Efficacy of Dofetilide in the Treatment of Atrial Fibrillation-Flutter in Patients With Reduced Left Ventricular Function: A Danish Investigations of Arrhythmia and Mortality ON Dofetilide (DIAMOND) Substudy
Open accessAbstract
BACKGROUND: In patients with left ventricular dysfunction, atrial fibrillation and flutter (AF and AFl, respectively) are common arrhythmias associated with increased morbidity and mortality. The present study investigated the potential of dofetilide in AF-AFl patients with left ventricular dysfunction to restore and maintain sinus rhythm, which might reduce mortality and hospitalizations. METHODS AND RESULTS: In the Danish Investigations of Arrhythmia and Mortality ON Dofetilide (DIAMOND) studies, 506 patients were in AF-AFl at baseline. Over the course of study, cardioversion occurred in 148 (59%) dofetilide- and 86 (34%) placebo-treated patients. In these patients, the probability of maintaining sinus rhythm for 1 year was 79% with dofetilide versus 42% with placebo (P<0.001). Dofetilide had no effect on all-cause mortality, but restoration and maintenance of sinus rhythm was associated with significant reduction in mortality (risk ratio [RR], 0.44; 95% CI, 0.30 to 0.64; P<0.0001). In addition, dofetilide therapy was associated with a significantly lower risk ratio versus placebo for either all-cause (RR, 0.70; 95% CI, 0.56 to 0.89; P</=0.005) or congestive heart failure (RR, 0.69; 95% CI, 0.51 to 0.93; P</=0.02) rehospitalization. CONCLUSIONS: Dofetilide is safe and increases the probability of obtaining and maintaining sinus rhythm in patients with structural heart disease. The present study suggests that restoration of sinus rhythm is associated with improved survival.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dofetilide restores and maintains sinus rhythm in heart failure patients.
“Dofetilide restores and maintains sinus rhythm in heart failure patients 666”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [666]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Prediction of Creatinine Clearance from Serum Creatinine
Cockcroft, D. W., & Gault, H. (2008) · The Nephron journals/Nephron journals · doi:10.1159/000180580 · Cited by 15,291 · see citing works
The SOLVD Investigators* (1991) · New England Journal of Medicine · doi:10.1056/nejm199108013250501 · Cited by 8,029 · see citing works
Effects of Enalapril on Mortality in Severe Congestive Heart Failure
The Consensus Trial Study Group* (1987) · New England Journal of Medicine · doi:10.1056/nejm198706043162301 · Cited by 5,109 · see citing works
Swedberg, K. B., & KJEKSHUS, J. K. (1988) · The American Journal of Cardiology · doi:10.1016/s0002-9149(88)80087-0 · Cited by 3,762 · see citing works
(1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271003 · Cited by 3,725 · see citing works
Dofetilide in Patients with Congestive Heart Failure and Left Ventricular Dysfunction
Torp-Pedersen, C. T., Møller, M., Bloch-Thomsen, P.-E., Køber, L., Sandøe, E., Egstrup, K., Agner, E., Carlsen, J. E., Videbæk, J., Marchant, B., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411201 · Cited by 1,012 · see citing works
Self-citationDries, D. L., Exner, D., Gersh, B., DOMANSKI, M. J., Waclawiw, M. A., & Stevenson, L. W. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00297-6 · Cited by 963 · see citing works
Randomised trial of low-dose amiodarone in severe congestive heart failure
Doval, H., Nul, D. R., Grancelli, H., Perrone, S. V., Bortman, G., & Curiel, R. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91895-3 · Cited by 913 · see citing works
Prognostic significance of atrial fibrillation in advanced heart failure. A study of 390 patients.
Middlekauff, H. R., Stevenson, W., & Stevenson, L. W. (1991) · Circulation · doi:10.1161/01.cir.84.1.40 · Cited by 585 · see citing works
DEEDWANIA, P. C., Singh, B. N., Ellenbogen, K. A., Fisher, S. G., Fletcher, R. D., & Singh, S. N. (1998) · Circulation · doi:10.1161/01.cir.98.23.2574 · Cited by 505 · see citing works
Singh, S., Zoble, R. G., Yellen, L., Brodsky, M. A., Feld, G. K., Berk, M., & Billing, C. B. (2000) · Circulation · doi:10.1161/01.cir.102.19.2385 · Cited by 433 · see citing works
Køber, L., Thomsen, P. E. B., Møller, M., Torp-Pedersen, C., Carlsen, J. E., Sandøe, E., Egstrup, K., Agner, E., Videbæk, J., Marchant, B., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03402-4 · Cited by 337 · see citing works
Self-citationManagement of Atrial Fibrillation
Wood, A. J. J., & Pritchett, E. L. C. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205073261906 · Cited by 322 · see citing works
Atrial fibrillation: current knowledge and recommendations for management*1
Lévy, S. (1998) · European Heart Journal · doi:10.1053/euhj.1998.1050 · Cited by 321 · see citing works
Carson, P. E., Johnson, G. R., Dunkman, W. B., Fletcher, R. D., Farrell, L., & Cohn, J. N. (1993) · PubMed · Cited by 319 · see citing works
Gosselink, A. T. M. (1992) · JAMA · doi:10.1001/jama.1992.03480240051033 · Cited by 274 · see citing works
Gelder, I. C. V., Crijns, H. J. G. M., Blanksma, P. K., Landsman, M. L. J., Posma, J. L., van den Berg, M. P., MEIJLER, F. L., & Lie, K. I. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90352-d · Cited by 269 · see citing works
Improving survival for patients with atrial fibrillation and advanced heart failure
Stevenson, W. G., Stevenson, L. W., Middlekauff, H. R., Fonarow, G. C., Hamilton, M. A., Woo, M. A., Saxon, L. A., Natterson, P. D., Steimle, A. E., Walden, J. A., et al. (1996) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00358-0 · Cited by 218 · see citing works
(1965) · American Heart Journal · doi:10.1016/0002-8703(65)90198-5 · Cited by 153 · see citing works
Systematic review of the management of atrial fibrillation in patients with heart failure
Khand, A. U. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1767 · Cited by 144 · see citing works
Kieny, J. R., Sacrez, A., FACELLO, A., Arbogast, R., Bareiss, P., Roul, G., Demangeat, J.-L., Brunot, B., & Constantinesco, A. (1992) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a060351 · Cited by 103 · see citing works
Cardiac performance early after cardioversion from atrial fibrillation
Raymond, R. J., Lee, A. J., Messineo, F. C., Manning, W. J., & Silverman, D. I. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70217-0 · Cited by 84 · see citing works
Prophylactic treatment after electroconversion of atrial fibrillation
Karlson, B. W., Herlitz, J. D., Edvardsson, N. G., & Olsson, S. B. (1990) · Clinical Cardiology · doi:10.1002/clc.4960130409 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H., Cigarroa, J. E., Cleveland, J. C., Conti, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.022 · Cited by 2,955 · see citing works
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177292 · Cited by 2,805 · see citing works
Calkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Europace · doi:10.1093/europace/eus027 · Cited by 2,722 · see citing works
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H., Cigarroa, J. E., Cleveland, J. C., Conti, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000040 · Cited by 2,056 · see citing works
Calkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2011.12.016 · Cited by 1,456 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Blomstrom-Lundqvist (2003) · doi:10.1161/01.cir.0000091380.04100.84 · Cited by 955 · see citing works
2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation
Joglar, J. A., Chung, M. K., Armbruster, A. L., Benjamin, E. J., Chyou, J. Y., Cronin, E. M., Deswal, A., Eckhardt, L. L., Goldberger, Z. D., Gopinathannair, R., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.08.017 · Cited by 933 · see citing works
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Le Huezey, J.-Y., Lowe, J. E., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318214876d · Cited by 859 · see citing works
Khairy, P., Van Hare, G. F., Balaji, S., Berul, C. I., Cecchin, F., Cohen, M. I., Daniels, C. J., Deal, B. J., Dearani, J. A., Groot, N. D., et al. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.05.009 · Cited by 709 · see citing works
Swedberg, K., Olsson, L. G., Charlesworth, A., Cleland, J., Hanrath, P., Komajda, M., Metra, M., Torp-Pedersen, C., & Poole-Wilson, P. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi166 · Cited by 647 · see citing works
Self-citationJones, D. G., Haldar, S. K., Hussain, W., Sharma, R., Francis, D. P., Rahman-Haley, S. L., McDonagh, T. A., Underwood, S. R., Markides, V., & Wong, T. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.01.069 · Cited by 481 · see citing works
2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia
Page, R. L., Joglar, J. A., Caldwell, M. A., Calkins, H., Conti, J. B., Deal, B. J., Estes, N. A. M., Field, M. E., Goldberger, Z. D., Hammill, S. C., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.08.856 · Cited by 439 · see citing works
A Meta-Analysis of the Prognostic Significance of Atrial Fibrillation in Chronic Heart Failure
Mamas, M. A., Caldwell, J. C., Chacko, S., Garratt, C. J., Fath-Ordoubadi, F., & Neyses, L. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfp085 · Cited by 393 · see citing works
Management of atrial fibrillation
Lip, G. Y., & Tse, H.-F. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61300-2 · Cited by 229 · see citing works
Hunter, R. J., McCready, J., Diab, I., Page, S. P., Finlay, M., Richmond, L., French, A., Earley, M. J., Sporton, S., Jones, M., et al. (2012) · Heart · doi:10.1136/heartjnl-2011-300720 · Cited by 183 · see citing works
Steinberg, B. A., Kim, S., Fonarow, G. C., Thomas, L., Ansell, J., Kowey, P. R., Mahaffey, K. W., Gersh, B. J., Hylek, E., Naccarelli, G., et al. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.02.003 · Cited by 154 · see citing works
Da Costa, A., Thévenin, J., Roche, F., Romeyer-Bouchard, C., Abdellaoui, L., Messier, M., Denis, L., Faure, E., Gonthier, R., Kruszynski, G., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.638395 · Cited by 140 · see citing works
Elesber, A. A., Rosales, A. G., Herges, R. M., Shen, W.-K., Moon, B. S., Malouf, J. F., Ammash, N. M., Somers, V., Hodge, D. O., Gersh, B. J., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi753 · Cited by 34 · see citing works
- Authors
- Pedersen, O. D., Bagger, H., Keller, N., Marchant, B., Køber, L., & Torp-Pedersen, C.
- Affiliations
- Pfizer (United Kingdom) (GB)
- Venue
- Circulation
- Published
- 2001-07-17
- Volume
- 104
- Issue
- 3
- Pages
- 292-296
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2126749500
- Cited by
- 496
- References
- 23
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 13 · 2021: 11 · 2020: 14 · 2019: 15 · 2018: 14 · 2017: 18 · 2016: 21 · 2015: 24 · 2014: 24 · 2013: 35 · 2012: 23
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- dofetilide, atrial fibrillation, atrial flutter, left ventricular dysfunction, sinus rhythm restoration, sinus rhythm maintenance, cardioversion, all-cause mortality, structural heart disease
- MeSH terms
- Administration, Oral, Adult, Aged, Aged, 80 and over, Anti-Arrhythmia Agents, Atrial Fibrillation, Atrial Flutter, Chronic Disease, Denmark, Double-Blind Method, Female, Follow-Up Studies, Heart Failure, Humans, Male, Middle Aged, Myocardial Infarction, Phenethylamines, Sulfonamides, Survival Rate, Odds Ratio, Treatment Outcome, Ventricular Dysfunction, Left
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review