The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Uric Acid and the Development of Hypertension: The Normative Aging Study
Open accessAbstract
Experimental evidence supports a causative role for uric acid in the pathogenesis of hypertension. Prospective studies have variably adjusted for relevant confounders and have been of relatively limited duration. We prospectively examined the relationship between uric acid level and the development of hypertension in the Normative Aging Study, a longitudinal cohort of healthy adult men. Of the 2280 initial men in the Normative Aging Study, 2062 had available information for inclusion in the analysis. Cox proportional hazards model was used to examine the relationship between baseline serum uric acid level and the development of hypertension adjusting for age, body mass index, abdominal circumference, smoking, alcohol, plasma triglycerides, total cholesterol, and plasma glucose. A total of 892 men developed hypertension over a mean of 21.5 years of follow-up. Serum uric acid level independently predicted the development of hypertension in age-adjusted (relative risk [RR]: 1.10; 95% CI: 1.06 to 1.15: P <0.001) and multivariable (RR: 1.05; 95% CI: 1.01 to 1.10; P =0.02) models. Among 1277 men at risk for the development of hypertension at the time of their first serum creatinine measurement, 508 (39.8%) developed hypertension over a mean of 10.3±5.5 years of follow-up. Additionally adjusting for calculated glomerular filtration rate in this subset, serum uric acid remained associated with the development of hypertension (RR: 1.06; 95% CI: 1.01 to 1.12; P =0.03). The baseline serum uric acid level is a durable marker of risk for the development of hypertension. The association is independent of elements of the metabolic syndrome, alcohol intake, and renal function.
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Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
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Cited by
Johnson, R. J., Segal, M. S., Sautin, Y., Nakagawa, T., Feig, D. I., Kang, D.-H., Gersch, M. S., Benner, S., & Sánchez-Lozada, L. G. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.4.899 · Cited by 1,075
Chen‐Xu, M., Yokose, C., Rai, S. K., Pillinger, M. H., & Choi, H. K. (2019) · Arthritis & Rheumatology · doi:10.1002/art.40807 · Cited by 1,072
Feig, D. I., Soletsky, B., & Johnson, R. J. (2008) · JAMA · doi:10.1001/jama.300.8.924 · Cited by 914
Seravalle, G., & Grassi, G. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.013 · Cited by 909
Hyperuricemia and incident hypertension: A systematic review and meta‐analysis
Grayson, P. C., Kim, S. Y., LaValley, M., & Choi, H. K. (2011) · Arthritis Care & Research · doi:10.1002/acr.20344 · Cited by 756
Metadata
- Authors
- Perlstein, T. S., Gumieniak, O., Williams, G. H., Sparrow, D., Vokonas, P. S., Gaziano, M., Weiss, S. T., & Litonjua, A. A.
- Venue
- Hypertension
- Published
- 2006-12
- Volume
- 48
- Issue
- 6
- Pages
- 1031-1036
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2111277253
- Cited by
- 294
- References
- 37
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Perlstein, T. S., Gumieniak, O., Williams, G. H., Sparrow, D., Vokonas, P. S., Gaziano, M., Weiss, S. T., & Litonjua, A. A. (2006). Uric Acid and the Development of Hypertension: The Normative Aging Study. Hypertension. https://doi.org/10.1161/01.hyp.0000248752.08807.4c
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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