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Cited by 1,005Cardiovascular and exercise physiologyBlood Pressure and Hypertension StudiesPhysical Activity and Health

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Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors

Cornelissen, Véronique A., Fagard, Robert H.·2005·Hypertension
DOI 10.1161/01.hyp.0000184225.05629.51
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Abstract

Previous meta-analyses of randomized controlled trials on the effects of chronic dynamic aerobic endurance training on blood pressure reported on resting blood pressure only. Our aim was to perform a comprehensive meta-analysis including resting and ambulatory blood pressure, blood pressure–regulating mechanisms, and concomitant cardiovascular risk factors. Inclusion criteria of studies were: random allocation to intervention and control; endurance training as the sole intervention; inclusion of healthy sedentary normotensive or hypertensive adults; intervention duration of ≥4 weeks; availability of systolic or diastolic blood pressure; and publication in a peer-reviewed journal up to December 2003. The meta-analysis involved 72 trials, 105 study groups, and 3936 participants. After weighting for the number of trained participants and using a random-effects model, training induced significant net reductions of resting and daytime ambulatory blood pressure of, respectively, 3.0/2.4 mm Hg ( P <0.001) and 3.3/3.5 mm Hg ( P <0.01). The reduction of resting blood pressure was more pronounced in the 30 hypertensive study groups (−6.9/−4.9) than in the others (−1.9/−1.6; P <0.001 for all). Systemic vascular resistance decreased by 7.1% ( P <0.05), plasma norepinephrine by 29% ( P <0.001), and plasma renin activity by 20% ( P <0.05). Body weight decreased by 1.2 kg ( P <0.001), waist circumference by 2.8 cm ( P <0.001), percent body fat by 1.4% ( P <0.001), and the homeostasis model assessment index of insulin resistance by 0.31 U ( P <0.01); HDL cholesterol increased by 0.032 mmol/L −1 ( P <0.05). In conclusion, aerobic endurance training decreases blood pressure through a reduction of vascular resistance, in which the sympathetic nervous system and the renin-angiotensin system appear to be involved, and favorably affects concomitant cardiovascular risk factors.

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  1. 10.1097/00004872-200306000-00001 · DOI
  2. 10.1249/01.MSS.0000115224.88514.3A · DOI
  3. 10.1097/00005768-200106001-00018 · DOI · Paper page
  4. Fagard R M’Buyamba JR Staessen J Vanhees L Amery A. Physical activity and blood pressure. In: Bulpitt CJ ed. Handbook of Hypertension. Vol 6: Epidemiology of Hypertension. Amsterdam the Netherlands: Elsevier Science; 1985: 104–130.
  5. Fagard RH Tipton CM. Physical activity fitness and hypertension. In: Bouchard C Shephard RJ Stephens T eds. Physical Activity Fitness and Health. Champaign Ill: Human Kinetics; 1994: 633–655.
  6. 10.1097/00005768-199911001-00022 · DOI
  7. 10.1016/0002-9343(69)90054-0 · DOI
  8. Gettman LR, Pollock ML, Durstine JL, Ward A, Ayres J, Linnerud AC. Physiological responses of men to 1, 3 and 5 day per week training programs. Res Q. 1976; 47: 638–645.
  9. Myrtek M, Villinger U. Psychologische und physiologische Wirkungen eines fünfwöchigen Ergometertrainings bei Gesunden. Med Klin. 1976; 71: 1623–1630.
  10. Lansimies E Hietanen E Huttunen JK Hanninen O Kukkonen K Rauramaa R Voutilainen E. Metabolic and hemodynamic effects of physical training in middle-aged men—a controlled trial. In: Komi PV Nelson RC Morehouse CA eds. Exercise and Sport Biology. Champaign Ill: Human Kinetics; 1979: 199–206.
  11. De Plaen JF, Detry JM. Hemodynamic effects of physical training in established arterial hypertension. Acta Cardiol. 1980; 35: 179–188.
  12. Kukkonen K, Rauramaa R, Voutilainen E, Lansimies E. Physical training of middle-aged men with borderline hypertension. Ann Clin Res. 1982; 14 (suppl 34): 139–145.
  13. 10.1001/jama.1985.03360180113036 · DOI
  14. 10.1161/circ.73.1.3510088 · DOI
  15. 10.1016/S0140-6736(86)90354-5 · DOI
  16. 10.1161/01.hyp.9.3.245 · DOI
  17. 10.1016/0002-9149(88)91370-7 · DOI
  18. Vroman NB, Healy JA, Kertzer R. Cardiovascular response to lower body negative pressure (LBNP) following endurance training. Aviat Space Environ Med. 1988; 59: 330–334.
  19. 10.1016/0002-9149(89)90533-X · DOI
  20. Tanabe Y, Urata H, Kiyonaga A, Ikeda M, Tanak H, Shindo M, Arakawa K Changes in serum concentrations of taurine and other amino acids in clinical antihypertensive exercise therapy. Clin Exper Hypertens. 1989; A11: 149–165.
  21. 10.1016/0002-9149(89)90145-8 · DOI
  22. 10.1055/s-2007-1024832 · DOI
  23. 10.1161/circ.81.5.2184945 · DOI
  24. 10.1097/00004872-199009000-00010 · DOI
  25. Oluseye KA. Cardiovascular responses to exercise in Nigerian women. J Hum Hypertens. 1990; 4: 77–79.
  26. Coconie CC, Graves JE, Pollock ML, Philips MI, Sumners C, Hagberg JM. Effect of exercise training on blood pressure in 70- to 79-yr-old men and women. Med Sci Sports Exerc. 1991; 23: 505–511.
  27. 10.1001/jama.1991.03470230053030 · DOI
  28. 10.1001/jama.1991.03470110081037 · DOI · Paper page
  29. 10.1161/01.hyp.18.5.575 · DOI · Paper page
  30. 10.1016/0022-3999(92)90111-E · DOI
  31. De Geus EJC, Kluft C, De Bart ACW, Van Doornen LJP. Effects of exercise training on plasminogen activator inhibitor activity. Med Sci Sports Exerc. 1992; 24: 1210–1219.
  32. Hamdorf PA, Withers RT, Penhall RK, Haslam MV. Physical training effects on the fitness and habitual activity patterns of elderly women. Arch Phys Med Rehabil. 1992; 73: 603–608.
  33. 10.1111/j.1532-5415.1992.tb01820.x · DOI
  34. 10.1016/0021-9150(93)90042-S · DOI
  35. 10.5694/j.1326-5377.1993.tb121740.x · DOI
  36. 10.1161/circ.88.6.8252694 · DOI
  37. 10.1016/0002-9149(94)90294-1 · DOI
  38. Lindheim SR, Notelovitz M, Feldman EB, Larsen S, Khan FY, Lobo RA. The independent effects of exercise and estrogen on lipids and lipoproteins in postmenopausal women. Obstet Gynecol. 1994; 83: 167–172.
  39. 10.1097/00004872-199403000-00011 · DOI
  40. 10.1055/s-2007-1021012 · DOI
  41. 10.3109/08037059509077619 · DOI
  42. Arroll B. Salt restriction and physical activity in treated hypertensives. N Z Med J. 1995; 108: 266–268.
  43. 10.1161/atvb.15.10.1668 · DOI
  44. 10.1080/08964289.1996.9933757 · DOI
  45. 10.1097/00004872-199606000-00015 · DOI
  46. 10.1097/00008483-199605000-00006 · DOI
  47. 10.1097/00005768-199609000-00004 · DOI
  48. 10.1097/00004872-199611000-00017 · DOI
  49. 10.1097/00004872-199715060-00012 · DOI
  50. 10.1152/jappl.1997.83.6.2080 · DOI
  51. Duey WJ, O’Brien W, Crutchfield A, Brown LA, Williford HN, Sharff-Olson M. Effects of exercise training on aerobic fitness in african-american females. Ethn Dis. 1998; 8: 306–311.
  52. 10.1023/A:1008287320868 · DOI
  53. Murphy MH, Hardman AE. Training effects of short and long bouts of brisk walking in sedentary women. Med Sci Sports Exerc. 1998; 30: 152–157.
  54. 10.1038/sj.jhh.1000608 · DOI
  55. 10.1111/j.1445-5994.1999.tb01584.x · DOI
  56. 10.1161/hyp.33.1.591 · DOI
  57. 10.1161/circ.100.11.1194 · DOI
  58. 10.1001/archinte.160.13.1947 · DOI · Paper page
  59. Cooper AR, Moore LA, McKenna J, Riddoch CJ. What is the magnitude of blood pressure response to a programme of moderate intensity exercise? Randomised controlled trial among sedentary adults with unmedicated hypertension. Br J Gen Pract. 2000; 50: 958–962.
  60. 10.1161/hyp.38.2.222 · DOI
  61. 10.1007/s004210100435 · DOI
  62. Kraemer WJ, Keuning M, Ratamess NA, Volek JS, McCormick M, Bush JA, Nindl BC, Gordon SE, Mazzetti SA, Newton RU, Gomez AL, Wickham RB, Rubin MR, Häkkinen K. Resistance training combined with bench-step aerobics enhances women’s health profile. Med Sci Sports Exerc. 2001; 33: 259–269.
  63. 10.1042/cs1010477 · DOI
  64. 10.1097/00005768-200111000-00005 · DOI
  65. 10.1097/00043798-200110000-00007 · DOI
  66. 10.1097/00005768-200110000-00021 · DOI · Paper page
  67. 10.1291/hypres.25.507 · DOI · Paper page
  68. 10.1139/h02-001 · DOI
  69. 10.1081/CEH-120004234 · DOI
  70. 10.1016/S0895-7061(02)02273-2 · DOI
  71. 10.1034/j.1600-0838.2003.00331.x · DOI
  72. 10.1177/1099800403005001005 · DOI
  73. 10.1016/S0002-9149(03)00128-0 · DOI
  74. 10.1046/j.1440-1681.2003.03846.x · DOI
  75. 10.1136/bmj.315.7109.629 · DOI · Paper page
  76. 10.1097/00005768-200106001-00012 · DOI · Paper page
  77. 10.1152/physrev.1974.54.1.75 · DOI
  78. Fagard RH. Physical activity fitness and blood pressure. In: Birkenhäger WH Reid JL Bulpitt CJ eds. Handbook of Hypertension: Epidemiology of Hypertension. Amsterdam the Netherlands: Elsevier; 2000: 191–211.
  79. 10.1097/00005768-200111000-00009 · DOI
  80. 10.1016/S0895-7061(97)00109-X · DOI
  81. Dubbert PM, Martin JE, Cushman WC, Meydrech EF, Carroll RG. Endurance exercise in mild hypertension: effects on blood pressure and associated metabolic and quality of life variables. J Hum Hypertens. 1994; 8: 265–272.
  82. Guyton AC. Kidneys and fluids in pressure regulation. Hypertension. 1992; 19 (suppl I): I-2–I-8.
  83. 10.1161/circ.100.13.1481 · DOI
  84. Shaper AG, Wannamethee G, Walker M. Physical activity, hypertension and risk of heart attack in men without evidence of ischemic heart disease. J Hum Hypertens. 1994; 8: 3–10.
  85. 10.1097/00005768-199607000-00004 · DOI
  86. 10.3109/07853899109148065 · DOI
  87. Fagard RH, Staessen JA, Thijs L Advantages and disadvantages of the meta-analysis approach. J Hypertens. 1996; 14 (suppl 2): S9–S13.

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Metadata

Authors
Cornelissen, V. A., & Fagard, R. H.
Affiliations
  • From the Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Catholic University of Leuven, Belgium.
  • UCLouvain (BE)
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-10
Volume
46
Issue
4
Pages
667-675
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.0000184225.05629.51
OpenAlex
W2163161539
Cited by
1,005
References
0
Citations by year
2026: 28 · 2025: 47 · 2024: 33 · 2023: 38 · 2022: 52 · 2021: 41 · 2020: 49 · 2019: 46 · 2018: 47 · 2017: 52 · 2016: 49 · 2015: 63 · 2014: 76 · 2013: 79 · 2012: 58
FWCI
64.83
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion)
Funders
  • Fonds Wetenschappelijk Onderzoek
  • Vlaamse regering
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords
aerobic endurance training, blood pressure, ambulatory blood pressure, systemic vascular resistance, plasma norepinephrine, plasma renin activity, renin-angiotensin system, sympathetic nervous system, cardiovascular risk factors, insulin resistance, HDL cholesterol, body weight, waist circumference, fat mass
MeSH terms
Blood Pressure, Cardiovascular Diseases, Hemodynamics, Humans, Norepinephrine, Physical Education and Training, Physical Endurance, Regression Analysis, Renin, Rest, Risk Factors, Vascular Resistance, Randomized Controlled Trials as Topic, Cross-Over Studies, Blood Pressure Monitoring, Ambulatory

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