Cited by 232Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsNeuroprotection in Cerebral Ischemia

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment

Erkinjuntti, Timo, Román, Gustavo, Gauthier, Serge, Feldman, Howard, Rockwood, Kenneth·2004·Stroke

DOI 10.1161/01.str.0000120731.88236.33

Open this paper in CoChat — free account

Abstract

Background— Cerebrovascular disease (CVD) and ischemic brain injury secondary to cardiovascular disease are common causes of dementia and cognitive decline in the elderly. CVD also contributes to cognitive loss in Alzheimer disease (AD). Summary— Progress in understanding vascular cognitive impairment (VCI) and vascular dementia (VaD) has resulted in promising symptomatic and preventive treatments. Cholinergic deficits in VaD due to ischemia of basal forebrain nuclei and cholinergic pathways can be treated with cholinesterase inhibitors used in AD. Controlled clinical trials with donepezil and galantamine in patients with VaD, as well as in patients with AD plus CVD, have demonstrated improvement in cognition, behavior, and activities of daily living. The N -methyl- d -aspartate receptor antagonist memantine stabilized progression of VaD compared with placebo. Primary and secondary stroke prevention, in particular with control of hypertension and hyperlipidemia, can decrease VaD incidence. Conclusions— From a public health viewpoint, recognition of VCI before the development of dementia and correction of vascular burden on the brain may lead to a global decrease of incident dementia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.str.0000120731.88236.33

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568
Vascular dementia: Diagnostic criteria for research studies: Report of the NINDS‐AIREN International Workshop*
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921
Self-citation
The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117
. Cerebral blood flow in dementia.
Hachinski, V. C., Iliff, L. D., Zilhka, E., Du Boulay, G. H., McAllister, V. L., Marshall, J., Russell, R. W. R., & Symon, L. (1975) · Archives of Neurology · doi:10.1001/archneur.1975.00490510088009 · Cited by 3,186
Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>
Snowdon, D. A. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340047031 · Cited by 1,590
Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales
(2001) · The Lancet · doi:10.1016/s0140-6736(00)03589-3 · Cited by 1,338
Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers
Chui, H. C., Victoroff, J. I., Margolin, D., Jagust, W., Shankle, R., & Katzman, R. (1992) · Neurology · doi:10.1212/wnl.42.3.473 · Cited by 1,201
Vascular Cognitive Impairment
O'Brien, J. T., Erkinjuntti, T., Reisberg, ‌., Román, G. C., Pantoni, L., Bowler, J., Ballard, C., DeCarli, C., Gorelick, P., Rockwood, K., et al. (2014) · International Journal of Stroke · doi:10.1111/ijs.12374_18 · Cited by 1,165
Self-citation
Vascular cognitive impairment
O'Brien, J. T., Erkinjuntti, T., Reisberg, B., Roman, G., Sawada, T., Pantoni, L., Bowler, J. V., Ballard, C., DeCarli, C., Gorelick, P. B., et al. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00305-3 · Cited by 1,139
Self-citation
Subcortical ischaemic vascular dementia
Román, G. C., Erkinjuntti, T., Wallin, A., Pantoni, L., & Chui, H. C. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00190-4 · Cited by 1,067
Self-citation

Show all 85 references

Research works printed but not linked: 11

10.1161/str.28.4.729 · DOI
Erkinjuntti T, Hachinski VC. Rethinking vascular dementia. Cerebrovasc Dis. 1993; 3: 3–23.
10.1161/str.31.12.2952 · DOI
10.1161/str.33.3.862 · DOI
10.1161/str.27.8.1283 · DOI
Ferris S Gauthier S. Cognitive outcome measures in vascular dementia. In: Erkinjuntii T Gauthier S eds. Vascular Cognitive Impairment. London UK: Martin Duniz Ltd; 2002: 395–400.
Chui E Yastrubetskaya O Williams M. Pharmacotherapy of mood and behavior symptoms. In: Erkinjuntti T Gauthier S eds. Vascular Cognitive Impairment. London UK: Martin Duniz Ltd; 2002: 597–605.
