Cited by 1,970Atrial Fibrillation Management and OutcomesHeart Failure Treatment and ManagementCardiac Health and Mental Health

The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.

Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality: The Framingham Heart Study

Wang, Thomas J., Larson, Martin G., Levy, Daniel, Vasan, Ramachandran S., Leip, Eric P., Wolf, Philip A., D’Agostino, Ralph B., Murabito, Joanne M., Kannel, William B., Benjamin, Emelia J.·2003·Circulation

DOI 10.1161/01.cir.0000072767.89944.6e

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Abstract

Background— Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of these conditions on mortality. Methods and Results— We studied participants in the Framingham Study with new-onset AF or CHF. Multivariable Cox proportional hazards models with time-dependent variables were used to evaluate whether mortality after AF or CHF was affected by the occurrence and timing of the other condition. Hazard ratios (HRs) were adjusted for time period and cardiovascular risk factors. During the study period, 1470 participants developed AF, CHF, or both. Among 382 individuals with both conditions, 38% had AF first, 41% had CHF first, and 21% had both diagnosed on the same day. The incidence of CHF among AF subjects was 33 per 1000 person-years, and the incidence of AF among CHF subjects was 54 per 1000 person-years. In AF subjects, the subsequent development of CHF was associated with increased mortality (men: HR 2.7; 95% CI, 1.9 to 3.7; women: HR 3.1; 95% CI, 2.2 to 4.2). Similarly, in CHF subjects, later development of AF was associated with increased mortality (men: HR 1.6; 95% CI, 1.2 to 2.1; women: HR 2.7, 95% CI, 2.0 to 3.6). Preexisting CHF adversely affected survival in individuals with AF, but preexisting AF was not associated with adverse survival in those with CHF. Conclusions— Individuals with AF or CHF who subsequently develop the other condition have a poor prognosis. Additional studies addressing the pathogenesis, prevention, and optimal management of the joint occurrence of AF and CHF appear warranted.

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Background
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Background
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Background
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Background
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Background
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“7) Sex, women 1251 (64) 1218 (63) 1144 (59) 1081 (56) 856 (44) Race, African American 498 (26) 362 (19) 350 (18) 326 (17) 512 (26) Height, cm Men 177 (7) 177 (7) 177 (7) 176 (7) 176 (6) Women 162 (6) 162 (6) 162 (6) 162 (6) 163 (6) Body mass index, kg/m(2) Men 28.”
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Background
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Background
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BackgroundResult
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Background
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Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation
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Characteristics, management and prognosis of elderly patients in the Euro Heart Survey on atrial fibrillation
Fumagalli, S., Nieuwlaat, R., Tarantini, F., de Vos, C. B., Werter, C. J. P. J., Heuzey, J. L., Marchionni, N., & Crijns, H. J. G. M. (2012) · Aging Clinical and Experimental Research · doi:10.1007/bf03654822 · Cited by 21
Enhanced Sensitivity to Drug‐Induced QT Interval Lengthening in Patients With Heart Failure Due to Left Ventricular Systolic Dysfunction
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Cost-effectiveness of the convergent procedure and catheter ablation for non-paroxysmal atrial fibrillation
Anderson, L. H., Black, E. J., Civello, K. C., Martinson, M., & Kress, D. C. (2014) · Journal of Medical Economics · doi:10.3111/13696998.2014.911185 · Cited by 21
Low Atrial Fibrillatory Rate Is Associated With Poor Outcome in Patients With Mild to Moderate Heart Failure
Platonov, P. G., Cygankiewicz, I., Stridh, M., Holmqvist, F., Vázquez, R., Bayés‐Genís, A., McNitt, S. A., Zaręba, W., & Bayés‐Genís, A. (2012) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.111.964395 · Cited by 21
Role of Connexins in Atrial Fibrillation
Dhein, S. (2006) · KARGER eBooks · doi:10.1159/000092568 · Cited by 21
Automatic Detection of Atrial Fibrillation and Other Arrhythmias in ECG Recordings Acquired by a Smartphone Device
Billeci, L., Costi, M., Lombardi, D., Chiarugi, F., & Varanini, M. (2018) · Electronics · doi:10.3390/electronics7090199 · Cited by 20
“AF is associated with increased cardiovascular problems, especially stroke and heart failure, as well as increased mortality [5].”
Background
Atrial Fibrillation in Heart Failure Is Associated with High Levels of Circulating microRNA-199a-5p and 22–5p and a Defective Regulation of Intracellular Calcium and Cell-to-Cell Communication
García-Elías, A., Tajes, M., Yáñez-Bisbe, L., Enjuanes, C., Colet, J. C., Serra, S. A., Fernández‐Fernández, J. M., Aguilar‐Agon, K. W., Reilly, S. N., Martí‐Almor, J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910377 · Cited by 20
Long-term risk of adverse outcomes according to atrial fibrillation type
Blum, S., Aeschbacher, S., Coslovsky, M., Meyre, P. B., Reddiess, P., Ammann, P., Erné, P., Moschovitis, G., Valentino, M. D., Shah, D. C., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-05688-9 · Cited by 20
Liraglutide inhibits AngII-induced cardiac fibroblast proliferation and ECM deposition through regulating miR-21/PTEN/PI3K pathway
Wang, J., Guo, R., Ma, X., Wang, Y., Zhang, Q., Zheng, N., Zhang, J., & Li, C. (2022) · Cell and Tissue Banking · doi:10.1007/s10561-022-10021-9 · Cited by 20
“It has been demonstrated that AF patients have an enhanced risk of suffering stroke (4 ~ fivefold) (Wolf et al., 1991) and heart failure (2 ~ threefold) (Wang et al., 2003), thus leading to an almost twofold elevated overall mortality (De la Fuente-Martínez et al., 2021).”
Background
Clinical Outcomes of Rhythm Control Strategies for Asymptomatic Atrial Fibrillation According to the Quality‐of‐Life Score: The CODE‐AF (Comparison Study of Drugs for Symptom Control and Complication Prevention of Atrial Fibrillation) Registry
Kim, J. Y., Park, H., Park, H. W., Choi, E., Park, J., Kim, J., Kang, K., Uhm, J., Joung, B., & Park, K. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.025956 · Cited by 20
Catheter ablation in patients with atrial fibrillation and heart failure with preserved ejection fraction: A systematic review and meta‐analysis
Siddiqui, M. U., Junarta, J., Riley, J. M., Ahmed, A., Pasha, A. K., Limbrick, K., Alvarez, R., & Frisch, D. R. (2022) · Journal of Arrhythmia · doi:10.1002/joa3.12794 · Cited by 20
Causal effects between atrial fibrillation and heart failure: evidence from a bidirectional Mendelian randomization study
Zhang, Z., Li, L., Zhao, H., Zhou, L., Zhang, Z., Xiong, Y., & Yao, Y. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01606-8 · Cited by 21
“Previous studies exploring the bidirectional relationship between HF and AF have suggested that one condition directly predisposes to the other [6].”
Background
Outcomes of patients with atrial fibrillation on oral anticoagulation with and without heart failure: the ETNA-AF-Europe registry
Schnabel, R. B., Ameri, P., Siller-Matula, J. M., Diemberger, I., Gwechenberger, M., Pecen, L., Manu, M. C., de Souza, J. A. G., Caterina, R. D., & Kirchhof, P. F. (2023) · EP Europace · doi:10.1093/europace/euad280 · Cited by 20
Prolonged Atrial Effective Refractory Periods in Atrial Fibrillation Patients Associated with Structural Heart Disease or Sinus Node Dysfunction Compared with Lone Atrial Fibrillation
Uhm, J., Mun, H.-S., Wi, J. H., Uhm, J., Joung, B., Lee, M., & Pak, H. (2012) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12037 · Cited by 20
“(4) The clinical outcomes of RFCA were not significantly different between SHD/SND and lone AF for 14.”
Background
Omega-3 Fatty Acids and Vitamin D in Cardiology
Güttler, N., Zheleva, K., Parahuleva, M. S., Chasan, R., Bilgin, M., Neuhof, C., Burgazli, K. M., Niemann, B., Erdogan, A. R., & Böning, A. (2012) · Cardiology Research and Practice · doi:10.1155/2012/729670 · Cited by 21
“Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with considerable morbidity and mortality [21].”
Background
Can We Predict Outcomes in Atrial Fibrillation?
Desai, N. R., & Giugliano, R. P. (2012) · Clinical Cardiology · doi:10.1002/clc.20989 · Cited by 20
Ventricular rate monitoring as a tool to predict and prevent atrial fibrillation-related inappropriate shocks in heart failure patients treated with cardiac resynchronisation therapy defibrillators
Ricci, R. P., Pignalberi, C., Landolina, M., Santini, M., Lunati, M., Boriani, G., Proclemer, A., Facchin, D., Catanzariti, D., Morani, G., et al. (2014) · Heart · doi:10.1136/heartjnl-2013-305259 · Cited by 20
Executive Summary of the II Brazilian Guidelines for Atrial Fibrillation
de Magalhães, L. P., Figueiredo, M. J. D. O., Cintra, F. D., Saad, E., Kuniyoshi, R. R., Filho, A. M. L., d’Ávila, A., de Paola, Â. A. V., Kalil, C., Moreira, D. A. R., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160190 · Cited by 19
Sex differences of in-hospital outcome and long-term mortality in patients with Takotsubo cardiomyopathy
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“Interestingly, a prolongation of the QT interval on ECG recordings was shown to be associated with depressive symptoms in patients after suffering from an acute coronary syndrome.(27) Accordingly, the present study shows that the incidence of QT-interval prolongation is very high.”
Prognostic significance of residual functional mitral regurgitation in hospitalized heart failure patients with chronic atrial fibrillation and preserved ejection fraction after medical therapies
Ito, K., Abe, Y., Watanabe, H., Shimada, Y., Shibayama, K., Oe, H., Hyodo, E., Miyazaki, C., Takahashi, Y., Shibata, T., et al. (2018) · Journal of Echocardiography · doi:10.1007/s12574-018-0412-6 · Cited by 20
Guideline-directed therapy at discharge in patients with heart failure and atrial fibrillation
Ahn, M., Yoo, B., Yoon, J., Lee, S., Kim, J., Ahn, S. G., Youn, Y. J., Lee, J., Son, J., Kim, H. S., et al. (2019) · Heart · doi:10.1136/heartjnl-2019-315240 · Cited by 20
Abutting Left Atrial Appendage and Left Superior Pulmonary Vein Predicts Recurrence of Atrial Fibrillation After Point-by-Point Pulmonary Vein Isolation
Szegedi, N., Simon, J., Szilveszter, B., Salló, Z., Herczeg, S., Száraz, L., Kolossváry, M., Orbán, G., Széplaki, G., Nagy, K. V., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.708298 · Cited by 20
Prognostic Significance of Atrial Arrhythmias in a Primary Prevention ICD Population
Gelder, I. C. V., Phan, H., Wilkoff, B. L., BROWN, M. L., Rogers, T. B., PETERSON, B. J., & Birgersdotter-Green, U. M. (2011) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2011.03124.x · Cited by 20
Preoperative atrial fibrillation is an independent predictor of worse early and late outcomes after isolated coronary artery bypass graft surgery
Saxena, A., Kapoor, J., Dinh, D. T., Smith, J. A., Shardey, G. C., & Newcomb, A. E. (2014) · Journal of Cardiology · doi:10.1016/j.jjcc.2014.06.003 · Cited by 20
ACC/AHA/ESC: Guías de Práctica Clínica 2006 para el manejo de pacientes con fibrilación auricular. Versión resumida
Informe del Grupo de Trabajo para la elaboración de guías de práctica clínica del American College of Cardiology y de la American Heart Association, del Comité de Guías de Práctica Clínica de la Sociedad Europea de Cardiología (comité de redacción para la revisión de la Guía de práctica clínica sobre el manejo de pacientes con fibrilación auricular, 2., & Desarrollado en colaboración con las asociaciones European Heart Rhythm Association y Heart Rhythm Society (2006) · Revista Española de Cardiología · doi:10.1157/13096583 · Cited by 20
Heart failure management guided by remote multiparameter monitoring: A meta-analysis
