Cited by 2,886Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

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NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease

Griendling, Kathy K., Sorescu, Dan, Ushio-Fukai, Masuko·2000·Circulation Research

DOI 10.1161/01.res.86.5.494

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Abstract

Abstract —Reactive oxygen species have emerged as important molecules in cardiovascular function. Recent work has shown that NAD(P)H oxidases are major sources of superoxide in vascular cells and myocytes. The biochemical characterization, activation paradigms, structure, and function of this enzyme are now partly understood. Vascular NAD(P)H oxidases share some, but not all, characteristics of the neutrophil enzyme. In response to growth factors and cytokines, they produce superoxide, which is metabolized to hydrogen peroxide, and both of these reactive oxygen species serve as second messengers to activate multiple intracellular signaling pathways. The vascular NAD(P)H oxidases have been found to be essential in the physiological response of vascular cells, including growth, migration, and modification of the extracellular matrix. They have also been linked to hypertension and to pathological states associated with uncontrolled growth and inflammation, such as atherosclerosis.

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Authors: Griendling, K. K., Sorescu, D., & Ushio-Fukai, M.
Affiliations: Emory University (US)
From the Department of Medicine, Division of Cardiology, Emory University, Atlanta, Ga.
ORCID: Griendling, Kathy K.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-03-17
Volume: 86
Issue: 5
Pages: 494-501
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.86.5.494
OpenAlex: W2123799914
Cited by: 2,886
References: 94
Citations by year: 2026: 14 · 2025: 29 · 2024: 27 · 2023: 39 · 2022: 43 · 2021: 62 · 2020: 70 · 2019: 51 · 2018: 64 · 2017: 54 · 2016: 79 · 2015: 79 · 2014: 124 · 2013: 131 · 2012: 137
FWCI: 19.54
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL 58000, HL38206, HL58863, P01HL058000, R01HL058863)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: NADPH oxidase, reactive oxygen species, superoxide, hydrogen peroxide, vascular cells, growth factor signaling, cytokine signaling, intracellular signaling, cell migration, extracellular matrix remodeling, hypertension, atherosclerosis, inflammation
MeSH terms: Arteries, Arteriosclerosis, Humans, Myocardium, Reactive Oxygen Species, NADPH Oxidases

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NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease

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