Cited by 582Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

Levine, Glenn N., Frei, Balz, Koulouris, Spyridon N., Gerhard, Marie D., Keaney, John F., Vita, Joseph A.·1996·Circulation

DOI 10.1161/01.cir.93.6.1107

Open this paper in CoChat — free account

Abstract

Background In the setting of atherosclerosis, endothelial vasomotor function is abnormal. Increased oxidative stress has been implicated as one potential mechanism for this observation. We therefore hypothesized that an antioxidant, ascorbic acid, would improve endothelium-dependent arterial dilation in patients with coronary artery disease. Methods and Results Brachial artery endothelium-dependent dilation in response to hyperemia was assessed by high-resolution vascular ultrasound before and 2 hours after oral administration of either 2 g ascorbic acid or placebo in a total of 46 patients with documented coronary artery disease. Plasma ascorbic acid concentration increased 2.5-fold 2 hours after treatment (46±8 to 114±11 μmol/L, P =.001). In the prospectively defined group of patients with an abnormal baseline response (<5% dilation), ascorbic acid produced marked improvement in dilation (2.0±0.6% to 9.7±2.0%), whereas placebo had no effect (1.1±1.5% to 1.7±1.5%, P =.003 for ascorbic acid versus placebo). Ascorbic acid had no effect on hyperemic flow or arterial dilation to sublingual nitroglycerin. Conclusions Ascorbic acid reverses endothelial vasomotor dysfunction in the brachial circulation of patients with coronary artery disease. These findings suggest that increased oxidative stress contributes to endothelial dysfunction in patients with atherosclerosis and that endothelial dysfunction may respond to antioxidant therapy.

Integrity signals

Registry

Crossref · 10.1161/01.cir.93.6.1107

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
Role of oxidized low density lipoprotein in atherogenesis.
Witztum, J. L., & Steinberg, D. H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115499 · Cited by 2,675
Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries
Ludmer, P. L., Selwyn, A. P., Shook, T., Wayne, R. R., Mudge, G. H., Alexander, R. W., & Ganz, P. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610233151702 · Cited by 2,422
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,400
Vitamin E Consumption and the Risk of Coronary Heart Disease in Men
Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E. L., Colditz, G. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282004 · Cited by 2,345
Vitamin E Consumption and the Risk of Coronary Disease in Women
Stampfer, M. J., Hennekens, C. H., Manson, J. E., Colditz, G. A., ROSNER, B. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282003 · Cited by 2,085
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870
Self-citation
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765

Flagged first, then by citations

Show all 53 references

Research works printed but not linked: 6

10.1161/res.65.3.2548765 · DOI
10.1161/circ.81.2.2105174 · DOI
10.1161/circ.90.1.8026037 · DOI
10.1161/circ.73.6.3698244 · DOI
Corretti MC, Plotnick GD, Vogel RA. Technical aspects of evaluating brachial artery endothelium-dependent vasodilatation using high frequency ultrasound. Am J Physiol. 1995;268:H1397-H1404.
10.1161/circ.91.5.1525 · DOI

