The DOI matches its Crossref record, with a small difference in title or year; 36 of the 36 references it cites were found in a registry or an index.
Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction: Time-Course Analysis of the Results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione
Abstract
Background — Our purpose was to assess the time course of the benefit of n-3 polyunsaturated fatty acids (PUFAs) on mortality documented by the GISSI-Prevenzione trial in patients surviving a recent (<3 months) myocardial infarction. Methods and Results — In this study, 11 323 patients were randomly assigned to supplements of n-3 PUFAs, vitamin E (300 mg/d), both, or no treatment (control) on top of optimal pharmacological treatment and lifestyle advice. Intention-to-treat analysis adjusted for interaction between treatments was carried out. Early efficacy of n-3 PUFA treatment for total, cardiovascular, cardiac, coronary, and sudden death; nonfatal myocardial infarction; total coronary heart disease; and cerebrovascular events was assessed by right-censoring follow-up data 12 times from the first month after randomization up to 12 months. Survival curves for n-3 PUFA treatment diverged early after randomization, and total mortality was significantly lowered after 3 months of treatment (relative risk [RR] 0.59; 95% CI 0.36 to 0.97; P =0.037). The reduction in risk of sudden death was specifically relevant and statistically significant already at 4 months (RR 0.47; 95% CI 0.219 to 0.995; P =0.048). A similarly significant, although delayed, pattern after 6 to 8 months of treatment was observed for cardiovascular, cardiac, and coronary deaths. Conclusions — The early effect of low-dose (1 g/d) n-3 PUFAs on total mortality and sudden death supports the hypothesis of an antiarrhythmic effect of this drug. Such a result is consistent with the wealth of evidence coming from laboratory experiments on isolated myocytes, animal models, and epidemiological and clinical studies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“contemporary high-intensity statin formulations achieve greater low-density lipoprotein–lowering effects and cardiovascular endpoint reduction than were used during the first mixed EPA/DHA trials, such as GISSI-P.17,27,44”
From Effects of Eicosapentaenoic Acid vs Eicosapentaenoic/Docosahexaenoic Acids on Cardiovascular Mortality (2025) · cites this paper as [44]
Experimental — accuracy not yet measuredIn the citing paper
“Data from meta-analyses suggest that a reduction of calculated glomerular filtration rate (GFR) does not reflect any adverse effects on kidney function [315].”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [315]
In the citing paper
“Results from other meta-analyses suggest reduced major CVD events in patients with high TGs and low HDL-C in fibrate-treated patients, but no decrease in CVD or total mortality [314-316].”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [315]
In the citing paper
“A post hoc subgroup analysis revealed that this reduction in mortality and SCD was concentrated in the approximately 2000 patients with reduced left ventricular ejection fraction [67].”
From Update on Omega-3 Polyunsaturated Fatty Acids on Cardiovascular Health (2022) · cites this paper as [67]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
de Lorgeril, M., Salen, P., Martin, J.-L., Monjaud, I., Delaye, J., & Mamelle, N. (1999) · Circulation · doi:10.1161/01.cir.99.6.779 · Cited by 2,910
Burr, M. L., Gilbert, J. F., Holliday, R. M., Elwood, P. C., Fehily, A. M., Rogers, S., Sweetnam, P. M., & Deadman, N. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90828-3 · Cited by 2,610
The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease
Kromhout, D., Bosschieter, E. B., & Coulander, C. D. L. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121901 · Cited by 2,177
(1999) · PubMed · Cited by 2,062
Self-citationn-3 fatty acids and serum lipoproteins: human studies
Harris, W. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1645s · Cited by 1,243
Fish Consumption and Risk of Sudden Cardiac Death
Albert, C. M. (1998) · JAMA · doi:10.1001/jama.279.1.23 · Cited by 990
The Composition of Food Consumed by Greenland Eskimos
Bang, H. O., Dyerberg, J., & Hjørne, N. (1976) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1976.tb08198.x · Cited by 950
Siscovick, D. S. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03530170043030 · Cited by 920
Fish consumption and the 30-year risk of fatal myocardial infarction
Daviglus, M. L., Stamler, J., Orencia, A. J., Dyer, A. R., Liu, K., Greenland, P., Walsh, M. K., Morris, D., & Shekelle, R. B. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361502 · Cited by 902
