Incidence and mortality risk of congestive heart failure in atrial fibrillation patients: a community-based study over two decades
Abstract
AIMS: We sought to determine whether the incidence of and survival following congestive heart failure (CHF) in patients with atrial fibrillation (AF) have changed over time. METHODS AND RESULTS: Olmsted County, Minnesota residents diagnosed with first AF during 1980-2000 were identified and followed in medical records to 2004. The trends of incidence and survival of CHF over time were assessed. Of the 3288 subjects (mean age 71+/-15 years) diagnosed with first AF and without CHF prior to or at AF diagnosis, 790 (24%) developed a first CHF during a mean follow-up of 6.1+/-5.2 years (unadjusted incidence, 44 per 1000 person years). Age- and sex-adjusted CHF incidence was unrelated to calendar year of AF diagnosis (P = 0.86). The age- and sex-adjusted mortality risk following CHF was higher than that in patients without CHF (hazard ratio 3.4, 95% confidence interval 3.1-3.8, P < 0.0001). There were no detectable changes over time with respect to the absolute (P = 0.94) or the relative (P = 0.68) mortality risk after CHF diagnosis. CONCLUSION: In this study spanning two decades, there appeared to have been no significant reduction in terms of the incidence and mortality risk of CHF following first AF diagnosis.
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Plasma concentrations of C-reactive protein and fibroblast growth factor-23 are higher in women than in men in epidemiological studies.
“The plasma concentrations of the inflammatory marker C-reactive protein143 and of fibroblast growth factor-23144 have been found to be higher in women than in men in epidemiological studies.”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [144]
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- Authors
- Miyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W., Seward, J. B., Iwasaka, T., & Tsang, T. S. M.
- Affiliations
- Mayo Clinic (US)
- Kansai Medical University (JP)
- Corresponding author
- Miyasaka, Yoko
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-01-06
- Volume
- 27
- Issue
- 8
- Pages
- 936-941
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2069444518
- Cited by
- 192
- References
- 27
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 12 · 2023: 16 · 2022: 14 · 2021: 8 · 2020: 6 · 2019: 11 · 2018: 12 · 2017: 13 · 2016: 11 · 2015: 8 · 2014: 11 · 2013: 14 · 2012: 9
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- American Heart Association
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- congestive heart failure, atrial fibrillation, heart failure incidence, heart failure mortality, temporal trends, Olmsted County, Minnesota
- MeSH terms
- Aged, Atrial Fibrillation, Epidemiologic Methods, Female, Heart Failure, Humans, Male, Minnesota, Mortality, Prognosis, Sex Distribution
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