Cited by 168Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsCoronary Interventions and Diagnostics

Non–High-Density Lipoprotein Cholesterol Levels Predict Five-Year Outcome in the Bypass Angioplasty Revascularization Investigation (BARI)

Bittner, Vera, Hardison, Regina, Kelsey, Sheryl F., Weiner, Bonnie H., Jacobs, Alice K., Sopko, George·2002·Circulation

Abstract

Background— Current National Cholesterol Education Program guidelines recommend that non–high-density lipoprotein cholesterol (non-HDL-C) be considered a secondary target of therapy among individuals with triglycerides >2.26 mmol/L. It is not known whether non-HDL-C relates to prognosis among patients with coronary heart disease. Methods and Results— Lipid levels were available at baseline among 1514 patients (73% men; mean age, 61 years) enrolled in the Bypass Angioplasty Revascularization Investigation (BARI); all had multivessel coronary artery disease. Patients were followed for 5 years. Outcomes of death, nonfatal myocardial infarction, and death or myocardial infarction were modeled using univariate and multivariate time-dependent proportional hazards methods; angina pectoris at 5 years was modeled using univariate and multivariate logistic regression. Non-HDL-C was a strong and independent predictor of nonfatal myocardial infarction (multivariate relative risk, 1.049 [95% confidence intervals, 1.006 to 1.093] for every 0.26 mmol/L increase) and angina pectoris (multivariate odds ratio, 1.049 [95% confidence intervals, 1.004 to 1.096] for every 0.26 mmol/L increase), but it did not relate to mortality. HDL-C and LDL-C did not predict events during follow-up. Conclusions— Among patients with lipid values in BARI, non-HDL-C is a strong and independent predictor of nonfatal myocardial infarction and angina pectoris at 5 years, even after consideration of powerful clinical variables. Our data suggest that non-HDL-C is an appropriate treatment target among patients with coronary heart disease.

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Crossref · 10.1161/01.cir.0000038496.57570.06

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  • The value of non-HDL-C in CVD risk assessment was first proposed by Frost and Havel in 1998, and this relationship has now been confirmed in many studies.

    “The value of non-HDL-C in CVD risk assessment was first proposed by Frost and Havel in 1998, 61 and this relationship has now been confirmed in many studies. [203]3][204][205][206][207][208][209][210][211][212][213][214][215][216]”

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Authors
Bittner, V., Hardison, R., Kelsey, S. F., Weiner, B. H., Jacobs, A. K., & Sopko, G.
Affiliations
Boston University (US)
Venue
Circulation
Published
2002-11-12
Volume
106
Issue
20
Pages
2537-2542
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2113541168
Cited by
168
References
16
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 5 · 2013: 13 · 2012: 4
FWCI
9.86
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5u01hl038532-11, 5u01hl038504-10, 5u01hl038556-10, 5u01hl038512-10, 5u01hl038642-11, 2u01hl038514-09, 5u01hl038509-10, 5u01hl038518-11, 5u01hl038529-11, 2u01hl038524-09, 2u01hl038493-09)
  • National Heart, Lung, and Blood Institute (HL 38610, HL-38509, HL42145, HL-38529, HL38514-6, HL38556, HL-38493, HL-38532, HL38642, HL-38504, HL-38518, HL 38512, U01HL038610, HL38524)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
Keywords
non-HDL cholesterol, coronary artery disease, multivessel coronary artery disease, nonfatal myocardial infarction, angina pectoris, cardiovascular mortality, prognostic factors, triglycerides, HDL cholesterol, LDL cholesterol
MeSH terms
Angina Pectoris, Coronary Artery Bypass, Cholesterol, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Myocardial Infarction, Prognosis, Risk, Triglycerides, Angioplasty, Balloon, Coronary, Treatment Outcome

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