Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease

Hemodynamic Patterns of Age-Related Changes in Blood Pressure: The Framingham Heart Study

Franklin, S. S., Gustin, W., Wong, N. D., Larson, M. G., Weber, M. A., Kannel, W. B., & Levy, D. (1997) · Circulation · doi:10.1161/01.cir.96.1.308 · Cited by 2,321

Impact of Aortic Stiffness on Survival in End-Stage Renal Disease

Blacher, J., Guerin, A. P., Pannier, B., Marchais, S. J., Safar, M. E., & London, G. M. (1999) · Circulation · doi:10.1161/01.cir.99.18.2434 · Cited by 2,138

Is Pulse Pressure Useful in Predicting Risk for Coronary Heart Disease?

Franklin, S. S., Khan, S. A., Wong, N. D., Larson, M. G., & Levy, D. A. (1999) · Circulation · doi:10.1161/01.cir.100.4.354 · Cited by 1,756

Aortic Stiffness Is an Independent Predictor of Primary Coronary Events in Hypertensive Patients

Boutouyrie, P., Tropeano, A., Asmar, R. G., Gautier, I., Bénétos, A., Lacolley, P. J., & Laurent, S. (2002) · Hypertension · doi:10.1161/hy0102.099031 · Cited by 1,745

Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients

Blacher, J., Asmar, R., Djane, S., London, G. M., & Safar, M. E. (1999) · Hypertension · doi:10.1161/01.hyp.33.5.1111 · Cited by 1,493

Does the Relation of Blood Pressure to Coronary Heart Disease Risk Change With Aging?: The Framingham Heart Study

Franklin, S. S., Larson, M. G., Khan, S. A., Wong, N. D., Leip, E. P., Kannel, W. B., & Levy, D. (2001) · Circulation · doi:10.1161/01.cir.103.9.1245 · Cited by 1,390

Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women

Celermajer, D. S., Sørensen, K. E., Spiegelhalter, D. J., Georgakopoulos, D., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90305-0 · Cited by 1,354

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

Lakatta, E. G., & Levy, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048893.62841.f7 · Cited by 1,257

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

Lakatta, E. G. (2003) · Circulation · doi:10.1161/01.cir.0000048894.99865.02 · Cited by 1,105

Effects of age and aerobic capacity on arterial stiffness in healthy adults.

Vaitkevicius, P. V., Fleg, J. L., Engel, J.-H., O’Connor, F. C., Wright, J. G., Lakatta, L. E., Yin, F. C. P., & Lakatta, E. G. (1993) · Circulation · doi:10.1161/01.cir.88.4.1456 · Cited by 1,085

Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group.

Furberg, C. D., Adams, H. P., Applegate, W. B., Byington, R. P., Espeland, M. A., Hartwell, T., Hunninghake, D. B., Lefkowitz, D. S., Probstfield, J. L., & Riley, W. A. (1994) · Circulation · doi:10.1161/01.cir.90.4.1679 · Cited by 865

Pulse pressure—a review of mechanisms and clinical relevance

Dart, A. M., & Kingwell, B. A. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01108-1 · Cited by 836

Cardiovascular regulatory mechanisms in advanced age.

Lakatta, E. G. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.2.413 · Cited by 791

Improved Arterial Compliance by a Novel Advanced Glycation End-Product Crosslink Breaker

Kass, D. A., Shapiro, E. P., Kawaguchi, M., Capriotti, A. R., Scuteri, A., deGroof, R. C., & Lakatta, E. G. (2001) · Circulation · doi:10.1161/hc3801.097806 · Cited by 735

Effects of Ramipril and Vitamin E on Atherosclerosis: The Study to Evaluate Carotid Ultrasound Changes in Patients Treated With Ramipril and Vitamin E (SECURE)

Lonn, E. M., Yusuf, S., Dzavik, V., Doris, C. I., Yi, Q., Smith, S., Moore-Cox, A., Bosch, J., Riley, W. A., & Teo, K. K. (2001) · Circulation · doi:10.1161/01.cir.103.7.919 · Cited by 712

A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.

Stary, H. C., Blankenhorn, D. H., Chandler, A. B., Glagov, S. K., Insull, W., Richardson, M., Rosenfeld, M. E., Schaffer, S. A., Schwartz, C. J., & Wagner, W. D. (1992) · Circulation · doi:10.1161/01.cir.85.1.391 · Cited by 624

Systolic and Diastolic Blood Pressure, Pulse Pressure, and Mean Arterial Pressure as Predictors of Cardiovascular Disease Risk in Men

Sesso, H. D., Stampfer, M. J., ROSNER, B. A., Hennekens, C. H., Gaziano, J. M., Manson, J. E., & Glynn, R. J. (2000) · Hypertension · doi:10.1161/01.hyp.36.5.801 · Cited by 599

Pulse Pressure Not Mean Pressure Determines Cardiovascular Risk in Older Hypertensive Patients

Blacher, J., Staessen, J. A., Girerd, X. J., Gąsowski, J., Thijs, L., Liu, L., Wang, J. G., Fagard, R. H., & Safar, M. E. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.8.1085 · Cited by 580

Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women

Fleg, J. L., O'Connor, F., Gerstenblith, G., Becker, L. C., Clulow, J., Schulman, S. P., & Lakatta, E. G. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.3.890 · Cited by 506

Absence of Age-Related Increase in Central Arterial Stiffness in Physically Active Women

Tanaka, H., DeSouza, C. A., & Seals, D. R. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.1.127 · Cited by 490

Breakers of advanced glycation end products restore large artery properties in experimental diabetes

Wolffenbuttel, B. H. R., Boulanger, C. M., Crijns, F. R. L., Huijberts, M. S., Poitevin, P., Swennen, G., Vasan, S., Egan, J. J., Ulrich, P. C., Cerami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4630 · Cited by 434

Isolated Systolic Hypertension

DOMANSKI, M. J., Davis, B. R., Pfeffer, M. A., Kastantin, M. J., & Mitchell, G. F. (1999) · Hypertension · doi:10.1161/01.hyp.34.3.375 · Cited by 409

Importance of Systolic Blood Pressure in Older Americans

Izzo, J. L., Levy, D. A., & Black, H. R. (2000) · Hypertension · doi:10.1161/01.hyp.35.5.1021 · Cited by 404

Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities.

Virmani, R., Avolio, A. P., Mergner, W. J., Robinowitz, M., Herderick, E. E., Cornhill, J. F., Guo, S., Liu, T. H., Ou, D. Y., & O’Rourke, M. F. (1991) · PubMed Central · Cited by 371

An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness

Asif, M., Egan, J. J., Vasan, S., Jyothirmayi, G. N., Masurekar, M. R., Lopez, S., Williams, C., Torres, R. L., Wagle, D., Ulrich, P. C., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040558497 · Cited by 336

Low-Dose Metoprolol CR/XL and Fluvastatin Slow Progression of Carotid Intima-Media Thickness

Hedblad, B., Wikstrand, J., Janzon, L., Wedel, H., & Berglund, G. (2001) · Circulation · doi:10.1161/01.cir.103.13.1721 · Cited by 324

Reduction in Carotid Arterial Wall Thickness Using Lovastatin and Dietary Therapy

Hodis, H. N., Mack, W. J., LaBree, L., Selzer, R. H., Liu, C.-R., Liu, C.-H., Alaupovic, P., Kwong-Fu, H., & Azen, S. P. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-6-199603150-00002 · Cited by 323

The Natural History of Borderline Isolated Systolic Hypertension

Sagie, A., Larson, M. G., & Levy, D. A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312233292602 · Cited by 290

Improved arterial distensibility in normotensive subjects on a low salt diet.

Avolio, A. P., Clyde, K. M., Beard, T. C., Cooke, H., Ho, K. K. Y., & OʼRourke, M. F. (1986) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.6.2.166 · Cited by 261

A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys

Vaitkevicius, P. V., Lane, M. A., Spurgeon, H. A., Ingram, D. K., Roth, G. S., Egan, J. J., Vasan, S., Wagle, D., Ulrich, P. C., Brines, M. L., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1171 · Cited by 260

Stroke Volume/Pulse Pressure Ratio and Cardiovascular Risk in Arterial Hypertension

SIMONE, G. D., Roman, M. J., Koren, M. J., Mensah, G. A., Ganau, A., & Devereux, R. B. (1999) · Hypertension · doi:10.1161/01.hyp.33.3.800 · Cited by 260

Vascular Endothelium, Hemodynamic Forces, and Atherogenesis

Gimbrone, M. A. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65090-0 · Cited by 258

Pulse Pressure and Mortality in Older People

Glynn, R. J., Chae, C. U., Guralnik, J. M., Taylor, J. O., & Hennekens, C. H. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.18.2765 · Cited by 258

B-Mode Ultrasound Assessment of Pravastatin Treatment Effect on Carotid and Femoral Artery Walls and Its Correlations With Coronary Arteriographic Findings: A Report of the Regression Growth Evaluation Statin Study (REGRESS)

de Groot, E., Jukema, J. W., van Swijndregt, A. D. M., Zwinderman, A. H., Ackerstaff, R. G. A., van der Steen, A. F. W., Bom, N., Lie, K. I., & Bruschke, A. V. G. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00170-3 · Cited by 258

A decrease in diastolic blood pressure combined with an increase in systolic blood pressure is associated with a higher cardiovascular mortality in men

Benetos, A., Zureik, M., Morcet, J., Thomas, F., Bean, K., Safar, M., Ducimetière, P., & Guize, L. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00586-0 · Cited by 207

Leisure-time physical activities and their relationship to cardiorespiratory fitness in healthy men and women 18???95 years old

Talbot, L. A., Metter, E. J., & Fleg, J. L. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200002000-00024 · Cited by 192

Pulse Pressure Compared With Other Blood Pressure Indexes in the Prediction of 25-Year Cardiovascular and All-Cause Mortality Rates

Miura, K., Dyer, A. R., Greenland, P., Daviglus, M. L., Hill, M., Liu, K., Garside, D. B., & Stamler, J. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.232 · Cited by 181

Effect of chronic ANG I-converting enzyme inhibition on aging processes. II. Large arteries

Michel, J., Heudes, D., Michel, O., Poitevin, P., Philippe, M., Scalbert, E., Corman, B., & Levy, B. I. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.267.1.r124 · Cited by 179

Stiffness of Carotid Artery Wall Material and Blood Pressure in Humans

Safar, M. E., Blacher, J., Mourad, J., & London, G. M. (2000) · Stroke · doi:10.1161/01.str.31.3.782 · Cited by 142

Cross-Sectional and 4-Year Longitudinal Associations Between Brachial Pulse Pressure and Common Carotid Intima-Media Thickness in a General Population

Zureik, M., Touboul, P., Bonithon‐Kopp, C., Courbon, D., Berr, C., Leroux, C., & Ducimetière, P. (1999) · Stroke · doi:10.1161/01.str.30.3.550 · Cited by 139

Does Reduced Vascular Stiffening Fully Explain Preserved Cardiovagal Baroreflex Function in Older, Physically Active Men?

Hunt, B. E., Farquhar, W. B., & Taylor, J. A. (2001) · Circulation · doi:10.1161/01.cir.103.20.2424 · Cited by 117

Enhanced endothelial vasoreactivity in endurance-trained older men

Rywik, T. M., Blackman, M. R., Yataco, A. R., Vaitkevicius, P. V., Zink, R. C., Cottrell, E. H., Wright, J. G., Katzel, L. I., & Fleg, J. L. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.6.2136 · Cited by 103

Aging and atherosclerosis in the rabbit

Spagnoli, L. G., Orlandi, A., Mauriello, A., Santeusanio, G., de Angelis, C., Lucreziotti, R., & Ramacci, M. T. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90003-l · Cited by 103

Genetic and Environmental Factors in the Function and Structure of the Arterial Wall

Avolio, A. P. (1995) · Hypertension · doi:10.1161/01.hyp.26.1.34 · Cited by 77

The pulse pressure-to-stroke index ratio predicts cardiovascular events and death in uncomplicated hypertension

Fagard, R. H., Pardaens, K., Staessen, J. A., & Thijs, L. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01362-6 · Cited by 67

Nonhuman Primate Models of Atherosclerosis

Shelton, K. A., Clarkson, T. B., & Kaplan, J. R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381366-4.00008-0 · Cited by 65

Remodeling of Heart and Arteries by Chronic Converting Enzyme Inhibition in Spontaneously Hypertensive Rats

Levy, B. I., Michel, J., Salzmann, J. L., Devissaguet, M., & Safar, M. E. (1991) · American Journal of Hypertension · doi:10.1093/ajh/4.3.240s · Cited by 31

Expert consensus document on arterial stiffness: methodological issues and clinical applications

Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I., Struijker-Boudier, H., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl254 · Cited by 6,077

Exercise and Physical Activity for Older Adults

Chodzko-Zajko, W. J., Proctor, D. N., Fiatarone Singh, M. A., Minson, C. T., Nigg, C. R., Salem, G. J., & Skinner, J. S. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181a0c95c · Cited by 5,153

Use of Carotid Ultrasound to Identify Subclinical Vascular Disease and Evaluate Cardiovascular Disease Risk: A Consensus Statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force Endorsed by the Society for Vascular Medicine

Stein, J. H., Korcarz, C. E., Hurst, R. T., Lonn, E., Kendall, C. B., Mohler, E. R., Najjar, S. S., Rembold, C. M., & Post, W. S. (2008) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2007.11.011 · Cited by 2,454

Exercise Standards for Testing and Training: A Scientific Statement From the American Heart Association

Fletcher, G. F., Ades, P. A., Kligfield, P., Arena, R., Balady, G. J., Bittner, V. A., Coke, L. A., Fleg, J. L., Forman, D. E., Gerber, T. C., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829b5b44 · Cited by 2,235

Myocardial Fatty Acid Metabolism in Health and Disease

Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,228

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part III: cellular and molecular clues to heart and arterial aging. Circulation

Lakatta, E. G., Levy, D. A., & Levy, D. A. (2015)

Aging and Cardiovascular Disease

Wissler, R. W., & Robert, L. (1996) · Circulation · doi:10.1161/01.cir.93.9.1608 · Cited by 19

Aging of the Heart and Arteries: A Set-up for Cardiovascular Disease Leading to Heart Failure

Lakatta, E. G. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.08.040

Aging’s Accomplice in Harming the Cardiovascular System

Wei, Y. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315217

Aging Issues in Cardiology

(2004) · Developments in cardiovascular medicine · doi:10.1007/978-1-4419-8865-2 · Cited by 6