Cited by 810Heart Failure Treatment and ManagementCardiac Fibrosis and RemodelingInflammatory Biomarkers in Disease Prognosis

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Plasma Cytokine Parameters and Mortality in Patients With Chronic Heart Failure

Rauchhaus, Mathias, Doehner, Wolfram, Francis, Darrel P., Davos, Constantinos, Kemp, Michael, Liebenthal, Christa, Niebauer, Josef, Hooper, James, Volk, Hans-Dieter, Coats, Andrew J. S., Anker, Stefan D.·2000·Circulation

DOI 10.1161/01.cir.102.25.3060

Open this paper in CoChat — free account

Abstract

Background —Inflammatory immune activation is an important feature in chronic heart failure (CHF). Little is known about the prognostic importance of tumor necrosis factor-α (TNF-α), soluble TNF-receptor 1 and 2 (sTNF-R1/sTNF-R2), interleukin-6 (IL-6), and soluble CD14 receptors (sCD14) in CHF patients. Methods and Results —In 152 CHF patients (age 61±1 years, New York Heart Association [NYHA] class 2.6±0.1, peak V̇ o 2 17.3±0.6 mL · kg −1 · min −1 , mean±SEM) plasma concentrations of immune variables were prospectively assessed. During a mean follow-up of 34 months (>12 months in all patients), 62 patients (41%) died. Cumulative mortality was 28% at 24 months. In univariate analyses, increased total and trimeric TNF-α, sTNF-R1, and sTNF-R2 (all P ≤0.0001), sCD14 ( P =0.0007), and IL-6 ( P =0.005) predicted 24-month mortality. With multivariate analysis and receiver operating characteristics, sTNF-R1 emerged among all cytokine parameters as the strongest and most accurate prognosticator in this CHF population, regardless of follow-up duration and independently of NYHA class, peak V̇ o 2 , V̇ e /V̇ co 2 slope, left ventricular ejection fraction, and wasting ( P <0.001). The receiver operating characteristic area under the curve for sTNF-R1 was greater than for sTNF-R2 at 6, 12, and 18 months (all P <0.05). Conclusions —sTNF-R1 was the strongest and most accurate prognosticator, independent of established markers of CHF severity. Assessment of sTNF-R1 may be useful in identifying patients who are at high risk of death and in monitoring patients undergoing anti–TNF-α treatment.

Integrity signals

Registry

Crossref · 10.1161/01.cir.102.25.3060

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The meaning and use of the area under a receiver operating characteristic (ROC) curve.
Hanley, J. A., & McNeil, B. J. (1982) · Radiology · doi:10.1148/radiology.143.1.7063747 · Cited by 21,856
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582
Wasting as independent risk factor for mortality in chronic heart failure
Anker, S. D., Ponikowski, P. P., Varney, S. J., Chua, T. P., Clark, A. L., Webb-Peploe, K., Harrington, D., Kox, W. J., Poole-Wilson, P. A., & Coats, A. J. S. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07015-8 · Cited by 1,399
Self-citation
Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)
Torre-Amione, G., Kapadia, S., Benedict, C., Oral, H., Young, J. B., & Mann, D. L. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00589-7 · Cited by 1,211
Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.
Swedberg, K. B., Eneroth, P. H. E., KJEKSHUS, J. K., & Wilhelmsen, L. (1990) · Circulation · doi:10.1161/01.cir.82.5.1730 · Cited by 1,147
Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart
Torre‐Amione, G., Kapadia, S. R., Lee, J. J., Durand, J., Bies, R. D., Young, J. B., & Mann, D. L. (1996) · Circulation · doi:10.1161/01.cir.93.4.704 · Cited by 991
Endotoxin and immune activation in chronic heart failure: a prospective cohort study
Niebauer, J., Volk, H.-D., Kemp, M., Dominguez, M., Schumann, R. R., Rauchhaus, M., Poole-Wilson, P. A., Coats, A. J., & Anker, S. D. (1999) · The Lancet · doi:10.1016/s0140-6736(98)09286-1 · Cited by 877
Self-citation
Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia
Anker, S. D., Chua, T. P., Ponikowski, P., Harrington, D., Swan, J. W., Kox, W. J., Poole-Wilson, P. A., & Coats, A. J. S. (1997) · Circulation · doi:10.1161/01.cir.96.2.526 · Cited by 800
Self-citation
Mechanisms and Models in Heart Failure
Mann, D. L. (1999) · Circulation · doi:10.1161/01.cir.100.9.999 · Cited by 769
Plasma Brain Natriuretic Peptide as an Indicator of Left Ventricular Systolic Function and Long-term Survival After Acute Myocardial Infarction
Omland, T., Aakvaag, A., Bonarjee, V., Caidahl, K., Lie, R. T., Nilsen, D. W. T., Sundsfjord, J., & Dickstein, K. (1996) · Circulation · doi:10.1161/01.cir.93.11.1963 · Cited by 698

