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Cited by 419

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Genetic and Environmental Risk Factors for Intracerebral Hemorrhage: Preliminary Results of a Population-Based Study

Woo, Daniel, Sauerbeck, Laura R., Kissela, Brett M., Khoury, Jane C., Szaflarski, Jerzy P., Gebel, James, Shukla, Rakesh, Pancioli, Arthur M., Jauch, Edward C., Menon, Anil G., Deka, Ranjan, Carrozzella, Janice A., Moomaw, Charles J., Fontaine, Robert N., Broderick, Joseph P.·2002·Stroke
DOI 10.1161/01.str.0000014774.88027.22
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Abstract

Background and Purpose — Intracerebral hemorrhage (ICH) has a 30-day mortality rate of 40% to 50% and lacks a proven treatment. We report a preplanned, midpoint analysis of the first population-based, case-control study that examines both genetic and environmental risk factors of ICH. Methods — We prospectively identified cases of hemorrhagic stroke at all 16 hospitals in the Greater Cincinnati/Northern Kentucky region. All cases underwent medical record and neuroimaging review. Cases enrolled in the direct interview and genetic sampling arm of the study were matched to population-based control subjects by age, race, and sex. Multivariable logistic regression was performed to identify significant independent risk factors. Results — We enrolled 188 cases of ICH (67 lobar, 121 nonlobar) and 366 control subjects in the direct interview arm of the study. Significant independent risk factors for lobar ICH included the presence of an apolipoprotein E2 or E4 allele, frequent alcohol use, prior stroke, and first-degree relative with ICH. Significant independent risk factors for nonlobar ICH were hypertension, prior stroke, and first-degree relative with ICH. An increasing level of education was associated with a decreased risk of nonlobar ICH. The attributable risk of apolipoprotein E2 or E4 for lobar ICH was 29%, and the attributable risk of hypertension for nonlobar ICH was 54%. Conclusions — There is significant epidemiological evidence that the pathophysiology of ICH varies by location. We estimate that a third of all cases of lobar ICH are attributable to possession of an apolipoprotein E4 or E2 allele and that half of all cases of nonlobar ICH are attributable to hypertension.

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Metadata

Authors
Woo, D., Sauerbeck, L. R., Kissela, B. M., Khoury, J. C., Szaflarski, J. P., Gebel, J., Shukla, R., Pancioli, A. M., Jauch, E. C., Menon, A. G., Deka, R., Carrozzella, J. A., Moomaw, C. J., Fontaine, R. N., & Broderick, J. P.
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-05
Volume
33
Issue
5
Pages
1190-1196
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.0000014774.88027.22
OpenAlex
W1674692411
Cited by
419
References
40
FWCI
12.98
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Genetic and Environmental Risk Factors for Intracerebral Hemorrhage: Preliminary Results of a Population-Based Study. https://app.cochat.ai/papers/10.1161/01.str.0000014774.88027.22
The paper
Woo, D., Sauerbeck, L. R., Kissela, B. M., Khoury, J. C., Szaflarski, J. P., Gebel, J., Shukla, R., Pancioli, A. M., Jauch, E. C., Menon, A. G., Deka, R., Carrozzella, J. A., Moomaw, C. J., Fontaine, R. N., & Broderick, J. P. (2002). Genetic and Environmental Risk Factors for Intracerebral Hemorrhage: Preliminary Results of a Population-Based Study. Stroke. https://doi.org/10.1161/01.str.0000014774.88027.22

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.