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Cited by 482

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Active Serum Vitamin D Levels Are Inversely Correlated With Coronary Calcification

Watson, Karol E., Abrolat, Marla L., Malone, Lonzetta L., Hoeg, Jeffrey M., Doherty, Terry, Detrano, Robert, Demer, Linda L.·1997·Circulation

Abstract

Background Arterial calcification is a common feature of atherosclerosis, occurring in >90% of angiographically significant lesions. Recent evidence from this and other studies suggests that development of atherosclerotic calcification is similar to osteogenesis; thus, we undertook the current investigation on the potential role of osteoregulatory factors in arterial calcification. Methods and Results We studied two human populations (173 subjects) at high and moderate risk for coronary heart disease and assessed them for associations between vascular calcification and serum levels of the osteoregulatory molecules osteocalcin, parathyroid hormone, and 1α,25-dihydroxyvitamin D 3 (1,25-vitamin D). Our results revealed that 1,25-vitamin D levels are inversely correlated with the extent of vascular calcification in both groups. No correlations were found between extent of calcification and levels of osteocalcin or parathyroid hormone. Conclusions These data suggest a possible role for vitamin D in the development of vascular calcification. Vitamin D is also known to be important in bone mineralization; thus, 1,25-vitamin D may be one factor to explain the long observed association between osteoporosis and vascular calcification.

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Crossref · 10.1161/01.cir.96.6.1755

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Metadata

Authors
Watson, K. E., Abrolat, M. L., Malone, L. L., Hoeg, J. M., Doherty, T., Detrano, R., & Demer, L. L.
Venue
Circulation
Published
1997-09-16
Volume
96
Issue
6
Pages
1755-1760
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2000458563
Cited by
482
References
1
FWCI
5.72
Type
journal article
Language
en
Open access
closed

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