Gauthier S Gélinas I. Evaluation of daily activities in vascular cognitive impairment. In: Erkinjuntti T Gauthier S eds. Vascular Cognitive Impairment. London UK: Martin Duniz Ltd; 2002: 411–416.
Görtelmeyer R, Erbler H. Memantine in treatment of mild to moderate dementia syndrome. Drug Res. 1992; 42: 904–912.
Court JA Perry EK Kalaria RN. Neurotransmitter control of the cerebral vasculature and abnormalities in vascular dementia. In: Erkinjuntti T Gauthier S eds. Vascular Cognitive Impairment. London UK: Martin Duniz Ltd; 2002: 167–185.
Rockwood K. Clinical meaningfulness in relation to the size of the treatment effect of cholinesterase inhibition on cognition in Alzheimer’s disease. Neurobiol Aging. 2002; 23: S168, 628.

Sorted by citations

Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811
Risk of dementia in diabetes mellitus: a systematic review
Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C., & Scheltens, P. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70284-2 · Cited by 2,187
White Matter Lesions and Glial Activation in a Novel Mouse Model of Chronic Cerebral Hypoperfusion
Shibata, M., Ohtani, R., Ihara, M., & Tomimoto, H. (2004) · Stroke · doi:10.1161/01.str.0000143725.19053.60 · Cited by 583
Smoking and increased Alzheimer's disease risk: A review of potential mechanisms
Durazzo, T. C., Mattsson, N., Weiner, M. W., & Initiative, A. D. N. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.009 · Cited by 501
Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study
Diener, H.-C., Sacco, R. L., Yusuf, S., Cotton, D., Ôunpuu, S., Lawton, W. A., Palesch, Y., Martin, R. H., Albers, G. W., Bath, P., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70198-4 · Cited by 359
Vascular cognitive impairment: current concepts and clinical developments
Moorhouse, P., & Rockwood, K. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70040-1 · Cited by 358
Self-citation
Vascular Dysfunction in Alzheimer’s Disease: A Prelude to the Pathological Process or a Consequence of It?
Govindpani, K., McNamara, L. G., Smith, N. R., Vinnakota, C., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050651 · Cited by 281
Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?
Biessels, G. J., & Kappelle, L. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331041 · Cited by 293
Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson’s disease dementia
Kandiah, N., Pai, M.-C., Senanarong, V., Looi, I., Ampil, E. R., Park, K. W., Karanam, A. K., & Christopher, S. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s129145 · Cited by 232
Consensus statement for diagnosis of subcortical small vessel disease
Rosenberg, G. A., Wallin, A., Wardlaw, J. M., Markus, H. S., Montaner, J., WOLFSON, L. I., Iadecola, C., Zloković, B. V., Joutel, A., Dichgans, M., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.172 · Cited by 228
Vascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia.
Román, G. C., & Kalaria, R. N. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.004 · Cited by 213
Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies
Anderson, C., Teo, K., Gao, P., Arima, H., Dans, A., Unger, T., Commerford, P., Dyal, L., Schumacher, H., Pogue, J., et al. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70250-7 · Cited by 216
A Review for the Pharmacological Effect of Lycopene in Central Nervous System Disorders
Chen, D., Huang, C., & Chen, Z. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.151 · Cited by 206
The impact of cerebrovascular aging on vascular cognitive impairment and dementia
Yang, T., Sun, Y., Lu, Z., Leak, R. K., & Zhang, F. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.007 · Cited by 214
Clinical Determinants of Dementia and Mild Cognitive Impairment following Ischaemic Stroke: The Sydney Stroke Study
Sachdev, P. S., Brodaty, H., Valenzuela, M., Lorentz, L., Looi, J. C., Berman, K., Ross, A., Wen, W., & Zagami, A. S. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000091434 · Cited by 201
Donepezil in Alzheimer’s disease: from conventional trials to pharmacogenetics
Cacabelos, R. (2007) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a908 · Cited by 196
Determinants of vascular dementia in the Cardiovascular Health Cognition Study
Kuller, L. H., Lopez, O. L., Jagust, W. J., Becker, J. T., DeKosky, S. T., Lyketsos, C., Kawas, C., Breitner, J. C. S., Fitzpatrick, A., & Dulberg, C. (2005) · Neurology · doi:10.1212/01.wnl.0000160115.55756.de · Cited by 179
Screening Patients with Stroke for Rehabilitation Needs: Validation of the Post-Stroke Rehabilitation Guidelines
Edwards, D. F., Hahn, M. G., Baum, C. M., Perlmutter, M. S., Sheedy, C., & Dromerick, A. W. (2006) · Neurorehabilitation and neural repair · doi:10.1177/1545968305283038 · Cited by 182
Astrocyte‐derived lipocalin‐2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia
Kim, J., Ko, P., Lee, H., Jeong, J., Lee, M., Kim, J., Lee, W., Yu, R., Oh, W., & Suk, K. (2017) · Glia · doi:10.1002/glia.23174 · Cited by 163
Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments: a network meta-analysis
Battle, C. E., Abdul‐Rahim, A. H., Shenkin, S. D., Hewitt, J., & Quinn, T. J. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013306.pub2 · Cited by 165
Socio-demographic and health-related factors associated with cognitive impairment in the elderly in Taiwan
Wu, M., Lan, T., Chen, C.-M., Chiu, H.-C., & Lan, T.-Y. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-22 · Cited by 144
Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?
Humpel, C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.11.032 · Cited by 126
18FDG PET in Vascular Dementia: Differentiation from Alzheimer's Disease Using Voxel-Based Multivariate Analysis
Kerrouche, N., Herholz, K., Mielke, R., Holthoff, V., & Baron, J.-C. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600296 · Cited by 120
Attenuation of brain damage and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion
Dong, Y.-F., Kataoka, K., Toyama, K., Sueta, D., Koibuchi, N., Yamamoto, E., Yata, K., Tomimoto, H., Ogawa, H., & Kim-Mitsuyama, S. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.173534 · Cited by 109
NADPH Oxidase 1, a Novel Molecular Source of ROS in Hippocampal Neuronal Death in Vascular Dementia
Choi, D.-H., Lee, K.-H., Kim, J.-H., Seo, J.-H., Kim, H. Y., Shin, C. Y., Han, J., Han, S., Kim, Y.-S., & Lee, J. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5129 · Cited by 101
Memantine Blocks Mitochondrial OPA1 and Cytochrome c Release and Subsequent Apoptotic Cell Death in Glaucomatous Retina
Ju, W., Keun-young Kim, A., Angert, M., Duong‐Polk, K., Lindsey, J. D., Ellisman, M. H., & Weinreb, R. N. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2499 · Cited by 98
