Cited by 400Adipokines, Inflammation, and Metabolic DiseasesBlood Pressure and Hypertension StudiesCardiovascular Disease and Adiposity

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Adiponectin Replenishment Ameliorates Obesity-Related Hypertension

Ohashi, Koji, Kihara, Shinji, Ouchi, Noriyuki, Kumada, Masahiro, Fujita, Koichi, Hiuge, Aki, Hibuse, Toshiyuki, Ryo, Miwa, Nishizawa, Hitoshi, Maeda, Norikazu, Maeda, Kazuhisa, Shibata, Rei, Walsh, Kenneth, Funahashi, Tohru, Shimomura, Iichiro·2006·Hypertension

DOI 10.1161/01.hyp.0000222368.43759.a1

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Abstract

Patients with obesity are susceptible to hypertension. We have reported that the plasma adiponectin levels are decreased in obesity and that adiponectin has many defensive properties against obesity-related diseases, such as type 2 diabetes and coronary artery disease. The aim of this study was to determine the relationship between adiponectin and hypertension in mice. We measured blood pressure and heart rate directly by a catheter in the carotid artery and indirectly by automatic sphygmomanometer at the tail artery. Obese KKAy mice had significantly lower plasma adiponectin levels and higher systolic blood pressure than control C57BL/6J mice at 21 weeks of age. Adenovirus-delivered adiponectin significantly decreased blood pressure in KKAy mice. The direct role of adiponectin on blood pressure regulation under insulin resistance–free state was investigated in adiponectin-knockout (KO) mice. Adiponectin KO mice developed hypertension when maintained on a high-salt diet (8% NaCl) without insulin resistance. The hypertension of salt-fed adiponectin KO mice was associated with reduced mRNA levels of endothelial NO synthase (eNOS) and prostaglandin I 2 synthase in aorta and low metabolite levels of endothelial NO synthase and prostaglandin I 2 synthase in plasma. Adiponectin therapy lowered the elevated blood pressure and corrected the above mRNA levels to those of the wild type. Our results suggest that hypoadiponectinemia contributes to the development of obesity-related hypertension, at least in part, directly, in addition to its effect via insulin resistance, and that adiponectin therapy can be potentially useful for hypertension in patients with the metabolic syndrome.

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Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Self-citation
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Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541
Self-citation
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
Self-citation
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526

Show all 36 references

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10.1161/circ.102.11.1296 · DOI
10.1161/circ.103.8.1057 · DOI
10.1161/circ.100.25.2473 · DOI
10.1161/atvb.20.6.1595 · DOI
10.1161/circ.100.22.2231 · DOI

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Self-citation
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Withers, S., Forman, R. A., Meza‐Perez, S., Sorobetea, D., Sitnik, K., Hopwood, T. W., Lawrence, C. B., Agace, W. W., Else, K. J., Heagerty, A. M., et al. (2017) · Scientific Reports · doi:10.1038/srep44571 · Cited by 101
Adiponectin and Its Receptors in Diabetic Kidney Disease: Molecular Mechanisms and Clinical Potential
Zha, D., Wu, X., & Gao, P. H. (2017) · Endocrinology · doi:10.1210/en.2016-1765 · Cited by 102
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Chow, W. S., Tso, A. W. K., Xu, A., Yuen, M. M. A., Fong, C. H. Y., Lam, T. H., Lo, S. V., Tse, H., Woo, Y. C., Yeung, C. Y., et al. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.112.004176 · Cited by 101
Adipokines and blood pressure control
Yiannikouris, F. B., Gupte, M., Putnam, K., & Cassis, L. A. (2010) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3283366cd0 · Cited by 98
Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats.
Tanida, M., Shen, J., Horii, Y., Matsuda, M., Kihara, S., Funahashi, T., Shimomura, I., Sawai, H., Fukuda, Y., Matsuzawa, Y., et al. (2007) · PubMed · Cited by 95
Self-citation
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L’Abbate, A., Neglia, D., Vecoli, C., Novelli, M., Ottaviano, V., Baldi, S., Barsacchi, R., Paolicchi, A., Masiello, P., Drummond, G. S., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00826.2007 · Cited by 95
The Independent Association Between 25‐Hydroxyvitamin D and Adiponectin and Its Relation With BMI in Two Large Cohorts: The NHS and the HPFS
Vaidya, A., Williams, J. S., & Forman, J. P. (2011) · Obesity · doi:10.1038/oby.2011.210 · Cited by 95
Obesity and kidney disease
Declèves, A., & Sharma, K. (2014) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000087 · Cited by 96
Adipocytokines, cardiovascular pathophysiology and myocardial protection
Smith, C., & Yellon, D. M. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.003 · Cited by 96
Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality
Teoh, H., Quan, A., Bang, K. W. A., Wang, G., Lovren, F., Vu, V. P., Haitsma, J. J., Szmitko, P. E., Al-Omran, M. A., Wang, C., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90384.2008 · Cited by 91
Impact of a Single Intracoronary Administration of Adiponectin on Myocardial Ischemia/Reperfusion Injury in a Pig Model
Kondo, K., Shibata, R., Unno, K., Shimano, M., Ishii, M., Kito, T., Shintani, S., Walsh, K. X., Ouchi, N., & Murohara, T. (2010) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.109.872044 · Cited by 89
Self-citation
Adiponectin Deficiency, Diastolic Dysfunction, and Diastolic Heart Failure
Sam, F., Duhaney, T.-A. S., Sato, K., Wilson, R. M., Ohashi, K., Sono-Romanelli, S., Higuchi, A., Silva, D. S. D., Qin, F., Walsh, K., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0806 · Cited by 90
Self-citation
Effect of PPAR-γ Agonist on Adiponectin Levels in the Metabolic Syndrome: Lessons From the High Fructose Fed Rat Model
Sharabi, Y., Oron‐Herman, M., Kamari, Y., Avni, I., Peleg, E., Shabtay, Z., Grossman, E., & Shamiss, A. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2006.08.002 · Cited by 89
Oral administration of a zinc complex improves type 2 diabetes and metabolic syndromes
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Redón, J., Cífková, R., Laurent, S., Nilsson, P. M., Narkiewicz, K., Erdine, S. E., & Mancia, G. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32831e13e5 · Cited by 86
Additive Effects of Maternal High Fat Diet during Lactation on Mouse Offspring
Masuyama, H., & Hiramatsu, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092805 · Cited by 85
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Su, J., Lucchesi, P. A., González-Villalobos, R. A., Palen, D. I., Rezk, B. M., Suzuki, Y., Boulares, H. A., & Matrougui, K. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.167205 · Cited by 85
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Ohashi, K., Ouchi, N., Sato, K., Higuchi, A., Ishikawa, T., Herschman, H. R., Kihara, S., & Walsh, K. X. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00126-09 · Cited by 83
Self-citation
Activation of AMPK/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion (I/R) injury in rats
Potenza, M. A., Sgarra, L., Nacci, C., Leo, V., Salvia, M. A. D., & Montagnani, M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210654 · Cited by 81
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Lei, X., Qiu, S., Yang, G., & Wu, Q. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.10.018 · Cited by 91
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Rosa, S. C. D. S., Liu, M., & Sweeney, G. (2021) · Physiology · doi:10.1152/physiol.00031.2020 · Cited by 80
Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs
Abu‐Farha, M., Behbehani, K., & Elkum, N. B. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-76 · Cited by 78
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Hirata, M., Ishigami, M., Matsushita, Y., Ito, T., Hattori, H., Hibi, H., Goto, H., Ueda, M., & Yamamoto, A. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0353 · Cited by 78

Authors: Ohashi, K., Kihara, S., Ouchi, N., Kumada, M., Fujita, K., Hiuge, A., Hibuse, T., Ryo, M., Nishizawa, H., Maeda, N., Maeda, K., Shibata, R., Walsh, K., Funahashi, T., & Shimomura, I.
Affiliations: Boston University (US)
ORCID: Ohashi, Koji
Kihara, Shinji
Ouchi, Noriyuki
Fujita, Koichi
Nishizawa, Hitoshi
Maeda, Norikazu
Maeda, Kazuhisa
Shibata, Rei
Walsh, Kenneth
Shimomura, Iichiro
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-06
Volume: 47
Issue: 6
Pages: 1108-1116
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/01.hyp.0000222368.43759.a1
OpenAlex: W2166751358
Cited by: 400
References: 36
Citations by year: 2026: 5 · 2025: 11 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 61 · 2019: 13 · 2018: 6 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 25 · 2013: 22 · 2012: 30
FWCI: 24.90
Type: journal article
Language: en
Update notices: correction (2006-12-26)
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adiponectin, obesity-related hypertension, hypoadiponectinemia, KK-Ay mice, adiponectin knockout mice, high-salt diet, endothelial nitric oxide synthase, PTGIS, nitric oxide, insulin resistance, metabolic syndrome, blood pressure regulation
MeSH terms: Adenoviridae, Animals, Aorta, Blood Pressure, Cytochrome P-450 Enzyme System, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Enzyme Inhibitors, Genetic Vectors, Hypertension, Insulin Resistance, Male, Mice, Inbred Strains, Obesity, RNA, Messenger, Sodium Chloride, Dietary, Gene Transfer Techniques, Mice, Knockout, NG-Nitroarginine Methyl Ester, Intramolecular Oxidoreductases, Mice, Adiponectin, Nitric Oxide Synthase Type III

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Adiponectin Replenishment Ameliorates Obesity-Related Hypertension

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