The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Enhanced Ca 2+ Release and Na/Ca Exchange Activity in Hypertrophied Canine Ventricular Myocytes: Potential Link Between Contractile Adaptation and Arrhythmogenesis
Open accessAbstract
Background —Ventricular arrhythmias are a major cause of sudden death in patients with heart failure and hypertrophy. The dog with chronic complete atrioventricular block (CAVB) has biventricular hypertrophy and ventricular arrhythmias and is a useful model to study underlying cellular mechanisms. We investigated whether changes in Ca 2+ homeostasis are part of the contractile adaptation to CAVB and might contribute to arrhythmogenesis. Methods and Results —In enzymatically isolated myocytes, cell shortening, Ca 2+ release from the sarcoplasmic reticulum (SR), and SR Ca 2+ content were enhanced at low stimulation frequencies. Ca 2+ influx through L-type Ca 2+ channels was unchanged, but Ca 2+ influx via the Na/Ca exchanger was increased and contributed to Ca 2+ loading of the SR. Inward Na/Ca exchange currents were also larger. Changes in Ca 2+ fluxes were less pronounced in the right versus left ventricle. Conclusions —Enhanced Na/Ca exchange activity may improve contractile adaptation to CAVB but at the same time facilitate arrhythmias by (1) increasing the propensity to Ca 2+ overload, (2) providing more inward current leading to (nonhomogeneous) action potential prolongation, and (3) enhancing (arrhythmogenic) currents during spontaneous Ca 2+ release.
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Cited by
Pogwizd, S. M., Schlotthauer, K., Li, L., Yuan, W., & Bers, D. M. (2001) · Circulation Research · doi:10.1161/hh1101.091193 · Cited by 758
INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE
Wehrens, X. H. T., Lehnart, S. E., & Marks, A. R. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.114521 · Cited by 355
Cellular mechanisms underlying the long QT syndrome
Antzelevitch, C., & Shimizu, W. (2002) · Current Opinion in Cardiology · doi:10.1097/00001573-200201000-00007 · Cited by 313
Torsade de Pointes Due to Noncardiac Drugs: Most Patients Have Easily Identifiable Risk Factors
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Computational biology in the study of cardiac ion channels and cell electrophysiology
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Metadata
- Authors
- Sipido, K. R., Volders, P. G. A., de Groot, S. H. M., Verdonck, F., Van de Werf, F., Wellens, H. J. J., & Vos, M. A.
- Venue
- Circulation
- Published
- 2000-10-24
- Volume
- 102
- Issue
- 17
- Pages
- 2137-2144
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2124910398
- Cited by
- 263
- References
- 28
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Enhanced Ca 2+ Release and Na/Ca Exchange Activity in Hypertrophied Canine Ventricular Myocytes: Potential Link Between Contractile Adaptation and Arrhythmogenesis. https://app.cochat.ai/papers/10.1161/01.cir.102.17.2137
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- Sipido, K. R., Volders, P. G. A., de Groot, S. H. M., Verdonck, F., Van de Werf, F., Wellens, H. J. J., & Vos, M. A. (2000). Enhanced Ca 2+ Release and Na/Ca Exchange Activity in Hypertrophied Canine Ventricular Myocytes: Potential Link Between Contractile Adaptation and Arrhythmogenesis. Circulation. https://doi.org/10.1161/01.cir.102.17.2137
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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