The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Independent Association Between Plasma Leptin and C-Reactive Protein in Healthy Humans
Abstract
Background— C-reactive protein (CRP) is synthesized from the liver and is regulated by cytokines, especially interleukin-6. Leptin, the adipocyte-derived protein product of the ob gene, is related to amount of body fat. The long form of the leptin receptor resembles cytokine receptors, which include the interleukin-6 receptor. Both leptin and CRP may be increased in women, in obesity, and in inflammation, and both have been linked to cardiovascular pathophysiological processes and increased cardiovascular risk. We tested the hypothesis that leptin is associated with CRP levels independently of the influences of gender, body mass index (BMI), waist-to-hip ratio, and other variables. Methods and Results— We studied 100 healthy volunteers (48 men, and 52 women). For all subjects, leptin was independently associated with CRP after adjustment for age, gender, BMI, waist-to-hip ratio, smoking, and alcohol consumption (F=12.39, P =0.0007). There was a strong and significant positive relationship between leptin and CRP in both women ( R =0.61, P <0.0001) and men ( R =0.55, P <0.0001) considered separately. The association between leptin and CRP was significant even after adjustment for age, BMI, waist-to-hip ratio, smoking, and alcohol consumption in women (F=7.13, P =0.01) and men (F=5.69, P =0.02). When only subjects with BMI <25 kg/m 2 were considered (n=47), CRP was not linked to BMI ( R =0.02, P =0.96), but a significant association between leptin and CRP was still evident ( R =0.55, P <0.0001). Conclusions— Leptin and CRP levels are independently associated in normal humans, providing further evidence linking metabolic and inflammatory cardiovascular disease mechanisms.
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Cites
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
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Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
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Clinical application of C-reactive protein for cardiovascular disease detection and prevention
Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000053730.47739.3c · Cited by 2,513
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Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
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Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
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Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
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Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein
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Cited by
Pathophysiology of type 2 diabetes mellitus
Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176275 · Cited by 3,360
“In the liver, IR impairs glycogen synthesis, fails to suppress glucose production, enhances lipogenesis, and increases the synthesis of proteins such as the proinflammatory CRP.”
BackgroundAdipose Tissue, Inflammation, and Cardiovascular Disease
Berg, A. H., & Scherer, P. E. (2005) · Circulation Research · doi:10.1161/01.res.0000163635.62927.34 · Cited by 2,113
The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers
Kasapis, C., & Thompson, P. D. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.077 · Cited by 1,149
Martin, S. S., Qasim, A., & Reilly, M. P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.060 · Cited by 516
Induction of leptin resistance through direct interaction of C-reactive protein with leptin
Chen, K., Li, F., Li, J., Cai, H., Strom, S., Bisello, A., Kelley, D. E., Friedman-Einat, M., Skibinski, G. A., McCrory, M. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1372 · Cited by 325
Metadata
- Authors
- Shamsuzzaman, A. S. M., Winnicki, M., Wolk, R., Svatikova, A., Phillips, B. G., Davison, D. E., Berger, P. B., & Somers, V. K.
- Venue
- Circulation
- Published
- 2004-05-11
- Volume
- 109
- Issue
- 18
- Pages
- 2181-2185
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2019361383
- Cited by
- 261
- References
- 49
- FWCI
- 18.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shamsuzzaman, A. S. M., Winnicki, M., Wolk, R., Svatikova, A., Phillips, B. G., Davison, D. E., Berger, P. B., & Somers, V. K. (2004). Independent Association Between Plasma Leptin and C-Reactive Protein in Healthy Humans. Circulation. https://doi.org/10.1161/01.cir.0000127960.28627.75
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