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Cited by 49Neurogenesis and neuroplasticity mechanismsRedox biology and oxidative stressNitric Oxide and Endothelin Effects

Nox4-Generated Superoxide Drives Angiotensin II-Induced Neural Stem Cell Proliferation

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Topchiy, Elena, Panzhinskiy, Evgeniy, Griffin, W. Sue T., Barger, Steven W., Das, Mita, Zawada, W. Michael·2013·Developmental Neuroscience
DOI 10.1159/000350502PMC PMC3889712
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Abstract

Reactive oxygen species (ROS) have been reported to affect neural stem cell self-renewal and therefore may be important for normal development and may influence neurodegenerative processes when ROS activity is elevated. To determine if increasing production of superoxide, via activation of NADPH oxidase (Nox), increases neural stem cell proliferation, 100 nM angiotensin II (Ang II) - a strong stimulator of Nox - was applied to cultures of a murine neural stem cell line, C17.2. Twelve hours following a single treatment with Ang II, there was a doubling of the number of neural stem cells. This increase in neural stem cell numbers was preceded by a gradual elevation of superoxide levels (detected by dihydroethidium fluorescence) from the steady state at 0, 5, and 30 min and gradually increasing from 1 h to the maximum at 12 h, and returning to baseline at 24 h. Ang II-dependent proliferation was blocked by the antioxidant N-acetyl-L-cysteine. Confocal microscopy revealed the presence of two sources of intracellular ROS in C17.2 cells: (i) mitochondrial and (ii) extramitochondrial; the latter indicative of the involvement of one or more specific isoforms of Nox. Of the Nox family, mRNA expression for one member, Nox4, is abundant in neural stem cell cultures, and Ang II treatment resulted in elevation of the relative levels of Nox4 protein. SiRNA targeting of Nox4 mRNA reduced both the constitutive and Ang II-induced Nox4 protein levels and attenuated Ang II-driven increases in superoxide levels and stem cell proliferation. Our findings are consistent with our hypothesis that Ang II-induced proliferation of neural stem cells occurs via Nox4-generated superoxide, suggesting that an Ang II/Nox4 axis is an important regulator of neural stem cell self-renewal and as such may fine-tune normal, stress- or disease-modifying neurogenesis.

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  • NOX4 is a major source of superoxide production in human brain and promotes neural stem cell growth.

    “As a member of the NOX family genes that encode subunits of NADPH oxidase, NOX4 is a major source of superoxide production in human brain and a promoter of neural stem cell growth (Kuroda et al., 2014; Topchiy et al., 2013).”

    From Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders (2019) · cites this paper as Topchiy et al., 2013

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Cited by

Sorted by citations

Authors
Topchiy, E., Panzhinskiy, E., Griffin, W. S. T., Barger, S. W., Das, M., & Zawada, W. M.
Affiliations
  • Oregon Health & Science University (US)
  • Central Arkansas Veterans Healthcare System (US)
ORCID
Venue
Developmental Neuroscience
Publisher
S. Karger AG
Published
2013
Volume
35
Issue
4
Pages
293-305
ISSN
  • 0378-5866 (ISSN-L)
  • 1421-9859
DOI
10.1159/000350502
PMC
PMC3889712
OpenAlex
W2004244982
Cited by
49
References
6
Citations by year
2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 10 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 2
FWCI
1.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Developmental Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • University of Colorado Denver
  • National Institute on Alcohol Abuse and Alcoholism (U01AA016654)
  • National Institute on Aging (P01AG012411)
  • National Heart, Lung, and Blood Institute (R01HL064917)
  • National Institute on Drug Abuse (T32DA007262)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
NOX4, NADPH oxidase, superoxide, angiotensin II, neural stem cell proliferation, reactive oxygen species, C17.2 cells, mitochondrial reactive oxygen species, N-acetylcysteine, neurogenesis, stem cell self-renewal
MeSH terms
NADPH Oxidase 4, Angiotensin II, Animals, Cell Count, Cells, Cultured, Data Interpretation, Statistical, Superoxides, Blotting, Western, Reactive Oxygen Species, Microscopy, Confocal, NADPH Oxidases, RNA Interference, Cell Proliferation, Mice, Neural Stem Cells, Real-Time Polymerase Chain Reaction

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