and NF-κB crosstalk in Apo E−/− mice
Bhat, O. M., Kumar, P., Giridharan, N. V., Kaul, D., Kumar, M., & Dhawan, V. (2014) · Journal of Cardiology · doi:10.1016/j.jjcc.2014.10.012 · Cited by 68
Circulating adhesion molecules in apoE-deficient mouse strains with different atherosclerosis susceptibility
Tian, J., Pei, H., James, J. C., Li, Y., Matsumoto, A. H., Helm, G. A., & Shi, W. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.090 · Cited by 68
Determination of the lower threshold of apolipoprotein E resulting in remnant lipoprotein clearance
Hasty, A. H., Linton, M. F., Swift, L. L., & Fazio, S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33397-6 · Cited by 68
Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice
Claudio Napoli, A., Ackah, E., de Nigris, F., Soldato, P. D., D’Armiento, F. P., Crimi, E., Condorelli, M., & Sessa, W. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192244499 · Cited by 74
The results in rodent models of atherosclerosis are not interchangeable
Joven, J., Rull, A., Ferré, N., Escolá‐Gil, J. C., Marsillach, J., Coll, B., Alonso‐Villaverde, C., Aragonès, G., Clària, J., & Camps, J. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.06.012 · Cited by 67
Pivotal Role of Serum- and Glucocorticoid-Inducible Kinase 1 in Vascular Inflammation and Atherogenesis
Borst, O., Schaub, M., Walker, B., Schmid, E., Münzer, P., Voelkl, J. G. J., Alesutan, I., Rodríguez, J. M., Vogel, S., Schoenberger, T., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304454 · Cited by 67
Inhibitory effects of myricitrin on oxidative stress‐induced endothelial damage and early atherosclerosis in ApoE ‐/‐ mice (1146.5)
Sun, G., Qin, M., Meng, X., & Sun, X. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.1146.5 · Cited by 66
Apolipoprotein E, an important player in longevity and age-related diseases
Ang, L. S., Cruz, R. P., Hendel, A., & Granville, D. J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.03.010 · Cited by 70
Angiotensin II injures the arterial wall causing increased aortic stiffening in apolipoprotein E-deficient mice
Tham, D. M., Martin-McNulty, B., Wang, Y.-X., da Cunha, V., Wilson, D. W., Athanassious, C. N., Powers, A. F., Sullivan, M. E., & Rutledge, J. C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00295.2002 · Cited by 66
Sildenafil restores endothelial function in the apolipoprotein E knockout mouse
Balarini, C. M., Leal, M. A. S., Gomes, I. B., Pereira, T. M. C., Gava, A. L., Meyrelles, S. S., & Vasquez, E. C. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-3 · Cited by 66
Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging
Senders, M. L., Meerwaldt, A. E., van Leent, M. M. T., Sánchez-Gaytán, B. L., van de Voort, J. C., Toner, Y. C., Maier, A., Klein, E. D., Sullivan, N. A. T., Sofias, A. M., et al. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0642-4 · Cited by 65
Macrophage-Derived Myeloid Differentiation Protein 2 Plays an Essential Role in ox-LDL-Induced Inflammation and Atherosclerosis
Chen, T., Huang, W., Qian, J., Luo, W., Shan, P., Cai, Y., Lin, K., Wu, G., & Liang, G. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102706 · Cited by 67
Role of Histamine Produced by Bone Marrow–Derived Vascular Cells in Pathogenesis of Atherosclerosis
Sasaguri, Y., Wang, K., Tanimoto, A., Tsutsui, M., Ueno, H., Murata, Y., Kohno, Y., Yamada, S., & Ohtsu, H. (2005) · Circulation Research · doi:10.1161/01.res.0000166325.00383.ed · Cited by 65
Detection of vulnerable plaque in a murine model of atherosclerosis with optical coherence tomography
Çilingiroğlu, M., Oh, J., Sugunan, B., Kemp, N. J., Kim, J., Lee, S., Zaatari, H. N., Escobedo, D., Thomsen, S., Milner, T. E., et al. (2006) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.20717 · Cited by 65
Complete Atherosclerosis Regression After Human ApoE Gene Transfer in ApoE-Deficient/Nude Mice
Desurmont, C., Caillaud, J., Emmanuel, F., Benoit, P., Fruchart, J., Castro, G. R., Branellec, D., Heard, J., & Duverger, N. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.435 · Cited by 65
Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice
Tung, M.-C., Lan, Y.-W., Li, H.-H., Chen, H.-L., Chen, S.-Y., Chen, Y.-H., Lin, C.-C., Tu, M.-Y., & Chen, C.-M. (2020) · Scientific Reports · doi:10.1038/s41598-020-65782-8 · Cited by 57
Baicalin and geniposide attenuate atherosclerosis involving lipids regulation and immunoregulation in ApoE−/− mice
Liao, P., Liu, L., Wang, B., Li, W., Fang, X., & Guan, S. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.039 · Cited by 63
Hyperlipidemia Disrupts Cerebrovascular Reflexes and Worsens Ischemic Perfusion Defect
Ayata, C., Shin, H. K., Dileköz, E., Atochin, D. N., Kashiwagi, S., Eikermann‐Haerter, K., & Huang, P. L. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.38 · Cited by 64
Sphingosine-1-Phosphate Analogue FTY720 Causes Lymphocyte Redistribution and Hypercholesterolemia in ApoE-Deficient Mice
Klingenberg, R., Nofer, J., Rudling, M., Bea, F., Blessing, E., Preusch, M. R., Gröne, H. ‐., Katus, H. A., Hansson, G. K., & Dengler, T. J. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.149476 · Cited by 64
Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy
Milad, N., White, Z. R., Tehrani, A. Y., Sellers, S., Rossi, F. M. V., & Bernatchez, P. N. (2017) · Skeletal Muscle · doi:10.1186/s13395-017-0135-9 · Cited by 60

Authors: Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R.
Affiliations: University of Washington (US)
ORCID: Nakashima, Y
Breslow, J L
Venue: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1994-01
Volume: 14
Issue: 1
Pages: 133-140
ISSN: 1049-8834 (ISSN-L)
DOI: 10.1161/01.atv.14.1.133
OpenAlex: W1964814612
Cited by: 1,693
References: 28
Citations by year: 2026: 18 · 2025: 32 · 2024: 40 · 2023: 42 · 2022: 54 · 2021: 60 · 2020: 47 · 2019: 57 · 2018: 45 · 2017: 66 · 2016: 50 · 2015: 69 · 2014: 71 · 2013: 73 · 2012: 78
FWCI: 14.99
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis and Thrombosis A Journal of Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Bristol-Myers Squibb
National Institutes of Health (5r01hl033714-17, 18645, HL 18645)
National Heart, Lung, and Blood Institute (HL-18645, HL 33714, R01HL032435, HL32435, P01HL018645)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: apolipoprotein E deficiency, atherosclerosis, atherosclerotic plaque development, Western diet, hypercholesterolemia, fibrous cap, necrotic core, aortic root lesions, mouse model of atherosclerosis, atherogenesis
MeSH terms: Animals, Aorta, Aorta, Thoracic, Apolipoproteins E, Arteriosclerosis, Carotid Arteries, Coronary Vessels, Diet, Endothelium, Vascular, Hypercholesterolemia, Leukocytes, Mononuclear, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Pulmonary Artery, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks