Cited by 3,162Lipoproteins and Cardiovascular HealthCardiovascular Health and Risk FactorsDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.

Open access

Gordon, D J, Probstfield, J L, Garrison, R J, Neaton, J D, Castelli, W P, Knoke, J D, Jacobs, D R, Bangdiwala, S, Tyroler, H A·1989·Circulation

DOI 10.1161/01.cir.79.1.8

Open this paper in CoChat — free account Open PDF

Abstract

The British Regional Heart Study (BRHS) reported in 1986 that much of the inverse relation of high-density lipoprotein cholesterol (HDLC) and incidence of coronary heart disease was eliminated by covariance adjustment. Using the proportional hazards model and adjusting for age, blood pressure, smoking, body mass index, and low-density lipoprotein cholesterol, we analyzed this relation separately in the Framingham Heart Study (FHS), Lipid Research Clinics Prevalence Mortality Follow-up Study (LRCF) and Coronary Primary Prevention Trial (CPPT), and Multiple Risk Factor Intervention Trial (MRFIT). In CPPT and MRFIT (both randomized trials in middle-age high-risk men), only the control groups were analyzed. A 1-mg/dl (0.026 mM) increment in HDLC was associated with a significant coronary heart disease risk decrement of 2% in men (FHS, CPPT, and MRFIT) and 3% in women (FHS). In LRCF, where only fatal outcomes were documented, a 1-mg/dl increment in HDLC was associated with significant 3.7% (men) and 4.7% (women) decrements in cardiovascular disease mortality rates. The 95% confidence intervals for these decrements in coronary heart and cardiovascular disease risk in the four studies overlapped considerably, and all contained the range 1.9-2.9%. HDLC levels were essentially unrelated to non-cardiovascular disease mortality. When differences in analytic methodology were eliminated, a consistent inverse relation of HDLC levels and coronary heart disease event rates was apparent in BRHS as well as in the four American studies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.cir.79.1.8

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
High density lipoprotein as a protective factor against coronary heart disease
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B., & Dawber, T. R. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90874-9 · Cited by 5,059
Self-citation
Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia
Frick, M. H., Elo, O., Haapa, K., Heinonen, O. P., Heinsalmi, P., Helo, P., Huttunen, J. K., Kaitaniemi, P., Koskinen, P., Manninen, V., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711123172001 · Cited by 3,881
A SIMPLIFIED METHOD FOR THE ESTIMATION OF TOTAL CHOLESTEROL IN SERUM AND DEMONSTRATION OF ITS SPECIFICITY
Abell, L. L., Levy, B. B., Brodie, B. B., & Kendall, F. E. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50907-3 · Cited by 3,085
Incidence of Coronary Heart Disease and Lipoprotein Cholesterol Levels
Castelli, W. P. (1986) · JAMA · doi:10.1001/jama.256.20.2835 · Cited by 2,512
Self-citation
Epidemiological approaches to heart disease: the Framingham study
Dawber, T. R., Meadors, G. F., & Moore, F. E. (1951) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.41.3.279 · Cited by 2,148
Beneficial Effects of Combined Colestipol-Niacin Therapy on Coronary Atherosclerosis and Coronary Venous Bypass Grafts
Blankenhorn, D. H. (1987) · JAMA · doi:10.1001/jama.1987.03390230069027 · Cited by 1,654
High density lipoprotein metabolism.
Eisenberg, S. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37713-0 · Cited by 1,212

Show all 27 references

Research works printed but not linked: 8

Miller NE, Forde OH, Thelle DS, Mjos OD: The Tromso Heart Study: High-density lipoprotein and coronary heart disease: A prospective case-control study. Lancet 1977; 1:965-970
Gordon DJ, Knoke J, Probstfield JL, Superko R, Tyroler HA (for the Lipid Research Clinics Program): High-density lipoprotein cholesterol and coronary heart disease in hyper- cholesterolemic men: The Lipid Research Clinics Coronary Primary Prevention Trial. Circulation 1986;74:1217-1225
The Lipid Research Clinics Program Epidemiology Commit- tee: Plasma Lipid Distribution in Selected North American Populations: The Lipid Research Clinics Program Preva- lence Study. Circulation 1979;60:427-439
The Lipid Research Clinics Program: The Coronary Primary Prevention Trial: Design and implementation. J Chronic Dis 1979;32:609-631
The Lipid Research Clinics Program: The Lipid Research Clinics Coronary Primary Prevention Trial Results: I. Reduc- tion in incidence of coronary heart disease. JA1M 1984; 251:351-364
The Multiple Risk Factor Intervention Trial Group: Statisti- cal design considerations in the NHLBI Multiple Risk Fac- tor Intervention Trial (MRFIT). J Chronic Dis 1977; 30:261-275
Multiple Risk Factor Intervention Trial Research Group: Multiple Risk Factor Intervention Trial: Risk factor changes and mortality results. JAMA 1982;248:1465-1477
Shestov DB: Results of four years of follow-up of USSR populations, in USA-USSR First Lipoprotein Symposium. US Department of Health and Human Services Publication (NIH) 83-1966, Bethesda, Md, 1982, pp 391-407

Sorted by citations

Items 701–800 of 1,007

Effects of Ocular Carteolol and Timolol on Plasma High-density Lipoprotein Cholesterol Level
Freedman, S. F., Freedman, N. J., Shields, M. B., Lobaugh, B., Samsa, G. P., Keates, E. U., & Ollie, A. R. (1993) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)73203-9 · Cited by 61
Hostility-related variables and plasma lipid levels
Dujovne, V. F., & Houston, B. K. (1991) · Journal of Behavioral Medicine · doi:10.1007/bf00867170 · Cited by 61
Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females
Silva, E. R. D. O. E., Kong, M., Han, Z., Starr, C. J., Kass, E. M., Juo, S. H., Foster, D., Dansky, H. M., Merkel, M., Cundey, K., et al. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33483-0 · Cited by 61
ApoA-II maintains HDL levels in part by inhibition of hepatic lipase: studies in apoA-II and hepatic lipase double knockout mice
Weng, W., Brandenburg, N. A., Zhong, S., Halkias, J., Wu, L., Jiang, X., Tall, A. R., & Breslow, J. L. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33510-0 · Cited by 61
Future of Cholesteryl Ester Transfer Protein Inhibitors
Rader, D. J., & deGoma, E. M. (2014) · Annual Review of Medicine · doi:10.1146/annurev-med-050311-163305 · Cited by 66
On- and Off-Target Pharmacology of Torcetrapib
Johns, D. G., Duffy, J., Fisher, T. S., Hubbard, B. K., & Forrest, M. J. (2012) · Drugs · doi:10.2165/11599310-000000000-00000 · Cited by 60
HDL-c is a powerful lipid predictor of cardiovascular diseases
Bruckert, É., & Hansel, B. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01509.x · Cited by 62
Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity
Nakanishi, S., Vikstedt, R., Söderlund, S., Lee‐Rueckert, M., Hiukka, A., Ehnholm, C., Muilu, M., Metso, J., Naukkarinen, J., Palotie, L., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800196-jlr200 · Cited by 60
Impact of coconut oil consumption on cardiovascular health: a systematic review and meta-analysis
Teng, M., Zhao, Y., Khoo, A. L., Yeo, T. C., Yong, Q. W., & Lim, B. P. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz074 · Cited by 60
Función antioxidante de las lipoproteínas de alta densidad: un nuevo paradigma en la arteriosclerosis
Tomás, M., Latorre, G. N., Sentı́, M., & Marrugat, J. (2004) · Revista Española de Cardiología · doi:10.1016/s0300-8932(04)77146-8 · Cited by 60
Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjects
Catalano, G., Duchêne, E., Julia, Z., Goff, W. L., Bruckert, É., Chapman, M. J., & Guérin, M. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700510-jlr200 · Cited by 60
Increases in high-density lipoprotein cholesterol with endurance exercise training are blunted in obese compared with lean men
Nicklas, B. J., Katzel, L. I., Busby‐Whitehead, J., & Goldberg, A. P. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90194-3 · Cited by 60
Prevalence and Treatment of Low HDL Cholesterol Among Primary Care Patients With Type 2 Diabetes
Grant, R. W., & Meigs, J. B. (2007) · Diabetes Care · doi:10.2337/dc06-1961 · Cited by 60
Lipid, lipoprotein, and apolipoprotein profiles in active and sedentary men with tetraplegia
Dallmeijer, A. J., Hopman, M. T. E., & van der Woude, L. H. V. (1997) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(97)90327-0 · Cited by 60
Invited Commentary: Can Selection Bias Explain the Cardiovascular Benefits of Estrogen Replacement Therapy?
Grodstein, F. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008679 · Cited by 60
Cardioprotective Properties of Fibrates
Barter, P. J., & Rye, K. (2006) · Circulation · doi:10.1161/circulationaha.105.620450 · Cited by 62
Prospective studies on the relationship between high-density lipoprotein cholesterol and cardiovascular risk: a systematic review
Chirovsky, D. R., Fedirko, V., Cui, Y. A., Sazonov, V., & Barter, P. J. (2009) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e32832c8891 · Cited by 58
Blood cadmium concentration and lipid profile in Korean adults
Kim, K. (2011) · Environmental Research · doi:10.1016/j.envres.2011.12.008 · Cited by 59
High-Density Lipoprotein Cholesterol in HIV-Infected Patients: Evidence for an Association with HIV-1 Viral Load, Antiretroviral Therapy Status, and Regimen Composition
Bernal, E., Masiá, M., Padilla, S., & Gutiérrez, F. (2008) · AIDS Patient Care and STDs · doi:10.1089/apc.2007.0186 · Cited by 59
Apolipoprotein A-I and A-I mimetic peptides: a role in atherosclerosis
Getz, G. S., & Reardon (2011) · Journal of Inflammation Research · doi:10.2147/jir.s12983 · Cited by 59
Effects of low molecular weight procyanidin rich extract from french maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: Randomized, double-blind, crossover, placebo-controlled intervention trial
Valls, R. M., Llauradó, E., Fernández‐Castillejo, S., Puiggròs, F., Solà, R., Arola, L., & Pedret, A. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.08.007 · Cited by 59
HDL Cholesterol Efflux Does Not Predict Cardiovascular Risk in Hemodialysis Patients
Kopecky, C., Ebtehaj, S., Genser, B., Drechsler, C., Krane, V., Antlanger, M., Kovarik, J. J., Kaltenecker, C. C., Parvizi, M., Wanner, C., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016030262 · Cited by 61
Association of lipoprotein cholesterol and triglycerides with the severity of coronary artery disease in men and women
Korhonen, T., Savolainen, M. J., Koistinen, M. J., Ikäheimo, M. J., Linnaluoto, M. K., Kervinen, K., & Kesäniemi, Y. A. (1996) · Atherosclerosis · doi:10.1016/s0021-9150(96)05958-8 · Cited by 57
Differential Effect of National Cholesterol Education Program (NCEP) Step II Diet on HDL Cholesterol, Its Subfractions, and Apoprotein A-I Levels in Hypercholesterolemic Women and Men After 1 Year
Walden, C. E., Retzlaff, B. M., Buck, B. L., Wallick, S., McCann, B. S., & Knopp, R. H. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1580 · Cited by 59
Dyslipidemia, gender, and the role of high-density lipoprotein cholesterol: implications for therapy
Legato, M. J. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01463-6 · Cited by 59
Accelerated atherosclerosis, dyslipidemia, and oxidative stress in end-stage renal disease
Mathur, S., Devaraj, S., & Jialal, I. (2002) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200203000-00003 · Cited by 59
Plasma lipids and desogestrel and ethinyl estradiol: a meta-analysis
Løbo, R. A., Skinner, J. B., Lippman, J. S., & Cirillo, S. J. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58321-6 · Cited by 59
Women have a larger and less atherogenic low density lipoprotein particle size than men
Nikkilä, M. T., Pitkäjärvi, T., Koivula, T. A., Solakivi, T., Lehtimäki, T. J., Laippala, P. J., Jokela, H., Lehtom̈aki, E., Seppä, K., & Sillanaukee, P. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05645-9 · Cited by 59
Fenofibrate: a novel formulation (Triglide?) in the treatment of lipid disorders: a review
Τζιόμαλος, Κ., & Athyros, V. G. (2006) · International Journal of Nanomedicine · doi:10.2147/nano.2006.1.2.129 · Cited by 58
Targeting paraoxonase-1 in atherosclerosis
Mackness, M., & Mackness, B. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.790367 · Cited by 58
Effects of 3-Week Consumption of Green Tea Extracts on Whole-Body Metabolism During Cycling Exercise in Endurance-Trained Men
Eichenberger, P. A., Colombani, P. C., & Mettler, S. (2009) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.79.1.24 · Cited by 58
Serum Lipid Profile of Newly Diagnosed Hypertensive Patients inNnewi, South‐East Nigeria
Osuji, C. U., Omejua, E. G., Onwubuya, E. I., & Ahaneku, G. I. (2012) · International Journal of Hypertension · doi:10.1155/2012/710486 · Cited by 59
Lipoproteins as modulators of atherothrombosis: From endothelial function to primary and secondary coagulation
Ouweneel, A. B., & Eck, M. V. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.10.009 · Cited by 60
Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles
Habánová, M., Saraiva, J. A., Habán, M., Schwarzová, M., Chlebo, P., Predná, L., Gažo, J., & Wyka, J. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.11.010 · Cited by 60
Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease: The Japan Public Health Center-based prospective (JPHC) study
Saito, I., Yamagishi, K., Kokubo, Y., Yatsuya, H., Iso, H., Sawada, N., Inoue, M., & Tsugane, S. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.08.032 · Cited by 58
HDL in atherosclerosis: actor or bystander?
Asztalos, B. F., & Schaefer, E. J. (2003) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(03)00006-0 · Cited by 59
Long-term (5-Year) Changes in HDL Cholesterol in Cardiac Rehabilitation Patients
Warner, J. G., Brubaker, P. H., Zhu, Y. Y., Morgan, T. M., Ribisl, P. M., Miller, H. S., & Herrington, D. M. (1995) · Circulation · doi:10.1161/01.cir.92.4.773 · Cited by 58
Role of ABCA1 in Cardiovascular Disease
Wang, J., Xiao, Q., Wang, L., Wang, Y., Wang, D. W., & Ding, H. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12061010 · Cited by 62
Effects of Increasing High-Density Lipoprotein Cholesterol and Decreasing Low-Density Lipoprotein Cholesterol on the Incidence of First Acute Coronary Events (from the Air Force/Texas Coronary Atherosclerosis Prevention Study)
Cui, Y. A., Watson, D. J., Girman, C. J., Shapiro, D. R., Gotto, A. M., Hiserote, P., & Clearfield, M. B. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.05.020 · Cited by 57
Identification of Genetic Markers Associated With High-Density Lipoprotein-Cholesterol by Genome-Wide Screening in a Japanese Population The Suita Study
Hiura, Y., Shen, C.-S., Kokubo, Y., Okamura, T., Morisaki, T., Tomoike, H., Yoshida, T., Sakamoto, H., Goto, Y., Nonogi, H., et al. (2009) · Circulation Journal · doi:10.1253/circj.cj-08-1101 · Cited by 57
Alterations in low-density lipoprotein and high-density lipoprotein subclasses among hispanic women with polycystic ovary syndrome: influence of insulin and genetic factors
Legro, R. S., Blanche, P. J., Krauss, R. M., & Løbo, R. A. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00401-x · Cited by 57
Ergostatrien-3β-ol fromAntrodia camphorataInhibits Diabetes and Hyperlipidemia in High-Fat-Diet Treated Mice via Regulation of Hepatic Related Genes, Glucose Transporter 4, and AMP-Activated Protein Kinase Phosphorylation
Kuo, Y., Lin, C., & Shih, C. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b00073 · Cited by 57
HDL of Patients with Type 2 Diabetes Mellitus Elevates the Capability of Promoting Breast Cancer Metastasis
Pan, B., Ren, H., He, Y., Lv, X., Ma, Y., Li, J., Huang, L. T., Yu, B., Kong, J., Niu, C., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0817 · Cited by 57
Rationale and design of dal-PLAQUE: A study assessing efficacy and safety of dalcetrapib on progression or regression of atherosclerosis using magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography/computed tomography
Fayad, Z. A., Mani, V., Woodward, M., Kallend, D. G., Bansilal, S., Pozza, J., Burgess, T., Fuster, V., Rudd, J. H. F., Tawakol, A. A., et al. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.05.006 · Cited by 57
Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway
Pamir, N., Hutchins, P. M., Ronsein, G. E., Vaisar, T., Reardon, C. A., Getz, G. S., Lusis, A. J., & Heinecke, J. W. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m063701 · Cited by 55
Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities
Mero, N., van Tol, A., Scheek, L. M., van Tol, A., Labeur, C., Rosseneu, M., & Taskinen, M. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32531-1 · Cited by 57
Dyslipidemia in midlife women: Approach and considerations during the menopausal transition
Torosyan, N., Visrodia, P., Torbati, T., Minissian, M., & SHUFELT, C. L. (2022) · Maturitas · doi:10.1016/j.maturitas.2022.08.001 · Cited by 60
Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raisingA systematic review and meta-analysis of relevant preclinical studies and clinical trials
Kühnast, S., Fiocco, M. F., van der Hoorn, J. W. A., Princen, H. M. G., & Jukema, J. W. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.089 · Cited by 58
Role of HDL in Those with Diabetes
Santos‐Gallego, C. G., & Rosenson, R. S. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0512-5 · Cited by 59
Maternal cigarette smoking is associated with reduced high-density lipoprotein cholesterol in healthy 8-year-old children
Ayer, J. G., Belousova, E., Harmer, J. A., David, C., Marks, G. B., & Celermajer, D. S. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr174 · Cited by 57
Risk of major limb amputation in diabetic foot ulcer and accompanying disease: A meta-analysis
Shin, J. Y., Roh, S., Sharaf, B. A., & Lee, N. (2017) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2017.07.015 · Cited by 57
Relation between lipids and atherosclerosis: Epidemiologie evidence and clinical implications
Zemel, P. C., & Sowers, J. R. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)91257-7 · Cited by 58
Dose–response effects of atorvastatin and simvastatin on high-density lipoprotein cholesterol in hypercholesterolaemic patients: a review of five comparative studies
Wierzbicki, A. S., & Mikhailidis, D. P. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00118-3 · Cited by 54
Lipids, lipoproteins, women and cardiovascular disease
Miller, V. T. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90154-6 · Cited by 56
Lack of Increased Coronary Atherosclerotic Risk Due to Elevated Lipoprotein(a) in Women ≥55 Years of Age
Sunayama, S., Daida, H., Mokuno, H., Miyano, H., Yokoi, H., Lee, Y. J., Sakurai, H., & Yamaguchi, H. (1996) · Circulation · doi:10.1161/01.cir.94.6.1263 · Cited by 56
HDL and triglyceride as therapeutic targets
Fruchart, J., & Duriez, P. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200212000-00003 · Cited by 56
Combination therapy for combined dyslipidemia
Xydakis, A. M., & Ballantyne, C. M. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02968-5 · Cited by 56
Apolipoprotein E polymorphism, age and coronary heart disease
Kolovou, G. D., & Anagnostopoulou, K. K. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.11.001 · Cited by 54
Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein–1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease
Bai, Q., Zhang, X., Xu, L., Kakiyama, G., Heuman, D. M., Sanyal, A. J., Pandak, W. M., Yin, L., Xie, W., & Ren, S. (2012) · Metabolism · doi:10.1016/j.metabol.2011.11.014 · Cited by 55
High density lipoprotein subfractions and the risk of coronary heart disease: 9-years follow-up in the Caerphilly Study
Yu, S., YARNELL, J. W. G., Sweetnam, P. M., & Bolton, C. H. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(02)00361-1 · Cited by 55
HDL Cholesterol, Apolipoproteins, and Cardiovascular Risk in Hemodialysis Patients
Silbernagel, G., Genser, B., Drechsler, C., Scharnagl, H., Grammer, T. B., Stojaković, T., Krane, V., Ritz, E., Wanner, C., & März, W. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013080816 · Cited by 58
Effects of menopause and obesity on lipid profiles in middle-aged Taiwanese women: the Chin-Shan Community Cardiovascular Cohort Study
Torng, P., Su, T., Sung, F. C., Chien, K., Huang, S., Chow, S., & Lee, Y. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(00)00423-8 · Cited by 55
Impact of Nutrients and Food Components on Dyslipidemias: What Is the Evidence?
Rosa, C. D. O. B., dos Santos, C. A., Leite, J. I. A., Caldas, A. P. S., & Bressan, J. (2015) · Advances in Nutrition · doi:10.3945/an.115.009480 · Cited by 56
Total but not High-Density Lipoprotein Cholesterol Is Consistently Associated with Coronary Heart Disease Mortality in Elderly Men in Finland, Italy, and the Netherlands
Houterman, S., Verschuren, W. M. M., Giampaoli, S., Nissinen, A. M., Feskens, E. J. M., Menotti, A., & Kromhout, D. (2000) · Epidemiology · doi:10.1097/00001648-200005000-00017 · Cited by 55
Estrogen Increases Apolipoprotein (Apo) A-I Secretion in Hep G2 Cells by Modulating Transcription of the Apo A-I Gene Promoter
Lamon‐Fava, S., Ordovás, J. M., & Schaefer, E. J. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.12.2960 · Cited by 55
Group V and X secretory phospholipase A2s-induced modification of high-density lipoprotein linked to the reduction of its antiatherogenic functions
Ishimoto, Y., Yamada, K., Yamamoto, S., Ono, T., Notoya, M., & Hanasaki, K. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(03)00120-4 · Cited by 55
Changes in lipid, lipoprotein and apolipoprotein profiles in persons with spinal cord injuries during the first 2 years post-injury
Dallmeijer, A. J., van der Woude, L. H. V., van Kamp, G. J., & Hollander, A. P. (1999) · Spinal Cord · doi:10.1038/sj.sc.3100776 · Cited by 55
Quantity and function of high density lipoprotein as an indicator of coronary atherosclerosis
Saku, K., Zhang, B., Ohta, T., & Arakawa, K. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00560-9 · Cited by 55
Increased Systemic and Plaque Inflammation in ABCA1 Mutation Carriers With Attenuation by Statins
Bochem, A. E., van der Valk, F. M., Tolani, S., Stroes, E. S. G., Westerterp, M., & Tall, A. R. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304959 · Cited by 56
Lipid-lowering effects of Danhong injection on hyperlipidemia rats
Chen, J., Deng, J., Zhang, Y., Yang, J., He, Y. T., Fu, W., Xing, P., & Wan, H. T. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.04.023 · Cited by 54
Current diagnostic concepts to detect coronary artery disease in women
Stangl, V., Witzel, V., Baumann, G., & Stangl, K. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn047 · Cited by 54
The effect of atorvastatin therapy on lecithin:cholesterol acyltransferase, cholesteryl ester transfer protein and the antioxidant paraoxonase
Kassai, A., Illyés, L., Mirdamadi, H. Z., Seres, I., Kalmár, T., Audikovszky, M., & Paragh, G. (2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.05.016 · Cited by 54
CETP (Cholesteryl Ester Transfer Protein) Concentration
Blauw, L. L., Li‐Gao, R., Noordam, R., de Mutsert, R., Trompet, S., Berbée, J. F. P., Wang, Y., van Klinken, J. B., Christen, T., van Heemst, D., et al. (2018) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.117.002034 · Cited by 54
High-Density Lipoprotein Cholesterol and All-Cause and Cause-Specific Mortality Among the Elderly
Li, Z., Lv, Y., Zhong, W.-F., Gao, X., Kraus, V. B., Zou, M., Zhang, X.-R., Li, F.-R., Yuan, J.-Q., Shi, X., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02511 · Cited by 55
A combination of high concentrations of serum triglyceride and non-high-density-lipoprotein-cholesterol is a risk factor for cardiovascular disease in subjects with abnormal glucose metabolism—The Hoorn Study
Bos, G., Dekker, J. M., Nijpels, G., de Vegt, F., Diamant, M., Stehouwer, C. D. A., Bouter, L. M., & Heine, R. J. (2003) · Diabetologia · doi:10.1007/s00125-003-1141-5 · Cited by 54
Alterations of HDL subclasses in hyperlipidemia
Xu, Y., & Fu, M. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00138-4 · Cited by 54
Chronic selective hypertriglyceridemia impairs endothelium-dependent vasodilatation in rats
Kusterer, K. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00331-9 · Cited by 54
CETP inhibition in cardiovascular risk management: a critical appraisal
Dullaart, R. P. F., Dallinga‐Thie, G. M., Wolffenbuttel, B. H. R., & van Tol, A. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01756.x · Cited by 54
Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study
Andrews, J., Janssan, A., Nguyen, T., Pisaniello, A. D., Scherer, D. J., Kastelein, J. J. P., Merkely, B., Nissen, S. E., Ray, K., Schwartz, G. G., et al. (2017) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt.2017.01.01 · Cited by 53
High-Density Lipoprotein Modifications: A Pathological Consequence or Cause of Disease Progression?
Márquez, A. B., Nazir, S., & van der Vorst, E. P. C. (2020) · Biomedicines · doi:10.3390/biomedicines8120549 · Cited by 57
NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24
Hunter, M. L., Angelicheva, D., Tournev, I., Ingley, E., Chan, D. C., Watts, G. F., Kremensky, I. M., & Kalaydjieva, L. V. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.050 · Cited by 51
HDL-C, triglycerides and carotid IMT: A meta-analysis of 21,000 patients with automated edge detection IMT measurement
Touboul, P., Labreuche, J., Bruckert, É., Schargrodsky, H., Prati, P., Tosetto, A., Hernández-Hernández, R., Woo, K.-S., Silva, H., Vicaut, É., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.10.011 · Cited by 52
Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance
Linke, A. H.-P., Sonnabend, M., Faßhauer, M., Höllriegel, R., Schuler, G. C., Niebauer, J., Stümvoll, M., & Blüher, M. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.11.026 · Cited by 53
High‐Density Lipoprotein Subclasses and Noncardiovascular, Noncancer Chronic Inflammatory‐Related Events Versus Cardiovascular Events: The Multi‐Ethnic Study of Atherosclerosis
Duprez, D. A., Otvos, J. D., Tracy, R. P., Feingold, K. R., Greenland, P., Gross, M. D., Lima, J. A. C., Mackey, R. H., Neaton, J. D., Sanchez, O. A., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002295 · Cited by 53
Self-citation
The studies of PLGA nanoparticles loading atorvastatin calcium for oral administration in vitro and in vivo
Li, Z., Tao, W., Zhang, D., Wu, C., Song, B., Wang, S., Wang, T., Hu, M., Liu, X., Wang, Y., et al. (2016) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2016.08.006 · Cited by 53
Quantifying HDL proteins by mass spectrometry: how many proteins are there and what are their functions?
Shao, B., & Heinecke, J. W. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1402680 · Cited by 55
Cholesteryl Ester Transfer Protein Inhibitors and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Taheri, H., Filion, K. B., Windle, S. B., Reynier, P., & Eisenberg, M. J. (2020) · Cardiology · doi:10.1159/000505365 · Cited by 54
Increasing HDL cholesterol with extended-release nicotinic acid: from promise to practice.
Birjmohun, R. S., Hutten, B. A., Kastelein, J. J. P., & Stroes, E. S. G. (2004) · PubMed · Cited by 52
Premenopausal determinants of menopausal estrogen use
Egeland, G. M., Kuller, L. H., Matthews, K. A., Kelsey, S. F., Cauley, J. A., & Guzick, D. S. (1991) · Preventive Medicine · doi:10.1016/0091-7435(91)90033-z · Cited by 52
A Genomewide Search Using an Original Pairwise Sampling Approach for Large Genealogies Identifies a New Locus for Total and Low-Density Lipoprotein Cholesterol in Two Genetically Differentiated Isolates of Sardinia
Falchi, M., Forabosco, P., Mocci, E., Borlino, C. C., Picciau, A., Virdis, E., Persico, I., Parracciani, D., Angius, A., & Pirastu, M. (2004) · The American Journal of Human Genetics · doi:10.1086/426155 · Cited by 53
Lipids and Lipoproteins in Women
O’Brien, T., & Nguyen, T. T. (1997) · Mayo Clinic Proceedings · doi:10.4065/72.3.235 · Cited by 53
Surrogate markers in clinical trials—Challenges and opportunities
Duivenvoorden, R., de Groot, E., Stroes, E. S. G., & Kastelein, J. J. P. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.12.009 · Cited by 52
Diet‐Induced Weight Loss in Overweight or Obese Women and Changes in High‐Density Lipoprotein Levels and Function
Aicher, B. O., Haser, E. K., Freeman, L. A., Carnie, A., Stonik, J. A., Wang, X., Remaley, A. T., Kato, G. J., & Cannon, R. O. (2012) · Obesity · doi:10.1038/oby.2012.56 · Cited by 52
Niacin Promotes Cholesterol Efflux through Stimulation of the PPARγ-LXRα-ABCA1 Pathway in 3T3-L1 Adipocytes
Wu, Z., & Zhao, S. (2009) · Pharmacology · doi:10.1159/000242999 · Cited by 52
Niacin in Cardiovascular Disease: Recent Preclinical and Clinical Developments
Digby, J. E., Ruparelia, N., & Choudhury, R. P. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.236315 · Cited by 53
Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1
Liu, D., Liang, J., Tong, X., Pan, B., Han, J.-Y., Huang, Y., Chen, Y. E., Pennathur, S., Zhang, Y., & Zheng, L. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00055.2011 · Cited by 52
Kinetics of lipids, apolipoproteins, and cholesteryl ester transfer protein in plasma after a bicycle marathon
Föger, B., Wohlfarter, T., Ritsch, A., Lechleitner, M., Miller, C. H., Dienstl, A., & Patsch, J. R. (1994) · Metabolism · doi:10.1016/0026-0495(94)90207-0 · Cited by 52
Inhibition of CETP as a novel therapeutic strategy for reducing the risk of atherosclerotic disease
Shah, P. K. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl392 · Cited by 51
Replacement of partially hydrogenated soybean oil by palm oil in margarine without unfavorable effects on serum lipoproteins
Müller, H., Jordal, O., Kierulf, P., Kirkhus, B., & Pedersen, J. I. (1998) · Lipids · doi:10.1007/s11745-998-0284-9 · Cited by 52
Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects: a study based on coronary angiography
Goto, A., Sasai, K., Suzuki, S., Fukutomi, T., Ito, S., Matsushita, T., Okamoto, M., Suzuki, T., Itoh, M., Okumura‐Noji, K., et al. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00476-2 · Cited by 52

Authors: Gordon, D. J., Probstfield, J. L., Garrison, R. J., Neaton, J. D., Castelli, W. P., Knoke, J. D., Jacobs, D. R., Bangdiwala, S., & Tyroler, H. A.
Affiliations: National Institutes of Health (US)
ORCID: Probstfield, J L
Neaton, J D
Knoke, J D
Jacobs, D R
Bangdiwala, S
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1989-01
Volume: 79
Issue: 1
Pages: 8-15
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.79.1.8
OpenAlex: W2077760013
Cited by: 3,162
References: 27
Citations by year: 2026: 35 · 2025: 41 · 2024: 62 · 2023: 69 · 2022: 90 · 2021: 90 · 2020: 90 · 2019: 84 · 2018: 96 · 2017: 87 · 2016: 81 · 2015: 125 · 2014: 137 · 2013: 125 · 2012: 129
FWCI: 61.95
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hv012156-034)
National Heart, Lung, and Blood Institute (N01-HV32961, N01-HV 12156, N01-HV 12159)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: HDL cholesterol, coronary artery disease, cardiovascular mortality, inverse association, Framingham Heart Study, Multiple Risk Factor Intervention Trial, British Regional Heart Study, cardiovascular risk, sex differences
MeSH terms: Adult, Aged, Cardiovascular Diseases, Clinical Trials as Topic, Female, Humans, Cholesterol, HDL, Male, Middle Aged, Prospective Studies, Regression Analysis, Risk Factors, Sex Factors, Statistics as Topic, Cohort Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks