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Cited by 1,411Lipoproteins and Cardiovascular HealthLipid metabolism and disordersDiabetes, Cardiovascular Risks, and Lipoproteins

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Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk

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Austin, M A, King, M C, Vranizan, K M, Krauss, R M·1990·Circulation
DOI 10.1161/01.cir.82.2.495
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Abstract

In a community-based study of 301 subjects from 61 nuclear families, two distinct phenotypes (denoted A and B) were identified by nondenaturing gradient gel electrophoretic analysis of low density lipoprotein (LDL) subclasses. Phenotype A was characterized by predominance of large, buoyant LDL particles, and phenotype B consisted of a major peak of small, dense LDL particles. Previous analysis of the family data by complex segregation analysis demonstrated that these phenotypes appear to be inherited as a single-gene trait. In the present study, the phenotypes were found to be closely associated with variations in plasma levels of other lipid, lipoprotein, and apolipoprotein measurements. Specifically, phenotype B was associated with increases in plasma levels of triglyceride and apolipoprotein B, with mass of very low and intermediate density lipoproteins, and with decreases in high density lipoprotein (HDL) cholesterol, HDL2 mass, and plasma levels of apolipoprotein A-I. Thus, the proposed genetic locus responsible for LDL subclass phenotypes also results in an atherogenic lipoprotein phenotype.

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Citations

Cites

Research works printed but not linked: 13

  1. Lipid Research Clinics Program: The Lipid Research Clinics Coronary Primary Prevention Trial: I. Reduction in incidence of coronary heart disease. JAMA 1984;251:351-364
  2. Heiss G, Tyroler HA: Are apolipoproteins useful for evaluat- ing ischemic heart disease? A brief overview of the literature, in Lippel K (ed): Proceeding ofthe Workshop on Apolipoprotein Quantification. National Institutes of Health publication No. (NIH) 83-1266, 1983, pp 7-19
  3. Krauss RM, Lindgren FT, Williams PT, Kelsy SF, Brensike J, Vranizan K, Detre KM, Levy RI: Intermediate density lipo- proteins and coronary artery disease progression in hypercho- lesterolemic men. Lancet 1987;2:62-66
  4. Ernst N, Fisher M, Smith W, Gordon W, Rifkind BM, Little JA, Mishkel MA, Williams DO: The association of plasma high-density lipoprotein cholesterol with dietary intake and alcohol consumption: The Lipid Research Clinics Program Prevalence Study. Circulation: 1980;62:41-52
  5. Lindgren FT, Jensen LC, Hatch FT: The isolation and quan- titative analysis of serum lipoproteins, in Nelson GJ (ed): Blood Lipids and Lipoproteins. New York, Wiley Interscience, 1972, pp 181-274
  6. Morton NE, Rao DC, Lalouel JM: Methods in genetic epi- demiology, in Klingberg MA (ed): Contributions to Epidemiol- ogy and Biostatistics. Basel, Karger, vol 4, 1983, pp 62-102
  7. Snedecor GW, Cochran WG: Statistical Methods, ed 6. Ames, Iowa, Iowa State University Press, 1967
  8. SAS Users Guide: Basics, Version 5 Edition.
  9. SAS User Guide: Statistics, Version 5 Edition.
  10. Criqui MH, Heiss G, Cohn R, Cowan LD, Suchindran CM, Bangeiwaia S: Triglyceride and Coronary Heart Disease Mortal- ity. The Lipid Research Clinics Follow-up Study presented at the American Heart Association 27th Conference on Cardio- vascular Disease Epidemiology, Chapel Hill, NC, 1987
  11. Steiner G, Schwartz L, Shumak S, Poapst M: The association of increased levels of intermediate density lipoproteins with smoking and coronary heart disease. Circulation 1987; 75:124-130
  12. Swinkels DW, Demacker PNM, Hendricks JCM, van t'Laar A: Low density lipoprotein subfractions and relationship to other risk factors in healthy individuals. Arteriosclerosis 1989; 9:604-613
  13. Krauss RM, Albers JJ, Brunzell JD: An apolipoprotein B- enriched low density lipoprotein subspecies in familial com- bined hyperlipidemia. Clin Res 1983;31:503a

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Metadata

Authors
Austin, M. A., King, M. C., Vranizan, K. M., & Krauss, R. M.
Affiliations
University of California, Berkeley (US)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1990-08
Volume
82
Issue
2
Pages
495-506
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.82.2.495
OpenAlex
W2089286420
Cited by
1,411
References
63
Citations by year
2026: 11 · 2025: 15 · 2024: 17 · 2023: 39 · 2022: 20 · 2021: 26 · 2020: 25 · 2019: 27 · 2018: 17 · 2017: 21 · 2016: 27 · 2015: 42 · 2014: 38 · 2013: 46 · 2012: 39
FWCI
47.63
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Energy (DE-AC03-?, AC03-76SF00098, DEAC03-76SF00098)
  • National Institutes of Health (7r29hl038760-03, 5p01hl018574-26, DE-AC03- 76SF00098)
  • National Heart, Lung, and Blood Institute (HL38760, HL-18574)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
atherogenic lipoprotein phenotype, LDL subclasses, low-density lipoprotein, coronary heart disease risk, genetic markers, single-gene inheritance, apolipoprotein B, apolipoprotein A-I, HDL cholesterol, HDL2, triglycerides, VLDL, intermediate density lipoprotein
MeSH terms
Adolescent, Adult, Aged, Arteriosclerosis, Child, Child, Preschool, Chromosome Mapping, Coronary Disease, Female, Genetic Markers, Humans, Lipids, Lipoproteins, Cholesterol, HDL, Male, Middle Aged, Phenotype, Risk Factors, Triglycerides, Multivariate Analysis

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