The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Increased Expression of Estrogen Receptor-β mRNA in Male Blood Vessels After Vascular Injury
Abstract
Abstract —Estrogen exerts direct effects on vascular endothelial and smooth muscle cells that are important for vascular protection. Estrogen receptor-α (ERα) is expressed in vascular cells from males and females and may mediate some of the effects of estrogen on vascular tissue. However, we recently found that estrogen is able to protect against vascular injury in ovariectomized female ERα knockout mice. These mice express the newly described estrogen receptor-β (ERβ) in their aortas, suggesting that ERβ may also mediate some of the direct effects of estrogen on the vasculature. In this study, the level of expression of ERα and ERβ mRNA in male rat aortas was examined before and after vascular injury using en face (Häutchen) preparations and in situ hybridization. Little or no change in ERα expression was observed after vascular injury in either vascular endothelial or smooth muscle cells at any time point. In contrast, ERβ mRNA was found to be expressed markedly after balloon injury. In endothelial cells, ERβ was increased by 2 days after injury, and high levels of expression were maintained at 8 and 14 days. Furthermore, ERβ expression was high in luminal smooth muscle cells at 8 and 14 days after injury and had decreased to low levels by 28 days after injury. These data demonstrate the presence of ERβ in male vascular tissues and the induction of ERβ mRNA expression after vascular injury, supporting a role for ERβ in the direct vascular effects of estrogen.
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Cites
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Cited by
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
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Self-citationCoordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain
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Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
Zhu, Y., Bian, Z., Lu, P., Karas, R. H., Bao, L., Cox, D., Hodgin, J., Shaul, P. W., Thorén, P., Smithies, O., et al. (2002) · Science · doi:10.1126/science.1065250 · Cited by 482
Self-citationCooke, P. S., Nanjappa, M. K., Ko, C., Prins, G. S., & Hess, R. A. (2017) · Physiological Reviews · doi:10.1152/physrev.00018.2016 · Cited by 466
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Metadata
- Authors
- Lindner, V., Kim, S. K., Karas, R. H., Kuiper, G. G. J. M., Gustafsson, J.-A., & Mendelsohn, M. E.
- Venue
- Circulation Research
- Published
- 1998-07-27
- Volume
- 83
- Issue
- 2
- Pages
- 224-229
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2112590471
- Cited by
- 294
- References
- 37
- FWCI
- 15.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lindner, V., Kim, S. K., Karas, R. H., Kuiper, G. G. J. M., Gustafsson, J.-A., & Mendelsohn, M. E. (1998). Increased Expression of Estrogen Receptor-β mRNA in Male Blood Vessels After Vascular Injury. Circulation Research. https://doi.org/10.1161/01.res.83.2.224
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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