Zito, A., Restivo, A., Ciliberti, G., Laborante, R., Princi, G., Romiti, G. F., Galli, M., Rodolico, D., Bianchini, E., Cappannoli, L., et al. (2023) · International Journal of Cardiology · doi:10.1016/j.ijcard.2023.131163 · Cited by 19
Sex-Specific Prevalence, Incidence, and Mortality Associated With Atrial Fibrillation in Heart Failure
Barillas-Lara, M. I., Monahan, K. M., Helm, R. H., Vasan, R. S., Schou, M., Køber, L., Gislason, G., Torp-Pedersen, C. T., & Andersson, C. (2021) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2021.02.021 · Cited by 19
Self-citation
Sacubitril/Valsartan Can Reduce Atrial Fibrillation Recurrence After Catheter Ablation in Patients with Persistent Atrial Fibrillation
Wang, Q., Zhuo, C., Xia, Q., Jiang, J., Wu, B., Zhou, D., Shu, Z., Zhao, J., Chen, M., Chen, H., et al. (2022) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-022-07315-1 · Cited by 19
Gender differences in patients with atrial fibrillation
BOSCH, R. F., Pittrow, D. B., Beltzer, A., Kruck, I., Kirch, W., Kohlhaußen, A., & Bonnemeier, H. (2013) · Herzschrittmachertherapie + Elektrophysiologie · doi:10.1007/s00399-013-0283-5 · Cited by 19
Atrial Fibrillation and Heart Failure: Cause or Effect?
Luong, C. L., Barnes, M. E., & Tsang, T. S. M. (2014) · Current Heart Failure Reports · doi:10.1007/s11897-014-0229-1 · Cited by 19
Arrhythmias in Structural Heart Disease
Gillespie, H. S., Lin, C. C. H., & Prutkin, J. M. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0510-7 · Cited by 18
Comparison of Rate Control versus Rhythm Control for Management of Atrial Fibrillation in Patients with Coexisting Heart Failure: A Cost‐Effectiveness Analysis
Pérez, A., Touchette, D. R., DiDomenico, R. J., Stamos, T. D., & Walton, S. M. (2011) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.31.6.552 · Cited by 19
“Atrial fibrillation and heart failure have common risk factors and frequently coexist.(4) When occurring simultaneously, these conditions contribute to each other’s physiologic development and maintenance, which leads to a worse prognosis than with either condition alone.”
Background
Conduction between left superior pulmonary vein and left atria and atria fibrillation under cervical vagal trunk stimulation.
Yuemei, H., Xiaoqin, Z., Song, J., & Ji-na, N. (2008) · Colombia medica · doi:10.25100/cm.v39i3.590 · Cited by 20
Surgical ablation of atrial fibrillation in patients with a giant left atrium undergoing mitral valve surgery
Kim, H. J., Kim, J. B., Jung, S., Choo, S. J., Chung, C. H., & Lee, J. W. (2016) · Heart · doi:10.1136/heartjnl-2015-308482 · Cited by 19
Risk factors for heart failure in a cohort of patients with newly diagnosed myocardial infarction: a matched, case-control study in Iran
Ahmadi, A., Etemad, K., & Khaledifar, A. (2016) · Epidemiology and Health · doi:10.4178/epih.e2016019 · Cited by 19
“The coincidence of HF and AF had a worse prognosis than the incidence of only HF or AF [26].”
Background
Individualized Ablation Strategy Guided By Live Simultaneous Global Mapping to Treat Persistent Atrial Fibrillation
Shi, R., Norman, M. W., Chen, Z., & Wong, T. (2018) · Future Cardiology · doi:10.2217/fca-2017-0109 · Cited by 19
Analysis of the anatomical features of pulmonary veins on pre-procedural cardiac CT images resulting in incomplete cryoballoon ablation for atrial fibrillation
Matsumoto, Y., Muraoka, Y., Funama, Y., Mito, S., Masuda, T., Sato, T., Akita, T., & Awai, K. (2018) · Journal of cardiovascular computed tomography · doi:10.1016/j.jcct.2018.11.005 · Cited by 19
Cardiac MRI and Fibrosis Quantification
Kholmovski, E. G., Morris, A. K., & Chelu, M. G. (2019) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2019.04.005 · Cited by 20
Predictors of improvement of left ventricular systolic function after catheter ablation of persistent atrial fibrillation in patients with heart failure with reduced ejection fraction
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Mechanisms and Clinical Manifestations of Cognitive Decline in Atrial Fibrillation Patients: Potential Implications for Preventing Dementia
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Impacts of Patient Characteristics on the Effectiveness of Landiolol in AF/AFL Patients Complicated with LV Dysfunction: Subgroup Analysis of the J-Land Study
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Can We Predict the Occurrence of Atrial Fibrillation?
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Effect of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Patients Following Ablation of Atrial Fibrillation
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“heart failure compared with RECORD (26%) and other studies, [20,21].”
Result
Simultaneous Right Atrioventricular Pacing: A Novel Model to Study Atrial Remodeling and Fibrillation in the Setting of Heart Failure
Laurent, G., Moe, G. W. P. L., Hu, X., So, P. P., Ramadeen, A., Leong-Poi, H. M., Doumanovskaia, L., König, A. A., Trogadis, J. E., Courtman, D. W., et al. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2007.10.021 · Cited by 19

Authors: Wang, T. J., Larson, M. G., Levy, D., Vasan, R. S., Leip, E. P., Wolf, P. A., D’Agostino, R. B., Murabito, J. M., Kannel, W. B., & Benjamin, E. J.
Affiliations: Boston University (US)
ORCID: Wang, Thomas J.
Larson, Martin G.
Levy, Daniel
Vasan, Ramachandran S.
Wolf, Philip A.
D’Agostino, Ralph B.
Murabito, Joanne M.
Benjamin, Emelia J.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-06-17
Volume: 107
Issue: 23
Pages: 2920-2925
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.0000072767.89944.6e
OpenAlex: W1998083759
Cited by: 1,970
References: 28
Citations by year: 2026: 49 · 2025: 65 · 2024: 114 · 2023: 93 · 2022: 117 · 2021: 137 · 2020: 109 · 2019: 103 · 2018: 120 · 2017: 107 · 2016: 111 · 2015: 115 · 2014: 112 · 2013: 101 · 2012: 84
FWCI: 27.01
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc25195-41-0-1)
National Heart, Lung, and Blood Institute (K24-HL-04334-01A1, N01‐HC25195, K24HL004334)
National Institute of Neurological Disorders and Stroke (5-RO1-NS-17950, R01NS017950)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords: atrial fibrillation, congestive heart failure, mortality, comorbidities, prognosis, Framingham Heart Study
MeSH terms: Aged, Atrial Fibrillation, Female, Follow-Up Studies, Heart Failure, Humans, Male, Massachusetts, Middle Aged, Prognosis, Risk Factors, Cohort Studies, Comorbidity, Incidence, Multivariate Analysis, Proportional Hazards Models, Survival Analysis, Disease Progression

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Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality: The Framingham Heart Study

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