The use of telomere length as a predictive biomarker for injury prognosis in juvenile rats following a concussion/mild traumatic brain injury

Hehar, Harleen; Mychasiuk, Richelle

doi:10.1016/j.nbd.2015.12.007

Cited by 60Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesTelomeres, Telomerase, and Senescence

The use of telomere length as a predictive biomarker for injury prognosis in juvenile rats following a concussion/mild traumatic brain injury

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Hehar, Harleen, Mychasiuk, Richelle·2016·Neurobiology of Disease

DOI 10.1016/j.nbd.2015.12.007

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Abstract

Telomeres were originally believed to be passive players in cellular replication, but recent research has highlighted their more active role in epigenetic patterning and promotion of cellular growth and survival. Furthermore, literature demonstrates that telomere length (TL) is responsive to environmental manipulations such as prenatal stress and dietary programming. As the search for a prognostic biomarker of concussion has had limited success, this study sought to examine whether or not telomere length (TL) could be an efficacious predictor of symptom severity in juvenile rats following concussion. Rats from four distinct experimental groups (caloric restriction (CR), high fat diet (HFD), exercise (EX), and standard controls (STD)) received a mild traumatic brain injury (mTBI)/concussion and were then subjected to a behavioural test battery. The test battery was scored and the animals were categorized as poor, average, or good, based on their performance on the 6 tests examined. Skin cells (from ear notch samples) were taken 17days post-injury and DNA was extracted for telomere length analysis. Ear notch skin cell TL was highly correlated with brain tissue TL for a given individual. Animals in the CR and EX cohorts had significantly longer telomeres, while animals in the HFD cohort had significantly shorter telomeres, when compared to controls. The mTBI/concussion reduced TL in all cohorts except the EX group. A significant linear relationship was found between TL and performance on the behavioural test battery, whereby shorter telomeres were associated with poorer performance and longer telomeres with better performance. As performance on the test battery is linked to symptom severity, this study found TL to be a reasonable tool for concussion prognosis. Future studies with human populations should examine the validity of TL in peripheral cells, as a predictor of concussion pathology.

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Evidence of reductions in telomere length and deficiencies in DNA repair following TBI could predispose neural cells to senescence.
“There is evidence of reductions in telomere length and deficiencies in DNA repair following TBI which could predispose neural cells to senescence [124–126].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [125]

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Telomere Length Associates With Symptom Severity After Mild Traumatic Brain Injury in Older Adults
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Possibile relazione tra decadimento cognitivo e lunghezza dei telomeri Possible relationship between cognitive impairment and telomere length
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Authors: Hehar, H., & Mychasiuk, R.
Affiliations: University of Calgary (CA)
Corresponding author: Mychasiuk, Richelle
ORCID: Mychasiuk, Richelle
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2016-03
Volume: 87
Pages: 11-18
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/j.nbd.2015.12.007
OpenAlex: W2208667142
Cited by: 60
References: 68
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 11 · 2019: 10 · 2018: 4 · 2017: 5 · 2016: 2
FWCI: 2.88
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Canadian Institute for Health Research
Alberta Children's Hospital Research Institute
Markin USRP for Health and Wellness
Topics: Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords: telomere length, concussion, mild traumatic brain injury, prognostic factors, symptom severity, young rats, caloric restriction, high-fat diet, physical activity, epigenetics, peripheral blood cells, behavioral performance
MeSH terms: Animals, Brain Concussion, Diet, Reducing, Disease Models, Animal, Ear, Female, Male, Motor Activity, Prognosis, Random Allocation, Severity of Illness Index, Skin, Cohort Studies, Linear Models, Telomere, Rats, Sprague-Dawley, Maze Learning, Recovery of Function, Diet, High-Fat, Telomere Shortening

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The use of telomere length as a predictive biomarker for injury prognosis in juvenile rats following a concussion/mild traumatic brain injury

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