Recent Updates on Subcortical Ischemic Vascular Dementia
Roh, J. H., & Lee, J.-H. (2014) · Journal of Stroke · doi:10.5853/jos.2014.16.1.18 · Cited by 93
The Combined Effect of Age, Education, and Stroke on Dementia and Cognitive Impairment No Dementia in the Elderly
Ronchi, D. D., Palmer, K., Pioggiosi, P. P., Atti, A. R., Berardi, D., Ferrari, B., Dalmonte, E., & Fratiglioni, L. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107102 · Cited by 90
The association of antihypertensive medication use with risk of cognitive decline and dementia: a meta-analysis of longitudinal studies
Chang-Quan, H., Hui, W., Chao-min, W., Zheng-Rong, W., Jun-Wen, G., Li, Y., Yan-You, L., & Qing‐Xiu, L. (2011) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2011.02810.x · Cited by 89
Acupuncture improved cognitive impairment caused by multi-infarct dementia in rats
YU, J., LIU, C., ZHANG, X., & HAN, J. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.07.015 · Cited by 85
Correction of post-stroke cognitive impairments using computer programs
Prokopenko, S. V., Mozheyko, E. Y., Петрова, М. М., Koryagina, T. D., Kaskaeva, D. S., Черных, Т. В., Shvetzova, I. N., & Bezdenezhnykh, A. F. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.12.024 · Cited by 81
Impact of Hyperbaric Oxygen Therapy on Cognitive Functions: a Systematic Review
Marcinkowska, A. B., Mankowska, N. D., Kot, J., & Winklewski, P. J. (2021) · Neuropsychology Review · doi:10.1007/s11065-021-09500-9 · Cited by 76
MRI confirms mild cognitive impairments prodromal for Alzheimer's, vascular and Parkinson-Lewy body dementias
Meyer, J. S., Huang, J., & Chowdhury, M. H. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.016 · Cited by 71
The Role of Biofeedback in Stroke Rehabilitation: Past and Future Directions
Nelson, L. A. (2007) · Topics in Stroke Rehabilitation · doi:10.1310/tsr1404-59 · Cited by 67
Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS
Mueller, S. G., Schuff, N. W., & Weiner, M. W. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1062 · Cited by 65
Early Protective Effect of Bone Marrow Mononuclear Cells Against Ischemic White Matter Damage Through Augmentation of Cerebral Blood Flow
Fujita, Y., Ihara, M., Ushiki, T., Hirai, H., Kizaka‐Kondoh, S., Hiraoka, M., Ito, H., & Takahashi, R. (2010) · Stroke · doi:10.1161/strokeaha.110.596379 · Cited by 64
Multifactorial Vascular Risk Factor Intervention to Prevent Cognitive Impairment after Stroke and TIA: A 12-month Randomized Controlled Trial
Ihle‐Hansen, H., Thommessen, B., Fagerland, M. W., Øksengård, A. R., Wyller, T. B., Engedal, K., & Fure, B. (2012) · International Journal of Stroke · doi:10.1111/j.1747-4949.2012.00928.x · Cited by 64
Treatment of dementia
Overshott, R. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.082537 · Cited by 72
Alzheimer's disease with cerebrovascular disease: current status in the Asia–Pacific region
Chen, C., Homma, A., Mok, V., Krishnamoorthy, E. S., Alladi, S., Meguro, K., Abe, K., Dominguez, J. C., Marasigan, S., Kandiah, N., et al. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12495 · Cited by 65
Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
Takahashi, H., Xia, P., Cui, J., Talantova, M. V., Bodhinathan, K., Li, W., Saleem, S., Holland, E. A., Tong, G., Piña-Crespo, J., et al. (2015) · Scientific Reports · doi:10.1038/srep14781 · Cited by 64
AD with subcortical white matter lesions and vascular dementia: CSF markers for differential diagnosis
Stefani, A., Bernardini, S., Panella, M., Pierantozzi, M., Nuccetelli, M., Koch, G., Urbani, A., Giordano, A., Martorana, A., Orlacchio, A., et al. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.05.016 · Cited by 64
Autophagy and Akt/CREB signalling play an important role in the neuroprotective effect of nimodipine in a rat model of vascular dementia
Hu, M. C., Liu, Z., Lv, P., Wang, H., Zhu, Y., Qi, Q., & Xu, J. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.11.053 · Cited by 62
Neuroprotective effect of treatment with galantamine and choline alphoscerate on brain microanatomy in spontaneously hypertensive rats
Tayebati, S. K., Tullio, M. A. D., Tomassoni, D., & Amenta, F. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.349 · Cited by 59
Cholinergic Neuronal Deficits in CADASIL
Kalaria, R. N., Keverne, J., Chuang, W., Low, R., Ziabreva, I., Court, J. A., Oakley, A. E., Wee, P., Low, C. R., Ziabreva, P. I., et al. (2015) · Cited by 59
Use of mobile applications in post-stroke rehabilitation: a systematic review
Zhou, X., Du, M., & Zhou, L. (2018) · Topics in Stroke Rehabilitation · doi:10.1080/10749357.2018.1482446 · Cited by 62
Effect of exercise-induced neurogenesis on cognitive function deficit in a rat model of vascular dementia
Choi, D., Lee, K. H., & Lee, J. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4891 · Cited by 54
Cholinesterase inhibitors: beyond Alzheimer’s disease
Larner, A. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.105 · Cited by 47
Cholinergic dysfunction in vascular dementia
Román, G. C. (2005) · Current Psychiatry Reports · doi:10.1007/s11920-005-0019-2 · Cited by 51
Rapamycin alleviates cognitive impairment in murine vascular dementia: The enhancement of mitophagy by PI3K/AKT/mTOR axis
Zheng, G., Wang, L., Li, X., Niu, X., Xu, G., & Lv, P. (2020) · Tissue and Cell · doi:10.1016/j.tice.2020.101481 · Cited by 52
Cholinesterases in human brain: the effect of cholinesterase inhibitors on Alzheimer's disease and related disorders
Giacobini, E. (2006) · CRC Press eBooks · doi:10.1201/b14486-19 · Cited by 50
Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study
Yang, J., Wang, X., Zhang, M., Xiao, L., Zhu, W. X., Ji, C., & Liu, C. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13063 · Cited by 48
Cholinergic Neuronal Deficits in CADASIL
Keverne, J. S., Low, W. C. R., Ziabreva, I., Court, J. A., Oakley, A. E., & Kalaria, R. N. (2006) · Stroke · doi:10.1161/01.str.0000251787.90695.05 · Cited by 48
Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease
Aguilar-Pineda, J. A., Vera-López, K. J., Shrivastava, P., Chávez‐Fumagalli, M. Á., Nieto-Montesinos, R., Alvarez, K. L. F., Goyzueta-Mamani, L. D., Dávila-Del-Carpio, G., Gómez, B., Miller, C. L., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102993 · Cited by 44
Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance to vascular dementia and Alzheimer's disease
Pirchl, M., Marksteiner, J., & Humpel, C. (2006) · Neurological Research · doi:10.1179/016164106x130371 · Cited by 45
Disease progression in vascular cognitive impairment: Cognitive, functional and behavioural outcomes in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) cohort study
Rockwood, K. J., Moorhouse, P., Song, X., MacKnight, C., Gauthier, S. G., KERTESZ, A. E., Montgomery, P. R., Black, S. E., Hogan, D. B., Guzmán, A. E., et al. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.10.015 · Cited by 42
Self-citation
Prevention of Hippocampal Neuronal Damage and Cognitive Function Deficits in Vascular Dementia by Dextromethorphan
Xu, X., Zhang, B., Lu, K., Deng, J., Zhao, F. L., Zhao, B., & Zhao, Y. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9786-5 · Cited by 38
Validation of biomarkers in subcortical ischaemic vascular disease of the Binswanger type: approach to targeted treatment trials
Rosenberg, G. A., Prestopnik, J., Adair, J. C., Huisa, B. N., Knoefel, J. E., Caprihan, A., Gasparovic, C., Thompson, J. F., Erhardt, E. B., & Schrader, R. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-309421 · Cited by 39
Electroacupuncture Protected Pyramidal Cells in Hippocampal CA1 Region of Vascular Dementia Rats by Inhibiting the Expression of P53 and Noxa
Zhu, Y., & Zeng, Y. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00192.x · Cited by 36
Understanding brain function in vascular cognitive impairment and dementia with EEG and MEG: A systematic review
Torres-Simón, L., Doval, S., Nebreda, A., Llinas, S. J., Marsh, E. B., & Maestú, F. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103040 · Cited by 52
ACUPUNCTURE INCREASES CEREBRAL GLUCOSE METABOLISM IN HUMAN VASCULAR DEMENTIA
Huang, Y., CHEN, J., HTUT, W. M., Lai, X., & Wik, G. (2007) · International Journal of Neuroscience · doi:10.1080/00207450600936825 · Cited by 35
Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment
Dam, K., Füchtemeier, M., Farr, T. D., Boehm‐Sturm, P., Foddis, M., Dirnagl, U., Malysheva, O., Caudill, M. A., & Jadavji, N. M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.12.041 · Cited by 36
Clinical diagnosis of vascular dementia
Nagata, K., Saito, H., Ueno, T., Sato, M., Nakase, T., Maeda, T., Satoh, Y., Komatsu, H., Suzuki, M., & Kondoh, Y. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.049 · Cited by 34
Cerebrovascular disease and dementia
Onyike, C. U. (2006) · International Review of Psychiatry · doi:10.1080/09540260600935421 · Cited by 34
Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts
Weaver, N. A., Kancheva, A. K., Lim, J., Biesbroek, J. M., Wajer, I. M. C. H., Kang, Y., Kim, B. J., Kuijf, H. J., Lee, B., Lee, K., et al. (2021) · International Journal of Stroke · doi:10.1177/1747493020984552 · Cited by 34
Estrogen receptor involvement in vascular cognitive impairment and vascular dementia pathogenesis and treatment
Nguyen, D. H., Cunningham, J. T., & Sumien, N. (2020) · GeroScience · doi:10.1007/s11357-020-00263-4 · Cited by 36
Soybean Supplementation Helps Reverse Age- and Scopolamine-Induced Memory Deficits in Mice
Bansal, N., & Parle, M. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1132 · Cited by 31
APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains
Ojo, J. O., Reed, J. M., Crynen, G. C., Vallabhaneni, P., Evans, J., Shackleton, B., Eisenbaum, M., Ringland, C., Edsell, A., MULLAN, M. J., et al. (2021) · Molecular Brain · doi:10.1186/s13041-021-00803-9 · Cited by 30
Functional MR Imaging Evidence of Altered Functional Activation in Metabolic Syndrome
Hoth, K. F., Gonzales, M. M., Tarumi, T., Miles, S. C., Tanaka, H., & Haley, A. P. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2315 · Cited by 31
Rivastigmine in vascular dementia
Moretti, R., Torre, P., Antonello, R. M., Cazzato, G., & Bava, A. (2004) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.5.6.1399 · Cited by 30
Effect of Propranolol on Naming in Chronic Broca's Aphasia with Anomia
Beversdorf, D. Q., Sharma, U. K., Phillips, N. N., Notestine, M. A., Slivka, A. P., Friedman, N. M., Schneider, S. L., Nagaraja, H. N., & Hillier, A. J. (2007) · Neurocase · doi:10.1080/13554790701595471 · Cited by 29
Donepezil Effects on Cerebral Blood Flow in Older Adults With Mild Cognitive Deficits
Chen, X., Magnotta, V. A., Duff, K. M., Ponto, L. L. B., & Schultz, S. K. (2006) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.18.2.178 · Cited by 29
Beneficial Effects of Combination of Valsartan and Amlodipine on Salt-Induced Brain Injury in Hypertensive Rats
Dong, Y., Kataoka, K., Tokutomi, Y., Nako, H., Nakamura, T., Toyama, K., Sueta, D., Koibuchi, N., Yamamoto, E., Ogawa, H., et al. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.182576 · Cited by 28
Case 36-2005
Dickerson, B. C., Holtzman, D. H., Grant, P. E., & Tian, D. (2005) · New England Journal of Medicine · doi:10.1056/nejmcpc059032 · Cited by 27
Treatment of Vascular Dementia and Vascular Cognitive Impairment
Demaerschalk, B. M., & Wingerchuk, D. M. (2007) · The Neurologist · doi:10.1097/01.nrl.0000252919.46622.28 · Cited by 27
Thinking About Dementia
Leibing, A., & Cohen, L. (2020) · Rutgers University Press eBooks · doi:10.36019/9780813539270 · Cited by 27
Cognitive Change in Donepezil Treated Patients with Vascular or Mixed Dementia
Rockwood, K. J., Mitnitski, A., Black, S. E., Richard, M., & Defoy, I. (2013) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100014670 · Cited by 27
Self-citation
Matrix Metalloproteinase-Mediated Neuroinflammation in Vascular Cognitive Impairment of the Binswanger Type
Rosenberg, G. A. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0277-4 · Cited by 27
Modulation of N-Methyl-d-aspartate Receptors by Donepezil in Rat Cortical Neurons
Moriguchi, S., Zhao, X., Marszalec, W., Yeh, J. Z., & Narahashi, T. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087908 · Cited by 27
Beneficial effect of chyawanprash on cognitive function in aged mice
Bansal, N., & Parle, M. (2010) · Pharmaceutical Biology · doi:10.3109/13880209.2010.489904 · Cited by 26
The pattern of brain gray matter impairments in patients with subcortical vascular dementia
Liu, C., Li, C., Gui, L., Zhao, L., Evans, A. C., Xie, B., Zhang, J., Wei, L., Zhou, D., Wang, J., et al. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.04.017 · Cited by 26
Vascular cognitive impairment, a cardiovascular complication
Adiukwu, F. N., Ofori, S., & Ohoreorovwori, U. L. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i2.199 · Cited by 26
Effect of electroacupuncture on the expression of mTOR and eIF4E in hippocampus of rats with vascular dementia
Zhu, Y., Zeng, Y., Wang, X., & Ye, X. (2012) · Neurological Sciences · doi:10.1007/s10072-012-1209-4 · Cited by 26
Biomarkers identify the Binswanger type of vascular cognitive impairment
Erhardt, E. B., Pesko, J. C., Prestopnik, J., Thompson, J., Caprihan, A., & Rosenberg, G. A. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18762655 · Cited by 25
The use of psychotropics and survival in demented elderly individuals
Hartikainen, S. A., Rahkonen, T., Kautiainen, H., & Sulkava, R. O. (2005) · International Clinical Psychopharmacology · doi:10.1097/00004850-200507000-00006 · Cited by 25
Pharmacological, Surgical, and Neurovascular Interventions to Augment Acute Aphasia Recovery
Hillis, A. E. (2007) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0b013e31805ba094 · Cited by 24
Cerebrovascular disease, vascular cognitive impairment and dementia
Erkinjuntti, T. (2005) · Psychiatry · doi:10.1383/psyt.4.1.48.58315 · Cited by 23
Self-citation
The art of managing dementia in the elderly.
Rosenblatt, A. (2005) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.72.suppl_3.s3 · Cited by 23
Molecular Pathobiology of the Cerebrovasculature in Aging and in Alzheimers Disease Cases With Cerebral Amyloid Angiopathy
Ojo, J. O., Reed, J. M., Crynen, G. C., Vallabhaneni, P., Evans, J., Shackleton, B., Eisenbaum, M., Ringland, C., Edsell, A., MULLAN, M. J., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.658605 · Cited by 22
Driving and dementia: a clinician's guide
Wilson, S., & Pinner, G. (2013) · Advances in Psychiatric Treatment · doi:10.1192/apt.bp.111.009555 · Cited by 19
Ameliorative role of rolipram, PDE-4 inhibitor, against sodium arsenite–induced vascular dementia in rats
Virk, D., Kumar, A., Jaggi, A. S., & Singh, N. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-15189-3 · Cited by 19
Protective effect of electroacupuncture on neurons autophagy in perfusion period of cerebral ischemia
Ting, Z., Jianbin, Z., & Luqi, H. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.06.043 · Cited by 19
Vascular dementia: Diagnostic criteria and supplementary exams: Recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology. Part I.
Engelhardt, E., Tocquer, C., André, C., Moreira, D. M., Okamoto, I. H., & Cavalcanti, J. L. D. S. (2011) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642011dn05040003 · Cited by 18
Progress in Clinical Neurosciences: Canadian Guidelines for the Development of Antidementia Therapies: A Conceptual Summary
Feldman, H., Gauthier, S. G., Chertkow, H. M., Conn, D. K., Freedman, M., MacKnight, C., & Guidelines, F. T. 2. C. C. O. A. (2006) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100004649 · Cited by 18
Self-citation
Hyperbaric oxygen therapy for vascular dementia
Xiao, Y., Wang, J., Jiang, S., & Luo, H. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009425.pub2 · Cited by 17
ST 09, a Novel Thioester Derivative of Tacrine, Alleviates Cognitive Deficits and Enhances Glucose Metabolism in Vascular Dementia Rats
Liu, J., Wu, P., Rao, J., Zhou, J., Shen, Z., Luo, H., Huang, J., Liang, X., Long, L., Xie, Q., et al. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12495 · Cited by 17
Rivastigmine for subcortical vascular dementia
Román, G. C. (2005) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.5.3.309 · Cited by 17
P300 auditory event-related potentials and neuropsychological study during donepezil treatment in vascular dementia
Paci, C., Gobbato, R., Carboni, T., Sanguigni, S., Santone, A., & Curatola, L. (2006) · Neurological Sciences · doi:10.1007/s10072-006-0528-8 · Cited by 17
The Neuroprotective Effects of Danggui-Shaoyao San on Vascular Cognitive Impairment: Involvement of the Role of the Low-Density Lipoprotein Receptor-Related Protein
Cai, H., Cai, T., Zheng, H., Liu, L., Zhou, L., Xile, P., Zhan, Q., Wang, Y., Yang, C., Guo, Z., et al. (2020) · Rejuvenation Research · doi:10.1089/rej.2019.2182 · Cited by 16
Ameliorative Effect of Phosphodiesterase-5 Inhibitor in Rat Model of Vascular Dementia
Bhatia, P., & Singh, N. (2019) · Current Neurovascular Research · doi:10.2174/1567202616666190130153954 · Cited by 15
A systematic review of the efficacy of donepezil hydrochloride combined with nimodipine on treating vascular dementia
Yang, Q., Liu, J., Huang, K.-L., Wang, G., Wang, M., Tan, A.-H., & Ran, S. (2022) · Medicine · doi:10.1097/md.0000000000029307 · Cited by 15

Authors: Erkinjuntti, T., Román, G., Gauthier, S., Feldman, H., & Rockwood, K.
Affiliations: Dalhousie University (CA)
From Helsinki University Central Hospital, Helsinki, Finland (T.E.); University of Texas Health Science Center at San Antonio and A. Murphy Veterans Administration Hospital, San Antonio, Tex (G.R.); Alzheimer’s Disease Research Unit, McGill Centre for Studies on Aging, Montreal, Quebec, Canada (S.G.); Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada (H.F.); and Queen Elizabeth II Health Science Centre, Geriatric Medicine Research Unit, Dalhousie University,...
ORCID: Erkinjuntti, Timo
Gauthier, Serge
Feldman, Howard
Rockwood, Kenneth
Venue: Stroke
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-04
Volume: 35
Issue: 4
Pages: 1010-1017
ISSN: 0039-2499 (ISSN-L)
1524-4628
DOI: 10.1161/01.str.0000120731.88236.33
OpenAlex: W2167597327
Cited by: 232
References: 85
Citations by year: 2026: 1 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 38 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 5 · 2013: 10 · 2012: 9
FWCI: 13.17
Type: journal article
Language: en
Open access: closed
Locations: Stroke (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: vascular dementia, vascular cognitive impairment, cholinesterase inhibitors, donepezil, galantamine, memantine, NMDA receptor antagonists, Alzheimer's disease, cerebrovascular disease, stroke prevention, hypertension, hyperlipidemia, cholinergic deficit, dementia prevention
MeSH terms: Rivastigmine, Donepezil, Carbamates, Cardiovascular Diseases, Cerebrovascular Disorders, Cholinesterase Inhibitors, Cognition Disorders, Galantamine, Humans, Indans, Terminology as Topic, Piperidines, Risk Factors, Dementia, Vascular, Controlled Clinical Trials as Topic, Stroke, Phenylcarbamates

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks