Cited by 810Heart Failure Treatment and ManagementCardiac Fibrosis and RemodelingInflammatory Biomarkers in Disease Prognosis

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Plasma Cytokine Parameters and Mortality in Patients With Chronic Heart Failure

Rauchhaus, Mathias, Doehner, Wolfram, Francis, Darrel P., Davos, Constantinos, Kemp, Michael, Liebenthal, Christa, Niebauer, Josef, Hooper, James, Volk, Hans-Dieter, Coats, Andrew J. S., Anker, Stefan D.·2000·Circulation

DOI 10.1161/01.cir.102.25.3060

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Abstract

Background —Inflammatory immune activation is an important feature in chronic heart failure (CHF). Little is known about the prognostic importance of tumor necrosis factor-α (TNF-α), soluble TNF-receptor 1 and 2 (sTNF-R1/sTNF-R2), interleukin-6 (IL-6), and soluble CD14 receptors (sCD14) in CHF patients. Methods and Results —In 152 CHF patients (age 61±1 years, New York Heart Association [NYHA] class 2.6±0.1, peak V̇ o 2 17.3±0.6 mL · kg −1 · min −1 , mean±SEM) plasma concentrations of immune variables were prospectively assessed. During a mean follow-up of 34 months (>12 months in all patients), 62 patients (41%) died. Cumulative mortality was 28% at 24 months. In univariate analyses, increased total and trimeric TNF-α, sTNF-R1, and sTNF-R2 (all P ≤0.0001), sCD14 ( P =0.0007), and IL-6 ( P =0.005) predicted 24-month mortality. With multivariate analysis and receiver operating characteristics, sTNF-R1 emerged among all cytokine parameters as the strongest and most accurate prognosticator in this CHF population, regardless of follow-up duration and independently of NYHA class, peak V̇ o 2 , V̇ e /V̇ co 2 slope, left ventricular ejection fraction, and wasting ( P <0.001). The receiver operating characteristic area under the curve for sTNF-R1 was greater than for sTNF-R2 at 6, 12, and 18 months (all P <0.05). Conclusions —sTNF-R1 was the strongest and most accurate prognosticator, independent of established markers of CHF severity. Assessment of sTNF-R1 may be useful in identifying patients who are at high risk of death and in monitoring patients undergoing anti–TNF-α treatment.

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The meaning and use of the area under a receiver operating characteristic (ROC) curve.
Hanley, J. A., & McNeil, B. J. (1982) · Radiology · doi:10.1148/radiology.143.1.7063747 · Cited by 21,856
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582
Wasting as independent risk factor for mortality in chronic heart failure
Anker, S. D., Ponikowski, P. P., Varney, S. J., Chua, T. P., Clark, A. L., Webb-Peploe, K., Harrington, D., Kox, W. J., Poole-Wilson, P. A., & Coats, A. J. S. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07015-8 · Cited by 1,399
Self-citation
Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)
Torre-Amione, G., Kapadia, S., Benedict, C., Oral, H., Young, J. B., & Mann, D. L. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00589-7 · Cited by 1,211
Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.
Swedberg, K. B., Eneroth, P. H. E., KJEKSHUS, J. K., & Wilhelmsen, L. (1990) · Circulation · doi:10.1161/01.cir.82.5.1730 · Cited by 1,147
Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart
Torre‐Amione, G., Kapadia, S. R., Lee, J. J., Durand, J., Bies, R. D., Young, J. B., & Mann, D. L. (1996) · Circulation · doi:10.1161/01.cir.93.4.704 · Cited by 991
Endotoxin and immune activation in chronic heart failure: a prospective cohort study
Niebauer, J., Volk, H.-D., Kemp, M., Dominguez, M., Schumann, R. R., Rauchhaus, M., Poole-Wilson, P. A., Coats, A. J., & Anker, S. D. (1999) · The Lancet · doi:10.1016/s0140-6736(98)09286-1 · Cited by 877
Self-citation
Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia
Anker, S. D., Chua, T. P., Ponikowski, P., Harrington, D., Swan, J. W., Kox, W. J., Poole-Wilson, P. A., & Coats, A. J. S. (1997) · Circulation · doi:10.1161/01.cir.96.2.526 · Cited by 800
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Omland, T., Aakvaag, A., Bonarjee, V., Caidahl, K., Lie, R. T., Nilsen, D. W. T., Sundsfjord, J., & Dickstein, K. (1996) · Circulation · doi:10.1161/01.cir.93.11.1963 · Cited by 698

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Authors: Rauchhaus, M., Doehner, W., Francis, D. P., Davos, C., Kemp, M., Liebenthal, C., Niebauer, J., Hooper, J., Volk, H.-D., Coats, A. J. S., & Anker, S. D.
Affiliations: Royal Brompton Hospital (GB)
From Clinical Cardiology, National Heart and Lung Institute (M.R., W.D., D.P.F., C.D., J.N., A.J.S.C., S.D.A.), and Biochemistry, Royal Brompton Hospital (M.K., J.H.), London, UK; the Universitätsklinik und Poliklinik für Innere Medizin III, Martin-Luther-Universität (M.R.), Halle, Germany; and the Institut für Medizinische Immunologie, Charité (Campus Mitte) (C.L., H.-D.V.), and Franz-Volhard-Klinik (Charité, Campus Berlin-Buch) am Max-Delbrück Centrum für Molekulare Medizin (S.D.A.),...
ORCID: Doehner, Wolfram
Davos, Constantinos
Niebauer, Josef
Hooper, James
Volk, Hans-Dieter
Coats, Andrew J. S.
Anker, Stefan D.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-12-19
Volume: 102
Issue: 25
Pages: 3060-3067
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.102.25.3060
OpenAlex: W2066885413
Cited by: 810
References: 27
Citations by year: 2026: 15 · 2025: 19 · 2024: 25 · 2023: 20 · 2022: 31 · 2021: 24 · 2020: 31 · 2019: 22 · 2018: 26 · 2017: 24 · 2016: 24 · 2015: 24 · 2014: 35 · 2013: 35 · 2012: 35
FWCI: 21.26
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords: chronic heart failure, plasma cytokines, soluble TNF receptor 1, soluble TNF receptor 2, TNF-α, interleukin-6, soluble CD14, inflammation, mortality prediction, prognostic factors, anti-TNF therapy
MeSH terms: Adult, Aged, Aged, 80 and over, Analysis of Variance, Cardiac Output, Low, Chronic Disease, Female, Humans, Immunoassay, Male, Middle Aged, Prognosis, ROC Curve, Solubility, Tumor Necrosis Factor-alpha, Biomarkers, Antigens, CD, Interleukin-6, Survival Analysis, Cytokines, Receptors, Tumor Necrosis Factor, Lipopolysaccharide Receptors, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II

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Plasma Cytokine Parameters and Mortality in Patients With Chronic Heart Failure

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