Cited by 185Regulation of Appetite and ObesityBlood Pressure and Hypertension StudiesRenin-Angiotensin System Studies

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Obesity-Induced Hypertension: New Concepts From the Emerging Biology of Obesity

Mark, Allyn L., Correia, Marcelo, Morgan, Donald A., Shaffer, Richard A., Haynes, William G.·1999·Hypertension

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Abstract

Abstract —Obesity is associated with an increased risk of hypertension. In the past 5 years there have been dramatic advances into the genetic and neurobiological mechanisms of obesity with the discovery of leptin and novel neuropeptide pathways regulating appetite and metabolism. In this brief review, we argue that these mounting advances into the neurobiology of obesity have and will continue to provide new insights into the regulation of arterial pressure in obesity. We focus our comments on the sympathetic, vascular, and renal mechanisms of leptin and melanocortin receptor agonists and on the regulation of arterial pressure in rodent models of genetic obesity. We suggest 3 concepts. First, the effect of obesity on blood pressure may depend critically on the genetic-neurobiological mechanisms underlying the obesity. Second, obesity is not consistently associated with increased blood pressure, at least in rodent models. Third, the blood pressure response to obesity may be critically influenced by modifying alleles in the genetic background.

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Authors: Mark, A. L., Correia, M., Morgan, D. A., Shaffer, R. A., & Haynes, W. G.
Affiliations: University of Iowa (US)
ORCID: Mark, Allyn L.
Correia, Marcelo
Morgan, Donald A.
Haynes, William G.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-01
Volume: 33
Issue: 1
Pages: 537-541
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/01.hyp.33.1.537
OpenAlex: W2081593602
Cited by: 185
References: 33
Citations by year: 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2019: 5 · 2017: 8 · 2016: 4 · 2015: 1 · 2014: 6 · 2013: 9 · 2012: 4
FWCI: 1.84
Type: journal article
Language: en
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p50hl044546-05, 5r29hl043514-05)
National Heart, Lung, and Blood Institute (HL-43514, HL-55006, HL-44546, P50HL055006)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords: obesity, leptin, melanocortin receptor agonist, sympathetic nervous system, renal mechanisms, vascular mechanisms, blood pressure regulation, genetic obesity model, appetite regulation, genetic background, rodent models
MeSH terms: Animals, Appetite, Carrier Proteins, Humans, Hypertension, Neuropeptides, Obesity, Proteins, Receptors, Cell Surface, Risk Factors, Receptors, Corticotropin, Leptin, Receptor, Melanocortin, Type 4, Receptors, Leptin

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Obesity-Induced Hypertension: New Concepts From the Emerging Biology of Obesity

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