Cited by 420Acute Ischemic Stroke ManagementDiabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, Diet

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Abdominal Obesity and Risk of Ischemic Stroke: The Northern Manhattan Stroke Study

Suk, Seung-Han, Sacco, Ralph L., Boden-Albala, Bernadette, Cheun, Jian F., Pittman, John G., Elkind, Mitchell S., Paik, Myunghee C.·2003·Stroke

DOI 10.1161/01.str.0000075294.98582.2f

Open this paper in CoChat — free account

Abstract

Background and Purpose— Obesity is well recognized as a risk factor for coronary heart disease and mortality. The relationship between abdominal obesity and ischemic stroke remains less clear. Our aim was to evaluate abdominal obesity as an independent risk factor for ischemic stroke in a multiethnic community. Methods— A population-based, incident case-control study was conducted July 1993 through June 1997 in northern Manhattan, New York, NY. Cases (n=576) of first ischemic stroke (66% ≥65 years of age; 56% women; 17% whites; 26% blacks; 55% Hispanics) were enrolled and matched by age, sex, and race-ethnicity to stroke-free community controls (n=1142). All subjects were interviewed and examined and had measurements of waist-to-hip ratio (WHR). Odds ratios (ORs) of ischemic stroke were calculated with gender-specific quartiles (GQs) and gender-specific medians of WHR adjusted for stroke risk factors and body mass index (BMI). Results— Compared with the first quartile, the third and fourth quartiles of WHR had an increased risk of stroke (GQ3: OR, 2.4; 95% CI, 1.5 to 3.9; GQ4: OR, 3.0; 95% CI, 1.8 to 4.8) adjusted for other risk factors and BMI. Those with WHR equal to or greater than the median had an overall OR of 3.0 (95% CI, 2.1 to 4.2) for ischemic stroke even after adjustment for other risk factors and BMI. Increased WHR was associated with a greater risk of stroke in men and women and in all race-ethnic groups. The effect of WHR was stronger among younger persons (test for heterogeneity, P <0.0002) (<65 years of age: OR, 4.4; 95%CI, 2.2 to 9.0; ≥65 years of age: OR, 2.2; 95% CI, 1.4 to 3.2). WHR was associated with an increased risk among those with and without large-artery atherosclerotic stroke. Conclusions— Abdominal obesity is an independent, potent risk factor for ischemic stroke in all race-ethnic groups. It is a stronger risk factor than BMI and has a greater effect among younger persons. Prevention of obesity and weight reduction need greater emphasis in stroke prevention programs.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.str.0000075294.98582.2f

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report
(1998) · PsycEXTRA Dataset · doi:10.1037/e565682010-001 · Cited by 9,453
The Disease Burden Associated With Overweight and Obesity
Must, A. (1999) · JAMA · doi:10.1001/jama.282.16.1523 · Cited by 4,827
Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.
Hubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P. (1983) · Circulation · doi:10.1161/01.cir.67.5.968 · Cited by 4,241
Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults
Calle, E. E., Thun, M. J., Petrelli, J. M., Rodriguez, C., & Heath, C. W. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910073411501 · Cited by 3,643
Overweight and obesity in the United States: prevalence and trends, 1960–1994
Flegal, K., Carroll, M., Kuczmarski, R., & Johnson, C. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800541 · Cited by 3,045
The Spread of the Obesity Epidemic in the United States, 1991-1998
Mokdad, A. H. (1999) · JAMA · doi:10.1001/jama.282.16.1519 · Cited by 2,384
Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913.
Larsson, B., Svärdsudd, K., Welin, L., Wilhelmsen, L., Björntorp, P. A., & Tibblin, G. (1984) · BMJ · doi:10.1136/bmj.288.6428.1401 · Cited by 1,931
Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden.
Lapidus, L., Bengtsson, C., Larsson, B., Pennert, K. M., Rybo, E., & Sjöström, L. (1984) · BMJ · doi:10.1136/bmj.289.6454.1257 · Cited by 1,657
The Degree of Masculine Differentiation of Obesities
Vague, J. (1956) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/4.1.20 · Cited by 1,393
The spread of the obesity epidemic in the United States
Mokdad, A. H., Serdula, M. K., & Dietz, W. H. (1999) · Cited by 985

Flagged first, then by citations

Show all 49 references

Research works printed but not linked: 10

10.1161/circ.67.5.6219830 · DOI
10.1161/circ.86.2.1638709 · DOI
10.1161/str.32.1.280 · DOI
10.1161/str.25.12.7974575 · DOI
10.1161/str.21.5.2339449 · DOI
10.1161/str.24.10.8378948 · DOI
10.1161/str.28.5.929 · DOI
10.1161/circ.99.4.541 · DOI
10.1161/str.32.8.1725 · DOI
10.1161/str.25.11.7974531 · DOI

Sorted by citations

Items 101–200 of 419

Associations between metabolic syndrome and type of dementia: analysis based on the National Health Insurance Service database of Gangwon province in South Korea
Kim, Y. J., Kim, S. M., Jeong, D. H., Lee, S., Ahn, M., & Ryu, O. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-020-00620-5 · Cited by 67
Primary Preventive Potential for Stroke by Avoidance of Major Lifestyle Risk Factors: The European Prospective Investigation Into Cancer and Nutrition-Heidelberg Cohort
Tikk, K., Sookthai, D., Monni, S., Gross, M.-L., Lichy, C., Kloss, M., & Kaaks, R. (2014) · Stroke · doi:10.1161/strokeaha.114.005025 · Cited by 64
Visceral fat area‐defined obesity and periodontitis among Koreans
Han, D., Lim, S., Sun, B., Paek, D., & Kim, H. (2009) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2009.01515.x · Cited by 68
Protein Intake Is Inversely Associated with Abdominal Obesity in a Multi-Ethnic Population
Merchant, A. T., Anand, S. S., Vuksan, V., Jacobs, R., Davis, B. C., Teo, K. K., & Yusuf, S. (2005) · Journal of Nutrition · doi:10.1093/jn/135.5.1196 · Cited by 66
Reductions in cardiovascular risk after bariatric surgery
Benraouane, F., & Litwin, S. E. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32834b7fc4 · Cited by 64
Association of abdominal obesity with decreased serum levels of carotenoids in a healthy Japanese population
Suzuki, K. A. O., Inoue, T., Hioki, R., Ochiai, J., Kusuhara, Y., Ichino, N., Osakabe, K., Hamajima, N., & Ito, Y. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.01.025 · Cited by 62
Differentiating ischemic stroke subtypes: Risk factors and secondary prevention
Kirshner, H. S. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.12.012 · Cited by 63
Immunologic profile of excessive body weight
Sharabiani, M. T. A., Vermeulen, R. C. H., Scoccianti, C., Hosnijeh, F. S., Minelli, L., Sacerdote, C., Palli, D., Krogh, V., Tumino, R., Chiodini, P., et al. (2011) · Biomarkers · doi:10.3109/1354750x.2010.547948 · Cited by 60
The use of telomere length as a predictive biomarker for injury prognosis in juvenile rats following a concussion/mild traumatic brain injury
Hehar, H., & Mychasiuk, R. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.12.007 · Cited by 60
“obesity and HFDs increase diseases susceptibility and reduce life expectancy (Elias et al., 2003; Suk et al., 2003; Valdes et al., 2005; Ferezou-Viala et al., 2007; Tzanetakou et al., 2012; Gaillard et al., 2014).”
Background
Are Network-Based Interventions a Useful Antiobesity Strategy? An Application of Simulation Models for Causal Inference in Epidemiology
El‐Sayed, A. M., Seemann, L., Scarborough, P., & Galea, S. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws455 · Cited by 61
“Obesity is an important determinant of chronic disease morbidity and mortality (5–7) and is associated with the risk of hypertension, hypercholesterolemia, coronary heart disease (5), stroke (8), and diabetes mellitus (9).”
Background
Weight reduction for primary prevention of stroke in adults with overweight or obesity
Curioni, C. C., André, C., & Veras, R. P. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006062.pub2 · Cited by 59
Thrombosis in the setting of obesity or inflammatory bowel disease
Lentz, S. R. (2016) · Blood · doi:10.1182/blood-2016-05-716720 · Cited by 61
“Obesity is also a risk factor for ischemic stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE) in both men and women.(8,9) In a meta-analysis of the influence of obesity on the risk of a first episode of venous thromboembolism (VTE), Ageno et al(10) estimated an overall odds ratio forVTEof 2.”
Background
Changes in waist circumference and risk of all-cause and CVD mortality: results from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) cohort study
Mulligan, A. A., Lentjes, M. A. H., Luben, R. N., Wareham, N. J., & Khaw, K.-T. (2019) · BMC Cardiovascular Disorders · doi:10.1186/s12872-019-1223-z · Cited by 62
Dietary intake alters behavioral recovery and gene expression profiles in the brain of juvenile rats that have experienced a concussion
Mychasiuk, R., Hehar, H., Ma, I. W. Y., & Esser, M. J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00017 · Cited by 57
“Indeed, obesity in humans has been shown to impair recovery from stroke (Kalichman et al., 2007), is a major risk factor for ischemic stroke across all ethnic groups, and is associated with the greatest risk of stroke in younger individuals (Suk et al., 2003).”
Background
Leptin and adiponectin: pathophysiological role and possible therapeutic target of inflammation in ischemic stroke
Gairolla, J., Kler, R., Modi, M., & Khurana, D. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0055 · Cited by 60
“Obesity is a well-known risk factor for ischemic stroke in all race-ethnic groups (Suk et al., 2003) and significantly increases the risk of atherosclerosis (Van Gaal et al.”
Background
The role of obesity in carotid plaque instability: interaction with age, gender, and cardiovascular risk factors
Rovella, V., Anemona, L., Cardellini, M., Scimeca, M., Saggini, A., Santeusanio, G., Bonanno, E., Montanaro, M., Legramante, I. M., Ippoliti, A., et al. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0685-0 · Cited by 58
“According to some authors, abdominal body fat might represent a stronger predictor of stroke risk than BMI [50].”
Background
Is Antioxidant and n–3 Supplementation Able to Improve Functional Status in Poststroke Patients? Results from the Nutristroke Trial
Garbagnati, F., Cairella, G., Martino, A. D., Multari, M., Scognamiglio, U., Venturiero, V., & Paolucci, S. (2009) · Cerebrovascular Diseases · doi:10.1159/000207441 · Cited by 56
Lifestyle Modification for Secondary Stroke Prevention
Bailey, R. R. (2016) · American Journal of Lifestyle Medicine · doi:10.1177/1559827616633683 · Cited by 61
Survival Benefit of Obese Patients With Pulmonary Embolism
Keller, K., Hobohm, L., Münzel, T. F., Ostad, M. A., Espinola–Klein, C., Lavie, C. J., Konstantinides, S., & Lankeit, M. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.04.035 · Cited by 56
The obesity paradox and survivors of ischemic stroke.
Wohlfahrt, P., Lopez-Jimenez, F., Krajčoviechová, A., Jozífová, M., Mayer, O., Vaněk, J., Filipovský, J., Llano, E. M., & Cífková, R. (2015) · Journal of Stroke & Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2015.03.008 · Cited by 54
The effect of commitment-making on weight loss and behaviour change in adults with obesity/overweight; a systematic review
Coupe, N., Peters, S., Rhodes, S., & Cotterill, S. (2019) · BMC Public Health · doi:10.1186/s12889-019-7185-3 · Cited by 62
Hyperglycemia and Stroke Mortality
Hyvärinen, M., Qiao, Q., Tuomilehto, J. O., Laatikainen, T. K., Heine, R. J., Stehouwer, C. D. A., Alberti, K. G. M. M., Pyörälà, K., Zethelius, B., Stegmayr, B., et al. (2008) · Diabetes Care · doi:10.2337/dc08-1411 · Cited by 50
“Abdominal adiposity, measured as waist circumference or as waist-to-hip ratio, has been found to increase the risk of ischemic stroke in both men and women (20) or in men only (21).”
Background
Body Fat Distribution and Long-Term Risk of Stroke Mortality
Tanné, D., Medalie, J. H., & Goldbourt, U. (2005) · Stroke · doi:10.1161/01.str.0000162584.39366.1c · Cited by 50
The neurology of enteric disease
Wills, A. J. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.085365 · Cited by 49
“Obesity is a risk factor for vascular disease, particularly hypertension and glucose intolerance. Abdominal obesity rather than increased body mass index is felt to be of particular relevance in stroke.”
Background
Ischemic Stroke and Its Risk Factors in a Registry-Based Large Cross-Sectional Diabetic Cohort in a Country Facing a Diabetes Epidemic
Al-Rubeaan, K. A., Al-Hussain, F., Youssef, A. M., Subhani, S., Al‐Sharqawi, A. H., & Ibrahim, H. M. (2016) · Journal of Diabetes Research · doi:10.1155/2016/4132589 · Cited by 49
“These findings are more predictive than surprising because many large studies have suggested abdominal obesity, rather than BMI, to be a potent risk factor for stroke [47, 48].”
Plasminogen activator inhibitor‐1 contributes to the deleterious effect of obesity on the outcome of thrombotic ischemic stroke in mice
NAGAI, N., HOEF, B. V., & LIJNEN, H. R. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02631.x · Cited by 47
A Gender-Stratified Comparative Analysis of Various Definitions of Metabolic Syndrome and Cardiovascular Risk in a Multiethnic U.S. Population
Hari, P., Nerusu, K. C., Veeranna, V., Sudhakar, R., ZALAWADIYA, S. K., Ramesh, K., & Afonso, L. (2011) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2011.0087 · Cited by 45
Cardiovascular disease risk factors, metabolic syndrome and obesity in an Iranian population.
Kelishadi, R., Gharipour, M., Sadri, G., Tavasoli, A. A., & Amani, A. (2008) · PubMed · Cited by 45
Measures of obesity are associated with MRI markers of brain aging
Caunca, M. R., Gardener, H. E., Simonetto, M., Cheung, Y. K., Alperin, N. J., Yoshita, M., DeCarli, C. S., Elkind, M. S. V., Sacco, R. L., Wright, C. B., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000007966 · Cited by 45
Self-citation
Metabolic syndrome and stroke
Towfighi, A., & Ovbiagele, B. I. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0008-z · Cited by 44
“The Northern Manhattan Stroke Study found those with a waist-tohip ratio of greater than the median had an overall OR of 3.0 (95% CI, 2.1–4.2) for ischemic stroke even after adjustment for other risk factors and body mass index, concluding that abdominal obesity is a potent independent risk factor for ischemic stroke…”
BackgroundInfluential
Thoracic periaortic and visceral adipose tissue and their cross‐sectional associations with measures of vascular function
Britton, K. A., Wang, N., Palmisano, J. N., Corsini, E. M., Schlett, C. L., Hoffmann, U., Larson, M. G., Vasan, R. S., Vita, J. A., Mitchell, G. F., et al. (2013) · Obesity · doi:10.1002/oby.20166 · Cited by 43
“VAT has previously been shown to be associated with certain measures of vascular functions (16), cardiometabolic risk factors (17,18), and clinical cardiovascular diseases (18-20).”
Background
Adipokines in neurovascular diseases
Opatřilová, R., Čaprnda, M., Kubatka, P., Valentová, V., Uramova, S., Nosáľ, V., Gašpar, Ľ., Zachar, L., Mozos, I. M., Petrovič, D., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.074 · Cited by 43
Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity
Zheng, Z., Nakamura, K., Gershbaum, S., Wang, X., Thomas, S., Bessler, M., Schrope, B., Krikhely, A., Liu, R.-M., Ozcan, L., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135919 · Cited by 43
Modifiable Risk Factors for Stroke and Strategies for Stroke Prevention
Towfighi, A., & Hill, V. A. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1603685 · Cited by 45
Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics
MacDougall, G., Anderton, R. S., Mastaglia, F. L., Knuckey, N. W., & Meloni, B. P. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.010 · Cited by 41
Obesity in neurobiology
Knecht, S., Ellger, T., & Levine, J. A. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.09.003 · Cited by 45
Dietary Total Fat Intake and Ischemic Stroke Risk: The Northern Manhattan Study
Boden-Albala, B. M., Elkind, M. S. V., White, H., Szumski, A. E., Paik, M. C., & Sacco, R. L. (2009) · Neuroepidemiology · doi:10.1159/000204914 · Cited by 42
Self-citation
Association between different obesity measures and the risk of stroke in the EPIC Spanish cohort
Abete, I., Arriola, L., Etxezarreta, N., Carollo, I. M., Moreno‐Iribas, C., Amiano, P., Egüés, N., Goyenechea, E., de Munaín, A. L., Martínez, M., et al. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0716-x · Cited by 43
“Nevertheless, very different associations have been found depending on the sex, the age and the obesity index used [14, 30, 31].”
Background
Diet, age, and prior injury status differentially alter behavioral outcomes following concussion in rats
Mychasiuk, R., Hehar, H., van Waes, L., & Esser, M. J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.09.003 · Cited by 39
“Human literature has capitalized on clinical databases to retrospectively examine the associations between obesity and neurological disorders such as dementia, Alzheimer's disease, and stroke (Luchsinger et al., 2002; Elias et al., 2003; Suk et al., 2003; de la Monte and Tong, 2014).”
Body Fat Measured by a Near‐Infrared Interactance Device as a Predictor of Cardiovascular Events: The FINRISK'92 Cohort
Pajunen, P., Jousilahti, P., Borodulin, K., Harald, K., Tuomilehto, J. O., & Salomaa, V. V. (2010) · Obesity · doi:10.1038/oby.2010.236 · Cited by 38
Association between stroke and relative fat mass: a cross-sectional study based on NHANES
Zheng, Y., Huang, C., Jin, J., Zhao, Y., Cui, H., & Wei, C. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02351-2 · Cited by 37
Age-Related Changes in Fat Mass and Distribution in Men—the Cross-Sectional STRAMBO Study
Szulc, P., Duboeuf, F., & Chapurlat, R. D. (2016) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2016.08.003 · Cited by 37
Obesity paradox in peripheral artery disease
Keller, K., Hobohm, L., Geyer, M., Münzel, T. F., Lavie, C. J., Ostad, M. A., & Espinola–Klein, C. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.09.031 · Cited by 36
Post-traumatic stress disorder and its association with stroke and stroke risk factors: A literature review
Perkins, J. D., Wilkins, S. S., Kamran, S., & Shuaib, A. M. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100332 · Cited by 38
Body Build and Risk of Cardiovascular Events in Hypertension and Left Ventricular Hypertrophy
SIMONE, G. D., Wachtell, K., Palmieri, V., Hille, D. A., Beevers, G., Dahlöf, B., Fairé, U. D., Fyhrquist, F., Ibsen, H., Julius, S., et al. (2005) · Circulation · doi:10.1161/01.cir.0000161799.91577.0a · Cited by 36
Obesity Measures in Relation to Cognition in the Northern Manhattan Study
Gardener, H. E., Caunca, M. R., Dong, C., Cheung, Y. K., Rundek, T., Elkind, M. S. V., Wright, C. B., & Sacco, R. L. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201071 · Cited by 34
Self-citation
Calf Circumference Is Inversely Associated With Carotid Plaques
Debette, S., Léone, N., Courbon, D., Gariépy, J., Tzourio, C., Dartigues, J., Ritchie, K. A., Alpérovitch, A., Ducimetière, P., Amouyel, P., et al. (2008) · Stroke · doi:10.1161/strokeaha.108.520106 · Cited by 32
“the inverse association between carotid plaques and CC was graded; (3) that it was independent of age, gender, vascular risk factors, BMI, and physical activity; and (4) that stratifying on gender, BMI, and physical activity or excluding subjects with a metabolic syndrome or a history of vascular event did not modify…”
Result
Statistical Security for Social Security
Soneji, S. S., & King, G. (2012) · Demography · doi:10.1007/s13524-012-0106-z · Cited by 34
“The obese, especially the morbidly obese, experience much greater risk of mortality, notably in mortality from cardiovascular disease (Flegal et al. 2007 ) and ischemic stroke (Suk et al. 2003).”
A qualitative study exploring patients’ experiences of standard care or cardiac rehabilitation post minor stroke and transient ischaemic attack
Hillsdon, K. M., Kersten, P., & Kirk, H. (2013) · Clinical Rehabilitation · doi:10.1177/0269215513478956 · Cited by 33
RISK FACTORS FOR STROKE, ASSESSING RISK, AND THE MASS AND HIGH-RISK APPROACHES FOR STROKE PREVENTION
Chong, J. Y., & Sacco, R. L. (2005) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000293708.61582.f4 · Cited by 34
“This risk was independent of body mass index and other known risk factors (Suk et al, 2003) (Figure 2-6).”
BackgroundSelf-citation
Cerebrovascular Disease: Consequences of Obesity-Induced Endothelial Dysfunction
Letra, L., & Sena, C. M. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_7 · Cited by 33
Evidence of hypercoagulability and inflammation in young patients long after acute cerebral ischaemia
Doma, S. A., Mijovski, M. B., Antovič, A., Peternel, P., Gašperšič, N., Rot, U., Tratar, G., & Stegnar, M. (2006) · Thrombosis Research · doi:10.1016/j.thromres.2006.08.005 · Cited by 33
“The data on obesity as an independent risk factor for cerebral ischaemia is controversial [1,3,10,40].”
Background
Stroke prevention
Isabel, C., Calvet, D., & Mas, J. (2016) · La Presse Médicale · doi:10.1016/j.lpm.2016.10.009 · Cited by 36
“with results of the Northern Manhattan Stroke study, which showed that abdominal obesity was a risk factor for ischemic stroke, independently of BMI, in all race-ethnic groups [31].”
Result
Diet, genes and disease: implications for nutrition policy
Gibney, M. J., & Gibney, E. R. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004369 · Cited by 32
“…obesity, alcohol and hyperhomocysteinaemia (Kromhout, 2001; Thomas et al. 2001; De Michele et al. 2002; Wilson et al. 2002; de Bree et al. 2003; Suk et al. 2003; Tanne et al. 2003); the metabolic pathways associated with all these factors may also be influenced by the underlying genetic…”
Background
Body mass index and mortality in patients with type 2 diabetes mellitus: A prospective cohort study of 11,449 participants
Liu, H., Wu, S., Li, Y., Sun, L., Huang, Z., Lin, L., Liu, Y., Ji, C., Zhao, H., Li, C., et al. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.10.015 · Cited by 31
The Role of Diabetes, Obesity, and Metabolic Syndrome in Stroke
Tang, X. N., Liebeskind, D. S., & Towfighi, A. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1603753 · Cited by 30
Phytosome Loading the Combined Extract of Mulberry Fruit and Ginger Protects against Cerebral Ischemia in Metabolic Syndrome Rats
Palachai, N., Wattanathorn, J., Muchimapura, S., & Thukham-mee, W. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5305437 · Cited by 28
Diet‐Derived Antioxidants Do Not Decrease Risk of Ischemic Stroke: A Mendelian Randomization Study in 1 Million People
Martens, L. G., Luo, J., van Dijk, K. W., Jukema, J. W., Noordam, R., & van Heemst, D. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022567 · Cited by 28
A new paradigm in the treatment of the cardiovascular disease continuum: focus on prevention.
Chrysant, S. G. (2011) · PubMed Central · Cited by 27
Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study
Xu, R., Hu, X., Wang, T., Yang, Y., Nan, J., Luo, J., Zhang, X., Patel, A. B., Dmytriw, A. A., & Jiao, L. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.804851 · Cited by 27
Secondary Stroke Prevention
Rincón, F., & Sacco, R. L. (2008) · The Journal of Cardiovascular Nursing · doi:10.1097/01.jcn.0000305059.81000.d3 · Cited by 26
Self-citation
Psychometric analysis of an eating behaviour questionnaire for an overweight and obese Chinese population in Singapore
Chong, M. F., Ayob, M. N. M., Chong, K. J., Tai, E. S., Khoo, C. M., Leow, M. K., Lee, Y. S., Tham, K. W., Venkataraman, K., Meaney, M. J., et al. (2016) · Appetite · doi:10.1016/j.appet.2016.03.005 · Cited by 29
Measurement of Nutritional Status Using Body Mass Index, Waist-to-Hip Ratio, and Waist Circumference to Predict Treatment Outcome in Females and Males with Acute First-Ever Ischemic Stroke
Bembenek, J. P., Karlinski, M. A., Niewada, M., Kurkowska‐Jastrzębska, I., & Członkowska, A. (2017) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2017.08.016 · Cited by 25
Recent Trends in Inpatient Mortality and Resource Utilization for Patients with Stroke in the United States: 2005-2009
Stepanova, M., Venkatesan, C., Altaweel, L. R., Mishra, A., & Younossi, Z. M. (2013) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2013.03.005 · Cited by 24
The Combined Extract of Black Sticky Rice and Dill Improves Poststroke Cognitive Impairment in Metabolic Syndrome Condition
Ohn-on, W., Wattanathorn, J., Thukham-mee, W., Muchimapura, S., Wannanon, P., & Tong-un, T. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9089035 · Cited by 24
Go red for women
Kornacewicz-Jach, Z., Kossuth, I., & Czechowska, M. (2006) · Menopause Review/Przegląd Menopauzalny · Cited by 24
Clot or Not? Reviewing the Reciprocal Regulation Between Lipids and Blood Clotting
Zhang, Z., Rodriguez, M., & Zheng, Z. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.318286 · Cited by 30
Platelet Functions are Decreased in Obesity and Restored after Weight Loss: Evidence for a Role of the SERCA3-Dependent ADP Secretion Pathway
Elaïb, Z., López, J., Coupaye, M., Zuber, K., Becker, Y., Kondratieff, A., Repérant, C., Pépin, M., Salomon, L., Teillet, F., et al. (2019) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1677033 · Cited by 18
Association of general and abdominal obesity and their changes with stroke in Chinese adults: Results from an 11.8-year follow-up study
Liu, S., Gao, Z., Dai, Y., Guo, R., Wang, Y., Sun, Z., Xing, L., Zhang, X., Sun, Y., & Zheng, L. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.06.011 · Cited by 23
Association between metabolic syndrome and previous ischemic lesions in patients with intracranial atherosclerotic stroke.
Park, J.-H., & Kwon, H.-M. (2008) · Clinical neurology and neurosurgery (Dutch-Flemish ed. Print) · doi:10.1016/j.clineuro.2007.10.016 · Cited by 26
Gender Differences in the Association between Parental Divorce during Childhood and Stroke in Adulthood: Findings from a Population-Based Survey
Fuller‐Thomson, E., & Dalton, A. D. (2012) · International Journal of Stroke · doi:10.1111/j.1747-4949.2012.00935.x · Cited by 23
Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Laso-García, F., Diekhorst, L., Frutos, M. C. G.-D., Otero‐Ortega, L., Fuentes, B., Ares, G. R., Díez‐Tejedor, E., & Gutiérrez‐Fernández, M. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00332 · Cited by 23
Circadian-Dependent Intermittent Fasting Influences Ischemic Tolerance and Dendritic Spine Remodeling
Jeong, S., Chokkalla, A. K., Davis, C. K., Jeong, H., Chelluboina, B., Arruri, V. K., Kim, B. R., Narman, A., Bathula, S., Arumugam, T. V., et al. (2024) · Stroke · doi:10.1161/strokeaha.124.046400 · Cited by 23
Thrombosis in the setting of obesity or inflammatory bowel disease
Lentz, S. R. (2016) · Hematology · doi:10.1182/asheducation-2016.1.180 · Cited by 22
State legislators' support for evidence-based obesity reduction policies
Welch, P., Dake, J. A., Price, J. H., Thompson, A. J., & Ubokudom, S. E. (2012) · Preventive Medicine · doi:10.1016/j.ypmed.2012.09.008 · Cited by 21
Stroke: A Brain Attack
Miss.B.M.Gund, G. (2013) · IOSR Journal of Pharmacy (IOSRPHR) · doi:10.9790/3013-038201-23 · Cited by 21
Genetic Determinants of Obesity and Related Vascular Diseases
Winter, Y., Sankowski, R., & Back, T. (2013) · Vitamins and hormones · doi:10.1016/b978-0-12-407766-9.00002-x · Cited by 23
Relations of Meeting National Public Health Recommendations for Muscular Strengthening Activities With Strength, Body Composition, and Obesity: The Women's Injury Study
Trudelle-Jackson, E. J., Jackson, A. W., & Morrow, J. R. (2011) · American Journal of Public Health · doi:10.2105/ajph.2011.300175 · Cited by 20
“creased risk for chronic diseases and adverse events that include heart disease,(6,7) type 2 diabetes, cancer,(11) and stroke.(7,12) Muscle”
Guía de práctica clínica sobre prevención primaria y secundaria del ictus
Comas, D. R., Álvarez‐Sabín, J., Núñez, A. G., Abilleira, S., Pérez, F. X. B., García, P. A., Antón, E. A., Fernández, E. M., Canales, J. C. M., Ortíz, A. M., et al. (2009) · Medicina Clínica · doi:10.1016/j.medcli.2009.02.037 · Cited by 23
Obesity and Abdominal Fat Markers in Patients with a History of Stroke and Transient Ischemic Attacks
Winter, Y., Pieper, L., Klotsche, J., Riedel, O., & Wïttchen, H. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2015.12.026 · Cited by 20
Development of an Algorithm for Stroke Prediction: A National Health Insurance Database Study in Korea
Min, S. N., Park, S. J., Kim, D. J., Subramaniyam, M., & Lee, K. (2018) · European Neurology · doi:10.1159/000488366 · Cited by 20
Multimodality Stroke Prevention
Sanossian, N., & Ovbiagele, B. I. (2006) · The Neurologist · doi:10.1097/01.nrl.0000186808.07659.c7 · Cited by 20
Changing stroke mortality trends in middle-aged people: an age–period–cohort analysis of routine mortality data in persons aged 40 to 69 in England
Sutton, C., Marsden, J., Watkins, C., Leathley, M., & Dey, P. (2009) · Journal of Epidemiology and Community Health · doi:10.1136/jech.2008.086785 · Cited by 19
“[26] However, although there is strong evidence that obesity is associated with an increased risk of stroke mortality,[27] the evidence to support an independent association is conflicting.[28,29] Some suggest that this may be due to the attenuating effect of other risk factors, such as diabetes and hypertension, whic…”
Background
The Obesity Epidemic: Scope of the Problem and Management Strategies
Graves, B. W. (2010) · Journal of Midwifery & Women s Health · doi:10.1016/j.jmwh.2010.05.001 · Cited by 19
Sex Differences of Combined Effects Between Hypertension and General or Central Obesity on Ischemic Stroke in a Middle-Aged and Elderly Population
Chen, M., Shi, W., Wang, H., & Sun, Y. (2021) · Clinical Epidemiology · doi:10.2147/clep.s295989 · Cited by 18
Associations of BMI with all-cause mortality in normoglycemia, impaired fasting glucose and type 2 diabetes mellitus among an elderly Chinese population: a cohort study
Song, R., Chen, X., He, K., Hu, X., Bai, K., Shi, W., & Shi, S. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03382-z · Cited by 19
Association between cytochrome P450 promoter polymorphisms and ischemic stroke.
Kim, S. K., Yim, S.-V., & Lee, B.-C. (2012) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2011.388 · Cited by 18
“Potent independent risk factors for IS include abdominal obesity and body mass index (BMI) (6,7).”
Background
Stroke risk in poliomyelitis survivors: a nationwide population-based study.
Wu, C.-H., Liou, T.-H., Chen, H.-H., Sun, T.-Y., Chen, K.-H., & Chang, K. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2012.06.020 · Cited by 19
Applying mutual information for discretization to support the discovery of rare-unusual association rule in cerebrovascular examination dataset
Wulandari, C. P., Ouyang, C., & Wang, H. (2018) · Expert Systems with Applications · doi:10.1016/j.eswa.2018.09.044 · Cited by 18
Digestion of starch in a dynamic small intestinal model
Jaime-Fonseca, M. R., Gouseti, O., Fryer, P., Wickham, M., & Bakalis, S. (2016) · European Journal of Nutrition · doi:10.1007/s00394-015-1044-5 · Cited by 18
Increases in waist circumference independent of weight in Mongolia over the last decade: the Mongolian STEPS surveys
Chimeddamba, O., Gearon, E., Brilleman, S. L., Tumenjargal, E., & Peeters, A. (2017) · BMC Obesity · doi:10.1186/s40608-017-0155-3 · Cited by 17
Regional fat localizations and racial/ethnic variations in odds of hypertension in at-risk American adults
Okosun, I. S., Boltri, J. M., Hepburn, V. A., Eriksen, M. P., & Davis‐Smith, M. (2006) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001993 · Cited by 17
Stopping the cardiovascular disease continuum: Focus on prevention
Chrysant, S. G. (2010) · World Journal of Cardiology · doi:10.4330/wjc.v2.i3.43 · Cited by 19
Stroke: Epidemiology, Risk Factors, Signaling Pathways, and Clinical Management
Ren, H., Liu, Y., Zhao, M., Shen, H., Nie, S., Gao, X., & Huang, Y. (2025) · MedComm · doi:10.1002/mco2.70558 · Cited by 24
Antiplatelets and profibrinolytic activity ofCitrullus colocynthisin control and high-fat diet-induced obese rats: mechanisms of action
Alhawiti, N. M. (2017) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2017.1369999 · Cited by 16
Association between Stroke and Abdominal Obesity in the Middle-Aged and Elderly Korean Population: KNHANES Data from 2011–2019
Kim, J. Y., Cho, S. M., Yoo, Y., Lee, T., & Kim, J.-K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19106140 · Cited by 16
“[11] analyzed subjects enrolled in the Northern Manhattan Stroke Study (NOMASS) and demonstrated that abdominal obesity is an independent and potent risk factor for ischemic stroke.”
Background
A new synthetic matrix metalloproteinase inhibitor reduces human mesenchymal stem cell adipogenesis
Bosco, D. B., Roycik, M. D., Jin, Y., Schwartz, M. A., Lively, T. J., Zorio, D. A. R., & Sang, Q. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172925 · Cited by 17
Which dietary and lifestyle behaviours may be important in the aetiology (and prevention) of stroke?
Yau, W. Y., & Hankey, G. J. (2010) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2010.05.014 · Cited by 16
Prevalence of Metabolic Syndrome and Related Risk Factors of Elderly Residents in Andong Rural Area 1. Based on the Anthropometric Measurements and Health Behaviors
Lee, H.-S., & Kwon, C.-S. (2010) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2010.39.4.511 · Cited by 16
“복부비만은 심 혈관 질환, 당뇨병, 암 등의 이환율과 치사율을 증가시키는 데 반해(27,28), 운동은 복부비만을 감소시킬 뿐 아니라 혈액 의 지질치도 개선하는 효과가 있는 것으로 알려져 있다(29).”
A large-scale study on relationship between cerebral blood flow velocity and blood pressure in a natural population
Zhang, P., Huang, Y., Li, Y., Lu, M., & Wu, Y. (2006) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002068 · Cited by 16

Authors: Suk, S.-H., Sacco, R. L., Boden-Albala, B., Cheun, J. F., Pittman, J. G., Elkind, M. S., & Paik, M. C.
Affiliations: Wonkwang University (KR)
ORCID: Suk, Seung-Han
Boden-Albala, Bernadette
Elkind, Mitchell S.
Paik, Myunghee C.
Venue: Stroke
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-07
Volume: 34
Issue: 7
Pages: 1586-1592
ISSN: 0039-2499 (ISSN-L)
1524-4628
DOI: 10.1161/01.str.0000075294.98582.2f
OpenAlex: W1972527308
Cited by: 420
References: 49
Citations by year: 2026: 11 · 2025: 17 · 2024: 11 · 2023: 5 · 2022: 12 · 2021: 21 · 2020: 13 · 2019: 14 · 2018: 11 · 2017: 17 · 2016: 21 · 2015: 22 · 2014: 27 · 2013: 18 · 2012: 18
FWCI: 13.39
Type: journal article
Language: en
Open access: closed
Locations: Stroke (publishedVersion)
PubMed (publishedVersion)
Funders: Wonkwang University
National Institute of Neurological Disorders and Stroke (R01NS029993, R01-NS 29993)
Topics: Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords: abdominal obesity, ischemic stroke, waist-to-hip ratio, stroke risk factors, body mass index, large artery atherosclerotic stroke, racial and ethnic differences, age differences, multi-ethnic communities, Northern Manhattan, young adults, sex differences, community control, body fat distribution, cardiovascular risk stratification, stroke prevention, stroke rehabilitation
MeSH terms: Abdomen, Aged, Black or African American, Body Constitution, Brain Ischemia, Demography, Female, Hispanic or Latino, Humans, Male, New York City, Obesity, Risk Factors, Comorbidity, Body Mass Index, Incidence, Odds Ratio, Case-Control Studies, Age Distribution, Sex Distribution, Stroke, Black People, White People

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Abdominal Obesity and Risk of Ischemic Stroke: The Northern Manhattan Stroke Study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks