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Cited by 354Blood Pressure and Hypertension StudiesCardiovascular and exercise physiologyPhysical Activity and Health

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Effects of Regular Exercise on Blood Pressure and Left Ventricular Hypertrophy in African-American Men with Severe Hypertension

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Kokkinos, Peter F., Narayan, Puneet, Colleran, John A., Pittaras, Andreas, Notargiacomo, Aldo, Reda, Domenic, Papademetriou, Vasilios·1995·New England Journal of Medicine
DOI 10.1056/nejm199511303332204
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Abstract

BACKGROUND: The prevalence of hypertension and its cardiovascular complications is higher in African Americans than in whites. Interventions to control blood pressure in this population are particularly important. Regular exercise lowers blood pressure in patients with mild-to-moderate hypertension, but its effects in patients with severe hypertension have not been studied. We examined the effects of moderately intense exercise on blood pressure and left ventricular hypertrophy in African-American men with severe hypertension. METHODS: We randomly assigned 46 men 35 to 76 years of age to exercise plus antihypertensive medication (23 men) or antihypertensive medication alone (23 men). A total of 18 men in the exercise group completed 16 weeks of exercise, and 14 completed 32 weeks of exercise, which was performed three times per week at 60 to 80 percent of the maximal heart rate. RESULTS: After 16 weeks, mean (+/- SD) diastolic blood pressure had decreased from 88 +/- 7 to 83 +/- 8 mm Hg in the patients who exercised, whereas it had increased slightly, from 88 +/- 6 to 90 +/- 7 mm Hg, in those who did not exercise (P = 0.002). Diastolic blood pressure remained significantly lower after 32 weeks of exercise, even with substantial reductions in the dose of antihypertensive medication. In addition, the thickness of the interventricular septum (P = 0.03), the left ventricular mass (P = 0.02), and the mass index (P = 0.04) had decreased significantly after 16 weeks in the patients who exercised, whereas there was no significant change in the nonexercisers. CONCLUSIONS: Regular exercise reduced blood pressure and left ventricular hypertrophy in African-American men with severe hypertension.

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Crossref · 10.1056/nejm199511303332204

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  • For a given fixed submaximal workload, individuals with greater cardiorespiratory fitness have lower exercise SBP.

    “When a workload is fixed at submaximal exercise intensity, individuals with greater cardiorespiratory fitness have lower exercise BP.”

    From Cardiorespiratory Fitness, Workload, and the Blood Pressure Response to Exercise Testing (2022) · cites this paper as [54]

    The Results (Table 3) show that after 16 weeks of training, peak oxygen uptake increased while systolic blood pressure at the fixed submaximal workload fell from 218 to 187 mm Hg. The study measured changes within African-American men with severe hypertension; it does not establish that fitter individuals generally have lower exercise blood pressure than less-fit individuals at the same workload. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • For a given fixed submaximal workload, individuals with greater cardiorespiratory fitness have lower exercise SBP.

    “When a workload is fixed at submaximal exercise intensity, individuals with greater cardiorespiratory fitness have lower exercise BP.”

    From Cardiorespiratory Fitness, Workload, and the Blood Pressure Response to Exercise Testing (2022) · cites this paper as [53]

    Table 3 reports that after 16 weeks of training, peak oxygen uptake rose and systolic blood pressure at the fixed workload fell from 218 to 187 mm Hg. The Methods (“Peak Oxygen Uptake and Blood Pressure”) explain that the baseline maximal workload was reused after training. This supports a within-person finding in African-American men with severe hypertension, but not the broader comparison between individuals of differing fitness stated in the claim. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Citations

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Research works printed but not linked: 11

  1. 10.1001/archinte.153.5.598 · DOI · Paper page
  2. 10.1001/archinte.153.2.186 · DOI
  3. 10.1001/archinte.152.1.56 · DOI · Paper page
  4. 10.1001/jama.242.23.2562 · DOI · Paper page
  5. 10.1001/jama.254.18.2609 · DOI
  6. 1993, Med Sci Sports Exerc, 25, i
  7. Kokkinos PF, 1994, Cardiol Elderly, 2, 433
  8. 10.1001/archinte.153.2.154 · DOI
  9. Frohlich ED, 1988, Circulation, 77, 502A
  10. Devereux RB, 1987, Hypertension, 9, II
  11. Devereux RB. Hypertensive cardiac hypertrophy: pathophysiologic and clinical characteristics. In: Laragh JH, Brenner BM, eds. Hypertension: pathophysiology, diagnosis, and management. Vol. 1. New York: Raven Press, 1990:359-77.

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Metadata

Authors
Kokkinos, P. F., Narayan, P., Colleran, J. A., Pittaras, A., Notargiacomo, A., Reda, D., & Papademetriou, V.
Affiliations
  • United States Department of Veterans Affairs (US)
  • Veterans Health Administration (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1995-11-30
Volume
333
Issue
22
Pages
1462-1467
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199511303332204
OpenAlex
W2314843894
Cited by
354
References
33
Citations by year
2026: 1 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 10 · 2019: 11 · 2018: 7 · 2017: 13 · 2016: 14 · 2015: 18 · 2014: 22 · 2013: 12 · 2012: 9
FWCI
6.24
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords
exercise therapy, severe hypertension, blood pressure reduction, left ventricular hypertrophy, African American men, antihypertensive drugs, left ventricular mass, interventricular septum thickness, cardiovascular risk reduction
MeSH terms
Adult, Aged, Antihypertensive Agents, Black or African American, Blood Pressure, Combined Modality Therapy, Humans, Hypertension, Indapamide, Male, Middle Aged, Verapamil, Exercise, Treatment Outcome, Hypertrophy, Left Ventricular, Black People

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