Cited by 1,693Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Nakashima, Y, Plump, A S, Raines, E W, Breslow, J L, Ross, R·1994·Arteriosclerosis and Thrombosis: A Journal of Vascular Biology

DOI 10.1161/01.atv.14.1.133

Open this paper in CoChat — free account

Abstract

Initial description of apolipoprotein (apo) E-deficient transgenic mice demonstrated the development of severe hypercholesterolemia due to probable delayed clearance of large atherogenic particles from the circulation. Examination of these mice demonstrated foam cell accumulation in the aortic root and pulmonary arteries by 10 weeks of age. In the present study, the animals were fed either chow or a high-fat, Western-type diet and examined at ages ranging from 6 to 40 weeks. Gross examination by dissection microscopy revealed a predilection for development of lesions in the aortic root, at the lesser curvature of the aortic arch, the principal branches of the aorta, and in the pulmonary and carotid arteries. Monocyte attachment to endothelial cells was observed by light and electron microscopic examination at 6 weeks, the earliest time point examined. Foam cell lesions developed as early as 8 weeks, and after 15 weeks advanced lesions (fibrous plaques) were observed. The latter consisted of a fibrous cap containing smooth muscle cells surrounded by connective tissue matrix that covered a necrotic core with numerous foamy macrophages. Mice fed the Western-type diet generally had more advanced lesions than those fed a chow diet. The apoE-deficient mouse contains the entire spectrum of lesions observed during atherogenesis and is the first mouse model to develop lesions similar to those in humans. This model should provide numerous opportunities to study the pathogenesis and therapy of atherosclerosis in a small, genetically defined animal.

Integrity signals

Registry

Crossref · 10.1161/01.atv.14.1.133

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
Self-citation
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Self-citation
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.
Rg, G. (1981) · PubMed Central · Cited by 1,314
Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.
Faggiotto, A., Ross, R., & Harker, L. A. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.4.323 · Cited by 978
Self-citation
Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.
Gown, A. M., Tsukada, T., & Ross, R. (1986) · PubMed · Cited by 678
Self-citation
Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.
Faggiotto, A., & Ross, R. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.4.341 · Cited by 466
Self-citation
The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.
Gerrity, R. G. (1981) · PubMed · Cited by 459
Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein
Marotti, K. R., Castle, C. K., Boyle, T. P., Lin, A. H., Murray, R. W., & Melchior, G. W. (1993) · Nature · doi:10.1038/364073a0 · Cited by 444
Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II
Warden, C. H., Hedrick, C. C., Qiao, J.-H., Castellani, L. W., & Lusis, A. J. (1993) · Science · doi:10.1126/science.8332912 · Cited by 359

Flagged first, then by citations

Show all 28 references

Sorted by citations

Items 101–200 of 1,000

Absence of heme oxygenase‐1 exacerbates atherosclerotic lesion formation and vascular remodeling
Yet, S., Layne, M. D., Liu, X., Chen, Y., Ith, B., Sibinga, N. E. S., & Perrella, M. A. (2003) · The FASEB Journal · doi:10.1096/fj.03-0187fje · Cited by 283
Chlamydia pneumoniae — an infectious risk factor for atherosclerosis?
Campbell, L. A., & Kuo, C. C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro796 · Cited by 284
Human Vascular Endothelial Cells Are a Rich and Regulatable Source of Secretory Sphingomyelinase
Marathe, S. V., Schissel, S. L., Yellin, M. J., Beatini, N., Mintzer, R., Williams, K. J., & Tabas, I. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4081 · Cited by 273
Targeting atherosclerosis by using modular, multifunctional micelles
Peters, D., Kastantin, M., Kotamraju, V. R., Karmali, P. P., Gujraty, K., Tirrell, M., & Ruoslahti, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903369106 · Cited by 271
Direct Demonstration of P-Selectin– and VCAM-1–Dependent Mononuclear Cell Rolling in Early Atherosclerotic Lesions of Apolipoprotein E–Deficient Mice
Ramos, C. L., Huo, Y., Jung, U., Ghosh, S., Manka, D. R., Sarembock, I. J., & Ley, K. F. (1999) · Circulation Research · doi:10.1161/01.res.84.11.1237 · Cited by 272
Mucosal Administration of Heat Shock Protein-65 Decreases Atherosclerosis and Inflammation in Aortic Arch of Low-Density Lipoprotein Receptor-Deficient Mice
Maron, R., Sukhova, G. K., Faria, A. M. C., Hoffmann, E. C., Mach, F., Libby, P., & Weiner, H. L. (2002) · Circulation · doi:10.1161/01.cir.0000029750.99462.30 · Cited by 267
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis
Wagschal, A., Najafi-Shoushtari, S. H., Wang, L., Goedeke, L., Sinha, S., deLemos, A. S., Black, J. C., Ramírez, C. M., Li, Y., Tewhey, R., et al. (2015) · Nature Medicine · doi:10.1038/nm.3980 · Cited by 254
Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis
George, J., Afek, A. B., Gilburd, B., Levkovitz, H., Shaish, A., Goldberg, I., Kopolovic, Y., Wick, G., Shoenfeld, Y., & Harats, D. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00015-x · Cited by 267
The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium
Huo, Y., Weber, C., Forlow, S. B., Sperandio, M., Thatte, J., Mack, M., Jung, S., Littman, D. R., & Ley, K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12877 · Cited by 266
Prominent Role of P-Selectin in the Development of Advanced Atherosclerosis in ApoE-Deficient Mice
Dong, Z. M., Brown, A. A., & Wagner, D. D. (2000) · Circulation · doi:10.1161/01.cir.101.19.2290 · Cited by 263
Prevention of Accelerated Atherosclerosis by Angiotensin-Converting Enzyme Inhibition in Diabetic Apolipoprotein E–Deficient Mice
Candido, R., Jandeleit-Dahm, K. A. M., Cao, Z., Nesteroff, S. P., Burns, W. C., Twigg, S. M., Dilley, R. J., Cooper, M. E., & Allen, T. J. (2002) · Circulation · doi:10.1161/01.cir.0000021122.63813.32 · Cited by 261
Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Limits Progression and Destabilization of Established Atherosclerosis in Apolipoprotein E–Knockout Mice
Inoue, S., Egashira, K., Ni, W., Kitamoto, S., Usui, M., Otani, K., Ishibashi, M., Hiasa, K., Nishida, K.-I., & Takeshita, A. (2002) · Circulation · doi:10.1161/01.cir.0000038140.80105.ad · Cited by 256
Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice.
Bourassa, P.-A. K., Milos, P. M., Gaynor, B. J., Breslow, J. L., & Aiello, R. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10022 · Cited by 254
Self-citation
Genetic Deficiency of Inducible Nitric Oxide Synthase Reduces Atherosclerosis and Lowers Plasma Lipid Peroxides in Apolipoprotein E–Knockout Mice
Kuhlencordt, P. J., Chen, J., Han, F., Astern, J., & Huang, P. L. (2001) · Circulation · doi:10.1161/01.cir.103.25.3099 · Cited by 252
The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice.
Daugherty, A., Puré, E., Delfel-Butteiger, D., Chen, S., Leferovich, J. M., Roselaar, S. E., & Rader, D. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119681 · Cited by 251
Absence of P-selectin delays fatty streak formation in mice.
Johnson, R. C., Chapman, S. M., Dong, Z. M., Ordovás, J. M., Mayadas, T. N., Herz, J., Hynes, R. O., Schaefer, E. J., & Wagner, D. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119231 · Cited by 250
Atherosclerosis and proteinase activation
DOLLERY, C. M., & Libby, P. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.11.003 · Cited by 249
Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice.