Sorted by citations

Items 401–500 of 581

Reactive hyperemic response of the brachial artery: Comparison of proximal and distal occlusion
Saouaf, R., Arora, S., Smakowski, P., Caballero, A. E., & Veves, A. (1998) · Academic Radiology · doi:10.1016/s1076-6332(98)80207-9 · Cited by 11
Effect of ascorbic acid on forearm reactive hyperaemia in patients with hypercholesterolaemia
Protogerou, A. D., Lekakis, J. P., Kontoyanni, D. D., Stamatelopoulos, K., Tsotsoros, N. D., Papaioannou, T., Tryfonopoulos, D. J., Papamichael, C. M., & Stamatelopoulos, S. (2004) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000095049.46631.b9 · Cited by 11
High-Fat Meals and Endothelial Function
Tomaino, R. M., & Decker, E. A. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb06135.x · Cited by 11
Role of Antioxidants in Horse Serum-mediated Vasculitis in Swine: Potential Relevance to Early Treatment in Mitigation of Coronary Arteritis in Kawasaki Disease
Philip, S., Lee, W., Cherian, K. M., Wu, M., & Lue, H. (2016) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2016.07.007 · Cited by 10
Spectrophotometric analysis of the protective effect of ascorbate against spontaneous oxidation of tetrahydrobiopterin in aqueous solution: kinetic characteristics and potentiation by catalase of ascorbate action
Valent, S., & Tóth, M. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.10.014 · Cited by 10
Pulsatility Index Change of Brachial Artery Shows Better Reproducibility than Flow-Mediated Vasodilation
Lima, J. C., Martins, W. P., Nastri, C. O., Nicolau, L. G., & Filho, F. M. (2010) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2010.09.005 · Cited by 10
Effects of BM-573 on Endothelial Dependent Relaxation and Increased Blood Pressure at Early Stages of Atherosclerosis
Romero, M., Gomez, E. L., Lobysheva, I. I., Rath, G., Dogné, J., Féron, O., & Dessy, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152579 · Cited by 10
Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid
Widlansky, M. E., Biegelsen, E. S., Hamburg, N. M., Duffy, S. J., Keaney, J. F., & Vita, J. A. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.016 · Cited by 10
Self-citation
Oxidants and Endothelial Dysfunction
Lund, A. K. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00712-0 · Cited by 12
The Relationship of Left Ventricular Mass to Endothelium-Dependent Vasodilation of the Brachial Artery in Patients with Hypertension
Motoyama, T., Kawano, H., Hirai, N., Tsunoda, R., Moriyama, Y., Miyao, Y., Sakamoto, T., Yoshimura, M., Kugiyama, K., Yasue, H., et al. (2001) · Cardiology · doi:10.1159/000047380 · Cited by 10
Mechanisms involved in the hemodynamic alterations in congestive heart failure as a basis for a rational pharmacological treatment
Marín, J. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00076-0 · Cited by 10
Lower urinary tract symptoms/benign prostatic hypertrophy and vascular function: Role of the nitric oxide–phosphodiesterase type 5–cyclic guanosine 3′,5′‐monophosphate pathway
Higashi, Y. (2017) · International Journal of Urology · doi:10.1111/iju.13336 · Cited by 10
Vitamin C Deficiency Exacerbates Dysfunction of Atherosclerotic Coronary Arteries in Guinea Pigs Fed a High-Fat Diet
Skovsted, G. F., Skat‐Rørdam, J., Frøkiær, A. P., Jensen, H. E., Tveden‐Nyborg, P., & Lykkesfeldt, J. (2022) · Antioxidants · doi:10.3390/antiox11112226 · Cited by 11
Oxidation by trace Cu2+ ions underlies the ability of ascorbate to induce vascular dysfunction in the rat perfused mesentery
Nelli, S., Craig, J., & Martin, W. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.033 · Cited by 9
Lack of antioxidant activity of the antiatherogenic compound l-arginine