Research works printed but not linked: 10
Cited by
Sorted by citations
Items 201–300 of 1,000
The omega-3 index: From biomarker to risk marker to risk factor
Harris, W. S. (2009) · Current Atherosclerosis Reports · doi:10.1007/s11883-009-0062-2 · Cited by 133
Diet and Rheumatoid Arthritis: A Review of the Literature
Stamp, L. K., James, M. J., & Cleland, L. G. (2005) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2005.05.001 · Cited by 135
Dietary fatty acids intake: possible role in cognitive decline and dementia
Solfrizzi, V., D’Introno, A., Colacicco, A. M., Capurso, C. A., DelParigi, A., Capurso, S. A., Gadaleta, A., Capurso, A., & Panza, F. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.01.001 · Cited by 136
Watanabe, Y., & Tatsuno, I. (2019) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.50658 · Cited by 135
Lip, G. Y. H., Barnett, A. H., Bradbury, A. W., Cappuccio, F. P., Gill, P. S., Hughes, E. A., Imray, C., Jolly, K. B., & Patel, K. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002126 · Cited by 132
Kong, W., Yen, J.-H. J., Vassiliou, E. K., Adhikary, S., Toscano, M. G., & Ganea, D. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-12 · Cited by 139
Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids
Adili, R., Hawley, M., & Holinstat, M. A. (2018) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2018.09.005 · Cited by 129
Iribarren, C., Markovitz, J. H., Jacobs, D. R., Schreiner, P. J., Daviglus, M. L., & Hibbeln, J. R. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601739 · Cited by 127
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz455 · Cited by 8,961
Harris, W. S., Pottala, J. V., Vasan, R. S., Larson, M. G., & Robins, S. J. (2012) · Journal of Nutrition · doi:10.3945/jn.112.158295 · Cited by 125
CYP-eicosanoids—A new link between omega-3 fatty acids and cardiac disease?
Westphal, C., Konkel, A., & Schunck, W. (2011) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2011.09.001 · Cited by 129
Risks and Benefits of Consumption of Great Lakes Fish
Turyk, M. E., Bhavsar, S. P., Bowerman, W. W., Boysen, E., Clark, M., Diamond, M. L., Mergler, D., Pantazopoulos, P., Schantz, S. L., & Carpenter, D. O. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1003396 · Cited by 126
Filion, K. B., Khoury, F. E., Bielinski, M., Schiller, I., Dendukuri, N., & Brophy, J. M. (2010) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-10-24 · Cited by 124
Stirban, A. O., Nandrean, S., Götting, C., Tamler, R., Pop, A., Negrean, M., Gawlowski, T., Stratmann, B., & Tschoepe, D. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28374 · Cited by 124
Nutrition and Cardiovascular Disease
Getz, G. S., & Reardon, C. A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.155853 · Cited by 123
Immediate effects of n-3 fatty acid infusion on the induction of sustained ventricular tachycardia
Schrepf, R., Limmert, T., Weber, P. C., Theisen, K., & Sellmayer, A. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16105-9 · Cited by 122
A Quantitative Analysis of Fish Consumption and Stroke Risk
Bouzan, C., Cohen, J. T., We, C., Kris‐Etherton, P. M., Gray, G. C., König, A., LAWRENCE, R., Savitz, D. A., & Teutsch, S. M. (2005) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2005.07.002 · Cited by 122
Brown, M. D., Hart, C. A., Gazi, E., Bagley, S., & Clarke, N. W. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603030 · Cited by 121
Solfrizzi, V., Frisardi, V., Capurso, C. A., D’Introno, A., Colacicco, A. M., Vendemiale, G., Capurso, A., & Panza, F. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.07.005 · Cited by 123
OMEGA‐3 FATTY ACIDS AND HYPERTENSION IN HUMANS
Mori, T. A. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04451.x · Cited by 121
Bonds, D. E., Harrington, M., Worrall, B. B., Bertoni, A. G., Eaton, C. B., Hsia, J., Robinson, J., Clemons, T. E., Fine, L. J., & Chew, E. Y. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.328 · Cited by 118
Fleming, J. A., & Kris‐Etherton, P. M. (2014) · Advances in Nutrition · doi:10.3945/an.114.005850 · Cited by 123
Cytochrome P450-derived eicosanoids and heart function
Jamieson, K. L., Endo, T. H., Darwesh, A. M., Samokhvalov, V., & Seubert, J. M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.005 · Cited by 122
Guidelines for the management of acute coronary syndromes 2006
(2006) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2006.tb00304.x · Cited by 118
Wohl, D. A., Tien, H.-C., Busby, M. G., Cunningham, C., MacIntosh, B., Napravnik, S., Danan, E. R., Donovan, K., Hossenipour, M., & Simpson, R. J. (2005) · Clinical Infectious Diseases · doi:10.1086/497273 · Cited by 118
Fish oil supplementation: evidence for health benefits.
Harris, W. S. (2004) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.71.3.208 · Cited by 120
Plasma omega-3 fatty acids and incident diabetes in older adults
Djoussé, L., Biggs, M. L., Lemaître, R. N., King, I. B., Song, X., Ix, J. H., Mukamal, K. J., Siscovick, D. S., & Mozaffarian, D. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.013334 · Cited by 120
Dyerberg, J., Eskesen, D. C., Andersen, P. W., Astrup, A. V., Buemann, B., Christensen, J., Clausen, P., Rasmussen, B. F., Schmidt, E. B., Tholstrup, T., et al. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601934 · Cited by 118
Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications
Khan, I. R., Hussain, M., Jiang, B., Zheng, L., Pan, Y., Hu, J., Khan, A., Ashraf, A., & Zou, X. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101255 · Cited by 123
Eicosanoids and Their Drugs in Cardiovascular Diseases: Focus on Atherosclerosis and Stroke
Capra, V., Bäck, M., Barbieri, S. S., Camera, M., Tremoli, E., & Rovati, G. E. (2012) · Medicinal Research Reviews · doi:10.1002/med.21251 · Cited by 118
Redox-Dependent Anti-Inflammatory Signaling Actions of Unsaturated Fatty Acids
Delmastro-Greenwood, M. M., Freeman, B. Α., & Wendell, S. G. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170341 · Cited by 117
Macchia, A., Levantesi, G., Franzosi, M. G., Geraci, E., Maggioni, A. P., Marfisi, R., Nicolosi, G. L., Schweiger, C., Tavazzi, L., Tognoni, G., et al. (2005) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2005.04.008 · Cited by 113
Self-citationSanders, T. A. B., Gleason, K. L. T., Griffin, B. A., & Miller, G. J. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051658 · Cited by 122
Rodrigo, R., Prieto, J. C., & Castillo, R. L. (2012) · Clinical Science · doi:10.1042/cs20110663 · Cited by 112
Safe and Nutritious Aquaculture Produce: Benefits and Risks of Alternative Sustainable Aquafeeds
Bell, J. G., & Waagbø, R. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6810-2_6 · Cited by 110
Postoperative Atrial Fibrillation
Chelazzi, C., Villa, G., & Gaudio, A. R. D. (2011) · ISRN Cardiology · doi:10.5402/2011/203179 · Cited by 110
Jude, S., Roger, S., Martel, E., Besson, P., Richard, S., Bougnoux, P., Champéroux, P., & Guennec, J. L. (2005) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2005.05.006 · Cited by 110
Nitro–Fatty Acids Reduce Atherosclerosis in Apolipoprotein E–Deficient Mice
Rudolph, T. K., Rudolph, V., Edreira, M. M., Cole, M. P., Bonacci, G., Schopfer, F. J., Woodcock, S. R., Franek, A., Pekarova, M., Khoo, N. K. H., et al. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.201582 · Cited by 109
Ninio, D. M., Murphy, K. J., Howe, P. R. C., & Saint, D. A. (2005) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2005.50007.x · Cited by 109
Mariani, J. A., Doval, H. C., Nul, D. R., Varini, S. D., Grancelli, H., Ferrante, D., Tognoni, G., & Macchia, A. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.112.005033 · Cited by 111
Self-citationMaki, K. C., Palacios, O. M., Bell, M., & Toth, P. P. (2017) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2017.07.010 · Cited by 107
Marine n-3 polyunsaturated fatty acids and coronary heart disease
Schmidt, E. B., Arnesen, H., Caterina, R. D., Rasmussen, L. H., & Kristensen, S. D. (2004) · Thrombosis Research · doi:10.1016/j.thromres.2004.09.006 · Cited by 105
Effects of n–3 fatty acids from fish on premature ventricular complexes and heart rate in humans
Geelen, A., Brouwer, I. A., Schouten, E. G., Maan, A. C., Katan, M., & Zock, P. L. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.416 · Cited by 106
Surette, M. E., Edens, M. B., Chilton, F. H., & Tramposch, K. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.6.1406 · Cited by 106
Role of ω3 Longchain Polyunsaturated Fatty Acids in Reducing Cardio- Metabolic Risk Factors
Abeywardena, M. Y., & Patten, G. S. (2011) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153011796429817 · Cited by 106
Health Benefits, Food Applications, and Sustainability of Microalgae-Derived N-3 PUFA
Liu, Y., Ren, X., Fan, C., Wu, W., Zhang, W., & Wang, Y. (2022) · Foods · doi:10.3390/foods11131883 · Cited by 115
Novel Chemical Mediators in the Resolution of Inflammation: Resolvins and Protectins
Serhan, C. N. (2006) · Anesthesiology Clinics of North America · doi:10.1016/j.atc.2006.01.003 · Cited by 104
The role of omega-3 fatty acids in cardiovascular disease
von Schacky, C. (2003) · Current Atherosclerosis Reports · doi:10.1007/s11883-003-0086-y · Cited by 103
Therapeutic use of omega-3 fatty acids in bipolar disorder
Balanzá‐Martínez, V., Fries, G. R., Colpo, G. D., Silveira, P. P., Portella, A. K., Tabarés‐Seisdedos, R., & Kapczinski, F. P. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.42 · Cited by 111
Cardiovascular friendly natural products: a promising approach in the management of CVD
Shukla, S. K., Gupta, S., Ojha, S. K., & Sharma, S. B. (2010) · Natural Product Research · doi:10.1080/14786410903417378 · Cited by 102
Wong, C. Y., Yiu, K., Li, S. ‐., Lee, S., Tam, S., Lau, C. P., & Tse, H. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02869.x · Cited by 104
von Schacky, C. (2006) · Vascular Health and Risk Management · doi:10.2147/vhrm.2006.2.3.251 · Cited by 103
Sanders, T. A. B., Hall, W. L., Maniou, Z., Lewis, F., Seed, P. T., & Chowienczyk, P. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.018036 · Cited by 103
Deranged Myocardial Fatty Acid Metabolism in Heart Failure
Yamamoto, T., & Sano, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020996 · Cited by 107
Serini, S., Fasano, E., Piccioni, E., Cittadini, A. R. M., & Calviello, G. (2011) · Chemical Research in Toxicology · doi:10.1021/tx200314p · Cited by 108
Lifestyle recommendations to prevent prostate cancer, part II: time to redirect our attention?
Moyad, M. A., & Carroll, P. R. (2004) · Urologic Clinics of North America · doi:10.1016/j.ucl.2004.03.007 · Cited by 101
Impact of Functional Foods on Prevention of Cardiovascular Disease and Diabetes
Sikand, G., Kris‐Etherton, P. M., & Boulos, N. M. (2015) · Current Cardiology Reports · doi:10.1007/s11886-015-0593-9 · Cited by 109
Current Clinical Applications of Ω‐6 and Ω‐3 Fatty Acids
Lee, S., Gura, K. M., Kim, S., Arsenault, D. A., Bistrian, B. R., & Puder, M. (2006) · Nutrition in Clinical Practice · doi:10.1177/0115426506021004323 · Cited by 100
Omega-3 Fatty Acids in Boxer Dogs with Arrhythmogenic Right Ventricular Cardiomyopathy
Smith, C. E., Freeman, L. M., Rush, J. E., Cunningham, S. M., & Biourge, V. C. (2007) · Journal of Veterinary Internal Medicine · doi:10.1892/0891-6640(2007)21[265:ofaibd]2.0.co;2 · Cited by 110
Fenton, J. I., Hord, N. G., Ghosh, S., & Gurzell, E. A. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.09.011 · Cited by 99
Nutritional strategies for healthy cardiovascular aging: Focus on micronutrients
Visioli, F., & HAGEN, T. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.008 · Cited by 98
Marine omega-3 fatty acids and coronary heart disease
Calder, P. C., & Yaqoob, P. (2012) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328353febd · Cited by 99
Effects of omega-3 fatty acids on cardiovascular disease.
Wang, C., Chung, M., Lichtenstein, A. H., Balk, E. M., Kupelnick, B., DeVine, D., Lawrence, A., & Lau, J. (2004) · PubMed Central · Cited by 96
Pottala, J. V., Garg, S. K., Cohen, B. E., Whooley, M. A., & Harris, W. S. (2010) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.109.896159 · Cited by 95
Fatty Acids and Cardiovascular Risk. Evidence, Lack of Evidence, and Diligence
Visioli, F., & Poli, A. (2020) · Nutrients · doi:10.3390/nu12123782 · Cited by 106
Katcher, H. I., Hill, A. M., Lanford, J. L., Yoo, J. S., & Kris‐Etherton, P. M. (2009) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.11.010 · Cited by 97
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health
Djuricic, I. D., & Calder, P. C. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051921-090208 · Cited by 107
Omega-3 Fatty Acids and Athletics
Simopoulos, A. P. (2007) · Current Sports Medicine Reports · doi:10.1007/s11932-007-0037-4 · Cited by 97
Prescription omega-3 fatty acids for the treatment of hypertriglyceridemia
McKenney, J. M., & Sica, D. A. (2007) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp060164 · Cited by 94
Gao, L.-G., Cao, J., Mao, Q., Lu, X., Zhou, X., & Fan, L. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.10.056 · Cited by 94
Practical Applications of Fish Oil ( -3 Fatty Acids) in Primary Care
Oh, R. (2005) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.18.1.28 · Cited by 94
Fish Oil for the Reduction of Atrial Fibrillation Recurrence, Inflammation, and Oxidative Stress
Nigam, A., Talajic, M. R., Roy, D., Nattel, S., Lambert, J., Nozza, A., Jones, P. J. H., Ramprasath, V. R., O’Hara, G. E., Kopecky, S. L., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.07.956 · Cited by 93
Moyad, M. A. (2005) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2005.03.001 · Cited by 95
Abdukeyum, G. G., Owen, A. J., & McLennan, P. L. (2008) · Journal of Nutrition · doi:10.1093/jn/138.10.1902 · Cited by 94
Omega-3 polyunsaturated fatty acids for cardiovascular diseases: present, past and future
Watanabe, Y., & Tatsuno, I. (2017) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2017.1333902 · Cited by 95
Chahoud, G., Aude, Y. W., & Mehta, J. L. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.07.109 · Cited by 94
A review on machine learning approaches for microalgae cultivation systems
Syed, T., Krujatz, F., Ihadjadene, Y., Mühlstädt, G., Hamedi, H., Mädler, J., & Urbas, L. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108248 · Cited by 92
Heart rate: a forgotten link in coronary artery disease?
Fox, K. M., & Ferrari, R. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.58 · Cited by 91
Wachira, J. K., Larson, M. K., & Harris, W. S. (2014) · British Journal of Nutrition · doi:10.1017/s000711451300425x · Cited by 91
Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases
Schopfer, F. J., Vitturi, D. A., Jorkasky, D. K., & Freeman, B. Α. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.06.006 · Cited by 93
A genetic framework for improving arrhythmia therapy
Knollmann, B. C., & Roden, D. M. (2008) · Nature · doi:10.1038/nature06799 · Cited by 89
n−3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects
Jung, U. J., Torrejón, C., Tighe, A. P., & Deckelbaum, R. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.2003s · Cited by 91
Howlett, J. G., McKelvie, R. S., Arnold, J. M. O., Costigan, J., Dorian, P., Ducharme, A., Estrella-Holder, E., Ezekowitz, J. A., Giannetti, N., Haddad, H. A., et al. (2009) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(09)70477-5 · Cited by 90
Blood Omega-3 and Trans Fatty Acids in Middle-Aged Acute Coronary Syndrome Patients
Harris, W. S., Reid, K. J., Sands, S. A., & Spertus, J. A. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.08.013 · Cited by 85
Endogenous lipid mediators in the resolution of airway inflammation
Haworth, O., & Levy, B. D. (2007) · European Respiratory Journal · doi:10.1183/09031936.00005807 · Cited by 90
Zhao, Y.-T., Chen, Q., Sun, Y.-X., Li, X.-B., Zhang, P., Xu, Y., & Guo, J.-H. (2009) · Annals of Medicine · doi:10.1080/07853890802698834 · Cited by 87
Fatty acids and cardiovascular disease
Lecerf, J. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00194.x · Cited by 90
Fischer, R., Dechend, R., Qadri, F., Markovic, M., Feldt, S., Herse, F., Park, J.-K., Gapelyuk, A., Schwarz, I., Zacharzowsky, U. B., et al. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.103143 · Cited by 86
Cardiac Autonomic Changes Associated With Fish Oil vs Soy Oil Supplementation in the Elderly
Holguín, F., Téllez‐Rojo, M. M., Lazo, M., Mannino, D. M., Schwartz, J. D., Hernández, M., & Romieu, I. (2005) · CHEST Journal · doi:10.1016/s0012-3692(15)34453-6 · Cited by 86
Dessein, P. H., Joffe, B. I., & Stanwix, A. E. (2002) · Arthritis Research & Therapy · doi:10.1186/ar597 · Cited by 85
Ottestad, I. O., Hassani, S., Borge, G. I. A., Köhler, A., Vogt, G., Hyötyläinen, T., Orešič, M., Brønner, K. W., Holven, K. B., Ulven, S. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042550 · Cited by 88
Mason, R. P., Dawoud, H., Jacob, R. F., Sherratt, S. C. R., & Maliñski, T. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.118 · Cited by 87
Nonpharmacologic Treatment of Dyslipidemia
Houston, M. C., Fazio, S., Chilton, F. H., Wise, D. E., Jones, K. B., Barringer, T. A., & Bramlet, D. A. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.02.002 · Cited by 85
Micallef, M. A., & Garg, M. L. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.06.009 · Cited by 83
Membrane Effects of the n-3 Fish Oil Fatty Acids, which Prevent Fatal Ventricular Arrhythmias
Leaf, A., Xiao, Y., Kang, J. X., & Billman, G. E. (2005) · The Journal of Membrane Biology · doi:10.1007/s00232-005-0789-9 · Cited by 84
Cardiovascular disease and long-chain omega-3 fatty acids
Harris, W. S., Park, Y., & Isley, W. L. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200302000-00003 · Cited by 83
Intensive Integrated Therapy of Type 2 Diabetes
Gæde, P., & Pedersen, O. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s39 · Cited by 108
The Effects of Fish Oil on Cardiovascular Diseases: Systematical Evaluation and Recent Advance
Liao, J., Xiong, Q., Yin, Y., Ling, Z., & Chen, S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.802306 · Cited by 89
The role of omega-3 fatty acids in cardiac protection: an overview
Hassan, M. I. (2005) · Frontiers in bioscience · doi:10.2741/1601 · Cited by 85
4-Hydroxy Hexenal Derived from Docosahexaenoic Acid Protects Endothelial Cells via Nrf2 Activation
Ishikado, A., Morino, K., Nishio, Y., Nakagawa, F., Mukose, A., Sono, Y., Nagisa, Y., Kondo, K., Sekine, O., Yoshizaki, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069415 · Cited by 89
Metadata
- Authors
- Marchioli, R., Barzi, F., Bomba, E., Chieffo, C., Di Gregorio, D., Di Mascio, R., Franzosi, M. G., Geraci, E., Levantesi, G., Maggioni, A. P., Mantini, L., Marfisi, R. M., Mastrogiuseppe, G., Mininni, N., Nicolosi, G. L., Santini, M., Schweiger, C., Tavazzi, L., Tognoni, G., Tucci, C., & Valagussa, F.
- Affiliations
- Mario Negri Institute for Pharmacological Research (IT)
- From the Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti (R.M., F.B., E.B., R.D.M., R.M.M., G.T.); Ospedale Civile, Caserta (C.C.); Ospedale Civile, Lanciano (D.D.G., L.M., G.M., C.T.); Department of Cardiovascular Research, Istituto Mario Negri, Milano (M.G.F.); Ospedale Cervello, Palermo (E.G.); Ospedale Civile, Vasto (G.L.); Centro Studi ANMCO, Firenze (A.P.M.); Ospedale Civile, Napoli (N.M.); Ospedale S. Maria degli Angeli, Pordenone (G...
- Corresponding author
- Marchioli, Roberto
- Venue
- Circulation
- Published
- 2002-04-23
- Volume
- 105
- Issue
- 16
- Pages
- 1897-1903
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2128788220
- Cited by
- 1,311
- References
- 36
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 27 · 2023: 18 · 2022: 21 · 2021: 17 · 2020: 30 · 2019: 20 · 2018: 33 · 2017: 42 · 2016: 42 · 2015: 49 · 2014: 64 · 2013: 87 · 2012: 84
- FWCI
- 60.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Istituto di Ricerche Farmacologiche Mario Negri - IRCCS
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- omega-3 fatty acids, myocardial infarction, sudden death, mortality, vitamin E, antiarrhythmic effect, time course of treatment effects, cardiovascular mortality, coronary artery disease, cerebrovascular events
- MeSH terms
- Anti-Arrhythmia Agents, Female, Follow-Up Studies, Humans, Italy, Kinetics, Lipids, Male, Middle Aged, Myocardial Infarction, Fatty Acids, Omega-3, Death, Sudden, Cardiac, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