Zhou, X., Stemme, S., & Hansson, G. K. (1996) · Europe PMC (PubMed Central) · Cited by 249
Murine Models ofChlamydia pneumoniaeInfection and Atherosclerosis
Moazed, T. C., Kuo, C., Grayston, J. T., & Campbell, L. A. (1997) · The Journal of Infectious Diseases · doi:10.1086/513986 · Cited by 249
Chlamydia pneumoniaeInfection Accelerates the Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice
Moazed, T. C., Campbell, L. A., Rosenfeld, M. E., Grayston, J. T., & Kuo, C. (1999) · The Journal of Infectious Diseases · doi:10.1086/314855 · Cited by 248
Leukotriene B4 Receptor Antagonism Reduces Monocytic Foam Cells in Mice
Aiello, R. J., Bourassa, P.-A. K., Lindsey, S., Weng, W., Freeman, A., & Showell, H. J. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0302.105593 · Cited by 247
Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice.
Rajavashisth, T. B., Qiao, J. H., Tripathi, S., Tripathi, J., Mishra, N. K., Hua, M., Wang, X. P., Loussararian, A. H., Clinton, S. K., Libby, P., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci119891 · Cited by 245
Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption.
Zhang, S. H., Reddick, R. L., Burkey, B., & Maeda, N. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117460 · Cited by 244
New Anti–Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Atherosclerosis in Apolipoprotein E–Knockout Mice
Ni, W., Egashira, K., Kitamoto, S., Kataoka, C., Koyanagi, M., Inoue, S., Imaizumi, K., Akiyama, C., Nishida, K., & Takeshita, A. (2001) · Circulation · doi:10.1161/01.cir.103.16.2096 · Cited by 243
Identification of integrin αMβ2 as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions
Schober, J. M., Chen, N., Grzeszkiewicz, T. M., Jovanovic, I., Emeson, E. E., Ugarova, T. P., Ye, R. D., Lau, L. F., & Lam, S. C.-T. (2002) · Blood · doi:10.1182/blood.v99.12.4457 · Cited by 242
Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification.
Qiao, J. H., Xie, P. Z., Fishbein, M. C., Kreuzer, J., Drake, T. A., Demer, L. L., & Lusis, A. J. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.9.1480 · Cited by 239
Induction of Rapid Atherogenesis by Perivascular Carotid Collar Placement in Apolipoprotein E–Deficient and Low-Density Lipoprotein Receptor–Deficient Mice
von der Thüsen, J. H., van Berkel, T. J. C., & Biessen, E. A. L. (2001) · Circulation · doi:10.1161/01.cir.103.8.1164 · Cited by 238
Tetrahydrobiopterin in Cardiovascular Health and Disease
Bendall, J. K., Douglas, G., McNeill, E., Channon, K. M., & Crabtree, M. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5566 · Cited by 231
Discovery and Development of Calcium Channel Blockers
Godfraind, T. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00286 · Cited by 252
Reversal of Hyperlipidemia With a Genetic Switch Favorably Affects the Content and Inflammatory State of Macrophages in Atherosclerotic Plaques
Feig, J. E., Parathath, S., Rong, J. X., Mick, S. L., Vengrenyuk, Y., Grauer, L., Young, S. G., & Fisher, E. A. A. (2011) · Circulation · doi:10.1161/circulationaha.110.984146 · Cited by 237
Shear stress induction of the tissue factor gene.
Lin, K. M.-C., Almus-Jacobs, F., Chen, H., Parry, G. C., Mackman, N., Shyy, J. Y., & Chien, S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119219 · Cited by 236
Vasa vasorum angiogenesis: key player in the initiation and progression of atherosclerosis and potential target for the treatment of cardiovascular disease
Sedding, D. G., Boyle, E. C., Demandt, J. A. F., Sluimer, J. C., Dutzmann, J., Haverich, A., & Bauersachs, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00706 · Cited by 228
Role of Vascular Cell Adhesion Molecule-1 and Fibronectin Connecting Segment-1 in Monocyte Rolling and Adhesion on Early Atherosclerotic Lesions
Huo, Y., Hafezi‐Moghadam, A., & Ley, K. F. (2000) · Circulation Research · doi:10.1161/01.res.87.2.153 · Cited by 233
Increased atherosclerosis in hyperlipidemic mice deficient in α-tocopherol transfer protein and vitamin E
Terasawa, Y., Ladha, Z., Leonard, S. W., Morrow, J. D., Newland, D., Sanan, D. A., Packer, L., Traber, M. G., & Farese, R. V. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240462697 · Cited by 232
Characteristics of Intact and Ruptured Atherosclerotic Plaques in Brachiocephalic Arteries of Apolipoprotein E Knockout Mice
Williams, H. J., Johnson, J. L., Carson, K. G. S., & Jackson, C. L. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000014587.66321.b4 · Cited by 228
The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans
Toyama, K., Wulff, H., Chandy, K. G., Azam, P., Raman, G., Saito, T., Fujiwara, Y., Mattson, D. L., Das, S., Melvin, J. E., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci30836 · Cited by 226
Genetic Ablation of Caveolin-1 Confers Protection Against Atherosclerosis
Frank, P. G., Lee, H., Park, D. S., Tandon, N. N., Scherer, P. E., & Lisanti, M. P. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000101182.89118.e5 · Cited by 224
Noninvasive In Vivo High-Resolution Magnetic Resonance Imaging of Atherosclerotic Lesions in Genetically Engineered Mice
Fayad, Z. A., Fallon, J. T., Shinnar, M., Wehrli, S. L., Dansky, H. M., Poon, M., Badimón, J. J., Charlton, S. A., Fisher, E. A. A., Breslow, J. L., et al. (1998) · Circulation · doi:10.1161/01.cir.98.15.1541 · Cited by 223
Self-citation
Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse
Johnson, J. L., & Jackson, C. L. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00515-3 · Cited by 221
A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet
Powell-Braxton, L., Véniant, M., Latvala, R. D., Hirano, K.-I., Won, W. B., Ross, J., Dybdal, N., Zlot, C. H., Young, S. G., & Davidson, N. O. (1998) · Nature Medicine · doi:10.1038/nm0898-934 · Cited by 192
Adhesion of Monocytes to Arterial Endothelium and Initiation of Atherosclerosis Are Critically Dependent on Vascular Cell Adhesion Molecule-1 Gene Dosage
Dansky, H. M., Barlow, C. B., Lominska, C. E., Sikes, J. L., Kao, C., Weinsaft, J. W., Cybulsky, M. I., & Smith, J. D. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1001.096625 · Cited by 219
Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation
Li, X., Fang, P., Li, Y., Kuo, Y., Andrews, A. J., Nanayakkara, G., Johnson, C., Fu, H., Shan, H., Du, F., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306964 · Cited by 220
Mouse Models of Atherosclerosis
Daugherty, A. (2002) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200201000-00002 · Cited by 218
Ezetimibe, a Potent Cholesterol Absorption Inhibitor, Inhibits the Development of Atherosclerosis in ApoE Knockout Mice
Davis, H. R., Compton, D. S., Hoos, L., & Tetzloff, G. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/hq1201.100260 · Cited by 182
Dietary Supplementation With Methionine and Homocysteine Promotes Early Atherosclerosis but Not Plaque Rupture in ApoE-Deficient Mice
Zhou, J., Møller, J., Danielsen, C. C., Bentzon, J. F., Ravn, H. B., Austin, R. C., & Falk, E. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0901.096582 · Cited by 217
T Helper–Cell Phenotype Regulates Atherosclerosis in Mice Under Conditions of Mild Hypercholesterolemia
Huber, S. A., Sakkinen, P. A., David, C. S., Newell, M. K., & Tracy, R. P. (2001) · Circulation · doi:10.1161/01.cir.103.21.2610 · Cited by 212
High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithinchoesteryl acyltransferase
Bérard, A. M., Föger, B., Remaley, A. T., Shamburek, R. D., Vaisman, B. L., Talley, G. D., Paigen, B. J., Hoyt, R. F., Marcovina, S. M., Brewer, H. B., et al. (1997) · Nature Medicine · doi:10.1038/nm0797-744 · Cited by 209
Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway
Yin, Y., Li, X., Sha, X., Xi, H., Li, Y., Shao, Y., Mai, J., Virtue, A. T., Lopez‐Pastrana, J., Meng, S., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305282 · Cited by 207
Deficiency in Inducible Nitric Oxide Synthase Results in Reduced Atherosclerosis in Apolipoprotein E-Deficient Mice
Detmers, P. A., Hernandez, M., Mudgett, J. S., Hassing, H., Burton, C. A., Mundt, S. S., Chun, S. H., Fletcher, D. S., Card, D., Lisnock, J., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3430 · Cited by 206
Antiatherosclerotic effect of farnesoid X receptor
Mencarelli, A., Renga, B., Distrutti, E., & Fiorucci, S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01075.2008 · Cited by 199
Modified natural nanoparticles as contrast agents for medical imaging
Cormode, D. P., Jarzyna, P. A., Mulder, W. J. M., & Fayad, Z. A. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.005 · Cited by 200
Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.
Purcell-huynh, D. A., Farese, R. V., Johnson, D. F., Flynn, L. M., Pierotti, V., Newland, D., Linton, M. F., Sanan, D. A., & Young, S. G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117915 · Cited by 197
Correlation of Peripheral-Blood Gene Expression With the Extent of Coronary Artery Stenosis
Wingrove, J. A., Daniels, S. E., Sehnert, A. J., Tingley, W. G., Elashoff, M. R., Rosenberg, S. J., Buellesfeld, L., Grube, E., Newby, L. K., Ginsburg, G. S., et al. (2008) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.108.782730 · Cited by 198
Oligoclonal T Cell Expansions in Atherosclerotic Lesions of Apolipoprotein E–Deficient Mice
Paulsson, G. B., Zhou, X., Törnquist, E., & Hansson, G. K. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.1.10 · Cited by 195
Arterial remodeling in atherosclerosis, restenosis and after alteration of blood flow: potential mechanisms and clinical implications
Pasterkamp, G. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00377-6 · Cited by 192
Neurovascular Dysfunction in Vascular Dementia, Alzheimer's and Atherosclerosis
Shabir, O., Berwick, J., & Francis, S. E. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0465-5 · Cited by 191
Lymphocyte Populations in Atherosclerotic Lesions of ApoE −/− and LDL Receptor −/− Mice
Roselaar, S. E., Kakkanathu, P. X., & Daugherty, A. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.8.1013 · Cited by 191
The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction
Sasso, G. L., Schlage, W. K., Boué, S., Veljkovic, E., Peitsch, M. C., & Hoeng, J. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0901-1 · Cited by 206
Protease sensors for bioimaging
Funovics, M. A., Weissleder, R., & Tung, C. (2003) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-003-2199-0 · Cited by 186
Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening
Kothapalli, D., Liu, S., Bae, Y., Monslow, J., Xu, T., Hawthorne, E. A., Byfield, F. J., Castagnino, P. A., Rao, S. J., Rader, D. J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.018 · Cited by 187
Reduction of Atherosclerosis by the Peroxisome Proliferator-activated Receptor α Agonist Fenofibrate in Mice*
Duez, H., Chao, Y., Hernandez, M., Torpier, G., Poulain, P., Mundt, S., Mallat, Z., Teissier, E., Burton, C. A., Tedgui, A., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206966200 · Cited by 201
LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression
Feig, J. E., Pineda‐Torra, I., Sanson, M., Bradley, M. N., Vengrenyuk, Y., Bogunovic, D., Gautier, E. L., Rubinstein, D., Hong, C., Liu, J., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38911 · Cited by 191