Adams, M. R., Phu, C. V., Stocker, R., & Celermajer, D. S. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00157-4 · Cited by 9
The endothelium: a gynecological and obstetric point of view
Verhaar, M. C., & Rabelink, T. J. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00334-1 · Cited by 9
Relationships between Endothelium-Dependent Vasodilation, Serum Vitamin E and Plasma Isoprostane 8-Iso-PGF2α Levels in Healthy Subjects
Sarabi, M., Vessby, B. O., Basu, S., Millgård, J., & Lind, L. (1999) · Journal of Vascular Research · doi:10.1159/000025691 · Cited by 9
Impaired hemodynamic response to exercise in patients with peripheral artery disease: evidence of a link to inflammation and oxidative stress
Craig, J. C., Hart, C. R., Layec, G., Kwon, O. S., Richardson, R. S., & Trinity, J. D. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00159.2022 · Cited by 8
Effect of Vitamins and Dietary Supplements on Cardiovascular Health
Goudarzi, S., Montazerin, S. M., Najafi, H., Shojaei, F., & Chi, G. (2020) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/hpc.0000000000000212 · Cited by 8
Does Vitamin C improve endothelial function in patients with Kawasaki disease?
Sabri, M. R., Tavana, E. N., Ahmadi, A., & Mostafavy, N. (2015) · Europe PMC (PubMed Central) · Cited by 8
Effect of transfusion on the endothelium dependent dilatation of brachial artery in patients with chronic anemia.
Nagy, L., Tóth, K., Rőth, E., & Tarján, J. (1999) · PubMed · Cited by 8
Strategies to Improve Endothelial Function and its Clinical Relevance to Erectile Dysfunction
Aversa, A. (2008) · European Urology Supplements · doi:10.1016/j.eursup.2008.10.008 · Cited by 8
Diurnal variation of flow-mediated dilatation in healthy humans
Kim, Y., Yun, K. H., Woo, S. H., Jeong, Y., Lim, J. H., Hwang, K. B., Jeong, J. W., Lee, M. R., Lee, J. M., Rhee, S. J., et al. (2015) · Clinical Hypertension · doi:10.1186/s40885-015-0019-4 · Cited by 7
Effects of modest hyperoxia and oral vitamin C on exercise hyperaemia and reactive hyperaemia in healthy young men
Caruana, H., & Marshall, J. M. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3182-0 · Cited by 7
Synergistic Application of Zinc and Vitamin C to Support Memory and Attention and to Decrease the Risk of Developing Nervous System Diseases
Громова, О. А., Torshin, I. Y., Пронин, А. В., & Kilchevsky, M. A. (2019) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-019-00740-0 · Cited by 7
Contrast-Induced Nephropathy
Shawky, A., & Abdelsalam, T. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.90457 · Cited by 7
Review: Interaction among angiotensin II, nitric oxide and oxidative stress
Zhou, M.-S., Adam, A., & Raij, L. R. (2001) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/14703203010020011001 · Cited by 7
Features of Cardiac Allograft Coronary Endothelial Dysfunction
Raichlin, E., Kushwaha, S. S., Lennon, R. J., Frantz, R. P., Edwards, B. S., Prasad, A., Rihal, C. S., & Lerman, A. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.12.039 · Cited by 7
Gender and Its Impact on Risk Factors for Cardiovascular Disease
Bassuk, S. S., & Manson, J. E. (2004) · Principles of Gender-Specific Medicine · doi:10.1016/b978-012440905-7/50286-3 · Cited by 7
Atherosklerose und Urämie: Die Bedeutung nicht-traditioneller Risikofaktoren
Hörl, W. H. (2003) · Wiener klinische Wochenschrift · doi:10.1007/bf03040320 · Cited by 7
Nitric Oxide and Endothelial Dysfunction
Dillon, G. A., & Vita, J. A. (2000) · doi:10.1007/978-1-59259-002-5_13 · Cited by 7
Self-citation
Function of Vascular Endothelium
Wilson, S. H., & Lerman, A. (2001) · Elsevier eBooks · doi:10.1016/b978-012656975-9/50029-8 · Cited by 6
Daily White kwao krua dietary supplement alleviates LDL oxidative susceptibility, plasma LDL level and improves vasculature in a hypercholesterolemia rabbit model
Ratanachamnong, P., Phivthong‐ngam, L., & Namchaiw, P. (2020) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2020.05.001 · Cited by 6
Effect of smoking on vitamin C and MDA: a cross sectional comparative study
Kubihal, C. V., & Naik, H. D. (2019) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20190511 · Cited by 6
Lifestyle behaviors and serum vitamin C in the Thai population in Bangkok Metropolitan
Boonpangrak, S., Tantimongcolwat, T., Treeratanapiboon, L., Leelahakul, P., & Prachayasittikul, V. (2018) · EXCLI journal · doi:10.17179/excli2018-1203 · Cited by 6
Vitamin C twice a day enhances health
Ordman, A. R. (2010) · Health · doi:10.4236/health.2010.28123 · Cited by 6
Vitamin C Deficiency Exerts Paradoxical Cardiovascular Effects in Osteogenic Disorder Shionogi (ODS) Rats
Vergely, C., Goirand, F., Laubriet, A., Renard, C., Moreau, D., Guilland, J.-C., Dumas, M., & Rochette, L. (2004) · Journal of Nutrition · doi:10.1093/jn/134.4.729 · Cited by 6
Endotheliale Funktionsstörung bei Patienten mit akutem Koronarsyndrom
Fichtlscherer, S., & Zeiher, A. M. (1999) · Herz · doi:10.1007/bf03044225 · Cited by 6
Bewegungstherapie bei koronarer Herzkrankheit
Niederseer, D., & Niebauer, J. (2010) · Springer eBooks · doi:10.1007/978-3-642-01332-4_10 · Cited by 6
Antioxidants and Restenosis: Animal Studies
Lafont, A. M., Vinchon, F., Addad, F., & Durand, É. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-94-011-4375-2_11 · Cited by 6
The 1998 Nobel prize in Medicine: clinical implications for 1999 and beyond
Cooke, J. P. (1999) · Vascular Medicine · doi:10.1177/1358836x9900400201 · Cited by 6
Smoking Cessation Reverses Arterial Endothelium-Dependent Relaxation Injury
Mays, B. W., Ripple, T., Eginton, M. T., Seabrook, G. R., Cambria, R. A., Towne, J. B., & Freischlag, J. A. (1998) · Vascular Surgery · doi:10.1177/153857449803200502 · Cited by 6
Antioxidant therapy of endothelialdysfunction
Tyurenkov, I. N., Voronkov, A. V., Альбертовна, С. А., Dorkina, Y. G., & Snigur, G. L. (2013) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf11114-25 · Cited by 5
The Antioxidant Hypothesis
Bierl, C., Forgione, M. A., & Loscalzo, J. (2006) · Developments in cardiovascular medicine · doi:10.1007/0-387-29553-4_4 · Cited by 5
Nitric oxide delivery from polymeric wound dressings
Bhide, M. (2009) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 5
OBSOLETE: Relationship Between Vegetables and Fruits (Antioxidant Vitamins, Minerals, and Fiber) Intake and Risk of Cardiovascular Disease
Iso, H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99601-6 · Cited by 5
Oxidants and Endothelial Dysfunction
Lund, A. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65250-9 · Cited by 6
High dose ascorbic acid does not reverse central sympathetic overactivity in chronic heart failure
Gomes, M. E., Messaoudi, S. E., Lenders, J. W. M., Bellersen, L., Verheugt, F. W. A., Smits, P., & Tack, C. J. (2010) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2010.01205.x · Cited by 5
Nutraceuticals in the Early Infancy
Pignatelli, P., & Basili, S. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00194.x · Cited by 5
Human Studies of Antioxidants and Vascular Function
Biegelsen, E. S., & Vita, J. A. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-4649-8_12 · Cited by 6
Self-citation
The effects of vitamin C and nitric oxide synthase inhibition on coronary flow and oxidative stress markers in isolated rat heart
Jakovljevic, V. L., Djordjevic, D. Z., & Djuric, D. M. (2011) · General Physiology and Biophysics · doi:10.4149/gpb_2011_03_293 · Cited by 5
Antioxidantes y enfermedad vascular
Mendivil, C. O., Sierra, I. D., Pérez, C., & Abad, B. H. (2002) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(02)78822-0 · Cited by 5
Clinical significance of myocardial perfusion abnormalities in patients with varying degree of coronary artery stenosis
Rasulova, N., Singh, A., Demetriadou, O., Georgiou, G. M., Yiannakkaras, C., Khodjibekov, M., & AL-NAHHAS, A. M. (2008) · Nuclear Medicine Communications · doi:10.1097/mnm.0b013e3282f30461 · Cited by 5
Maintaining the Endothelium: Preventive Strategies for Vessel Integrity
Lissin, L. W., & Cooke, J. P. (2001) · Preventive Cardiology · doi:10.1111/j.1520-037x.2001.90810.x · Cited by 5
Vitamin C protects against lysophosphatidylcholine-induced expression of monocyte chemoattractant protein-1 in cultured human umbilical vein endothelial cells.
Pan, J. P., Cheng, T., Chou, S.-C., & Lai, S. T. (2003) · PubMed · Cited by 5
Determination of vitamins in five selected West African green leafy vegetables
Adetutu, A., Adesokan, A. A., & Alani, E. A. (2013) · Cited by 5
Assessment of the Antioxidant/Hypolipidemic Relationship of Sideritis hyssopifolia in an Experimental Animal Model
Coto, E., Fernández, N., Garcia, J. J., Diez, M. J., Sahagún, A. M., & Sierra, M. (2019) · Molecules · doi:10.3390/molecules24112049 · Cited by 7
Requirement for flow in the blockade of endothelium‐derived hyperpolarizing factor (EDHF) by ascorbate in the bovine ciliary artery
Nelli, S., Dowell, F. J., Wilson, W. S., Stirrat, A., & Martin, W. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705816 · Cited by 5
Vascular basis for the treatment of myocardial ischemia study: Trial design and baseline characteristics
Stone, P. H., Lloyd‐Jones, D. M., Johnstone, M. T., Carlson, W., Rubenstein, J. J., Creager, M. A., Frei, B. B., Sopko, G. S., Clark, M. E., MacCallum, G., et al. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.10.046 · Cited by 5
Self-citation
Relationship Between Vegetables and Fruits (Antioxidant Vitamins, Minerals, and Fiber) Intake and Risk of Cardiovascular Disease
ISHIHARA, J., Umesawa, M., Okada, C., Kokubo, Y., & Iso, H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809657-4.99601-7 · Cited by 5
RETRACTED: The effect of vitamin C on the JAK/STAT3 pathway in ischemic stroke: based on the molecular interaction between FOXP3 protein and stat3 protein
Lyu, G., Wei, W., Fan, X., Zhong, D., & Li, G. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144069 · Cited by 4
Retracted
The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular health as mice age
Dyson, N., Khambata, R. S., Parakaw, T., Massimo, G., Khuat, N. H., Noor, A. A., Gee, L. C., Lim, I., Siddique, U., Sullivan, A. J., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103923 · Cited by 6
Antioxidants and cardiovascular diseases
Mandal, A., Hossain, U., & Sil, P. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819096-8.00072-0 · Cited by 4
Nitric Oxide and Cardiovascular Diseases: Cardioprotection, Complications and Therapeutics
Kumar, G., Dey, S. K., & Kundu, S. (2023) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-24778-1_3 · Cited by 4
Oxidative Stress, Endothelial Dysfunction, and Its Impact on Smooth Muscle Signaling
Münzel, T. F., & Gori, T. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381510-1.00091-0 · Cited by 4
Antiatherogene Wirkungsmechanismen des körperlichen Trainings bei Patienten mit koronarer Herzkrankheit
Niebauer, J., & Schuler, G. (2001) · Zeitschrift für Kardiologie · doi:10.1007/s003920170078 · Cited by 4
