The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Adiponectin Replenishment Ameliorates Obesity-Related Hypertension
Abstract
Patients with obesity are susceptible to hypertension. We have reported that the plasma adiponectin levels are decreased in obesity and that adiponectin has many defensive properties against obesity-related diseases, such as type 2 diabetes and coronary artery disease. The aim of this study was to determine the relationship between adiponectin and hypertension in mice. We measured blood pressure and heart rate directly by a catheter in the carotid artery and indirectly by automatic sphygmomanometer at the tail artery. Obese KKAy mice had significantly lower plasma adiponectin levels and higher systolic blood pressure than control C57BL/6J mice at 21 weeks of age. Adenovirus-delivered adiponectin significantly decreased blood pressure in KKAy mice. The direct role of adiponectin on blood pressure regulation under insulin resistance–free state was investigated in adiponectin-knockout (KO) mice. Adiponectin KO mice developed hypertension when maintained on a high-salt diet (8% NaCl) without insulin resistance. The hypertension of salt-fed adiponectin KO mice was associated with reduced mRNA levels of endothelial NO synthase (eNOS) and prostaglandin I 2 synthase in aorta and low metabolite levels of endothelial NO synthase and prostaglandin I 2 synthase in plasma. Adiponectin therapy lowered the elevated blood pressure and corrected the above mRNA levels to those of the wild type. Our results suggest that hypoadiponectinemia contributes to the development of obesity-related hypertension, at least in part, directly, in addition to its effect via insulin resistance, and that adiponectin therapy can be potentially useful for hypertension in patients with the metabolic syndrome.
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In the citing paper
“Adiponectin supplementation reduced BP in salt-fed, adiponectin-knockout mice and in KKAy mice, which develop obesity via ectopic expression of agouti protein117.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [117]
In the citing paper
“The role of adiponectin in cardiometabolic regulation was examined in adiponectin-knockout mice, which had normal BP when maintained on a normal salt intake117. By contrast, when fed a high-salt diet, these mice had greater increases in BP than did control mice, suggesting salt sensitivity of BP.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [117]
In the citing paper
“Antidiabetic (162), anti-inflammatory (348), and antihypertensive (259) effects have all been established to occur in response to adiponectin.”
From Cardiac remodeling in obesity (2008) · cites this paper as [259]
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Metadata
- Authors
- Ohashi, K., Kihara, S., Ouchi, N., Kumada, M., Fujita, K., Hiuge, A., Hibuse, T., Ryo, M., Nishizawa, H., Maeda, N., Maeda, K., Shibata, R., Walsh, K., Funahashi, T., & Shimomura, I.
- Affiliations
- Boston University (US)
- ORCID
- Venue
- Hypertension
- Published
- 2006-06
- Volume
- 47
- Issue
- 6
- Pages
- 1108-1116
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2166751358
- Cited by
- 400
- References
- 36
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 61 · 2019: 13 · 2018: 6 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 25 · 2013: 22 · 2012: 30
- FWCI
- 24.90
- Type
- journal article
- Language
- en
- Update notices
- correction (2006-12-26)
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adiponectin, obesity-related hypertension, hypoadiponectinemia, KK-Ay mice, adiponectin knockout mice, high-salt diet, endothelial nitric oxide synthase, PTGIS, nitric oxide, insulin resistance, metabolic syndrome, blood pressure regulation
- MeSH terms
- Adenoviridae, Animals, Aorta, Blood Pressure, Cytochrome P-450 Enzyme System, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Enzyme Inhibitors, Genetic Vectors, Hypertension, Insulin Resistance, Male, Mice, Inbred Strains, Obesity, RNA, Messenger, Sodium Chloride, Dietary, Gene Transfer Techniques, Mice, Knockout, NG-Nitroarginine Methyl Ester, Intramolecular Oxidoreductases, Mice, Adiponectin, Nitric Oxide Synthase Type III
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