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Cited by 135Thyroid Disorders and TreatmentsBlood Pressure and Hypertension StudiesThyroid and Parathyroid Surgery

Hypothyroidism as a cause of hypertension.

Open access
Saito, I, Ito, K, Saruta, T·1983·Hypertension
DOI 10.1161/01.hyp.5.1.112
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Abstract

To study whether there is an association between hypertension and hypothyroidism, measurements of blood pressure and thyroid function were determined in 477 female patients with chronic thyroiditis. Based on the blood levels of thyroxine (T4) and thyroid stimulating hormone (TSH), 308 patients were considered euthyroid and 169 were hypothyroid [T4 = 2.9 +/- 0.1 micrograms/dl and TSH = 105.8 +/- 6.8 microU/ml (mean +/- SEM)]. Diastolic, but not systolic, blood pressure in hypothyroid patients over 50 years was higher than in euthyroid patients of corresponding age groups. The prevalence of hypertension was higher in hypothyroid patients when hypertension was defined as the systolic and/or diastolic blood pressure above 160/95 mm Hg (14.8% vs 5.5%; p less than 0.01). Correlations between diastolic, but not systolic, blood pressure and either the blood level of triiodothyronine (T3) or T4 was significant (r = - 0.174, p less than 0.01, and r = 0.208, p less than 0.01, respectively) when data from both euthyroid and hypothyroid patients were combined. Adequate thyroid hormone replacement therapy for an average 14.8 months in 14 patients resulted in a normalization of thyroid function and a reduction of blood pressure (p less than 0.01). In four who showed no change in thyroid function due to inadequate replacement therapy, blood pressure remained elevated. These results suggest a close association between hypertension and hypothyroidism.

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  • Observational studies have shown a high prevalence of hypertension, particularly in chronic hypothyroidism.

    “Observational studies in the literature have pointed out a high prevalence of hypertension, particularly in chronic hypothyroidism (1)(2)(3)(4)(5)”

    From The Role of Thyroid Hormone in Blood Pressure Homeostasis: Evidence from Short-Term Hypothyroidism in Humans (2002) · cites this paper as [2]

    The Summary (pp. 112–115) reports a higher prevalence of hypertension in hypothyroid than euthyroid patients with chronic thyroiditis (14.8% versus 5.5%). The Discussion emphasizes the finding in patients over 50, but the paper does not establish that hypertension is particularly prevalent in chronic, as opposed to other, hypothyroidism. (LLM, conf=0.82)

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  • The prevalence of hypothyroidism in the general nonselected hypertensive population is 3-4%.

    “the consistent prevalence (3-4%) of hypothyroidism in the general nonselected hypertensive population (1,2,36)”

    From The Role of Thyroid Hormone in Blood Pressure Homeostasis: Evidence from Short-Term Hypothyroidism in Humans (2002) · cites this paper as [2]

    The Patient Population section describes women with chronic thyroiditis, not a general nonselected hypertensive population. The Age-Matched Comparisons section reports the prevalence of hypertension among hypothyroid patients (14.8%), which reverses the direction of the claimed prevalence. A search for the 3–4% estimate and for unselected hypertensive patients found neither in our copy. (LLM, conf=0.78)

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Cites

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Research works printed but not linked: 2

  1. Strong CG. Northcutt RC. Sheps SG Clinical examination and investigation of the hypertensive patients In Hypertension, edited by Gcnest J. Koiw E. Kuchcl O. New York McGraw- Hill Book Company. 1977. p 659
  2. Chiang BN. Perlman LV. Epstein FH: Overweight and hyper- tension. A review. Circulation 39: 403, 1969

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Authors
Saito, I., Ito, K., & Saruta, T.
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1983-01
Volume
5
Issue
1
Pages
112-115
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.5.1.112
OpenAlex
W2165877509
Cited by
135
References
14
Citations by year
2025: 4 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 10 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 3 · 2013: 4 · 2012: 6
FWCI
1.87
Type
journal article
Language
en
Open access
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Cleveland Clinic
  • Cleveland Clinic Foundation
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
hypothyroidism, chronic thyroiditis, thyroid function, thyroxine, thyroid-stimulating hormone, triiodothyronine, blood pressure, thyroid hormone replacement, diastolic blood pressure, women
MeSH terms
Adult, Aged, Aging, Autoantibodies, Blood Pressure, Humans, Hypertension, Hypothyroidism, Microsomes, Middle Aged, Thyroglobulin, Thyroid Hormones, Thyrotropin, Thyroxine, Triiodothyronine

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