The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Role of the Pulmonary Circulation in the Distribution of Human Fetal Cardiac Output During the Second Half of Pregnancy
Abstract
Background By using Doppler echocardiography, we determined the normal distribution of human fetal combined cardiac output (CCO) from the left and right ventricles. We also established weight-indexed pulmonary and systemic vascular resistances (R Pi and R Si , respectively) and changes during the second half of pregnancy. Methods and Results Blood flows at the aortic and pulmonary valve annuli (LVCO and RVCO, respectively), right and left pulmonary arteries (Q P ), and ductus arteriosus (Q DA ) were calculated in 63 normal fetuses. Foramen ovale blood flow (Q FO =LVCO−Q P ) was estimated. From 20 to 30 weeks of gestation, the proportion of Q P of the CCO increased (from 13% to 25%, P <.001), while the proportion of Q FO decreased (from 34% to 18%, P <.001). After 30 weeks, the proportions of Q P and Q FO were unchanged. At 38 weeks, the proportion of RVCO (60%) was higher ( P <.05) than that of LVCO (40%). The proportion of Q DA did not change significantly. The correlation between RVCO calculated from blood flow through the pulmonary valve and from Q DA and Q P was good ( r =.97, P <.0001). R Pi ( P <.001) decreased from 20 to 30 weeks of gestation. From 30 to 38 weeks, R Pi increased ( P <.0001). R Si increased ( P <.001) from 20 to 38 weeks. The ratio of R Pi to R Si decreased ( P <.01) from 20 to 30 weeks and later remained unchanged. Conclusions The human fetal pulmonary circulation has an important role in the distribution of cardiac output.
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Circulatory Changes during Growth in the Fetal Lamb
RUDOLPH, A. M., & HEYMANN, M. A. (1970) · Circulation Research · doi:10.1161/01.res.26.3.289 · Cited by 487
Versmold, H. T., Kitterman, J. A., Phibbs, R. H., Gregory, G. A., & Tooley, W. H. (1981) · Pediatrics · doi:10.1542/peds.67.5.607 · Cited by 328
Kenny, J. F., Plappert, T., Doubilet, P., Saltzman, D. H., Cartier, M., Zollars, L., Leatherman, G. F., & St John Sutton, M. G. (1986) · Circulation · doi:10.1161/01.cir.74.6.1208 · Cited by 249
Cardiac Doppler flow velocities in human fetuses.
Reed, K. L., Meijboom, E. J., Sahn, D. J., Scagnelli, S. A., Valdes-Cruz, L. M., & Shenker, L. (1986) · Circulation · doi:10.1161/01.cir.73.1.41 · Cited by 231
Methodology and basic problems related to blood flow studies in the human fetus
Eik-Nes, S. H., Maršál, K., & Kristoffersen, K. (1984) · Ultrasound in Medicine & Biology · doi:10.1016/0301-5629(84)90167-4 · Cited by 194
Huhta, J. C., Moise, K. J., Fisher, D. J., Sharif, D. S., Wasserstrum, N., & Martin, C. (1987) · Circulation · doi:10.1161/01.cir.75.2.406 · Cited by 184
Self-citationFetal cardiac output estimated by Doppler echocardiography during mid- and late gestation
De Smedt, M. C. H., Visser, G. H. A., & Meijboom, E. J. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)90238-4 · Cited by 181
Studies on the Circulation of the Previable Human Fetus
Rudolph, A. M., Heymann, M. A., Teramo, K. A., Barrett, C. T., & Räihä, N. C. R. (1971) · Pediatric Research · doi:10.1203/00006450-197109000-00003 · Cited by 148
Development of pulmonary vascular response to oxygen
Morin, F. C., Egan, E. A., Ferguson, W., & Lundgren, C. E. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.254.3.h542 · Cited by 132
Cited by
Donofrio, M. T., Moon-Grady, A. J., Hornberger, L. K., Copel, J. A., Sklansky, M. S., Abuhamad, A., Cuneo, B. F., Huhta, J. C., Jonas, R. A., Krishnan, A., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437597.44550.5d · Cited by 1,275
Self-citationThe Transitional Heart: From Early Embryonic and Fetal Development to Neonatal Life
Tan, C. M. J., & Lewandowski, A. J. (2020) · Fetal Diagnosis and Therapy · doi:10.1159/000501906 · Cited by 253
Physiology of the fetal circulation
Kiserud, T. (2005) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2005.08.007 · Cited by 253
Prsa, M., Sun, L., van Amerom, J., Yoo, S.-J., Grosse-Wortmann, L., Jaeggi, E., Macgowan, C., & Seed, M. (2014) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.113.001859 · Cited by 168
Metadata
- Authors
- Rasanen, J., Wood, D. C., Weiner, S., Ludomirski, A., & Huhta, J. C.
- Venue
- Circulation
- Published
- 1996-09
- Volume
- 94
- Issue
- 5
- Pages
- 1068-1073
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2017055786
- Cited by
- 347
- References
- 13
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rasanen, J., Wood, D. C., Weiner, S., Ludomirski, A., & Huhta, J. C. (1996). Role of the Pulmonary Circulation in the Distribution of Human Fetal Cardiac Output During the Second Half of Pregnancy. Circulation. https://doi.org/10.1161/01.cir.94.5.1068
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