RP5-833A20.1/miR-382-5p/NFIA–Dependent Signal Transduction Pathway Contributes to the Regulation of Cholesterol Homeostasis and Inflammatory Reaction
Hu, Y., Zhao, J., Li, S., Huang, J.-L., Qiu, Y., Ma, X., Wu, S.-G., Chen, Z., Hu, Y.-R., Yang, J., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304296 · Cited by 184
Murine Models of Vascular Thrombosis
Westrick, R. J., Winn, M. E., & Eitzman, D. T. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.142810 · Cited by 184
Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association
Daugherty, A., Tall, A. R., Daemen, M. J. A. P., Falk, E., Fisher, E. A. A., García‐Cardeña, G., Lusis, A. J., Owens, A. P., Rosenfeld, M. E., & Virmani, R. (2017) · Circulation Research · doi:10.1161/res.0000000000000169 · Cited by 186
Fetuin-A Protects against Atherosclerotic Calcification in CKD
Westenfeld, R., Diaeresis]fer, C. S., Diaeresis]ger, T. K., Haarmann, C., Schurgers, L. J., Reutelingsperger, C. P. M., Ivanovski, O., Drüeke, T. B., Massy, Z. A., Ketteler, M., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008060572 · Cited by 186
Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E–deficient mice
Nigro, P., Satoh, K., O’Dell, M. R., Soe, N. N., Cui, Z., Mohan, A. M., Abe, J., Alexis, J. D., Sparks, J. D., & Berk, B. C. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101174 · Cited by 181
Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery
Eitzman, D. T., Westrick, R. J., Xu, Z., Tyson, J. A., & Ginsburg, D. (2000) · Blood · doi:10.1182/blood.v96.13.4212 · Cited by 182
Inhibition of α 4 Integrin and ICAM-1 Markedly Attenuate Macrophage Homing to Atherosclerotic Plaques in ApoE-Deficient Mice
Patel, S. S., Thiagarajan, R., Willerson, J. T., & Yeh, E. T. H. (1998) · Circulation · doi:10.1161/01.cir.97.1.75 · Cited by 182
Increased atherosclerosis in streptozotocin-induced diabetic mice.
Kunjathoor, V. V., Wilson, D. L., & LeBoeuf, R. C. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118604 · Cited by 182
Effect of Immune Deficiency on Lipoproteins and Atherosclerosis in Male Apolipoprotein E–Deficient Mice
Reardon, C. A., Blachowicz, L., White, T., Cabana, V. G., Wang, Y., Lukens, J. R., Bluestone, J. A., & Getz, G. S. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.1011 · Cited by 182
Iron-Deficient Diet Reduces Atherosclerotic Lesions in ApoE-Deficient Mice
Lee, T.-S., Shiao, M.-S., Pan, C.-C., & Chau, L.-Y. (1999) · Circulation · doi:10.1161/01.cir.99.9.1222 · Cited by 179
Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis
Qiao, L., Ma, J., Zhang, Z., Sui, W., Zhai, C., Xu, D., Wang, Z., Lu, H., Zhang, M., Zhang, C., et al. (2021) · Circulation Research · doi:10.1161/circresaha.121.318908 · Cited by 186
Mouse Models for Atherosclerosis Research—Which Is My Line?
Oppi, S., Lüscher, T. F., & Stein, S. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00046 · Cited by 195
ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis
Lemaître, V., O’Byrne, T. K., Borczuk, A., Okada, Y., Tall, A. R., & D'Armiento, J. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci9626 · Cited by 180
Infectious Agents Are Not Necessary for Murine Atherogenesis
Wright, S. D., Burton, C., Hernandez, M., Hassing, H., Montenegro, J., Mundt, S., Patel, S., Card, D. J., Hermanowski-Vosatka, A., Bergstrom, J. D., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1437 · Cited by 176
The Expression and Functions of Toll-Like Receptors in Atherosclerosis
Cole, J. E., Georgiou, E. X., & Monaco, C. G. (2010) · Mediators of Inflammation · doi:10.1155/2010/393946 · Cited by 180
The atherogenic effect of excess methionine intake
Troen, A. M., Lutgens, E., Smith, D. E., Rosenberg, I. H., & Selhub, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436385100 · Cited by 180
Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice
Hara, T., Fukuda, D., Tanaka, K., Higashikuni, Y., Hirata, Y., Nishimoto, S., Yagi, S., Yamada, H., Soeki, T., Wakatsuki, T., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.03.023 · Cited by 178
Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis
der Heiden, K. V., Hierck, B. P., Krams, R., de Crom, R., Cheng, C., Baiker, M., Pourquie, M. J. B. M., Alkemade, F. E., DeRuiter, M. C., Groot, A. C. G., et al. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.05.030 · Cited by 176
Assessment of atherosclerotic plaque burden with an elastin-specific magnetic resonance contrast agent
Makowski, M. R., Wiethoff, A. J., Blume, U. A., Cuello, F., Warley, A., Jansen, C. H. P., Nagel, E. C., Razavi, R., Onthank, D. C., Cesati, R. R. I., et al. (2011) · Nature Medicine · doi:10.1038/nm.2310 · Cited by 176
Hyperlipidemia and Atherosclerotic Lesion Development in LDL Receptor–Deficient Mice Fed Defined Semipurified Diets With and Without Cholate
Lichtman, A. H., Clinton, S. K., Iiyama, K., Connelly, P. W., Libby, P., & Cybulsky, M. I. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.8.1938 · Cited by 174
Adipocyte Fatty Acid–Binding Protein, aP2, Alters Late Atherosclerotic Lesion Formation in Severe Hypercholesterolemia
Boord, J. B., Maeda, K., Makowski, L., Babaev, V. R., Fazio, S., Linton, M. F., & Hotamışlıgil, G. S. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000033090.81345.e6 · Cited by 172
Immune cell census in murine atherosclerosis: cytometry by time of flight illuminates vascular myeloid cell diversity
Cole, J. E., Park, I., Ahern, D., Kassiteridi, C., Danso‐Abeam, D., Goddard, M. E., Green, P. A., Maffia, P., & Monaco, C. G. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy109 · Cited by 177
Genetic Modifiers of Atherosclerosis in Mice
Knowles, J. W., & Maeda, N. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.11.2336 · Cited by 176
Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration
Lim, H. Y., Rutkowski, J. M., Helft, J., Reddy, S. T., Swartz, M. A., Randolph, G. J., & Angeli, V. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080963 · Cited by 171
Atherosclerosis, Vascular Remodeling, and Impairment of Endothelium-Dependent Relaxation in Genetically Altered Hyperlipidemic Mice
Bonthu, S., Heistad, D. D., Chappell, D. A., Lamping, K. G., & Faraci, F. M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2333 · Cited by 171
β-casein A1, ischaemic heart disease mortality, and other illnesses
McLachlan, C. N. S. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1265 · Cited by 170
Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice
Caligiuri, G., Levy, B. I., Pernow, J., Thorén, P., & Hansson, G. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6920 · Cited by 171
Functional Blockade of Platelet-Derived Growth Factor Receptor-β but Not of Receptor-α Prevents Vascular Smooth Muscle Cell Accumulation in Fibrous Cap Lesions in Apolipoprotein E–Deficient Mice
Sano, H., Sudo, T., Yokode, M., Murayama, T., Kataoka, H., Takakura, N., Nishikawa, S., Nishikawa, S.-I., & Kita, T. (2001) · Circulation · doi:10.1161/01.cir.103.24.2955 · Cited by 169
Rapid Endothelial Turnover in Atherosclerosis-Prone Areas Coincides With Stem Cell Repair in Apolipoprotein E–Deficient Mice
Foteinos, G., Hu, Y., Xiao, Q., Metzler, B., & Xu, Q. (2008) · Circulation · doi:10.1161/circulationaha.107.746008 · Cited by 169
Treatment With Simvastatin Suppresses the Development of Experimental Abdominal Aortic Aneurysms in Normal and Hypercholesterolemic Mice
Steinmetz, E. F., Buckley, C., Shames, M. L., Ennis, T. L., VanVickle-Chavez, S. J., Mao, D., Goeddel, L. A., Hawkins, C. J., & Thompson, R. W. (2005) · Annals of Surgery · doi:10.1097/01.sla.0000150258.36236.e0 · Cited by 169
Mouse models of atherosclerosis: a historical perspective and recent advances
Lee, Y. T., Lin, H. Y., Chan, Y. W. F., Li, K. H. C., To, O. T. L., Yan, B. P., Liu, T., Li, G., Wong, W. T., Keung, W., et al. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-016-0402-5 · Cited by 183
RAGE: A New Target for the Prevention and Treatment of the Vascular and Inflammatory Complications of Diabetes
Schmidt, A., & Stern, D. M. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00311-8 · Cited by 167
Review of MRI-based measurements of pulse wave velocity: a biomarker of arterial stiffness.
Wentland, A. L., Grist, T. M., & Wieben, O. E. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2223-3652.2014.03.04 · Cited by 167
Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues
Thiriot, A., Perdomo, C., Cheng, G., Novitzky‐Basso, I., McArdle, S., Kishimoto, J. K., Barreiro, O., Mazo, I. B., Triboulet, R., Ley, K. F., et al. (2017) · BMC Biology · doi:10.1186/s12915-017-0381-7 · Cited by 164
Genetic Background Determines the Extent of Atherosclerosis in ApoE-Deficient Mice
Dansky, H. M., Charlton, S. A., Sikes, J. L., Heath, S. C., Simantov, R., Levin, L. F., Shu, P., Moore, K. J., Breslow, J. L., & Smith, J. D. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.8.1960 · Cited by 167
Self-citation
Spontaneous plaque rupture and secondary thrombosis in apolipoprotein E-deficient and LDL receptor-deficient mice
Calara, F. B., Silvestre, M., Casanada, F., Yuan, N., Claudio Napoli, A., & Palinski, W. (2001) · The Journal of Pathology · doi:10.1002/path.915 · Cited by 167
Atherosclerotic Lesions Grow Through Recruitment and Proliferation of Circulating Monocytes in a Murine Model
Lessner, S. M., Prado, H. L., Waller, E. K., & Galis, Z. S. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61163-7 · Cited by 166
Adenovirus-Mediated Overexpression of Tissue Inhibitor of Metalloproteinase-1 Reduces Atherosclerotic Lesions in Apolipoprotein E–Deficient Mice
Rouis, M., Adamy, C., Duverger, N., Lesnik, P., Horellou, P., Moreau, M., Emmanuel, F., Caillaud, J., Laplaud, P. M., Dachet, C., et al. (1999) · Circulation · doi:10.1161/01.cir.100.5.533 · Cited by 166

Authors: Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R.
Affiliations: University of Washington (US)
ORCID: Nakashima, Y
Breslow, J L
Venue: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1994-01
Volume: 14
Issue: 1
Pages: 133-140
ISSN: 1049-8834 (ISSN-L)
DOI: 10.1161/01.atv.14.1.133
OpenAlex: W1964814612
Cited by: 1,693
References: 28
Citations by year: 2026: 18 · 2025: 32 · 2024: 40 · 2023: 42 · 2022: 54 · 2021: 60 · 2020: 47 · 2019: 57 · 2018: 45 · 2017: 66 · 2016: 50 · 2015: 69 · 2014: 71 · 2013: 73 · 2012: 78
FWCI: 14.99
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis and Thrombosis A Journal of Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Bristol-Myers Squibb
National Institutes of Health (5r01hl033714-17, 18645, HL 18645)
National Heart, Lung, and Blood Institute (HL-18645, HL 33714, R01HL032435, HL32435, P01HL018645)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: apolipoprotein E deficiency, atherosclerosis, atherosclerotic plaque development, Western diet, hypercholesterolemia, fibrous cap, necrotic core, aortic root lesions, mouse model of atherosclerosis, atherogenesis
MeSH terms: Animals, Aorta, Aorta, Thoracic, Apolipoproteins E, Arteriosclerosis, Carotid Arteries, Coronary Vessels, Diet, Endothelium, Vascular, Hypercholesterolemia, Leukocytes, Mononuclear, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Pulmonary Artery, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks