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Cited by 301

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

In Vivo Detection of Macrophages in Human Carotid Atheroma: Temporal Dependence of Ultrasmall Superparamagnetic Particles of Iron Oxide-Enhanced MRI

Open access
Trivedi, Rikin A., U-King-Im, Jean-Marie, Graves, Martin J., Cross, Justin J., Horsley, Jo, Goddard, Martin J., Skepper, Jeremy N., Quartey, George, Warburton, Elizabeth, Joubert, Ilse, Wang, Liqun, Kirkpatrick, Peter J., Brown, John, Gillard, Jonathan H.·2004·Stroke
DOI 10.1161/01.str.0000131268.50418.b7
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Abstract

Background— It has been suggested that inflammatory cells within vulnerable plaques may be visualized by superparamagnetic iron oxide particle-enhanced MRI. The purpose of this study was to determine the time course for macrophage visualization with in vivo contrast-enhanced MRI using an ultrasmall superparamagnetic iron oxide (USPIO) agent in symptomatic human carotid disease. Methods— Eight patients scheduled for carotid endarterectomy underwent multisequence MRI of the carotid bifurcation before and 24, 36, 48, and 72 hours after Sinerem (2.6 mg/kg) infusion. Results— USPIO particles accumulated in macrophages in 7 of 8 patients given Sinerem. Areas of signal intensity reduction, corresponding to USPIO/macrophage-positive histological sections, were visualized in all 7 of these patients, optimally between 24 and 36 hours, decreasing after 48 hours, but still evident up to 96 hours after infusion. Conclusions— USPIO-enhanced MRI of carotid atheroma can be used to identify macrophages in vivo. The temporal change in the resultant signal intensity reduction on MRI suggests an optimal time window for the detection of macrophages on postinfusion imaging.

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Metadata

Authors
Trivedi, R. A., U-King-Im, J.-M., Graves, M. J., Cross, J. J., Horsley, J., Goddard, M. J., Skepper, J. N., Quartey, G., Warburton, E., Joubert, I., Wang, L., Kirkpatrick, P. J., Brown, J., & Gillard, J. H.
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-07
Volume
35
Issue
7
Pages
1631-1635
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.0000131268.50418.b7
OpenAlex
W2039963413
Cited by
301
References
13
FWCI
16.92
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: In Vivo Detection of Macrophages in Human Carotid Atheroma: Temporal Dependence of Ultrasmall Superparamagnetic Particles of Iron Oxide-Enhanced MRI. https://app.cochat.ai/papers/10.1161/01.str.0000131268.50418.b7
The paper
Trivedi, R. A., U-King-Im, J.-M., Graves, M. J., Cross, J. J., Horsley, J., Goddard, M. J., Skepper, J. N., Quartey, G., Warburton, E., Joubert, I., Wang, L., Kirkpatrick, P. J., Brown, J., & Gillard, J. H. (2004). In Vivo Detection of Macrophages in Human Carotid Atheroma: Temporal Dependence of Ultrasmall Superparamagnetic Particles of Iron Oxide-Enhanced MRI. Stroke. https://doi.org/10.1161/01.str.0000131268.50418.b7

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.