Rationale for Use of Vitamin and Mineral Supplements
Perelson, A., & Ellenbogen, L. (2001) · CRC Press eBooks · doi:10.1201/9781420038392-77 · Cited by 4
Evaluación de la función endotelial por eco-Doppler. Influencia de la edad, sexo y factores de riesgo
Vilariño, J. O., Cacharrón, J. L., Suarez, D. H., Kura, M., Machado, R. A., Bolaño, A. L., & Esper, R. J. (2026) · Revista Argentina de Cardiología · doi:10.7775/rac.v66i5.3769 · Cited by 4
General Concepts about Oxidative Stress
Landmesser, U., & Drexler, H. (2006) · Developments in cardiovascular medicine · doi:10.1007/0-387-29553-4_1 · Cited by 4
Atherosclerosis, Oxidative Stress, and Endothelial Function
Keaney, J. F. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-4649-8_9 · Cited by 4
Self-citation
Vitamin C and Endothelial Dysfunction: What Is New?
Ceriello, A. (1999) · Circulation · doi:10.1161/circ.99.9.1272/a · Cited by 4
Ascorbic Acid and Endothelial NO Synthesis
Packer, L. (2003) · AOCS Publishing eBooks · doi:10.4324/9780429270710-5 · Cited by 4
Smoking and Oxidative Stress: Vascular Damage
Münzel, T. F., Post, F., & Warnholtz, A. (2007) · Springer eBooks · doi:10.1007/3-540-32232-9_13 · Cited by 3
Effect of Hyperbaric Oxygen on Flow-Mediated Vasodilation
Sağlam, M., Bozlar, U., Kantarcı, F., Ay, H., Battal, B., & Coşkun, Ü. (2008) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2008.27.2.209 · Cited by 3
Exercise and the Endothelium
Tremblay, J. C., & Pyke, K. E. (2019) · Springer eBooks · doi:10.1007/978-3-030-04816-7_6 · Cited by 3
Potential Benefi ts for the Use of Vitamin and Mineral Supplements
Cotter, R. L., Moreines, J., & Ellenbogen, L. (2007) · CRC Press eBooks · doi:10.1201/9781420008890-15 · Cited by 3
Metal-to-Ligand Charge-Transfer-based Visual Detection of Alkaline Phosphatase Activity
He, M., Hu, Q., Mei, Y., Zhou, B., Kong, J., & Zhang, X. (2018) · Analytical Sciences · doi:10.2116/analsci.34.341 · Cited by 3
Micronutrients and Cardiovascular Disease
WATSON, R. R., & Preedy, V. R. (2003) · CRC Press eBooks · doi:10.1201/9780203507629-12 · Cited by 3
Oxidant injury and antioxidant prevention: Role of dietary antioxidants, minerals, and drugs in the management of coronary heart disease [Part II]
Pandya, D. P. (2002) · Comprehensive Therapy · doi:10.1007/s12019-002-0043-7 · Cited by 3
RESTORATION OF NITRIC OXIDE FUNCTION IN HUMAN HYPERLIPIDAEMIA, CONGESTIVE HEART FAILURE AND LIVER CIRRHOSIS
Chin-Dusting, J. P. F., & Kaye, D. M. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02271.x · Cited by 3
Evidence exists for some advertising claims made on the internet
Lawson, S. (1999) · BMJ · doi:10.1136/bmj.318.7196.1484 · Cited by 3
Vitamin C and Cardiovascular Diseases
Carr, A. C., & Frei, B. B. (2001) · doi:10.1201/9780203904046-14 · Cited by 3
Self-citation
Vitamin C
Ball, G. F. M. (2004) · Wiley eBooks · doi:10.1002/9780470774571.ch19 · Cited by 3
Antioxidants and Endothelium-Derived Nitric Oxide Action
Huang, A., & Keaney, J. F. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-002-5_26 · Cited by 3
Self-citation
Oxidants and Endothelial Dysfunction
Lund, A. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00071-1 · Cited by 2
Oxidative Stress in the Development of Diabetes and its Complications
Chiasson, J., RABASA-LHORET, R. P. R., & Srivastava, A. K. (2006) · Developments in cardiovascular medicine · doi:10.1007/0-387-29553-4_16 · Cited by 2
The Endothelium and Cardiovascular Disease – A Mini Review
El‐Sabban, F. M. F. (2015) · MOJ Anatomy & Physiology · doi:10.15406/mojap.2015.01.00011 · Cited by 2
Lipoproteins and Apoproteins
Citkowitz, E., & Herbert, P. N. (1999) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-5007-5_3 · Cited by 2
Vitamin C and Cardiovascular Diseases
Frei, B. B., & Carr, A. C. (2001) · CRC Press eBooks · doi:10.1201/9780203904046.ch8 · Cited by 2
Self-citation
Assessing Age-Related Changes in Antioxidant Status: The FRASC Assay for Total Antioxidant Power and Ascorbic Acid Concentration in Biological Fluids
Benzie, I. F. F., & Strain, J. (2003) · Humana Press eBooks · doi:10.1385/1-59259-070-5:133 · Cited by 2
Oxidants and Vascular Nitric Oxide Signaling
Wolin, M. S., Gupte, S. A., Iesaki, T., & Mohazzab-H., K. M. (2000) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-1326-0_3 · Cited by 2
Antioxidants and hypertension: another false dawn?
McInnes, G. T. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000186834.86867.96 · Cited by 2
Ascorbate elevates perfusion pressure in the bovine extraocular long posterior ciliary artery: Role of endothelium-derived hyperpolarizing factor (EDHF)
Stirrat, A., Nelli, S., McGuckin, A., Ho, V. W. M., Wilson, W. S., & Martin, W. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.01.029 · Cited by 2
Clinical Assessment of Endothelial Function
Vita, J. A. (2002) · Springer eBooks · doi:10.1007/978-3-642-56225-9_46 · Cited by 2
Self-citation
Therapeutische Optionen zur Verbesserung der Myokardperfusion bei koronarer Atherosklerose
Schächinger, V. (1998) · Herz · doi:10.1007/bf03044542 · Cited by 2
Endothelial Function and Insights for Prevention
Lieberman, E. H., Garces, M. R., & López-Jiménez, F. A. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-096-6_2 · Cited by 2
EFFECTS OF ANTIOXIDANT ON CARDIOVASCULAR PERFORMANCE, EXERCISE CAPACITY, AND FUNCTIONAL STATUS IN PATIENTS WITH CHRONIC HEART FAILURE
Ho, C.-C. (2007) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1
A comparative study between Antioxidant vitamin and Kellgren–Lawrence grading scale in knee osteoarthritis patients
Dawn, I., Sarkar, S., & De, C. (2013) · Bangladesh Journal of Medical Science · doi:10.3329/bjms.v13i1.14046 · Cited by 1
Ascorbic acid attenuates the pressor response to voluntary apnea in postmenopausal women
Randolph, B. J., Patel, H. M., & Muller, M. D. (2015) · Physiological Reports · doi:10.14814/phy2.12384 · Cited by 1
Blood pressure control in chronic hemodialysis patients
London, G. M., Marchais, S. J., Guérin, A. P., & Métivier, F. (2004) · Springer eBooks · doi:10.1007/978-1-4020-2275-3_29 · Cited by 1

Authors: Levine, G. N., Frei, B., Koulouris, S. N., Gerhard, M. D., Keaney, J. F., & Vita, J. A.
Affiliations: Boston University (US)
ORCID: Levine, Glenn N.
Keaney, John F.
Vita, Joseph A.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-03-15
Volume: 93
Issue: 6
Pages: 1107-1113
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.93.6.1107
OpenAlex: W2035433779
Cited by: 582
References: 53
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 12 · 2018: 8 · 2017: 12 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 14 · 2012: 12
FWCI: 34.16
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: National Institutes of Health (1f32hl008635-01, 7r29hl049954-05, 1r01hl053398-01a1)
National Heart, Lung, and Blood Institute (HL 53398, HL-08635, HL49954)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: vitamin C, endothelial dysfunction, endothelium-dependent vasodilation, coronary artery disease, oxidative stress, antioxidant therapy, brachial artery, atherosclerosis, hyperemic flow
MeSH terms: Adult, Aged, Aged, 80 and over, Antioxidants, Ascorbic Acid, Coronary Circulation, Coronary Disease, Endothelium, Vascular, Female, Humans, Male, Middle Aged, Nitric Oxide, Vasodilation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks