Leptin resistance

Positional cloning of the mouse obese gene and its human homologue

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Inflammation, Atherosclerosis, and Coronary Artery Disease

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Prevalence of Overweight and Obesity in the United States, 1999-2004

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Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

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Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works

C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433 · see citing works

Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works

Identification and expression cloning of a leptin receptor, OB-R.

Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496 · see citing works

European Guidelines for Obesity Management in Adults

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Adipocytokines: mediators linking adipose tissue, inflammation and immunity

Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,195 · see citing works

Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men

Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429 · see citing works

Abnormal splicing of the leptin receptor in diabetic mice

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Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214 · see citing works

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

Lord, G. M., Matarese, G., Howard, J. K., Baker, R. J., Bloom, S. R., & Lechler, R. I. (1998) · Nature · doi:10.1038/29795 · Cited by 2,150 · see citing works

A family of cytokine-inducible inhibitors of signalling

Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066 · see citing works

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998 · see citing works

Leptin

Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428 · see citing works

Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial

Heymsfield, S. B., Greenberg, A. S., Fujioka, K., Dixon, R. M., Kushner, R., Hunt, T., Lubina, J. A., Patane, J., Self, B., Hunt, P., et al. (1999) · JAMA · doi:10.1001/jama.282.16.1568 · Cited by 1,422 · see citing works

A new protein containing an SH2 domain that inhibits JAK kinases

Endo, T. A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Tanimura, S., Ohtsubo, M., Misawa, H., et al. (1997) · Nature · doi:10.1038/43213 · Cited by 1,408 · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,359 · see citing works

Structure and function of a new STAT-induced STAT inhibitor

Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K., et al. (1997) · Nature · doi:10.1038/43219 · Cited by 1,287 · see citing works

Leptin-Replacement Therapy for Lipodystrophy

Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247 · see citing works

Leptin enters the brain by a saturable system independent of insulin

Banks, W. A., Kastin, A. J., Huang, W., Jaspan, J. B., & Maness, L. M. (1996) · Peptides · doi:10.1016/0196-9781(96)00025-3 · Cited by 1,222 · see citing works

Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women

Pai, J. K., Pischon, T., Ma, J., Manson, J. E., Hankinson, S. E., JOSHIPURA, K. J., Curhan, G. C., Rifai, N., Cannuscio, C. C., Stampfer, M. J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040967 · Cited by 1,174 · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105 · see citing works

OBESE, A NEW MUTATION IN THE HOUSE MOUSE*

INGALLS, A. M., DICKIE, M. M., & SNELL, G. D. (1950) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a106073 · Cited by 1,090 · see citing works

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014 · see citing works

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., & Flier, J. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80062-3 · Cited by 1,014 · see citing works

Leptin: a review of its peripheral actions and interactions

Margetic, S., Gazzola, C., Pegg, G. G., & Hill, R. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802142 · Cited by 1,001 · see citing works

Elevation of Tumor Necrosis Factor-α and Increased Risk of Recurrent Coronary Events After Myocardial Infarction

Ridker, P. M., Rifai, N., Pfeffer, M., Sacks, F., Lepage, S., & Braunwald, E. (2000) · Circulation · doi:10.1161/01.cir.101.18.2149 · Cited by 934 · see citing works

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

Bjørbæk, C., Uotani, S., da Silva, B., & Flier, J. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32686 · Cited by 890 · see citing works

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.

Grünfeld, C., Zhao, C., Fuller, J., Pollack, A., Moser, A. H., Friedman, J. M., & Kr, F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118653 · Cited by 862 · see citing works

Plasma Leptin and the Risk of Cardiovascular Disease in the West of Scotland Coronary Prevention Study (WOSCOPS)

Wallace, A. M., McMahon, A. D., Packard, C. J., Kelly, A., Shepherd, J., Gaw, A., & Sattar, N. A. (2001) · Circulation · doi:10.1161/hc5001.101061 · Cited by 821 · see citing works

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

Baumann, H., Morella, K. K., White, D. W., Dembski, M., Bailon, P., Kim, H., Lai, C. F., & Tartaglia, L. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8374 · Cited by 810 · see citing works

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

van Heek, M., Compton, D. S., France, C. F., Tedesco, R. P., Fawzi, A. B., Graziano, M. P., Sybertz, E. J., Strader, C. D., & Davis, H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119171 · Cited by 752 · see citing works

Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated Defects

Ozata, M., Ozdemir, I. C., & Licinio, J. (1999) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.84.10.5999 · Cited by 739 · see citing works

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737 · see citing works

Effects of parabiosis of obese with diabetes and normal mice.

Coleman, D. L. (1973) · Diabetologia · doi:10.1007/bf01221857 · Cited by 729 · see citing works

Acute stimulation of glucose metabolism in mice by leptin treatment

Kamohara, S., Burcelin, R., Halaas, J. L., Friedman, J. M., & Charron, M. J. (1997) · Nature · doi:10.1038/38717 · Cited by 708 · see citing works

Crystal structure of the obese protein Ieptin-E100

Zhang, F. P. Y., Basinski, M. B., Beals, J. M., Briggs, S., Churgay, L. M., Clawson, D. K., DiMarchi, R. D., Furman, T. C., Hale, J. E., Hsiung, H. M., et al. (1997) · Nature · doi:10.1038/387206a0 · Cited by 669 · see citing works

The role of SOCS-3 in leptin signaling and leptin resistance

Bjørbæk, C., El-Haschimi, K., Frantz, J. D., & Flier, J. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30059 · Cited by 639 · see citing works

Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A

Yamagishi, S., Edelstein, D., Du, X.-L., Kaneda, Y., Guzmán, M., & Brownlee, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007383200 · Cited by 620 · see citing works

Obesity‐induced inflammation: a metabolic dialogue in the language of inflammation

Ferrante, A. W. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01852.x · Cited by 612 · see citing works

Inflammatory Cytokines Stimulated C-Reactive Protein Production by Human Coronary Artery Smooth Muscle Cells

Calabrò, P., Willerson, J. T., & Yeh, E. T. H. (2003) · Circulation · doi:10.1161/01.cir.0000096055.62724.c5 · Cited by 566 · see citing works

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.

Frederich, R. C., Löllmann, B., Hamann, A., Napolitano-Rosen, A., Kahn, B. B., Lowell, B. B., & Flier, J. S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118206 · Cited by 549 · see citing works

Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B

Cheng, A., Uetani, N., Simoncic, P. D., Chaubey, V. P., Lee-Loy, A., McGlade, C. J., Kennedy, B. P., & Tremblay, M. L. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00149-1 · Cited by 539 · see citing works

Prospective Study of C-Reactive Protein in Relation to the Development of Diabetes and Metabolic Syndrome in the Mexico City Diabetes Study

Han, T. S., Sattar, N. A., Williams, K., González‐Villalpando, C., Lean, M. E. J., & Haffner, S. M. (2002) · Diabetes Care · doi:10.2337/diacare.25.11.2016 · Cited by 514 · see citing works

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

Licinio, J., Caglayan, S., Ozata, M., Yildiz, B. O., de Miranda, P. B., O'Kirwan, F., Whitby, R., Liang, L., Cohen, P., Bhasin, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308767101 · Cited by 505 · see citing works

The Metabolic Significance of Leptin in Humans: Gender-Based Differences in Relationship to Adiposity, Insulin Sensitivity, and Energy Expenditure

Kennedy, A., Gettys, T. W., Watson, P. M., Wallace, P., Ganaway, E., Qin, P., & Garvey, W. T. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.4.3859 · Cited by 504 · see citing works

Leptin and atherosclerosis

Bełtowski, J. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.03.003 · Cited by 484 · see citing works

Plasma Leptin Levels Are Increased in Survivors of Acute Sepsis: Associated Loss of Diurnal Rhythm in Cortisol and Leptin Secretion

Bornstein, S. R., Licinio, J., Tauchnitz, R., Engelmann, L., Negrão, A., Gold, P. W., & Chrousos, G. P. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.1.4610 · Cited by 411 · see citing works

Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss

Havel, P. J., Kasim-karakas, S., Mueller, W. M., Johnson, P. R., Gingerich, R. L., & Stern, J. S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954050 · Cited by 406 · see citing works

Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity

Konstantinides, S., Schäfer, K., Koschnick, S., & Loskutoff, D. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13143 · Cited by 373 · see citing works

Leptin is associated with increased risk of myocardial infarction

Söderberg, S., Åhrén, B., Jansson, J., Johnson, O., Hallmans, G., Asplund, K., & Olsson, T. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00571.x · Cited by 356 · see citing works

Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity.

Considine, R. V., Considine, E. L., Williams, C. J., Nyce, M. R., Magosin, S., BAUER, T. L., Rosato, E., Colberg, J. E., & Caro, J. F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118007 · Cited by 353 · see citing works

Expression of Leptin Receptor Isoforms in Rat Brain Microvessels

Bjørbæk, C., Elmquist, J. K., Michl, P., Ahima, R. S., Bueren, A. M. V., McCall, A. L., & Flier, J. S. (1998) · Endocrinology · doi:10.1210/endo.139.8.6154 · Cited by 340 · see citing works

Leptin Signaling and Obesity

Yang, R., & Barouch, L. A. (2007) · Circulation Research · doi:10.1161/circresaha.107.156596 · Cited by 327 · see citing works

Induction of leptin resistance through direct interaction of C-reactive protein with leptin

Chen, K., Li, F., Li, J., Cai, H., Strom, S., Bisello, A., Kelley, D. E., Friedman-Einat, M., Skibinski, G. A., McCrory, M. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1372 · Cited by 325 · see citing works

Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension

Rahmouni, K., Morgan, D. A., Morgan, G. M., Mark, A. L., & Haynes, W. G. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2012 · Cited by 319 · see citing works

Short Term Effects of Leptin on Hepatic Gluconeogenesis and in Vivo Insulin Action

Rossetti, L., Massillon, D., Barzilai, N., Vuguin, P., Chen, W., Hawkins, M., Wu, J., & Wang, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27758 · Cited by 304 · see citing works

Soluble Leptin Receptor Represents the Main Leptin Binding Activity in Human Blood

Lammert, A., Kiess, W., Böttner, A., Glasow, A., & Kratzsch, J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4885 · Cited by 290 · see citing works

Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects.

Boden, G., Chen, X., Kolaczynski, J. W., & Polansky, M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119621 · Cited by 284 · see citing works

Leptin Suppression of Insulin Secretion and Gene Expression in Human Pancreatic Islets: Implications for the Development of Adipogenic Diabetes Mellitus1

Seufert, J., Kieffer, T. J., Leech, C. A., Holz, G. G., Moritz, W., Ricordi, C., & Habener, J. F. (1999) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.84.2.5460 · Cited by 278 · see citing works

Liporegulation in Diet-induced Obesity

Lee, Y., Wang, M.-Y., Kakuma, T., Wang, Z.-W., Babcock, E. E., McCorkle, K., Higa, M., Zhou, Y.-T., & Unger, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008553200 · Cited by 269 · see citing works

Independent Association Between Plasma Leptin and C-Reactive Protein in Healthy Humans

Shamsuzzaman, A., Winnicki, M., Wolk, R. A., Svatikova, A., Phillips, B. G., Davison, D. E., Berger, P. B., & Somers, V. K. (2004) · Circulation · doi:10.1161/01.cir.0000127960.28627.75 · Cited by 262 · see citing works

Endogenous Hormones and Carotid Atherosclerosis in Elderly Men

van den Beld, A. W. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf160 · Cited by 262 · see citing works

The role of leptin in leptin resistance and obesity

Zhang, Y., & Scarpace, P. J. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.038 · Cited by 253 · see citing works

Role of leptin in immunity.

Lam, Q. L. K., & Lu, L. (2007) · PubMed · Cited by 247 · see citing works

Leptin promotes aggregation of human platelets via the long form of its receptor.

Nakata, M., Yada, T., Soejima, N., & Maruyama, I. (1999) · Diabetes · doi:10.2337/diabetes.48.2.426 · Cited by 244 · see citing works

Plasma leptin and prognosis in patients with established coronary atherosclerosis

Wolk, R. A., Berger, P. B., Lennon, R. J., Brilakis, E. S., Johnson, B. D., & Somers, V. K. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.07.050 · Cited by 235 · see citing works

Effect of Leptin on Arterial Thrombosis Following Vascular Injury in Mice

Bodary, P. F. (2002) · JAMA · doi:10.1001/jama.287.13.1706 · Cited by 225 · see citing works

High Plasma Immunoreactive Leptin Level in Essential Hypertension

Agata, J. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00310-5 · Cited by 222 · see citing works

The Concept of Selective Leptin Resistance

Correia, M. L. G., Haynes, W. G., Rahmouni, K., Morgan, D. A., Sivitz, W. I., & Mark, A. L. (2002) · Diabetes · doi:10.2337/diabetes.51.2.439 · Cited by 218 · see citing works

Plasma Leptin Levels Are Associated with Coronary Atherosclerosis in Type 2 Diabetes

Reilly, M. P., Iqbal, N., Schutta, M. H., Wolfe, M. L., Scally, M., Localio, A. R., Rader, D. J., & Kimmel, S. E. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031676 · Cited by 216 · see citing works

Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications

Mark, A. L., Correia, M. L. G., Rahmouni, K., & Haynes, W. G. (2002) · Journal of Hypertension · doi:10.1097/00004872-200207000-00001 · Cited by 215 · see citing works

Role of leptin in blood pressure regulation and arterial hypertension

Bełtowski, J. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000222743.06584.66 · Cited by 214 · see citing works

A Prospective Study of Inflammatory Cytokines and Diabetes Mellitus in a Multiethnic Cohort of Postmenopausal Women

Liu, S. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.15.1676 · Cited by 198 · see citing works

The role of leptin in leptin resistance and obesity

Enriori, P. J., Evans, A. E., Sinnayah, P., & Cowley, M. A. (2006) · Obesity · Cited by 197 · see citing works

Plasma leptin is independently associated with the intima-media thickness of the common carotid artery

Ciccone, M. M., Vettor, R., Pannacciulli, N., Minenna, A., Bellacicco, M., RIZZON, P., GIORGINO, R., & Pergola, G. D. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801623 · Cited by 195 · see citing works

Association of Insulin Resistance, Hyperleptinemia, and Impaired Nitric Oxide Release With In-Stent Restenosis in Patients Undergoing Coronary Stenting

Piatti, P., Mario, C. D., Monti, L. D., Fragasso, G., Sgura, F. A., Caumo, A., Setola, E., Lucotti, P., Galluccio, E., Ronchi, C. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000095272.67948.17 · Cited by 192 · see citing works

Detection and Quantification of the Leptin Receptor Splice Variants Ob-Ra, b, and, e in Different Mouse Tissues

Löllmann, B., Grueninger, S., Stricker‐Krongrad, A., & Chiesi, M. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7205 · Cited by 191 · see citing works

Leptin Is a Risk Marker for First-Ever Hemorrhagic Stroke in a Population-Based Cohort

Söderberg, S., Åhrén, B., Stegmayr, B., Johnson, O., Wiklund, P.-G., Weinehall, L., Hallmans, G., & Olsson, T. (1999) · Stroke · doi:10.1161/01.str.30.2.328 · Cited by 176 · see citing works

Leptin, but not adiponectin, predicts stroke in males

Söderberg, S., Stegmayr, B. G., Stenlund, H. C., Sjöström, L., Ågren, Å., Johansson, L. O. M., Weinehall, L., & Olsson, T. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01351.x · Cited by 167 · see citing works

Relationship between Concentration of Serum Leptin and Fetal Growth

Harigaya, A., Nagashima, K., Nako, Y., & Morikawa, A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4321 · Cited by 161 · see citing works

Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats

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Plasma Leptin Level Is Associated With Myocardial Wall Thickness in Hypertensive Insulin-Resistant Men

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Metabolic Syndrome and Male Fertility

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Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in Japanese workers: a cross-sectional study

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Adipokines and Inflammation: Focus on Cardiovascular Diseases

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Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy

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Obesity, Subclinical Myocardial Injury, and Incident Heart Failure

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Chronic chlorpyrifos exposure elicits diet-specific effects on metabolism and the gut microbiome in rats

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The Leptin Resistance

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Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity

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The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis

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Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice

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Should Adipokines be Considered in the Choice of the Treatment of Obesity-Related Health Problems?

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Leptin in Sarcopenic Visceral Obesity: Possible Link between Adipocytes and Myocytes

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Obesidade e doença arterial coronariana: papel da inflamação vascular

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Leptin, Not Adiponectin, Predicts Hypertension in the Copenhagen City Heart Study

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Mouse models of nonalcoholic fatty liver disease (NAFLD): pathomechanisms and pharmacotherapies

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C-C Chemokine Receptor 2 Inhibitor Improves Diet-Induced Development of Insulin Resistance and Hepatic Steatosis in Mice

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Effect of soybean insoluble dietary fiber on prevention of obesity in high-fat diet fed mice via regulation of the gut microbiota

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Macrophages—common culprit in obesity and asthma

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Leptin in Atherosclerosis: Focus on Macrophages, Endothelial and Smooth Muscle Cells

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Associations between leptin and the leptin / adiponectin ratio and incident Type 2 diabetes in middle‐aged men and women: results from the MONICA / KORA Augsburg Study 1984–2002

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Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells

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Is diabetes in Cushing’s syndrome only a consequence of hypercortisolism?

Giordano, C., Guarnotta, V., Pivonello, R., Amato, M. C., Simeoli, C., Ciresi, A., Cozzolino, A., & Colao, A. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0754 · Cited by 79 · see citing works

Leptin and cardiovascular diseases

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Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity

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Inflammation Markers in Type 2 Diabetes and the Metabolic Syndrome in the Pediatric Population

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Adipocyte, Immune Cells, and miRNA Crosstalk: A Novel Regulator of Metabolic Dysfunction and Obesity

Kiran, S., Kumar, V., Kumar, S., Price, R. L., & Singh, U. P. (2021) · Cells · doi:10.3390/cells10051004 · Cited by 75 · see citing works

P Wave Indices, Obesity, and the Metabolic Syndrome: The Atherosclerosis Risk in Communities Study

Magnani, J. W., Norby, F. L., Soliman, E. Z., MacLehose, R. F., Crow, R. S., & Alonso, Á. (2011) · Obesity · doi:10.1038/oby.2011.53 · Cited by 75 · see citing works

Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease

Maioli, S., Lodeiro, M., Merino‐Serrais, P., Falahati, F., Khan, W., Puerta, E., Codita, A., Rimondini, R., Ramírez, M. J., Simmons, A., et al. (2014) · Aging Cell · doi:10.1111/acel.12281 · Cited by 75 · see citing works

Roux-en-Y gastric bypass decreases pro-inflammatory and thrombotic biomarkers in individuals with extreme obesity

Netto, B. D. M., Bettini, S. C., Clemente, A. P. G., de Carvalho Ferreira, J. P., Boritza, K., de Fátima Souza, S., Von der Heyde, M. E., Earthman, C. P., & Dâmaso, A. R. (2015) · Obesity Surgery · doi:10.1007/s11695-014-1484-7 · Cited by 74 · see citing works

Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells

Anfossi, G., Russo, I., Doronzo, G., Pomero, A., & Trovati, M. (2010) · Mediators of Inflammation · doi:10.1155/2010/174341 · Cited by 74 · see citing works

Role of C Reactive Protein (CRP) in Leptin Resistance

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Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes

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Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes

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Does the sympathetic nervous system contribute to the pathophysiology of metabolic syndrome?

Moreira, M. C. D. S., Pinto, I. S. D. J., Mourão, A. A., Fajemiroye, J. O., Colombari, E., Reis, Â. A. D. S., Freiria-Oliveira, A. H., Neto, M. L. F., & Pedrino, G. R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00234 · Cited by 72 · see citing works

Calorie Restriction, Aging and Longevity

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Prevalence, clinical characteristics, and predictors of obesity hypoventilation syndrome in a large sample of Saudi patients with obstructive sleep apnea

BaHammam, A. S. (2015) · Saudi Medical Journal · doi:10.15537/smj.2015.2.9991 · Cited by 71 · see citing works

Role of Leptin in Obstructive Sleep Apnea

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The role of leptin and obesity on male infertility

Khodamoradi, K., Parmar, M., Khosravizadeh, Z., Kuchakulla, M., Manoharan, M., & Arora, H. (2020) · Current Opinion in Urology · doi:10.1097/mou.0000000000000762 · Cited by 69 · see citing works

Leptin, adiponectin, their ratio and risk of coronary heart disease: Results from the MONICA/KORA Augsburg Study 1984–2002

Karakas, M., Zierer, A., Herder, C., Baumert, J. J., Meisinger, C., Köenig, W., & Thorand, B. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.08.020 · Cited by 68 · see citing works

Is overweight an issue in phenylketonuria?

Rocha, J. C., MacDonald, A., & Trefz, F. K. (2013) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2013.08.012 · Cited by 67 · see citing works

Obesity as a risk factor for malignant melanoma and non-melanoma skin cancer

Karimi, K., Lindgren, T., Koch, C. A., & Brodell, R. T. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9393-9 · Cited by 67 · see citing works

Circulating secreted frizzled‐related protein 5 (Sfrp5) and wingless‐type MMTV integration site family member 5a (Wnt5a) levels in patients with type 2 diabetes mellitus

Lu, Y., Wang, C.-P., Hsu, C., Chiu, C., Yu, T., Hung, W., Lu, L., Chung, F., Tsai, I., Lin, H., et al. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2426 · Cited by 66 · see citing works

Leptin and incident cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA)

Martin, S. S., Blaha, M. J., Muse, E. D., Qasim, A., Reilly, M. P., Blumenthal, R. S., Nasir, K., Criqui, M. H., McClelland, R. L., Hughes‐Austin, J. M., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.12.033 · Cited by 66 · see citing works

A Multifaceted Analysis of Immune-Endocrine-Metabolic Alterations in Patients with Pulmonary Tuberculosis

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Relationship of circulating spexin with markers of cardiovascular disease: a pilot study in adolescents with obesity

Kumar, S., Hossain, J., Javed, A., Kullo, I. J., & Balagopal, P. (2017) · Pediatric Obesity · doi:10.1111/ijpo.12249 · Cited by 66 · see citing works

Differential effects of leptin on adiponectin expression with weight gain versus obesity

Singh, P., Sharma, P., Sahakyan, K., Davison, D. E., Kuniyoshi, F. H. S., Romero‐Corral, A., Swain, J., Jensen, M. D., López-Jiménez, F. A., Kára, T., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.181 · Cited by 64 · see citing works

Adipocytokines, insulin resistance, and coronary atherosclerosis in rheumatoid arthritis

Rho, Y. H., Chung, C. P., Solus, J. F., Raggi, P., Oeser, A. M., Gebretsadik, T. S., Shintani, A., & Stein, C. M. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27376 · Cited by 62 · see citing works

Impact of obesity, steatosis and insulin resistance on progression and response to therapy of hepatitis C

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Oxytocin and cardioprotection in diabetes and obesity

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Leptin and coronary heart disease: A systematic review and meta-analysis

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The Impact of Obesity on Immune Response to Infection and Vaccine: An Insight into Plausible Mechanisms

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Cardio-oncology Related to Heart Failure

Blaes, A. H., Prizment, A. E., Koene, R. J., & Konety, S. (2017) · Heart Failure Clinics · doi:10.1016/j.hfc.2016.12.006 · Cited by 62 · see citing works

Association analysis of polymorphisms in LEP (rs7799039 and rs2167270) and LEPR (rs1137101) gene towards the development of type 2 diabetes in North Indian Punjabi population

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Insulin Resistance and Endothelial Dysfunction: A Mutual Relationship in Cardiometabolic Risk

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A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload

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C-Reactive Protein (CRP) and Leptin Receptor in Obesity: Binding of Monomeric CRP to Leptin Receptor

Sudhakar, M., Silambanan, S., Chandran, A. S., Prabhakaran, A. A., & Ramakrishnan, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01167 · Cited by 57 · see citing works

The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis

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Effect of Fructooligosaccharides Fraction from Psacalium decompositum on Inflammation and Dyslipidemia in Rats with Fructose-Induced Obesity

Merino-Aguilar, H., Arrieta‐Báez, D., Jiménez‐Estrada, M., Magos-Guerrero, G. A., Hernández-Bautista, R., Notario, A. D. C. S., Almanza-Pérez, J. C., Blancas‐Flores, G., Román‐Ramos, R., & Alarcón-Aguilar, F. J. (2014) · Nutrients · doi:10.3390/nu6020591 · Cited by 56 · see citing works

Bovine lactoferrin suppresses high-fat diet induced obesity and modulates gut microbiota in C57BL/6J mice

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Preventive mechanism of bioactive dietary foods on obesity-related inflammation and diseases

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Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats

Kilany, O. E., Abdelrazek, H. M. A., Aldayel, T. S., Abdo, S., & Mahmoud, M. M. A. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.06.026 · Cited by 60 · see citing works

Leptin Resistance and Cardiometabolic Disorders: Bridging Molecular Pathways, Genetic Variants, and Therapeutic Innovation

Roy, P., Kant, R., Kaur, A., Kumar, H., & Kumar, R. (2025) · Current Cardiology Reviews · doi:10.2174/011573403x356019250118170444 · Cited by 9 · see citing works

Leptin and cardiovascular health

Pereira, S. X. E. R. L. (2026) · Endocrinology · doi:10.1210/endocr/bqag050

Leptin and Cardiovascular Diseases

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Role of Leptin in Cardiovascular Diseases

Poetsch, M. S., Strano, A., & Guan, K. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00354 · Cited by 173 · see citing works

What Fans the Fire: Insights into Mechanisms of Leptin in Metabolic Syndrome- Associated Heart Diseases

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