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Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment
Abstract
Background— Cerebrovascular disease (CVD) and ischemic brain injury secondary to cardiovascular disease are common causes of dementia and cognitive decline in the elderly. CVD also contributes to cognitive loss in Alzheimer disease (AD). Summary— Progress in understanding vascular cognitive impairment (VCI) and vascular dementia (VaD) has resulted in promising symptomatic and preventive treatments. Cholinergic deficits in VaD due to ischemia of basal forebrain nuclei and cholinergic pathways can be treated with cholinesterase inhibitors used in AD. Controlled clinical trials with donepezil and galantamine in patients with VaD, as well as in patients with AD plus CVD, have demonstrated improvement in cognition, behavior, and activities of daily living. The N -methyl- d -aspartate receptor antagonist memantine stabilized progression of VaD compared with placebo. Primary and secondary stroke prevention, in particular with control of hypertension and hyperlipidemia, can decrease VaD incidence. Conclusions— From a public health viewpoint, recognition of VCI before the development of dementia and correction of vascular burden on the brain may lead to a global decrease of incident dementia.
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“Management of vascular risks and symptomatic pharmacotherapy targeting VaD has been the primary approach.390”
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Cites
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921
Self-citationBlessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117
. Cerebral blood flow in dementia.
Hachinski, V. C., Iliff, L. D., Zilhka, E., Du Boulay, G. H., McAllister, V. L., Marshall, J., Russell, R. W. R., & Symon, L. (1975) · Archives of Neurology · doi:10.1001/archneur.1975.00490510088009 · Cited by 3,186
Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>
Snowdon, D. A. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340047031 · Cited by 1,590
(2001) · The Lancet · doi:10.1016/s0140-6736(00)03589-3 · Cited by 1,338
Chui, H. C., Victoroff, J. I., Margolin, D., Jagust, W., Shankle, R., & Katzman, R. (1992) · Neurology · doi:10.1212/wnl.42.3.473 · Cited by 1,201
O'Brien, J. T., Erkinjuntti, T., Reisberg, ., Román, G. C., Pantoni, L., Bowler, J., Ballard, C., DeCarli, C., Gorelick, P., Rockwood, K., et al. (2014) · International Journal of Stroke · doi:10.1111/ijs.12374_18 · Cited by 1,165
Self-citationO'Brien, J. T., Erkinjuntti, T., Reisberg, B., Roman, G., Sawada, T., Pantoni, L., Bowler, J. V., Ballard, C., DeCarli, C., Gorelick, P. B., et al. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00305-3 · Cited by 1,139
Self-citationSubcortical ischaemic vascular dementia
Román, G. C., Erkinjuntti, T., Wallin, A., Pantoni, L., & Chui, H. C. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00190-4 · Cited by 1,067
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Research works printed but not linked: 11
- 10.1161/str.28.4.729 · DOI
- Erkinjuntti T, Hachinski VC. Rethinking vascular dementia. Cerebrovasc Dis. 1993; 3: 3–23.
- 10.1161/str.31.12.2952 · DOI
- 10.1161/str.33.3.862 · DOI
- 10.1161/str.27.8.1283 · DOI
- Ferris S Gauthier S. Cognitive outcome measures in vascular dementia. In: Erkinjuntii T Gauthier S eds. Vascular Cognitive Impairment. London UK: Martin Duniz Ltd; 2002: 395–400.
- Chui E Yastrubetskaya O Williams M. Pharmacotherapy of mood and behavior symptoms. In: Erkinjuntti T Gauthier S eds. Vascular Cognitive Impairment. London UK: Martin Duniz Ltd; 2002: 597–605.
- Gauthier S Gélinas I. Evaluation of daily activities in vascular cognitive impairment. In: Erkinjuntti T Gauthier S eds. Vascular Cognitive Impairment. London UK: Martin Duniz Ltd; 2002: 411–416.
- Görtelmeyer R, Erbler H. Memantine in treatment of mild to moderate dementia syndrome. Drug Res. 1992; 42: 904–912.
- Court JA Perry EK Kalaria RN. Neurotransmitter control of the cerebral vasculature and abnormalities in vascular dementia. In: Erkinjuntti T Gauthier S eds. Vascular Cognitive Impairment. London UK: Martin Duniz Ltd; 2002: 167–185.
- Rockwood K. Clinical meaningfulness in relation to the size of the treatment effect of cholinesterase inhibition on cognition in Alzheimer’s disease. Neurobiol Aging. 2002; 23: S168, 628.
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Larner, A. J. (2011) · Springer eBooks · doi:10.1007/978-1-4471-2377-4_6
Sullivan, V., Majumdar, B., Richman, A. V., & Vinjamuri, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108594714.016
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Estol, C. J. (2005) · International Journal of Stroke · doi:10.1111/j.1747-4949.2005.00010.x
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Joshi, S. M., McKee, A. M., Ille, S., Buss, K., Beach, T. G., Serrano, G. E., & Jadavji, N. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.21.689865
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Metadata
- Authors
- Erkinjuntti, T., Román, G., Gauthier, S., Feldman, H., & Rockwood, K.
- Affiliations
- Dalhousie University (CA)
- From Helsinki University Central Hospital, Helsinki, Finland (T.E.); University of Texas Health Science Center at San Antonio and A. Murphy Veterans Administration Hospital, San Antonio, Tex (G.R.); Alzheimer’s Disease Research Unit, McGill Centre for Studies on Aging, Montreal, Quebec, Canada (S.G.); Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada (H.F.); and Queen Elizabeth II Health Science Centre, Geriatric Medicine Research Unit, Dalhousie University,...
- Venue
- Stroke
- Published
- 2004-04
- Volume
- 35
- Issue
- 4
- Pages
- 1010-1017
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2167597327
- Cited by
- 232
- References
- 85
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 38 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 5 · 2013: 10 · 2012: 9
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- vascular dementia, vascular cognitive impairment, cholinesterase inhibitors, donepezil, galantamine, memantine, NMDA receptor antagonists, Alzheimer's disease, cerebrovascular disease, stroke prevention, hypertension, hyperlipidemia, cholinergic deficit, dementia prevention
- MeSH terms
- Rivastigmine, Donepezil, Carbamates, Cardiovascular Diseases, Cerebrovascular Disorders, Cholinesterase Inhibitors, Cognition Disorders, Galantamine, Humans, Indans, Terminology as Topic, Piperidines, Risk Factors, Dementia, Vascular, Controlled Clinical Trials as Topic, Stroke, Phenylcarbamates
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