Flagged first, then by citations

Show all 27 references

Research works printed but not linked: 7

10.1161/circ.96.2.526 · DOI
10.1161/circ.92.6.1479 · DOI
10.1161/circ.93.4.704 · DOI
10.1161/circ.82.5.2225374 · DOI
10.1161/circ.93.11.1963 · DOI
10.1161/circ.99.25.3224 · DOI
10.1161/circ.100.9.999 · DOI

Sorted by citations

Items 201–300 of 810

Statins and the Role of Nitric Oxide in Chronic Heart Failure
von Haehling, S., Anker, S. D., & Bassenge, E. (2003) · Heart Failure Reviews · doi:10.1023/a:1022103222857 · Cited by 73
Self-citation
Natriuretic peptides and other biomarkers in chronic heart failure: From BNP, NT-proBNP, and MR-proANP to routine biochemical markers
Lainščak, M., von Haehling, S., & Anker, S. D. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.11.149 · Cited by 72
Self-citation
Inflammatory Biomarkers in Heart Failure
Petersen, J. W., & Felker, G. M. (2006) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2006.05595.x · Cited by 72
A multi-biomarker risk score improves prediction of long-term mortality in patients with advanced heart failure
Richter, B., Koller, L., Hohensinner, P. J., Zorn, G., Brekalo, M., Berger, R., Mörtl, D., Maurer, G., Pacher, R., Huber, K., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.11.052 · Cited by 71
Novel Concept of a Heart-Gut Axis in the Pathophysiology of Heart Failure
Kamo, T., Akazawa, H., Suzuki, J.-I., & Komuro, I. (2017) · Korean Circulation Journal · doi:10.4070/kcj.2017.0028 · Cited by 73
Association of Hepatitis C Virus Seropositivity With Inflammatory Markers and Heart Failure in Persons With Coronary Heart Disease: Data From the Heart and Soul Study
Tsui, J. I., Whooley, M. A., Monto, A., Seal, K. H., Tien, P. C., & Shlipak, M. G. (2009) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2008.12.003 · Cited by 70
Capacidade dos biomarcadores inflamatórios em predizer a síndrome metabólica: Inflammation biomarkers capacity in predicting the metabolic syndrome
Volp, A. C. P., Alfenas, R. D. C. G., Costa, N. M. B., Minim, V. P. R., Stringheta, P. C., & Bressan, J. (2008) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302008000300015 · Cited by 70
The immunological axis in heart failure: importance of the leukocyte differential
Vaduganathan, M., Greene, S. J., Butler, J., Sabbah, H. N., Shantsila, E., Lip, G. Y. H., & Gheorghiade, M. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9352-9 · Cited by 69
Hyperuricaemia predicts poor outcome in patients with mild to moderate chronic heart failure
Jankowska, E. A., Ponikowska, B., Majda, J., Zymliński, R., Trzaska, M., Reczuch, K. W., Borodulin-Nadzieja, L., Banasiak, W., & Ponikowski, P. P. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.10.033 · Cited by 69
Micronutrient deficiency independently predicts time to event in patients with heart failure
Lennie, T. A., Andreae, C., Rayens, M. K., Song, E. K., Dunbar, S. B., Pressler, S. J., Heo, S., Kim, J., & Moser, D. K. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007251 · Cited by 69
Pro‐Inflammatory Biomarkers in Stable Versus Acutely Decompensated Heart Failure With Preserved Ejection Fraction
Abernethy, A. D., Raza, S. S., Sun, J., Anstrom, K. J., Tracy, R. P., Steiner, J., VanBuren, P., & LeWinter, M. M. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007385 · Cited by 69
Biomarkers in Anderson–Fabry Disease
Simonetta, I., Tuttolomondo, A., Daidone, M., & Pinto, A. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218080 · Cited by 70
Elevated Levels of Interleukin 6 and C‐Reactive Protein Associated With Cognitive Impairment in Heart Failure
Athilingam, P. R., Moynihan, J. A., Chen, L., D’Aoust, R., Groer, M. E., & Kip, K. E. (2012) · Congestive Heart Failure · doi:10.1111/chf.12007 · Cited by 70
Contributions of cardiomyocyte–cardiac fibroblast–immune cell interactions in heart failure development
Fujiu, K., & Nagai, R. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0357-x · Cited by 68
Effect of Exercise Training on Interleukin-6, Tumour Necrosis Factor Alpha and Functional Capacity in Heart Failure
Smart, N. A., Larsen, A. I., LeMaitre, J. P., & Ferraz, A. S. (2011) · Cardiology Research and Practice · doi:10.4061/2011/532620 · Cited by 68
Dietary Fat Intake and Proinflammatory Cytokine Levels in Patients With Heart Failure
Lennie, T. A., Chung, M. L., Habash, D., & Moser, D. K. (2005) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2005.06.434 · Cited by 68
The Effects of Atorvastatin (10 mg) on Systemic Inflammation in Heart Failure
Mozaffarian, D., Minami, E., Letterer, R. A., Lawler, R. L., McDonald, G. B., & Levy, W. C. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.07.092 · Cited by 68
Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure
Li, H., Chen, C., & Wang, D. W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.695047 · Cited by 73
Leptin in Anorexia and Cachexia Syndrome
Engineer, D. R., & Garcia, J. M. (2012) · International Journal of Peptides · doi:10.1155/2012/287457 · Cited by 70
TNF? in ischemia/reperfusion injury and heart failure
Heusch, G., Schulz, R., Aker, S., & Belosjorow, S. (2004) · Basic Research in Cardiology · doi:10.1007/s00395-003-0431-x · Cited by 67
The ‘skeletal muscle hypothesis in heart failure’ revised
Piepoli, M. F., & Coats, A. J. S. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs463 · Cited by 69
Self-citation
Association between C-reactive protein levels at hospital admission and long-term mortality in patients with acute decompensated heart failure
Matsumoto, H., Kasai, T., Sato, A., Ishiwata, S., Yatsu, S., Shitara, J., Murata, A., Kato, T., Suda, S., Matsue, Y., et al. (2019) · Heart and Vessels · doi:10.1007/s00380-019-01435-9 · Cited by 72
Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure
Földes, G., von Haehling, S., Okonko, D. O., Jankowska, E. A., Poole-Wilson, P. A., & Anker, S. D. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.12.024 · Cited by 66
Self-citation
Role of the hypothalamic PVN in the regulation of renal sympathetic nerve activity and blood flow during hyperthermia and in heart failure
Badoer, E. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00734.2009 · Cited by 66
Exercise Intolerance in Adults with Congenital Heart Disease
Dimopoulos, K., Diller, G., Piepoli, M. F., & Gatzoulis, M. Α. (2006) · Cardiology Clinics · doi:10.1016/j.ccl.2006.08.002 · Cited by 66
Central mineralocorticoid receptor blockade decreases plasma TNF-α after coronary artery ligation in rats
Francis, J., Weiss, R. M., Johnson, A. K., & Felder, R. B. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00376.2002 · Cited by 66
Prognostic value of osteoprotegerin in chronic heart failure: The GISSI-HF trial
Røysland, R., Masson, S., Omland, T., Milani, V., Bjerre, M., Flyvbjerg, A., Tano, G. D., Misuraca, G., Maggioni, A. P., Tognoni, G., et al. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.05.015 · Cited by 65
Lipopolysaccharide-promoted proliferation of endometriotic stromal cells via induction of tumor necrosis factor α and interleukin-8 expression
Iba, Y., Harada, T., Horie, S., Deura, I., Iwabe, T., & Terakawa, N. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.04.038 · Cited by 65
Immunological Mechanisms of Pentoxifylline in Chronic Heart Failure
Shaw, S. M., Shah, M., Williams, S. G., & Fildes, J. E. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfn040 · Cited by 65
Antiplatelet and Anticoagulant Agents in Heart Failure
Gurbel, P. A., & Tantry, U. S. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2013.07.007 · Cited by 66
The Pilot Randomized Study of Nesiritide Versus Dobutamine in Heart Failure (PRESERVD-HF)
Gheorghiade, M., Stough, W. G., Adams, K. F., Jaffe, A. S., Hasselblad, V., & O’Connor, C. M. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.07.017 · Cited by 63
Statin Therapy Is Associated With Improved Cardiovascular Outcomes and Levels of Inflammatory Markers in Patients With Heart Failure
Sola, S., Mir, M. Q. S., Rajagopalan, S., Helmy, T. A., Tandon, N., & Khan, B. V. (2005) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2005.05.011 · Cited by 63
Biomarkers in cardiovascular disease: Beyond natriuretic peptides
Boswood, A. (2009) · Journal of Veterinary Cardiology · doi:10.1016/j.jvc.2009.01.003 · Cited by 63
Admission Hyperglycemia Is an Independent Predictor of Acute Kidney Injury in Patients With Acute Myocardial Infarction
Moriyama, N., Ishihara, M., Noguchi, T., Nakanishi, M., Arakawa, T., Asaumi, Y., Kumasaka, L., Kanaya, T., Miyagi, T., Nagai, T., et al. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0117 · Cited by 63
Concentrations of C-Reactive Protein and B-Type Natriuretic Peptide 30 Days after Acute Coronary Syndromes Independently Predict Hospitalization for Heart Failure and Cardiovascular Death
Scirica, B. M., Cannon, C. P., Sabatine, M. S., Jarolı́m, P., Sloane, S., Rifai, N., Braunwald, E., Morrow, D. A., & for the PROVE IT–TIMI 22 Investigators (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.117192 · Cited by 62
Nutrition in heart failure: an update
Sandek, A., Doehner, W., Anker, S. D., & von Haehling, S. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32832cdb0f · Cited by 60
Self-citation
Cardiac cachexia in early literature: a review of research prior to Medline
Doehner, W., & Anker, S. D. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00230-9 · Cited by 62
Self-citation
Unraveling new mechanisms of exercise intolerance in chronic heart failure. Role of exercise training
Conraads, V. M., Craenenbroeck, E. M. V., Maeyer, C. D., Berendoncks, A. M. V., Beckers, P. J., & Vrints, C. J. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9324-0 · Cited by 62
Interleukin-6 (IL-6) expression and natural killer (NK) cell dysfunction and anergy in heart failure
Vredevoe, D. L., Widawski, M., Fonarow, G. C., Hamilton, M. A., Martı́nez-Maza, O., & Gage, J. R. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.12.054 · Cited by 61
Cardiac biomarkers in heart failure
Liquori, M. E., Christenson, R. H., Collinson, P. O., & deFilippi, C. R. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.01.032 · Cited by 60
White Blood Cell Count, C-Reactive Protein, and Incident Heart Failure in the Atherosclerosis Risk in Communities (ARIC) Study
Bekwelem, W., Lutsey, P. L., Loehr, L. R., Agarwal, S. K., Astor, B. C., Guild, C., Ballantyne, C. M., & Folsom, A. R. (2011) · Annals of Epidemiology · doi:10.1016/j.annepidem.2011.06.005 · Cited by 60
Novel applications for serum procalcitonin testing in clinical practice
Choi, J. J., & McCarthy, M. W. (2017) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1407244 · Cited by 59
Iron Regulatory Hormone Hepcidin Decreases in Chronic Heart Failure Patients With Anemia
Matsumoto, M., Tsujino, T., Lee‐Kawabata, M., Naito, Y., Akahori, H., Sakoda, T., Ohyanagi, M., Tomosugi, N., & Masuyama, T. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0663 · Cited by 59
Cardiac Intercellular Communication: Are Myocytes and Fibroblasts Fair-Weather Friends?
Martin, M. L., & Blaxall, B. C. (2012) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-012-9404-5 · Cited by 62
The incidence of new onset congestive heart failure and heart failure exacerbation in Veteran’s Affairs patients receiving tumor necrosis factor alpha antagonists
Cole, J., Busti, A. J., & Kazi, S. (2006) · Rheumatology International · doi:10.1007/s00296-006-0215-3 · Cited by 59
ERBB signaling attenuates proinflammatory activation of nonclassical monocytes
Ryzhov, S. V., Matafonov, A., Galindo, C. L., Zhang, Q., Tran, T., Lenihan, D. J., Lenneman, C. G., Feoktistov, I., & Sawyer, D. B. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00486.2016 · Cited by 58
Comparing Type D personality and older age as correlates of tumor necrosis factor-α dysregulation in chronic heart failure
Denollet, J., Vrints, C. J., & Conraads, V. M. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.10.015 · Cited by 58
The relationship between tumor necrosis factor-α, brain natriuretic peptide and atrial natriuretic peptide in patients with chronic heart failure
Pérez, A. V., Doehner, W., von Haehling, S., Schmidt, H., Zimmermann, A. V., Volk, H., Anker, S. D., & Rauchhaus, M. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.11.146 · Cited by 58
Self-citation
Autoimmunological features in inflammatory cardiomyopathy
Kallwellis-Opara, A., Dörner, A., Poller, W. C., Noutsias, M., Kühl, U., Schultheiß, H., & Pauschinger, M. (2007) · Clinical Research in Cardiology · doi:10.1007/s00392-007-0524-x · Cited by 58
Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cells
Liu, C., Cheng, Y., Lee, K.-W., Hsu, H.-H., Chu, C., Tsai, F., Tsai, C., Chu, C.-Y., Liu, J.-Y., Kuo, W., et al. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9754-0 · Cited by 58
Effects of exercise training on inflammatory markers in patients with heart failure
Niebauer, J. (2007) · Heart Failure Reviews · doi:10.1007/s10741-007-9050-1 · Cited by 58
Self-citation
The effect of statins on mortality in heart failure with preserved ejection fraction: a meta-analysis of propensity score analyses
Fukuta, H., Goto, T., Wakami, K., & Ohte, N. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.03.186 · Cited by 60
Cardiorenal acute kidney injury: Epidemiology, presentation, causes, pathophysiology and treatment
Lullo, L. D., Bellasi, A., Russo, D., Cozzolino, M. G., & Ronco, C. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.156 · Cited by 58
The Influence of Heart Failure Self-care on Health Outcomes
Lee, C. S., Tkacs, N. C., & Riegel, B. J. (2009) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0b013e31819b5419 · Cited by 57
Cognitive/affective and somatic/affective symptom dimensions of depression are associated with current and future inflammation in heart failure patients
Kupper, N. H. M., Widdershoven, J. W. M. G., & Pedersen, S. S. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.10.029 · Cited by 57
Inflammatory pathways in patients with heart failure and preserved ejection fraction
Niethammer, M., Sieber, M., von Haehling, S., Anker, S. D., Münzel, T. F., Horstick, G., & Genth‐Zotz, S. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.05.061 · Cited by 54
Self-citation
Risk Stratification of Chronic Heart Failure Patients by Multiple Biomarkers Implications of BNP, H-FABP, and PTX3
Ishino, M., Takeishi, Y., Niizeki, T., Watanabe, T., Nitobe, J., Miyamoto, T., Miyashita, T., Kitahara, T., Suzuki, S., Sasaki, T., et al. (2008) · Circulation Journal · doi:10.1253/circj.cj-08-0157 · Cited by 54
Cardiogenic Shock Due to End-Stage Heart Failure and Acute Myocardial Infarction: Characteristics and Outcome of Temporary Mechanical Circulatory Support
Lim, H. S., & Howell, N. (2017) · Shock · doi:10.1097/shk.0000000000001052 · Cited by 54
Myocardial Inflammation, Measured Using 18‐Fluorodeoxyglucose Positron Emission Tomography With Computed Tomography, Is Associated With Disease Activity in Rheumatoid Arthritis
Amigues, I., Tuğcu, A., Russo, C. A., Giles, J. T., Morgenstein, R., Zartoshti, A., Schulze, P. C., Flores, R. J., Bokhari, S., & Bathon, J. M. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40771 · Cited by 56
Plasma Levels of Soluble Tumor Necrosis Factor Receptor Type I During the Acute Phase Following Complicated Myocardial Infarction Predicts Survival in High-Risk Patients
Ueland, T., KJEKSHUS, J. K., Frøland, S. S., Omland, T., Squire, I. B., Gullestad, L. L., Dickstein, K., & Aukrust, P. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.039 · Cited by 54
Combined Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat of Metabolic Disease: A Review
Zhang, L., Liu, Y., Sun, Y., & Zhang, X. (2022) · Nutrients · doi:10.3390/nu14224774 · Cited by 60
The Influence of Aetiology on Inflammatory and Neurohumoral Activation in Patients with Severe Heart Failure: A Prospective Study Comparing Chagas’ Heart Disease and Idiopathic Dilated Cardiomyopathy
Mocelin, A. O., Issa, V. S., Bacal, F., Guimarães, G. V., Cunha‐Neto, E., & Bocchi, E. A. (2005) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2004.10.014 · Cited by 53
Relationship between red cell distribution width and right ventricular dysfunction in patients with chronic obstructive pulmonary disease
Sıncer, İ., Zorlu, A., Yılmaz, M. B., Doğan, Ö. T., Ege, M. R., Amioğlu, G., Aydın, G., Ardıç, İ., & Tandoğan, İ. (2011) · Heart & Lung · doi:10.1016/j.hrtlng.2011.07.011 · Cited by 53
New paradigms in neuroendocrinology: Relationships between obesity, systemic inflammation and the neuroendocrine system
Toni, R., Malaguti, A., Castorina, S., Roti, E., & Lechan, R. M. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03346266 · Cited by 56
Long-Term Effects of Levosimendan Infusion on Inflammatory Processes and sFas in Patients with Severe Heart Failure
Trikas, A. G., Antoniades, C. A., Latsios, G., Vasiliadou, K., Karamitros, I., Tousoulis, D., Tentolouris, C., & Stefanadis, C. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.03.003 · Cited by 52
Consequences of Chronic Inflammation in Peritoneal Dialysis
Wang, A. Y.-M. (2011) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2011.01.005 · Cited by 52
Reappraisal of Inflammatory Biomarkers in Heart Failure
Chaikijurajai, T., & Tang, W. H. W. (2020) · Current Heart Failure Reports · doi:10.1007/s11897-019-00450-1 · Cited by 54
ADAM17, A Key Player of Cardiac Inflammation and Fibrosis in Heart Failure Development During Chronic Catecholamine Stress
Adu‐Amankwaah, J., Adzika, G. K., Adekunle, A. O., Noah, M. L. N., Mprah, R., Bushi, A., Akhter, N., Huang, F., Xu, Y., Adzraku, S. Y., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.732952 · Cited by 53
Current Understanding of Molecular Pathophysiology of Heart Failure With Preserved Ejection Fraction
Budde, H., Hassoun, R., Mügge, A., Kov́acs, Á., & Hamdani, N. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.928232 · Cited by 56
Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota
Godos, J., Romano, G. L., Gozzo, L., Laudani, S., Paladino, N., Azpíroz, I. D., López, N. M. M., Giampieri, F., Quiles, J. L., Battino, M. A., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1368949 · Cited by 58
Functional improvement in heart failure patients treated with beta-blockers is associated with a decline of cytokine levels
Mayer, B., Holmer, S. R., Hengstenberg, C., Lieb, W., Pfeifer, M. A., & Schunkert, H. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.08.053 · Cited by 51
Depression in Patients with Heart Failure: Is Enough Being Done?
Mbakwem, A. C., Aina, F., & Amadi, C. E. (2016) · Cardiac failure review · doi:10.15420/cfr.2016:21:1 · Cited by 51
The Inflammatory Response to Ventricular Assist Devices
Radley, G., Pieper, I. L., Alì, S., Bhatti, F., & Thornton, C. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02651 · Cited by 51
Leukocyte Redistribution: Effects of Beta Blockers in Patients with Chronic Heart Failure
von Haehling, S., Schefold, J. C., Jankowska, E. A., Doehner, W., Springer, J., Strohschein, K., Genth‐Zotz, S., Volk, H., Poole-Wilson, P. A., & Anker, S. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006411 · Cited by 51
Self-citation
Heat Shock Protein 70 Acts as a Potential Biomarker for Early Diagnosis of Heart Failure
Li, Z., Song, Y., Xing, R., Yu, H., Zhang, Y., Li, Z., & Gao, W. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067964 · Cited by 51
Interleukin-6 and B-type natriuretic peptide are independent predictors for worsening of heart failure in patients with progressive congestive heart failure
Gwechenberger, M., Hülsmann, M., Berger, R., Graf, S., Springer, C., Stanek, B., & Pacher, R. (2004) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2003.07.023 · Cited by 51
Relation Between CD4+ T-Cell Activation and Severity of Chronic Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy
Fukunaga, T., Soejima, H., Irie, A., Sugamura, K., Oe, Y., Tanaka, T., Nagayoshi, Y., Kaikita, K., Sugiyama, S., Yoshimura, M., et al. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.03.052 · Cited by 50
The Correlation between Gut Microbiota and Serum Metabolomic in Elderly Patients with Chronic Heart Failure
Wang, Z., Cai, Z., Ferrari, M. W., Liu, Y., Li, C., Zhang, T., & Lyu, G. (2021) · Mediators of Inflammation · doi:10.1155/2021/5587428 · Cited by 49
Nuclear factor-kappa B activation in skeletal muscle of patients with chronic heart failure: correlation with the expression of inducible nitric oxide synthase
Adams, V., Sp??te, U., Kränkel, N., Schulze, P. C., Linke, A., Schuler, G. C., & Hambrecht, R. (2003) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/00149831-200308000-00009 · Cited by 50
Pathophysiological relationships between heart failure and depression and anxiety
Chapa, D. W., Akintade, B., Son, H., Woltz, P., Hunt, D., Friedmann, E., Hartung, M. K., & Thomas, S. A. (2014) · Critical Care Nurse · doi:10.4037/ccn2014938 · Cited by 47
Lipopolysaccharide upregulates uPA, MMP-2 and MMP-9 via ERK1/2 signaling in H9c2 cardiomyoblast cells
Cheng, Y., Chen, L.-M., Chang, M.-H., Chen, W.-K., Tsai, F., Tsai, C., Lai, T.-Y., Kuo, W., Huang, C., & Liu, C. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-0016-y · Cited by 48
Biomarkers of Myocardial Stress and Systemic Inflammation in Patients Who Engage in Heart Failure Self-care Management
Lee, C. S., Moser, D. K., Lennie, T. A., Tkacs, N. C., Margulies, K. B., & Riegel, B. J. (2011) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0b013e31820344be · Cited by 48
Increased High Mobility Group Box-1 Protein Levels are Associated With Impaired Cardiopulmonary and Echocardiographic Findings After Acute Myocardial Infarction
Cirillo, P. L., Giallauria, F., Pacileo, M., Petrillo, G., D’Agostino, M., Vigorito, C., & Chiariello, M. (2009) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2008.11.010 · Cited by 49
La vitamina D: evidencias y controversias
Gilaberte, Y., Aguilera, J. M., Carrascosa, J. M., Figueroa, F. L., Romaní, J., & Nagore, E. (2011) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2011.03.015 · Cited by 50
Soluble Tumor Necrosis Factor Receptors and Heart Failure Risk in Older Adults
Marti, C. N., Khan, H., Mann, D. L., Georgiopoulou, V. V., Bibbins-Domingo, K. B., Harris, T. B., Koster, A., Newman, A. B., Kritchevsky, S. B., Kalogeropoulos, A. P., et al. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000344 · Cited by 49
Wasting of the left ventricle in patients with cardiac cachexia: a cardiovascular magnetic resonance study
Florea, V. G., Moon, J., Pennell, D. J., Doehner, W., Coats, A. J. S., & Anker, S. D. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2003.05.050 · Cited by 48
Self-citation
Interleukin-6 is a stronger prognostic predictor than high-sensitive C-reactive protein in patients with chronic stable heart failure
Jug, B., Salobir, B., Vene, N., Šebeštjen, M., Šabović, M., & Keber, I. (2009) · Heart and Vessels · doi:10.1007/s00380-008-1111-4 · Cited by 47
Inflammation in right ventricular dysfunction due to thromboembolic pulmonary hypertension
von Haehling, S., von Bardeleben, R. S., Kramm, T., Thiermann, Y., Niethammer, M., Doehner, W., Anker, S. D., Münzel, T. F., Mayer, E., & Genth‐Zotz, S. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.04.019 · Cited by 47
Self-citation
The role of interleukins in heart failure with reduced ejection fraction
Segiet, O. A. (2019) · The Anatolian Journal of Cardiology · doi:10.14744/anatoljcardiol.2019.32748 · Cited by 47
The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex
Katayama, P. L., Leirão, I. P., Kanashiro, A., Luiz, J. P. M., Cunha, F. Q., Navegantes, L. C. C., Menani, J. V., Zoccal, D. B., Colombari, D. S. A., & Colombari, E. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.03.014 · Cited by 51
The Role of Inflammation in the Pathophysiology of Heart Failure
Amara, M., Stoler, O., & Birati, E. Y. (2025) · Cells · doi:10.3390/cells14141117 · Cited by 53
Is Vitamin D Deficiency Associated With Heart Failure? A Review of Current Evidence
Agarwal, M., Phan, A., Willix, R., Barber, M., & Schwarz, E. R. (2011) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248410390214 · Cited by 47
Pathogenesis and treatment of the cardiorenal syndrome: Implications of L-arginine-nitric oxide pathway impairment
Rajapakse, N. W., Nanayakkara, S., & Kaye, D. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.05.011 · Cited by 46
Persistent congestion, renal dysfunction and inflammatory cytokines in acute heart failure: a prognosis study
Pugliese, N. R., Fabiani, I., Conte, L., Nesti, L., Masi, S., Natali, A., Colombo, P. C., Pedrinelli, R., & Dini, F. L. (2020) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000974 · Cited by 47
Circulating levels of tumor necrosis factor receptors are highly predictive of mortality in patients with rheumatoid arthritis
Mattey, D. L., Glossop, J. R., Nixon, N. B., & Dawes, P. T. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23075 · Cited by 46
Elevated Plasma Levels of Soluble Receptors of TNF-α and Their Association with Smoking and Microvascular Complications in Young Adults with Type 1 Diabetes
Zoppini, G., Faccini, G., Muggeo, M., Zenari, L., Falezza, G., & Targher, G. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7786 · Cited by 46
Effects of Coping Skills Training on Quality of Life, Disease Biomarkers, and Clinical Outcomes in Patients With Heart Failure: A Randomized Clinical Trial
Sherwood, A., Blumenthal, J. A., Koch, G. G., Hoffman, B. M., Watkins, L. L., Smith, P. J., O’Connor, C. M., Adams, K. F., Rogers, J. G., Sueta, C., et al. (2017) · Circulation: Heart Failure · doi:10.1161/circheartfailure.116.003410 · Cited by 55
Preeclampsia: a gestational cardiorenal syndrome
Gyselaers, W., & Thilaganathan, B. (2019) · The Journal of Physiology · doi:10.1113/jp274893 · Cited by 47
Circulating CD34+/KDR+ endothelial progenitor cells are reduced in chronic heart failure patients as a function of Type D personality
Craenenbroeck, E. M. V., Denollet, J., Paelinck, B. P., Beckers, P. J., Possemiers, N. M., Hoymans, V. Y., Vrints, C. J., & Conraads, V. M. (2009) · Clinical Science · doi:10.1042/cs20080564 · Cited by 48
Ghrelin and cachexia: Will treatment with GHSR-1a agonists make a difference for patients suffering from chronic wasting syndromes?
DeBoer, M. D. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.02.012 · Cited by 44

Authors: Rauchhaus, M., Doehner, W., Francis, D. P., Davos, C., Kemp, M., Liebenthal, C., Niebauer, J., Hooper, J., Volk, H.-D., Coats, A. J. S., & Anker, S. D.
Affiliations: Royal Brompton Hospital (GB)
From Clinical Cardiology, National Heart and Lung Institute (M.R., W.D., D.P.F., C.D., J.N., A.J.S.C., S.D.A.), and Biochemistry, Royal Brompton Hospital (M.K., J.H.), London, UK; the Universitätsklinik und Poliklinik für Innere Medizin III, Martin-Luther-Universität (M.R.), Halle, Germany; and the Institut für Medizinische Immunologie, Charité (Campus Mitte) (C.L., H.-D.V.), and Franz-Volhard-Klinik (Charité, Campus Berlin-Buch) am Max-Delbrück Centrum für Molekulare Medizin (S.D.A.),...
ORCID: Doehner, Wolfram
Davos, Constantinos
Niebauer, Josef
Hooper, James
Volk, Hans-Dieter
Coats, Andrew J. S.
Anker, Stefan D.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-12-19
Volume: 102
Issue: 25
Pages: 3060-3067
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.102.25.3060
OpenAlex: W2066885413
Cited by: 810
References: 27
Citations by year: 2026: 15 · 2025: 19 · 2024: 25 · 2023: 20 · 2022: 31 · 2021: 24 · 2020: 31 · 2019: 22 · 2018: 26 · 2017: 24 · 2016: 24 · 2015: 24 · 2014: 35 · 2013: 35 · 2012: 35
FWCI: 21.26
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords: chronic heart failure, plasma cytokines, soluble TNF receptor 1, soluble TNF receptor 2, TNF-α, interleukin-6, soluble CD14, inflammation, mortality prediction, prognostic factors, anti-TNF therapy
MeSH terms: Adult, Aged, Aged, 80 and over, Analysis of Variance, Cardiac Output, Low, Chronic Disease, Female, Humans, Immunoassay, Male, Middle Aged, Prognosis, ROC Curve, Solubility, Tumor Necrosis Factor-alpha, Biomarkers, Antigens, CD, Interleukin-6, Survival Analysis, Cytokines, Receptors, Tumor Necrosis Factor, Lipopolysaccharide Receptors, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Plasma Cytokine Parameters and Mortality in Patients With Chronic Heart Failure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks