The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Ion Channels and Vascular Tone
Open accessAbstract
Abstract—Ion channels in the plasma membrane of vascular muscle cells that form the walls of resistance arteries and arterioles play a central role in the regulation of vascular tone. Current evidence indicates that vascular smooth muscle cells express at least 4 different types of K+channels, 1 to 2 types of voltage-gated Ca 2+channels, ≥2 types of Cl−channels, store-operated Ca+(SOC) channels, and stretch-activated cation (SAC) channels in their plasma membranes, all of which may be involved in the regulation of vascular tone. Calcium influx through voltage-gated Ca 2+, SOC, and SAC channels provides a major source of activator Ca 2+used by resistance arteries and arterioles. In addition, K+and Cl−channels and the Ca 2+channels mentioned previously all are involved in the determination of the membrane potential of these cells. Membrane potential is a key variable that not only regulates Ca+2 influx through voltage-gated Ca 2+channels, but also influences release of Ca 2+from internal stores and Ca 2+- sensitivity of the contractile apparatus. By controlling Ca 2+delivery and membrane potential, ion channels are involved in all aspects of the generation and regulation of vascular tone.
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Cites
Calcium's Role in Mechanotransduction during Muscle Development
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Relaxation of Arterial Smooth Muscle by Calcium Sparks
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Metadata
- Authors
- Jackson, W. F.
- Venue
- Hypertension
- Published
- 2000-01
- Volume
- 35
- Issue
- 1
- Pages
- 173-178
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2125766324
- Cited by
- 489
- References
- 65
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
