The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Isolation and Transplantation of Autologous Circulating Endothelial Cells Into Denuded Vessels and Prosthetic Grafts: Implications for Cell-Based Vascular Therapy
Abstract
Background— Blood-borne endothelial cells originating from adult bone marrow were reported previously. These cells have the properties of an endothelial progenitor cell (EPC) and can be mobilized by cytokines and recruited to sites of neovascularization, where they differentiate into mature endothelial cells. Current protocols for isolation of EPCs from peripheral blood rely on enrichment and selection of CD34+ mononuclear cells. Methods and Results— In this report, we describe a streamlined method for the isolation and expansion of EPCs from peripheral blood and evaluate their therapeutic potential for autologous cell-based therapy of injured blood vessels and prosthetic grafts. A subset of unfractionated mononuclear cells exhibited the potential to differentiate in vitro into endothelial cells under selective growth conditions. The cells were efficiently transduced ex vivo by a retroviral vector expressing the LacZ reporter gene and could be expanded to yield sufficient numbers for therapeutic applications. Transplantation of these cells into balloon-injured carotid arteries and into bioprosthetic grafts in rabbits led to rapid endothelialization of the denuded vessels and graft segments, resulting in significant reduction in neointima deposition. Conclusions— We conclude that transplantation of EPCs may play a crucial role in reestablishing endothelial integrity in injured vessels, thereby inhibiting neointimal hyperplasia. These findings may have implications for novel and practical cell-based therapies for vascular disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
Asahara, T., Masuda, H., Takahashi, T., Kalka, C., Pastore, C., Silver, M., Kearne, M., Magner, M., & Isner, J. M. (1999) · Circulation Research · doi:10.1161/01.res.85.3.221 · Cited by 3,253
Takahashi, T., Kalka, C., Masuda, H., Chen, D., Silver, M., Kearney, M., Magner, M., Isner, J. M., & Asahara, T. (1999) · Nature Medicine · doi:10.1038/7434 · Cited by 2,423
Peichev, M., Naiyer, A. J., Pereira, D., Zhu, Z., Lane, W. J., Williams, M., Oz, M. C., Hicklin, D. J., Witte, L., Moore, M. A. S., et al. (2000) · Blood · doi:10.1182/blood.v95.3.952.003k27_952_958 · Cited by 2,277
Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization
Kalka, C., Masuda, H., Takahashi, T., Kalka-Moll, W. M., Silver, M., Kearney, M., Li, T., Isner, J. M., & Asahara, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3422 · Cited by 1,863
Evidence for Circulating Bone Marrow-Derived Endothelial Cells
Shi, Q., Rafii, S., Wu, M. H.-D., Wijelath, E. S., Yu, C., Ishida, A., Fujita, Y., Kothari, S., Mohle, R., Sauvage, L. R., et al. (1998) · Blood · doi:10.1182/blood.v92.2.362 · Cited by 1,695
Origins of circulating endothelial cells and endothelial outgrowth from blood
Lin, Y., Weisdorf, D. J., Solovey, A., & Hebbel, R. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8071 · Cited by 1,531
Therapeutic Potential of Ex Vivo Expanded Endothelial Progenitor Cells for Myocardial Ischemia
Kawamoto, A., Gwon, H.-C., Iwaguro, H., Yamaguchi, J.-I., Uchida, S., Masuda, H., Silver, M., Ma, H., Kearney, M., Isner, J. M., et al. (2001) · Circulation · doi:10.1161/01.cir.103.5.634 · Cited by 1,220
Walter, D. H., Rittig, K., Bahlmann, F. H., Kirchmair, R., Silver, M., Murayama, T., Nishimura, H., Losordo, D. W., Asahara, T., & Isner, J. M. (2002) · Circulation · doi:10.1161/01.cir.0000018166.84319.55 · Cited by 918
Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo
Kaushal, S., Amiel, G. E., Guleserian, K. J., Shapira, O. M., Perry, T., Sutherland, F. W., Rabkin, E., Moran, A. M., Schoen, F. J., Atala, A., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1035 · Cited by 841
Cited by
Endothelial Progenitor Cells: Characterization and Role in Vascular Biology
Urbich, C., & Dimmeler, S. (2004) · Circulation Research · doi:10.1161/01.res.0000137877.89448.78 · Cited by 2,369
Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis?
Dimmeler, S., & Zeiher, A. M. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0580-x · Cited by 294
Tissue engineering of blood vessel
Zhang, W. J., Liu, W., Cui, L., & Cao, Y. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00099.x · Cited by 217
Adipurnama, I., Yang, M.-C., Ciach, T., & Butruk-Raszeja, B. (2017) · Biomaterials Science · doi:10.1039/c6bm00618c · Cited by 179
Polymeric Materials for Tissue Engineering of Arterial Substitutes
Ravi, S., Qu, Z., & Chaikof, E. L. (2009) · Vascular · doi:10.2310/6670.2008.00084 · Cited by 91
Metadata
- Authors
- Griese, D. P., Ehsan, A., Melo, L. G., Kong, D., Zhang, L., Mann, M. J., Pratt, R. E., Mulligan, R. C., & Dzau, V. J.
- Venue
- Circulation
- Published
- 2003-11-25
- Volume
- 108
- Issue
- 21
- Pages
- 2710-2715
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2036629390
- Cited by
- 441
- References
- 21
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Isolation and Transplantation of Autologous Circulating Endothelial Cells Into Denuded Vessels and Prosthetic Grafts: Implications for Cell-Based Vascular Therapy. https://app.cochat.ai/papers/10.1161/01.cir.0000096490.16596.a6
- The paper
- Griese, D. P., Ehsan, A., Melo, L. G., Kong, D., Zhang, L., Mann, M. J., Pratt, R. E., Mulligan, R. C., & Dzau, V. J. (2003). Isolation and Transplantation of Autologous Circulating Endothelial Cells Into Denuded Vessels and Prosthetic Grafts: Implications for Cell-Based Vascular Therapy. Circulation. https://doi.org/10.1161/01.cir.0000096490.16596.a6
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
