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Cited by 299

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Electrical Coupling Between Endothelial Cells and Smooth Muscle Cells in Hamster Feed Arteries: Role in Vasomotor Control

Emerson, Geoffrey G., Segal, Steven S.·2000·Circulation Research
DOI 10.1161/01.res.87.6.474
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Abstract

Abstract —Endothelial cells (ECs) govern smooth muscle cell (SMC) tone via the release of paracrine factors (eg, NO and metabolites of arachidonic acid). We tested the hypothesis that ECs can promote SMC relaxation or contraction via direct electrical coupling. Vessels (resting diameter, 57±3 μm; length, 4 mm) were isolated, cannulated, and pressurized (75 mm Hg; 37°C). Two microelectrodes were used to simultaneously impale 2 cells (ECs or SMCs) in the vessel wall separated by 500 μm. Impalements of one EC and one SMC (n=26) displayed equivalent membrane potentials at rest, during spontaneous oscillations, and during hyperpolarization and vasodilation to acetylcholine. Injection of −0.8 nA into an EC caused hyperpolarization (≈5 mV) and relaxation of SMCs (dilation, ≈5 μm) along the vessel segment. In a reciprocal manner, +0.8 nA caused depolarization (≈2 mV) of SMCs with constriction (≈2 μm). Current injection into SMCs while recording from ECs produced similar results. We conclude that ECs and SMCs are electrically coupled to each other in these vessels, such that electrical signals conducted along the endothelium can be directly transmitted to the surrounding smooth muscle to evoke vasomotor responses.

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Metadata

Authors
Emerson, G. G., & Segal, S. S.
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-09-15
Volume
87
Issue
6
Pages
474-479
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/01.res.87.6.474
OpenAlex
W2118540829
Cited by
299
References
33
FWCI
6.31
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Electrical Coupling Between Endothelial Cells and Smooth Muscle Cells in Hamster Feed Arteries: Role in Vasomotor Control. https://app.cochat.ai/papers/10.1161/01.res.87.6.474
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Emerson, G. G., & Segal, S. S. (2000). Electrical Coupling Between Endothelial Cells and Smooth Muscle Cells in Hamster Feed Arteries: Role in Vasomotor Control. Circulation Research. https://doi.org/10.1161/01.res.87.6.474

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.