The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Telomere Length as an Indicator of Biological Aging: The Gender Effect and Relation With Pulse Pressure and Pulse Wave Velocity
Open accessAbstract
Chronological age is the primary determinant of stiffness of central arteries. Increased stiffness is an independent indicator of cardiovascular risk. The aim of this study was to determine whether telomere length, a possible index of biological aging, provides a better account than chronological age for variation in arterial stiffness, evaluated by measuring pulse pressure and aortic pulse wave velocity. The study population included 193 French subjects (120 men, 73 women), with a mean age of 56±11 years, who were not on any antihypertensive medications. Telomere length was evaluated in white blood cells by measuring the mean length of the terminal restriction fragments. Age-adjusted telomere length was longer in women than in men (8.67±0.09 versus 8.37±0.07 kb; P =0.016). In both genders, telomere length was inversely correlated with age ( P <0.01). Multivariate analysis showed that in men, but not in women, telomere length significantly contributed to pulse pressure and pulse wave velocity variations. In conclusion, telomere length provides an additional account to chronological age of variations in both pulse pressure and pulse wave velocity among men, such that men with shorter telomere length are more likely to exhibit high pulse pressure and pulse wave velocity, which are indices of large artery stiffness. The longer telomere length in women suggests that for a given chronological age, biological aging of men is more advanced than that of women.
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Cites
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Heritability in the genomics era — concepts and misconceptions
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Obesity, cigarette smoking, and telomere length in women
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Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
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Metadata
- Authors
- Benetos, A., Okuda, K., Lajemi, M., Kimura, M., Thomas, F., Skurnick, J., Labat, C., Bean, K., & Aviv, A.
- Venue
- Hypertension
- Published
- 2001-02
- Volume
- 37
- Issue
- 2
- Pages
- 381-385
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W1973034871
- Cited by
- 620
- References
- 3
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Telomere Length as an Indicator of Biological Aging: The Gender Effect and Relation With Pulse Pressure and Pulse Wave Velocity. https://app.cochat.ai/papers/10.1161/01.hyp.37.2.381
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- Benetos, A., Okuda, K., Lajemi, M., Kimura, M., Thomas, F., Skurnick, J., Labat, C., Bean, K., & Aviv, A. (2001). Telomere Length as an Indicator of Biological Aging: The Gender Effect and Relation With Pulse Pressure and Pulse Wave Velocity. Hypertension. https://doi.org/10.1161/01.hyp.37.2.381
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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