Mechanisms of Sympathetic Activation in Obesity-Related Hypertension
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Cardiac norepinephrine spillover is decreased in obese normotensives and is only marginally increased in obese hypertensives.
“First, cardiac norepinephrine spillover is decreased in obese normotensives and is only marginally increased in obese hypertensives59,60–61.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [60]
Elevated sympathetic activity in obesity often occurs in the absence of hypertension.
“Most notably, elevated sympathetic activity in obesity often occurs in the absence of hypertension3,59,60–61.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [61]
Sophisticated studies using microneurography and/or radiolabeled norepinephrine spillover have unequivocally supported Landsberg's concept of sympathetic overactivity in most human obesity.
“Sophisticated studies using microneurography and/or radiolabeled norepinephrine spillover have unequivocally supported Landsberg’s concept of sympathetic overactivity in most human obesity3,60–61,64.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [61]
Cardiac norepinephrine spillover is decreased in obese normotensives and is only marginally increased in obese hypertensives.
“First, cardiac norepinephrine spillover is decreased in obese normotensives and is only marginally increased in obese hypertensives59,60–61.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [61]
In obese humans, renal norepinephrine spillover is not significantly higher in hypertensive than in normotensive subjects.
“Second, in obese humans renal norepinephrine spillover is not significantly higher in hypertensive than it is in normotensive subjects60–61.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [60]
Cardiac norepinephrine spillover is markedly elevated in lean hypertensives.
“This contrasts with marked elevation in cardiac norepinephrine spillover in lean hypertensives60.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [60]
Elevated sympathetic activity in obesity often occurs in the absence of hypertension.
“Most notably, elevated sympathetic activity in obesity often occurs in the absence of hypertension3,59,60–61.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [60]
Sophisticated studies using microneurography and/or radiolabeled norepinephrine spillover have unequivocally supported Landsberg's concept of sympathetic overactivity in most human obesity.
“Sophisticated studies using microneurography and/or radiolabeled norepinephrine spillover have unequivocally supported Landsberg’s concept of sympathetic overactivity in most human obesity3,60–61,64.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [60]
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“This possibility is supported by the demonstration of increased renal norepinephrine (NE) spillover in both the early prehypertensive and advanced stages of hypertension in obese human subjects [1, 18, 19].”
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Effects of sympathetic modulation in metabolic disease
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- Authors
- Esler, M., Straznicky, N., Eikelis, N., Masuo, K., Lambert, G., & Lambert, E.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- From the Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Australia.
- Venue
- Hypertension
- Published
- 2006-11
- Volume
- 48
- Issue
- 5
- Pages
- 787-796
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2119686163
- Cited by
- 443
- References
- 108
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 6 · 2023: 20 · 2022: 8 · 2021: 16 · 2020: 23 · 2019: 26 · 2018: 19 · 2017: 28 · 2016: 29 · 2015: 23 · 2014: 27 · 2013: 51 · 2012: 29
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- sympathetic activation, obesity, obesity-related hypertension, hypertension pathophysiology, sympathetic hyperactivity
- MeSH terms
- Animals, Disease Models, Animal, Humans, Hypertension, Hypothalamus, Obesity, Sympathetic Nervous System
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