The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages: Implications for Atherosclerosis
Abstract
Background —LDL and C-reactive protein (CRP) are important cardiovascular risk factors. Both LDL and CRP deposit in the arterial wall during atherogenesis. Stranded LDL is taken up by macrophages, causing foam cell formation. Because native LDL does not induce foam cell formation, we hypothesized that CRP may opsonize native LDL for macrophages. Methods and Results —Monocytes were isolated from human blood and transformed into macrophages. CRP/LDL uptake was assessed by immunofluorescent labeling and the use of confocal laser scanning microscopy. Native LDL coincubated with CRP was taken up by macrophages by macropinocytosis. Uptake of the CRP/LDL coincubate was mediated by the CRP receptor CD32. Conclusions —We conclude that foam cell formation in human atherogenesis may be caused in part by uptake of CRP-opsonized native LDL.
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Cites
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Cited by
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
C-reactive protein: a critical update
Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318921 · Cited by 3,436
Black, S., Kushner, I., & Samols, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400025200 · Cited by 1,844
Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes
Pickup, J. C. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.813 · Cited by 1,414
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195
Metadata
- Authors
- Zwaka, T. P., Hombach, V., & Torzewski, J.
- Venue
- Circulation
- Published
- 2001-03-06
- Volume
- 103
- Issue
- 9
- Pages
- 1194-1197
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2156722540
- Cited by
- 845
- References
- 4
- FWCI
- 19.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages: Implications for Atherosclerosis. https://app.cochat.ai/papers/10.1161/01.cir.103.9.1194
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- Zwaka, T. P., Hombach, V., & Torzewski, J. (2001). C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages: Implications for Atherosclerosis. Circulation. https://doi.org/10.1161/01.cir.103.9.1194
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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