Cited by 1,284Iron Metabolism and DisordersAcute Myocardial Infarction ResearchCardiovascular Health and Risk Factors

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High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men

Salonen, J T, Nyyssönen, K, Korpela, H, Tuomilehto, J, Seppänen, R, Salonen, R·1992·Circulation

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Abstract

BACKGROUND: Iron can induce lipid peroxidation in vitro and in vivo in humans and has promoted ischemic myocardial injury in experimental animals. We tested the hypothesis that high serum ferritin concentration and high dietary iron intake are associated with an excess risk of acute myocardial infarction. METHODS AND RESULTS: Randomly selected men (n = 1,931), aged 42, 48, 54, or 60 years, who had no symptomatic coronary heart disease at entry, were examined in the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) in Eastern Finland between 1984 and 1989. Fifty-one of these men experienced an acute myocardial infarction during an average follow-up of 3 years. On the basis of a Cox proportional hazards model adjusting for age, examination year, cigarette pack-years, ischemic ECG in exercise test, maximal oxygen uptake, systolic blood pressure, blood glucose, serum copper, blood leukocyte count, and serum high density lipoprotein cholesterol, apolipoprotein B, and triglyceride concentrations, men with serum ferritin greater than or equal to 200 micrograms/l had a 2.2-fold (95% CI, 1.2-4.0; p less than 0.01) risk factor-adjusted risk of acute myocardial infarction compared with men with a lower serum ferritin. An elevated serum ferritin was a strong risk factor for acute myocardial infarction in all multivariate models. This association was stronger in men with serum low density lipoprotein cholesterol concentration of 5.0 mmol/l (193 mg/dl) or more than in others. Also, dietary iron intake had a significant association with the disease risk in a Cox model with the same covariates. CONCLUSIONS: Our data suggest that a high stored iron level, as assessed by elevated serum ferritin concentration, is a risk factor for coronary heart disease.

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Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Beyond Cholesterol
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Cardiovascular Survey Methods.
Rose, G., & Blackburn, H. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-69-6-1335_2 · Cited by 3,090
BMPD statistical software manual
Dixon, W. (1988) · University of California Press eBooks · Cited by 2,536
Oxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856
Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease.
(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-5-786_2 · Cited by 1,426
Autoantibody against oxidised LDL and progression of carotid atherosclerosis
Salonen, J. T., Korpela, H., Salonen, R., Nyyssönen, K., Ylä‐Herttuala, S., Yamamoto, R., Butler, S., Palinski, W., & Witztum, J. L. (1992) · The Lancet · doi:10.1016/0140-6736(92)90926-t · Cited by 1,311
IRON AND THE SEX DIFFERENCE IN HEART DISEASE RISK
Sullivan, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92463-6 · Cited by 969
Menopause and Coronary Heart Disease
Gordon, T., Kannel, W. B., Hjortland, M. C., & McNAMARA, P. M. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-89-2-157 · Cited by 904

Show all 38 references

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Tang, Y., Zhang, S., Xiong, Y. Y., Zhao, Y., Fu, H., Zhang, H., & Xiong, K.-M. (2003) · Biological Trace Element Research · doi:10.1385/bter:92:2:97 · Cited by 75
Serum albumin concentration and incident type 2 diabetes risk: new findings from a population-based cohort study
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Sullivan, J. L. (1992) · Circulation · doi:10.1161/01.cir.86.3.1036 · Cited by 75
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Virtanen, J. K., Mursu, J., Tuomainen, T., Virtanen, H. E., & Voutilainen, S. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.104109 · Cited by 76
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Sedighi, M., Bahmani, M., Asgary, S., Beyranvand, F., & Rafieian‐Kopaei, M. (2017) · Journal of Research in Medical Sciences · doi:10.4103/1735-1995.202151 · Cited by 78
Lipid-induced changes in intracellular iron homeostasis in vitro and in vivo.
Lenten, B. J. V., Prieve, J., Navab, M., Hama, S. Y., Lusis, A. J., & Fogelman, A. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117898 · Cited by 74
Iron and the Genetics of Cardiovascular Disease
Sullivan, J. L. (1999) · Circulation · doi:10.1161/01.cir.100.12.1260 · Cited by 74
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Sullivan, J. L. (2003) · American Heart Journal · doi:10.1067/mhj.2003.142 · Cited by 72
Dementia-free centenarians
Perls, T. T. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.08.015 · Cited by 74
Erythropoietin for End-Stage Renal Disease
Adamson, J. W., & Eschbach, J. W. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808273390910 · Cited by 72
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Free-radical scavenging by tryptophan and its metabolites through electron transfer based processes
Pérez‐González, A., Alvarez-Idaboy, J. R., & Galano, A. (2015) · Journal of Molecular Modeling · doi:10.1007/s00894-015-2758-2 · Cited by 77
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Hunnicutt, J. N., He, K., & Xun, P. (2014) · Journal of Nutrition · doi:10.3945/jn.113.185124 · Cited by 72
Relative Impact of Hla Phenotype and Cd4–Cd8 Ratios on the Clinical Expression of Hemochromatosis
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Sox, H. C. (1993) · JAMA · doi:10.1001/jama.1993.03510230086042 · Cited by 76
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Authors: Salonen, J. T., Nyyssönen, K., Korpela, H., Tuomilehto, J., Seppänen, R., & Salonen, R.
Affiliations: University of Eastern Finland (FI)
ORCID: Korpela, H
Tuomilehto, J
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1992-09
Volume: 86
Issue: 3
Pages: 803-811
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.86.3.803
OpenAlex: W2065303599
Cited by: 1,284
References: 38
Citations by year: 2026: 8 · 2025: 15 · 2024: 16 · 2023: 17 · 2022: 43 · 2021: 32 · 2020: 27 · 2019: 33 · 2018: 36 · 2017: 42 · 2016: 47 · 2015: 35 · 2014: 38 · 2013: 40 · 2012: 48
FWCI: 34.96
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: serum ferritin, stored iron, acute myocardial infarction, coronary heart disease risk, iron intake, lipid peroxidation, LDL cholesterol, men, Eastern Finland
MeSH terms: Adult, Aging, Diet, Dose-Response Relationship, Drug, Ferritins, Finland, Hemoglobins, Humans, Iron, Cholesterol, LDL, Male, Middle Aged, Myocardial Infarction, Risk Factors, Smoking, Proportional Hazards Models

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High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men

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