The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Estradiol Accelerates Reendothelialization in Mouse Carotid Artery Through Estrogen Receptor-α but Not Estrogen Receptor-β
Abstract
Background—The atheroprotective effect of 17β-estradiol (E 2) has been suggested in women and clearly demonstrated in animals through both an effect on lipid metabolism and a direct effect on the cells of the arterial wall. It has been shown, for example, that E 2 promotes endothelium-dependent relaxation and accelerates reendothelialization in rats. Similar studies have been undertaken in mice to appreciate the molecular mechanism of this process. Methods and Results—We report here a model of electric carotid injury adapted from that described by Carmeliet et al (1997) that allows us to precisely evaluate the reendothelialization process. We demonstrate that E 2 accelerates endothelial regeneration in castrated female wild-type mice. In ovariectomized transgenic mice in which either the estrogen receptor (ER)-α or ERβ gene has been disrupted, E 2 accelerated reendothelialization in female ERβ knockout mice, whereas this effect was abolished in female ERα knockout mice. Conclusions—This study demonstrates that ERα but not ERβ mediates the beneficial effect of E 2 on reendothelialization and potentially the prevention of atherosclerosis.
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Cites
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Cited by
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Metadata
- Authors
- Brouchet, L., Krust, A., Dupont, S., Chambon, P., Bayard, F., & Arnal, J. F.
- Venue
- Circulation
- Published
- 2001-01-23
- Volume
- 103
- Issue
- 3
- Pages
- 423-428
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2053661133
- Cited by
- 268
- References
- 35
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Estradiol Accelerates Reendothelialization in Mouse Carotid Artery Through Estrogen Receptor-α but Not Estrogen Receptor-β. https://app.cochat.ai/papers/10.1161/01.cir.103.3.423
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- Brouchet, L., Krust, A., Dupont, S., Chambon, P., Bayard, F., & Arnal, J. F. (2001). Estradiol Accelerates Reendothelialization in Mouse Carotid Artery Through Estrogen Receptor-α but Not Estrogen Receptor-β. Circulation. https://doi.org/10.1161/01.cir.103.3.423
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