The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease
Abstract
Background In the setting of atherosclerosis, endothelial vasomotor function is abnormal. Increased oxidative stress has been implicated as one potential mechanism for this observation. We therefore hypothesized that an antioxidant, ascorbic acid, would improve endothelium-dependent arterial dilation in patients with coronary artery disease. Methods and Results Brachial artery endothelium-dependent dilation in response to hyperemia was assessed by high-resolution vascular ultrasound before and 2 hours after oral administration of either 2 g ascorbic acid or placebo in a total of 46 patients with documented coronary artery disease. Plasma ascorbic acid concentration increased 2.5-fold 2 hours after treatment (46±8 to 114±11 μmol/L, P =.001). In the prospectively defined group of patients with an abnormal baseline response (<5% dilation), ascorbic acid produced marked improvement in dilation (2.0±0.6% to 9.7±2.0%), whereas placebo had no effect (1.1±1.5% to 1.7±1.5%, P =.003 for ascorbic acid versus placebo). Ascorbic acid had no effect on hyperemic flow or arterial dilation to sublingual nitroglycerin. Conclusions Ascorbic acid reverses endothelial vasomotor dysfunction in the brachial circulation of patients with coronary artery disease. These findings suggest that increased oxidative stress contributes to endothelial dysfunction in patients with atherosclerosis and that endothelial dysfunction may respond to antioxidant therapy.
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“Hyperglycemic patients experiencing vasodilation have a positive effect following intravenous administration (24 mg/min for 10 min) or oral dose (6 g during 2 days) (Levine et al. 1996).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Levine et al. 1996
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Metadata
- Authors
- Levine, G. N., Frei, B., Koulouris, S. N., Gerhard, M. D., Keaney, J. F., & Vita, J. A.
- Affiliations
- Boston University (US)
- Venue
- Circulation
- Published
- 1996-03-15
- Volume
- 93
- Issue
- 6
- Pages
- 1107-1113
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2035433779
- Cited by
- 582
- References
- 53
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 12 · 2018: 8 · 2017: 12 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 14 · 2012: 12
- FWCI
- 34.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1f32hl008635-01, 7r29hl049954-05, 1r01hl053398-01a1)
- National Heart, Lung, and Blood Institute (HL 53398, HL-08635, HL49954)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- vitamin C, endothelial dysfunction, endothelium-dependent vasodilation, coronary artery disease, oxidative stress, antioxidant therapy, brachial artery, atherosclerosis, hyperemic flow
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antioxidants, Ascorbic Acid, Coronary Circulation, Coronary Disease, Endothelium, Vascular, Female, Humans, Male, Middle Aged, Nitric Oxide, Vasodilation
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