Cited by 292Fatty Acid Research and HealthAntioxidant Activity and Oxidative StressAdipokines, Inflammation, and Metabolic Diseases

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Supplementation With Conjugated Linoleic Acid Causes Isomer-Dependent Oxidative Stress and Elevated C-Reactive Protein: A Potential Link to Fatty Acid-Induced Insulin Resistance

Risérus, Ulf, Basu, Samar, Jovinge, Stefan, Fredrikson, Gunilla Nordin, Ärnlöv, Johan, Vessby, Bengt·2002·Circulation

DOI 10.1161/01.cir.0000033589.15413.48

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Abstract

BACKGROUND: Conjugated linoleic acids (CLAs), a group of fatty acids shown to have beneficial effects in animals, are also used as weight loss supplements. Recently, we reported that the t10c12 CLA-isomer caused insulin resistance in abdominally obese men via unknown mechanisms. The aim of the present study was to examine whether CLA has isomer-specific effects on oxidative stress or inflammatory biomarkers and to investigate the relationship between these factors and induced insulin resistance. METHODS AND RESULTS: In a double-blind placebo-controlled trial, 60 men with metabolic syndrome were randomized to one of 3 groups receiving t10c12 CLA, a CLA mixture, or placebo for 12 weeks. Insulin sensitivity (euglycemic clamp), serum lipids, in vivo lipid peroxidation (determined as urinary 8-iso-PGF(2alpha) [F2-isoprostanes]), 15-ketodihydro PGF(2alpha), plasma vitamin E, plasma C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 were assessed before and after treatment. Supplementation with t10c12 CLA markedly increased 8-iso-PGF(2alpha) (578%) and C-reactive protein (110%) compared with placebo (P<0.0001 and P<0.01, respectively) and independent of changes in hyperglycemia or dyslipidemia. The increases in 8-iso-PGF(2alpha), but not in C-reactive protein, were significantly and independently related to aggravated insulin resistance. Oxidative stress was related to increased vitamin E levels, suggesting a compensatory mechanism. CONCLUSIONS: t10c12 CLA supplementation increases oxidative stress and inflammatory biomarkers in obese men. The oxidative stress seems closely related to induced insulin resistance, suggesting a link between the fatty acid-induced lipid peroxidation seen in the present study and insulin resistance. These unfavorable effects of t10c12 CLA might be of clinical importance with regard to cardiovascular disease, in consideration of the widespread use of dietary supplements containing this fatty acid.

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Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465
A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
Morrow, J. D., Hill, K. E., Burk, R. F., Nammour, T., Badr, K. F., & Roberts, L. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.23.9383 · Cited by 1,898
Increase in Circulating Products of Lipid Peroxidation (F2-Isoprostanes) in Smokers — Smoking as a Cause of Oxidative Damage
Morrow, J. D., Frei, B. B., Longmire, A. W., Gaziano, J. M., Lynch, S. M., Shyr, Y., Strauss, W., Oates, J. A., & Roberts, L. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505043321804 · Cited by 1,340
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X
Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,246
In Vivo Formation of 8-Iso-Prostaglandin F2αand Platelet Activation in Diabetes Mellitus: Effects of Improved Metabolic Control and Vitamin E Supplementation
Davı̀, G., Ciabattoni, G., Consoli, A., Mezzetti, A., Falco, A., Santarone, S., Pennese, E., Vitacolonna, E., Bucciarelli, T., Costantini, F., et al. (1999) · Circulation · doi:10.1161/01.cir.99.2.224 · Cited by 742
Elevated C-Reactive Protein
Lemieux, I., Pascot, A., Prud’homme, D., Alméras, N., Bogaty, P. M., Nadeau, A., Bergeron, J., & Després, J. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.961 · Cited by 597
Conjugated Linoleic Acid Reduces Body Fat Mass in Overweight and Obese Humans
Gudmundsen, O., Blankson, H., Stakkestad, J. A., Fagertun, H., Thom, E., & Wadstein, J. (2000) · Journal of Nutrition · doi:10.1093/jn/130.12.2943 · Cited by 595
Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes.
Rudich, A., Tirosh, A., Potashnik, R., Hemi, R., Kanety, H., & Bashan, N. (1998) · Diabetes · doi:10.2337/diabetes.47.10.1562 · Cited by 483

Show all 32 references

Research works printed but not linked: 8

10.1161/atvb.19.4.972 · DOI
10.1161/atvb.18.8.1199 · DOI
10.1161/atvb.18.5.762 · DOI
10.1161/atvb.17.11.2309 · DOI
10.1161/atvb.21.6.961 · DOI
1994, Am J Physiol, 266, E248
10.1161/circ.99.2.224 · DOI
10.1161/atvb.17.11.3236 · DOI

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Cao, Y., Zhang, J., & Kris‐Etherton, P. M. (2006) · Fundamental and clinical cardiology · doi:10.3109/9781420019667.004
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Cao, Y., Zhang, J., & Kris‐Etherton, P. M. (2007) · CRC Press eBooks · doi:10.3109/9781420019667-5
Suplementação com acido linoleico conjugado
dos Santos, L. Z. F. (2007) · doi:10.47749/t/unicamp.2007.403865
References
(2005) · Wiley eBooks · doi:10.1002/9780470774663.refs
Fat oxidation, appetite and weight control
Leonhardt, M., & Langhans, W. (2010) · Woodhead Publishing Limited eBooks · doi:10.1533/9781845690840.3.356
Safety Data on Conjugated Linoleic Acid from Animal Studies
Menzel, A., van der Zee, M., & O’Hagan, S. (2006) · AOCS Publishing eBooks · doi:10.1201/9781439822432.ch14
Conjugated linoleic acid in milk and dairy products: A comprehensive review of biosynthesis pathways, enrichment strategies, health implications, and gastrointestinal delivery challenges
Zareie, Z., Nooshkam, M., Moayedi, A., Rahmani, F., Sarhadi, Y., Burke, N., & Garavand, F. (2026) · Future Foods · doi:10.1016/j.fufo.2026.101208
Lipid-Lowering Actions of trans-10, cis-12 Conjugated Linoleic Acid in Primary Cultures of Human (Pre) Adipocytes
Chung, S., McIntosh, M., & Brown, J. M. (2006) · AOCS Publishing eBooks · doi:10.1201/9781439822432.ch13
Is There a Role for Conjugated Linoleic Acid to Aid in the Prevention of Type 2 Diabetes?
Asp, M. L., Liu, L.-F., Collene, A. L., Belury, M. A., Koster, C., Purushotham, A., Wendel, A. A., & Shrode, G. E. (2006) · AOCS Publishing eBooks · doi:10.1201/9781439822418.ch18

Authors: Risérus, U., Basu, S., Jovinge, S., Fredrikson, G. N., Ärnlöv, J., & Vessby, B.
Affiliations: From the Department of Public Health and Caring Sciences/Geriatrics, Uppsala University (U.R., S.B., J.Ä., B.V.), Uppsala, Sweden, and the Department of Cardiology/Medicine, University Hospital MAS, Lund University (S.J., G.N.F.), Lund, Sweden.
Uppsala University (SE)
ORCID: Jovinge, Stefan
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-10-08
Volume: 106
Issue: 15
Pages: 1925-1929
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.0000033589.15413.48
OpenAlex: W2164592152
Cited by: 292
References: 32
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 4 · 2016: 10 · 2015: 7 · 2014: 9 · 2013: 20 · 2012: 9
FWCI: 20.90
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: Medical Research Council
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: conjugated linoleic acid, CLA isomers, oxidative stress, lipid peroxidation, C-reactive protein, inflammation, insulin resistance, metabolic syndrome, obesity, weight loss supplements, vitamin E, 8-isoprostane
MeSH terms: Adult, Aged, Blood Glucose, C-Reactive Protein, Double-Blind Method, Humans, Inflammation, Insulin Resistance, Isomerism, Kinetics, Linoleic Acids, Lipoproteins, VLDL, Male, Middle Aged, Triglycerides, Lipid Peroxidation, Biomarkers, Cytokines, Oxidative Stress, Anti-Obesity Agents, Metabolic Syndrome, F2-Isoprostanes

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Supplementation With Conjugated Linoleic Acid Causes Isomer-Dependent Oxidative Stress and Elevated C-Reactive Protein: A Potential Link to Fatty Acid-Induced Insulin Resistance

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