Measurement of Reactive Oxygen Species in Cardiovascular Studies

Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader11Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee by the United States Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.

Wang, H., & Joseph, J. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00107-0 · Cited by 2,355

Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression

Zelko, I. N., Mariani, T. J., & Folz, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00905-x · Cited by 2,212

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

Bass, D., Parce, J. W., DeChatelet, L. R., Szejda, P., Seeds, M. C., & Thomas, M. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.4.1910 · Cited by 1,811

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652

Topology of superoxide production from different sites in the mitochondrial electron transport chain

St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207217200 · Cited by 1,545

A Stable Nonfluorescent Derivative of Resorufin for the Fluorometric Determination of Trace Hydrogen Peroxide: Applications in Detecting the Activity of Phagocyte NADPH Oxidase and Other Oxidases

Zhou, M., Diwu, Z. J., Panchuk-Voloshina, N., & Haugland, R. P. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2391 · Cited by 1,400

Genetically encoded fluorescent indicator for intracellular hydrogen peroxide

Belousov, V. V., Fradkov, A. F., Lukyanov, K. A., Staroverov, D. B., Shakhbazov, K., Terskikh, A. V., & Lukyanov, S. (2006) · Nature Methods · doi:10.1038/nmeth866 · Cited by 1,286

Electron Paramagnetic Resonance: Elementary Theory and Practical Applications

Weil, J. A., Bolton, J. R., Wertz, J. E., & Buckmaster, H. A. (1995) · Physics Today · doi:10.1063/1.2808029 · Cited by 1,013

Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

Guzik, T. J., Mussa, S., Gastaldi, D., Sadowski, J., Ratnatunga, C., Pillai, R. G., & Channon, K. M. (2002) · Circulation · doi:10.1161/01.cir.0000012748.58444.08 · Cited by 979

Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology

Griendling, K. K., Sorescu, D., Lassegue, B. P., & Ushio‐Fukai, M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.10.2175 · Cited by 955

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

Cadenas, E., Boveris, A., Ragan, C. I., & Stoppani, A. O. M. (1977) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(77)90035-2 · Cited by 855

Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: Potential implications in intracellular fluorescence detection of superoxide

Zhao, H., Kalivendi, S., Zhang, H., Joseph, J., Nithipatikom, K., Vásquez-Vivar, J., & Kalyanaraman, B. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00142-4 · Cited by 803

Angiotensin II Stimulation of NAD(P)H Oxidase Activity

Seshiah, P., Weber, D. S., Ročić, P., Valppu, L., Taniyama, Y., & Griendling, K. K. (2002) · Circulation Research · doi:10.1161/01.res.0000033523.08033.16 · Cited by 711

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction

Doughan, A. K., Harrison, D. G., & Dikalov, S. I. (2008) · Circulation Research · doi:10.1161/circresaha.107.162800 · Cited by 710

Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols

Kuzkaya, N., Weissmann, N., Harrison, D. G., & Dikalov, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302227200 · Cited by 692

Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling

Mollnau, H., Wendt, M., Szöcs, K., Lassègue, B., Schulz, E., Oelze, M., Li, H., Bodenschatz, M., August, M., Kleschyov, A. L., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000012569.55432.02 · Cited by 676

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

Warnholtz, A., Nickenig, G., Schulz, E., Macharzina, R. R., Bräsen, J. H., Skatchkov, M. P., Heitzer, T. A., Stasch, J. P., Griendling, K. K., Harrison, D. G., et al. (1999) · Circulation · doi:10.1161/01.cir.99.15.2027 · Cited by 676

A Targetable Fluorescent Probe for Imaging Hydrogen Peroxide in the Mitochondria of Living Cells

Dickinson, B. C., & Chang, C. J. (2008) · Journal of the American Chemical Society · doi:10.1021/ja802355u · Cited by 646

Superoxide Production in Vascular Smooth Muscle Contributes to Oxidative Stress and Impaired Relaxation in Atherosclerosis

Miller, F. J., Gutterman, D. D., Rios, C., Heistad, D. D., & Davidson, B. L. (1998) · Circulation Research · doi:10.1161/01.res.82.12.1298 · Cited by 623

Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence

Zhao, H., Joseph, J., Fales, H. M., Sokoloski, E. A., Levine, R. L., Vasquez-Vivar, J., & Kalyanaraman, B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501719102 · Cited by 576

Structural Basis of the Redox Switch in the OxyR Transcription Factor

Choi, H., Kim, S.-J., Mukhopadhyay, P., Cho, S., Woo, J.-R., Storz, G., & Ryu, S.-E. (2001) · Cell · doi:10.1016/s0092-8674(01)00300-2 · Cited by 568

Boronate-based fluorescent probes for imaging cellular hydrogen peroxide.

Miller, E. W., Albers, A. E., Pralle, A., Isacoff, E., & Chang, C. J. (2005) · Journal of the American Chemical Society · doi:10.1021/ja054474f · Cited by 530

Validation of Lucigenin (Bis-N-methylacridinium) as a Chemilumigenic Probe for Detecting Superoxide Anion Radical Production by Enzymatic and Cellular Systems

Li, Y., Zhu, H., Kuppusamy, P., Roubaud, V., Zweier, J. L., & Trush, M. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.2015 · Cited by 526

Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

Han, D., WILLIAMS, E., & Cadenas, E. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530411 · Cited by 516

Oxidative Stress and Hypertension

Harrison, D. G., & Góngora, M. C. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2009.02.015 · Cited by 455

Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice

Dikalova, A., Clempus, R., Lassègue, B., Cheng, G., McCoy, J., Dikalov, S., Martin, A. S., Lyle, A., Weber, D. S., Weiss, D., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.538934 · Cited by 438

Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance.

Beckman, J. S., Minor, R. L., White, C. W., Repine, J. E., Rosen, G. M., & Freeman, B. Α. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68727-7 · Cited by 417

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production

Dikalov, S., Dikalova, A., Bikineyeva, A. T., Schmidt, H. H. H. W., Harrison, D. G., & Griendling, K. K. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.013 · Cited by 391

Evidence for free radical formation during the oxidation of 2′-7′-dichlorofluorescin to the fluorescent dye 2′-7′-dichlorofluorescein by horseradish peroxidase:

Rota, C., Chignell, C. F., & Mason, R. P. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00137-9 · Cited by 383

Atrial Fibrillation Increases Production of Superoxide by the Left Atrium and Left Atrial Appendage

Dudley, S. C., Hoch, N. E., McCann, L. A., Honeycutt, C., Diamandopoulos, L., Fukai, T., Harrison, D. G., Dikalov, S., & Langberg, J. J. (2005) · Circulation · doi:10.1161/circulationaha.105.538108 · Cited by 375

Redox Mechanisms in Blood Vessels

Mueller, C. F. H., Laude, K. M., McNally, J. S., & Harrison, D. G. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000149143.04821.eb · Cited by 351

Luminol and lucigenin as detectors for O2ṡ−

Faulkner, K. M., & Fridovich, I. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90044-u · Cited by 336

The use of acetylated ferricytochrome C for the detection of superoxide radicals produced in biological membranes

Azzi, A., Montecucco, C., & Richter, C. (1975) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(75)80188-4 · Cited by 329

Mitochondrial Sources of H 2 O 2 Generation Play a Key Role in Flow-Mediated Dilation in Human Coronary Resistance Arteries

Liu, Y., Zhao, H., Li, H., Kalyanaraman, B., Nicolosi, A. C., & Gutterman, D. D. (2003) · Circulation Research · doi:10.1161/01.res.0000091261.19387.ae · Cited by 323

Tetrahydrobiopterin-dependent preservation of nitric oxide–mediated endothelial function in diabetes by targeted transgenic GTP–cyclohydrolase I overexpression

Alp, N. J., Mussa, S., Khoo, J. P., Cai, S., Guzik, T. J., Jefferson, A., Goh, N., Rockett, K. A., & Channon, K. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17786 · Cited by 321

Detection of Superoxide in Vascular Tissue

Münzel, T. F., Afanasʹev, I. B., Kleschyov, A. L., & Harrison, D. G. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000034022.11764.ec · Cited by 281

Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay

Fink, B., Laude, K. M., McCann, L. A., Doughan, A. K., Harrison, D. G., & Dikalov, S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00028.2004 · Cited by 259

Chemiluminescence probe with Cypridina luciferin analog, 2-methyl-6-phenyl-3,7-dihydroimidazo[1,2-a]pyrazin-3-one, for estimating the ability of human granulocytes to generate O2−

Nakano, M., Sugioka, K., Ushijima, Y., & Goto, T. (1986) · Analytical Biochemistry · doi:10.1016/0003-2697(86)90354-4 · Cited by 253

Mitochondria: are they the seat of senescence?

Fridovich, I. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00075.x · Cited by 230

Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: Implications for uncoupling endothelial nitric oxide synthase

Kuzkaya, N., Weißmann, N., Harrison, D. G., & Dikalov, S. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.05.009 · Cited by 225

Vascular Oxidant Stress Enhances Progression and Angiogenesis of Experimental Atheroma

Khatri, J. J., Johnson, C., Magid, R., Lessner, S. M., Laude, K. M., Dikalov, S., Harrison, D. G., Sung, H., Rong, Y., & Galis, Z. S. (2004) · Circulation · doi:10.1161/01.cir.0000109698.70638.2b · Cited by 224

Opening mitoKATPincreases superoxide generation from complex I of the electron transport chain

Andrukhiv, A., Costa, A. D. T., West, I. C., & Garlid, K. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00272.2006 · Cited by 224

Lucigenin (Bis-N-methylacridinium) as a Mediator of Superoxide Anion Production

Liochev, S. I., & Fridovich, I. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.9766 · Cited by 223

Phenoxyl Free Radical Formation during the Oxidation of the Fluorescent Dye 2′,7′-Dichlorofluorescein by Horseradish Peroxidase

Rota, C., Fann, Y. C., & Mason, R. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28161 · Cited by 220

Angiotensin II Induces Endothelial Xanthine Oxidase Activation: Role for Endothelial Dysfunction in Patients With Coronary Disease

Landmesser, U., Spiekermann, S., Preuss, C., Sorrentino, S., Fischer, D., Manes, C., Mueller, M., & Drexler, H. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000258415.32883.bf · Cited by 210

Detection of hydrogen peroxide with Amplex Red: interference by NADH and reduced glutathione auto-oxidation

Votyakova, T. V., & Reynolds, I. J. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.07.025 · Cited by 207

Role of Extracellular Superoxide Dismutase in Hypertension

Gongora, M. C., Qin, Z., Laude, K., Kim, H. W., McCann, L., Folz, J. R., Dikalov, S., Fukai, T., & Harrison, D. G. (2006) · Hypertension · doi:10.1161/01.hyp.0000235682.47673.ab · Cited by 204

Superoxide anion formation from lucigenin: an electron spin resonance spin‐trapping study

Vasquez-Vivar, J. M., Hogg, N., Pritchard, K. A., Pavel Martasek, E., & Kalyanaraman, B. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00036-7 · Cited by 194

Oxidation of 2′,7′-Dichlorofluorescin by Peroxynitrite

Kooy, N. W., Royall, J. A., & Ischlropoulos, H. (1997) · Free Radical Research · doi:10.3109/10715769709065763 · Cited by 181

Photoreduction of the fluorescent dye 2′-7′-dichlorofluorescein: a spin trapping and direct electron spin resonance study with implications for oxidative stress measurements

Marchesi, E., Rota, C., Fann, Y. C., Chignell, C. F., & Mason, R. P. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00174-9 · Cited by 162

Chemiluminescent Detection of Oxidants in Vascular Tissue

Tarpey, M. M., White, C. R., Suarez, E., Richardson, G. R., Radí, R., & Freeman, B. Α. (1999) · Circulation Research · doi:10.1161/01.res.84.10.1203 · Cited by 162

Detection of superoxide anion using an isotopically labeled nitrone spin trap: potential biological applications

Zhang, H., Joseph, J., Vasquez-Vivar, J. M., Karoui, H., Nsanzumuhire, C., Pavel Martasek, E., Tordo, P., & Kalyanaraman, B. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01498-8 · Cited by 152

Detection of Superoxide and Peroxynitrite in Model Systems and Mitochondria by the Luminol Analogue L-012

Daiber, A., Oelze, M. W., August, M., Wendt, M., Sydow, K., Wieboldt, H., Kleschyov, A. L., & Münzel, T. F. (2004) · Free Radical Research · doi:10.1080/10715760410001659773 · Cited by 145

The kinetics of the reduction of cytochrome c by the superoxide anion radical

Koppenol, W. H., Buuren, K. J. H. V., Butler, J., & Braams, R. (1976) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(76)90130-4 · Cited by 126

Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport

Lambert, A. J., Buckingham, J. A., Boysen, H. M., & Brand, M. D. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.005 · Cited by 123

[22] Spin trapping

Janzen, E. G. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)05025-4 · Cited by 119

Hepatitis C virus‐core and non structural proteins lead to different effects on cellular antioxidant defenses

Abdalla, M. Y., Ahmad, I. M., Spitz, D. R., Schmidt, W. N., & Britigan, B. E. (2005) · Journal of Medical Virology · doi:10.1002/jmv.20388 · Cited by 119

Evaluation of assays for the measurement of bovine neutrophil reactive oxygen species

Rinaldi, M., Moroni, P., Paape, M. J., & Bannerman, D. D. (2006) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2006.09.009 · Cited by 115

Intracellular generation of reactive oxygen species in endothelial cells exposed to anoxia-reoxygenation

Zulueta, J. J., Sawhney, R., Yu, F., Côté, C., & Hassoun, P. M. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.272.5.l897 · Cited by 115

Regulation of Xanthine Oxidoreductase Protein Expression by Hydrogen Peroxide and Calcium

McNally, J. S., Saxena, A., Cai, H. “., Dikalov, S., & Harrison, D. G. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000170827.16296.6e · Cited by 113

Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle

Weber, D. S., Ročić, P., Mellis, A. M., Laude, K. M., Lyle, A. N., Harrison, D. G., & Griendling, K. K. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00638.2004 · Cited by 106

Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: Identification of homo- and heterodimers

Zielonka, J., Srinivasan, S., Hardy, M., Ouari, O., López, M., Vasquez-Vivar, J. M., Avadhani, N. G., & Kalyanaraman, B. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.11.013 · Cited by 105

Role of Oxalacetate in the Regulation of Mammalian Succinate Dehydrogenase

Ackrell, B. A. C., Kearney, E. B., & Mayr, M. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42790-7 · Cited by 102

Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine

Dikalov, S., Dikalova, A., & Mason, R. P. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00064-4 · Cited by 85

Functional association of nox1 with p22phox in vascular smooth muscle cells

Hanna, I. R., Hilenski, L. L., Dikalova, A., Taniyama, Y., Dikalov, S., Lyle, A. N., Quinn, M. T., Lassegue, B. P., & Griendling, K. K. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.011 · Cited by 82

Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C

Dikalov, S., Fink, B., Skatchkov, M. P., & Bassenge, E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00066-0 · Cited by 80

An in vivo ESR spin-trapping study: Free radical generation in rats from formate intoxication— role of the Fenton reaction

Dikalova, A., Kadiiska, M. B., & Mason, R. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251091098 · Cited by 77

Overstimation of verestimation of NADH-driven vascular oxidase activity due to lucigenin artifacts

Janiszewski, M., de Souza, H. P., Liu, X., Pedro, M. D. A., Zweier, J. L., & Laurindo, F. R. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00828-0 · Cited by 77

Properties of the radical intermediate obtained on oxidation of 2′,7′-dichlorodihydrofluorescein, a probe for oxidative stress

Wrona, M., & Wardman, P. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.006 · Cited by 76

Characterization of the high-resolution ESR spectra of superoxide radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N -oxide (DEPMPO) and 5,5-dimethyl-1-pyrroline N -oxide (DMPO). Analysis of conformational exchange

Dikalov, S., Jiang, J., & Mason, R. P. (2005) · Free Radical Research · doi:10.1080/10715760500155688 · Cited by 69

REESTIMATION OF CYPRIDINA LUCIFERIN ANALOGS (MCLA) AS A CHEMILUMINESCENCE PROBE TO DETECT ACTIVE OXYGEN SPECIES-CAUTIONARY NOTE FOR USE OF MCLA-

Kambayashi, Y., & Ogino, K. (2003) · The Journal of Toxicological Sciences · doi:10.2131/jts.28.139 · Cited by 64

Quantification of Superoxide Radicals and Peroxynitrite in Vascular Cells Using Oxidation of Sterically Hindered Hydroxylamines and Electron Spin Resonance

Dikalov, S., Skatchkov, M. P., Fink, B., & Bassenge, E. (1997) · Nitric Oxide · doi:10.1006/niox.1997.0139 · Cited by 61

Intracellular oxidant production and cytokine responses in lung macrophages: evaluation of fluorescent probes

Imrich, A., Ning, Y., & Kobzik, L. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.4.499 · Cited by 45

Free radicals induced by adriamycin-sensitive and adriamycin-resistant cells: a spin-trapping study

Alegrı́a, A. E., Samuni, A. M., Mitchell, J. B., Riesz, P., & Russo, A. (1989) · Biochemistry · doi:10.1021/bi00447a056 · Cited by 40

A new screening method to detect water-soluble antioxidants: acetaminophen (tylenol®) and other phenols react as antioxidants and destroy peroxynitrite-based luminol-dependent chemiluminescence

Dyke, K. V., Sacks, M., & Qazi, N. (1998) · Journal of Bioluminescence and Chemiluminescence · doi:10.1002/(sici)1099-1271(199811/12)13:6 · Cited by 39

Molecular Mechanisms in Hypertension

(2006) · CRC Press eBooks · doi:10.1201/b14627 · Cited by 36

Hypoxia-induced alterations in Ca2+mobilization in brain microvascular endothelial cells

Kimura, C., Oike, M., & Ito, Y. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.5.h2310 · Cited by 35

Inclusion complexes of EMPO derivatives with 2,6-di-O-methyl-β-cyclodextrin: synthesis, NMR and EPR investigations for enhanced superoxide detection

Bardelang, D., Rockenbauer, A., Karoui, H., Finet, J., Biskupska, I., Banaszak, K., & Tordo, P. (2006) · Organic & Biomolecular Chemistry · doi:10.1039/b606062e · Cited by 33

Superoxide anion impairs contractility in cultured aortic smooth muscle cells

Kimura, C., Cheng, W., Hisadome, K., Wang, Y., Koyama, T., Karashima, Y., Oike, M., & Ito, Y. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00574.2001 · Cited by 29

Hydroxyl radical generation: the effect of bicarbonate, dioxygen and buffer concentration on pH-dependent chemiluminescence

Oosthuizen, M. M. J., & Greyling, D. (2001) · Redox Report · doi:10.1179/135100001101536111 · Cited by 25

The excretion mechanism of the spin label proxyl carboxylic acid (PCA) from the rat monitored by X‐band ESR and PEDRI

Seimenis, I., Foster, M. A., Lurie, D. J., Hutchison, J. M. S., Whiting, P. H., & Payne, S. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370413 · Cited by 25

Kinetics of nitroxide spin label removal in biological systems: An in vitro and in vivo ESR study

Vianello, F., Momo, F., Scarpa, M., & Rigo, A. (1995) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(94)00121-i · Cited by 24

NADPH-Induced Contractions of Mouse Aorta Do Not Involve NADPH Oxidase: A Role for P2X Receptors

Judkins, C. P., Sobey, C. G., Dang, T. T., Miller, A. A., Dusting, G. J., & Drummond, G. R. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.096610 · Cited by 24

Cu,Zn-Superoxide Dismutase Is an Intracellular Catalyst for the H2O2-dependent Oxidation of Dichlorodihydrofluorescein

Kim, Y., Lim, J.-M., Kim, B.-C., & Han, S. (2006) · Molecules and Cells · doi:10.1016/s1016-8478(23)12915-3 · Cited by 21

Oxygen radical generation and enzymatic properties of mitochondria in hypoxia/reoxygenation.

Zwicker, K., Dikalov, S., MATUSCHKA, S., Mainka, L., Hofmann, M., Khramtsov, V. V., & Zimmer, G. (1998) · PubMed · Cited by 15

The use of acetylated cytochrome c in detecting superoxide anion production in rabbit alveolar macrophages.

Nasrallah, V. N., Shirley, P. S., Myrvik, Q. N., & Waite, M. B. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.5.2104 · Cited by 12

Carteolol Hydrochloride Protects Human Corneal Epithelial Cells From UVB-Induced Damage In Vitro

Kuwahara, K., Oizumi, N., Fujisawa, S., Tanito, M., & Ohira, A. (2005) · Cornea · doi:10.1097/01.ico.0000141232.41343.9d · Cited by 10

A reassessment of the product specificity of the NADPH:O2 oxidoreductase of human neutrophils

Green, T. R., & Pratt, K. L. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90473-6 · Cited by 10

Superoxide Ion: Generation and Chemical Implications

Hayyan, M., Hashim, M. A., & AlNashef, I. M. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00407 · Cited by 2,237

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

Kalyanaraman, B., Darley-Usmar, V. M., Davies, K. J. A., Dennery, P. A., Forman, H. J., Grisham, M. B., Mann, G. E., Moore, K. P., Roberts, L. J., & Ischiropoulos, H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.030 · Cited by 1,842

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

Heumüller, S., Wind, S., Barbosa-Sicard, E., Schmidt, H. H. H. W., Busse, R., Schröder, K., & Brandes, R. P. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.100214 · Cited by 735

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 745

Hypoxic Pulmonary Vasoconstriction

Sylvester, J. T., Shimoda, L. A., Aaronson, P. I., & Ward, J. P. T. (2012) · Physiological Reviews · doi:10.1152/physrev.00041.2010 · Cited by 741

Reactive Oxygen Species–Dependent Hypertension in

Escano, C., Jose, P. A., Arm, I., Wang, X., Anthony, V., Villar, M., Jones, J. E., Asico, L. D., Dopamine, D., Arm, I., et al. (2015)

Reactive Oxygen Species Impair Sympathetic Vasoregulation in Skeletal Muscle in

Zhao, W., Swanson, S. A., Ye, J., Li, X., Shelton, J. M., Zhang, W., Thomas, G. D., Hypertension, A. I., Zhao, W., Swanson, S. A., et al. (2006)

on Generation of Reactive Oxygen Species

Bleeke, T., Zhang, H., Madamanchi, N., Patterson, C., & Faber, J. E. (2004)

Dysfunction in Normocholesterolemic Hypertension via Reduced Production of Reactive Oxygen Species

Wassmann, S., Laufs, U., Bäumer, A. T., Müller, K., Ahlbory, K., Itter, G., Rösen, R., Böhm, M., Nickenig, G., Wassmann, S., et al. (2013)

Reactive Oxygen Species–Induced c-fos Expression

Ichiki, T., Tokunou, T., Fukuyama, K., Iino, N., Masuda, S., Ichiki, T., Tokunou, T., Fukuyama, K., Iino, N., Masuda, S., et al. (2013)