The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Design Principles of Vascular Beds
Abstract
Abstract Hemodynamic parameters were determined in each vessel segment of six complete microvascular networks in the rat mesentery by using a combination of experimental measurements and theoretical simulations. For a total number of 2592 segments, a strong unified dependence of wall shear stress on intravascular pressure for arterioles, capillaries, and venules was obtained. All three types of segments exhibit an essentially identical variation of shear stress from high to low values (from ≈100 to 10 dyne/cm 2 ) as intravascular pressure falls from 70 to 15 mm Hg. On the basis of these observations, it is proposed that vascular beds grow and adapt so as to maintain the shear stress in each vessel at a level that depends on local transmural pressure. In contrast to Murray’s classic ‘minimum-cost’ hypothesis, which implies uniformity of wall shear rate throughout the vasculature, the proposed design principle provides an explanation for the functionally important arteriovenous asymmetry of wall shear rates and flow resistance in the circulation.
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Citations
Cites
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The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume
Murray, C. D. (1926) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.12.3.207 · Cited by 2,087
Langille, B. L., & O'Donnell, F. (1986) · Science · doi:10.1126/science.3941904 · Cited by 1,113
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Structure and function of small arteries
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Small artery structure in hypertension. Dual processes of remodeling and growth.
Heagerty, A. M., Aalkjaer, C., Bund, S. J., Korsgaard, N., & Mulvany, M. J. (1993) · Hypertension · doi:10.1161/01.hyp.21.4.391 · Cited by 645
Resnick, N., Collins, T., Atkinson, W., Bonthron, D. T., Dewey, C. F., & Gimbrone, M. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4591 · Cited by 631
Mechanical stress mechanisms and the cell. An endothelial paradigm.
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Self-citationBlood flow in microvascular networks. Experiments and simulation.
Pries, A. R., Secomb, T. W., Gaehtgens, P., & Gross, J. F. (1990) · Circulation Research · doi:10.1161/01.res.67.4.826 · Cited by 566
Self-citation
Cited by
Deterministic hydrodynamics: Taking blood apart
Davis, J. A., Inglis, D. W., Morton, K. J., Lawrence, D. A., Huang, L. R., Chou, S. Y., Sturm, J. C., & Austin, R. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605967103 · Cited by 622
Biophysical aspects of blood flow in the microvasculature
Pries, A. R., Secomb, T. W., & Gaehtgens, P. (1996) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00065-x · Cited by 553
Self-citationReneman, R. S., Arts, T., & Hoeks, A. P. G. (2006) · Journal of Vascular Research · doi:10.1159/000091648 · Cited by 431
Vascular Adaptation and Mechanical Homeostasis at Tissue, Cellular, and Sub-cellular Levels
Humphrey, J. D. (2008) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-9002-3 · Cited by 408
Multiscale modelling and nonlinear simulation of vascular tumour growth
Macklin, P., McDougall, S., Anderson, A. R. A., Chaplain, M. A. J., Cristini, V., & Lowengrub, J. (2009) · Journal of Mathematical Biology · doi:10.1007/s00285-008-0216-9 · Cited by 363
Metadata
- Authors
- Pries, A. R., Secomb, T. W., & Gaehtgens, P.
- Venue
- Circulation Research
- Published
- 1995-11
- Volume
- 77
- Issue
- 5
- Pages
- 1017-1023
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W1988957088
- Cited by
- 321
- References
- 39
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pries, A. R., Secomb, T. W., & Gaehtgens, P. (1995). Design Principles of Vascular Beds. Circulation Research. https://doi.org/10.1161/01.res.77.5.1017
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
